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Drug: Estradiol

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Total 251 results found since Jan 2013.

Stroke and Etonogestrel/Ethinyl Estradiol Ring (NuvaRing): Clinical, Radiological, and Prognostic Features
A recent study found that NuvaRing (a vaginal contraceptive ring containing 15  µg ethinyl estradiol and 120 µg etonogestrel) has 2.5 times increased relative risk of thrombotic stroke compared to nonuse.
Source: Journal of Stroke and Cerebrovascular Diseases - December 29, 2016 Category: Neurology Authors: Prad Selvan, Pirouz Piran, Clotilde Balucani, Brian Tark, Zachary Adler, Steven R. Levine Source Type: research

Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression
Conclusions Stroke comprises ischemic stroke and ICH. The immuno-inflammatory process is involved in neural plasticity following events such as a hemorrhage or ischemic stroke. After ischemia, astrocytes, microglia, and MDMs play important roles during rehabilitation with the modulation of cytokines or chemokines, such as TNF-α and IL-1. Moreover, MiRNAs are also important posttranscriptional regulators in these glial mitochondrial responses to cerebral ischemia. ICH involves processes similar and different to those seen in ischemia, including neuronal injury, astrocytic and microglial/macrophage activation, and n...
Source: Frontiers in Psychiatry - April 10, 2019 Category: Psychiatry Source Type: research

Increased P450 aromatase levels in post-menopausal women after acute ischemic stroke
ConclusionsEstradiol levels correlated with functional outcomes (change in mRS) in both men and women, at least in the acute phase (24  h) of stroke. However, no significant difference in estradiol levels is seen 24 h post-stroke in men or women. Testosterone levels decrease at 24 h after stroke in men. As seen in animal models, aromatase levels increase after acute ischemic stroke, but this was only true for women. These ind icate an active aromatization process in post-menopausal women after acute ischemic stroke.
Source: Biology of Sex Differences - January 7, 2021 Category: Biology Source Type: research

Use of combined hormonal contraception and stroke: A case-control study of the impact of migraine type and estrogen dose on ischemic stroke risk
CONCLUSIONS: Overall stroke risk in our cohort of CHC users was low. When CHCs are used in those with migraine, formulations containing ≤30 μg EE are preferred. Shared decision-making should include discussions about ischemic stroke risks in patients with migraine, even those without aura.PMID:36752588 | DOI:10.1111/head.14473
Source: Headache - February 8, 2023 Category: Neurology Authors: Pelin Batur Meng Yao Julia Bucklan Payal Soni Aarushi Suneja Ruth Farrell Maryann Mays Source Type: research

Stroke Characteristics, Risk Factors, and Outcomes in Transgender Adults: A Case Series
Conclusions: Understanding unique vulnerabilities of the transgender community for cerebrovascular events is essential to provide culturally appropriate counseling for harm reduction.
Source: The Neurologist - March 1, 2019 Category: Neurology Tags: Case Report/Case Series Source Type: research

Stroke and Etonogestrel/Ethinyl Estradiol Ring (NuvaRing): Clinical, Radiological, and Prognostic Features. (P2.012)
Conclusions: In this largest case series of NuvaRing associated stroke to date, approximately half of the strokes are venous and half are arterial. Stroke typically occurred within the first year of use, and as soon as 2 weeks after NuvaRing initiation.Disclosure: Dr. Piran has nothing to disclose. Dr. Balucani has nothing to disclose. Dr. Tark has nothing to disclose. Dr. Adler has nothing to disclose. Dr. Levine has received personal compensation in an editorial capacity for MedLink. Dr. Levine has received royalty payments as editor of a book.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Piran, P., Balucani, C., Tark, B., Adler, Z., Levine, S. Tags: Cerebrovascular Disease and Interventional Neurology I Source Type: research

In older men, higher plasma testosterone or dihydrotestosterone are independent predictors for reduced incidence of stroke but not myocardial infarction.
Conclusions: Higher plasma T or DHT are biomarkers for reduced risk of stroke but not MI. Androgen exposure may influence outcomes following rather than incidence of MI, while androgens but not E2 are independent predictors of stroke risk. Randomised clinical trials are needed to clarify the impact of modifying T or DHT on the risk of stroke in ageing men. PMID: 25268392 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - September 30, 2014 Category: Endocrinology Authors: Yeap BB, Alfonso H, Paul Chubb SA, Hankey GJ, Handelsman DJ, Golledge J, Almeida OP, Flicker L, Norman PE Tags: J Clin Endocrinol Metab Source Type: research

The effect of exercise preconditioning on stroke outcome in ovariectomized mice with permanent middle cerebral artery occlusion.
Abstract Exercise preconditioning has been shown to be effective in improving behavioral and neuropathological indices after cerebral ischemia. We evaluated the effect of exercise preconditioning, 17β-estradiol, and their combination on stroke outcome using an experimental model of stroke in ovariectomized (OVX) mice. OVX mice were randomly assigned to four groups as follows: control (stroke), exercise (exercise and stroke), estradiol (17β-estradiol and stroke), and exercise+estradiol (exercise and 17β-estradiol and stroke). Exercise preconditioning was performed on a treadmill five days per week, 40 min/day, a...
Source: Canadian Journal of Physiology and Pharmacology - September 5, 2017 Category: Drugs & Pharmacology Authors: Naderi S, Alimohammadi R, Hakimizadeh E, Roohbakhsh A, Shamsizadeh A, Allahtavakoli M Tags: Can J Physiol Pharmacol Source Type: research

Risk of stroke in healthy postmenopausal women during and after hormone therapy: a meta-analysis
ConclusionsThese findings suggest that HT may increase the risk of stroke during, but not after, HT in healthy postmenopausal women.
Source: Menopause - October 30, 2014 Category: OBGYN Tags: Original Articles Source Type: research

Sex Differences in the Impact of Shift Work Schedules on Pathological Outcomes in an Animal Model of Ischemic Stroke.
Abstract Circadian clock desynchronization has been implicated in the pathophysiology of cardiovascular disease and related risk factors (e.g., obesity, diabetes). Thus, we examined the extent to which circadian desynchronization exacerbates ischemic stroke outcomes and whether its detrimental effects on stroke severity and functional impairments are further modified by biological sex. Circadian entrainment of activity rhythms in all male and female rats was observed during exposure to a fixed light:dark (LD) 12:12 cycle but was severely disrupted when this LD cycle was routinely shifted (12hr advance/5d) for ≈ ...
Source: Endocrinology - June 1, 2016 Category: Endocrinology Authors: Earnest DJ, Neuendorff N, Coffman J, Selvamani A, Sohrabji F Tags: Endocrinology Source Type: research

Differential effects of aging and sex on stroke induced inflammation across the lifespan.
Abstract Aging and biological sex are critical determinants of stroke outcome. Post-ischemic inflammatory response strongly contributes to the extent of ischemic brain injury, but how this response changes with age and sex is unknown. We subjected young (5-6months), middle aged (14-15months) and aged (20-22months), C57BL/6 male and female mice to transient middle cerebral artery occlusion (MCAO) and found that a significant age by sex interaction influenced histological stroke outcomes. Acute functional outcomes were worse with aging. Neutrophils, inflammatory macrophages, macrophages, dendritic cells (DCs) and mi...
Source: Experimental Neurology - August 29, 2013 Category: Neurology Authors: Manwani B, Liu F, Scranton V, Hammond MD, Sansing LH, McCullough LD Tags: Exp Neurol Source Type: research

Associations of Endogenous Estradiol and Testosterone Levels with Plaque Composition and Risk of Stroke in Subjects with Carotid Atherosclerosis.
Conclusions: TE was associated with presence of vulnerable carotid plaque as well as increased risk of stroke in women, whereas no consistent associations were found for TT in either sex. PMID: 29097437 [PubMed - as supplied by publisher]
Source: Circulation Research - November 2, 2017 Category: Cardiology Authors: Glisic M, Mujaj B, Rueda-Ochoa OL, Asllanaj E, Laven JS, Kavousi M, Ikram MK, Vernooij MW, Ikram MA, Franco OH, Bos D, Muka T Tags: Circ Res Source Type: research

Selective Non-nuclear Estrogen Receptor Activation Decreases Stroke Severity and Promotes Functional Recovery in Female Mice.
Abstract Estrogens provide neuroprotection in animal models of stroke, but uterotrophic effects and cancer risk limit translation. Classical estrogen receptors (ER) serve as transcription factors, whereas non-nuclear ER govern numerous cell processes and exert beneficial cardiometabolic effects without uterine or breast cancer growth in mice. Here we determined how non-nuclear ER stimulation with a pathway-preferential estrogen (PaPE-1) impacts stroke outcome in mice.Ovariectomized female mice received vehicle, estradiol (E2), or PaPE-1 before and following transient middle cerebral artery occlusion (tMCAo). MRI a...
Source: Endocrinology - September 25, 2018 Category: Endocrinology Authors: Selvaraj UM, Zuurbier K, Whoolery C, Plautz EJ, Chambliss KL, Kong X, Zhang S, Kim SH, Katzenellenbogen BS, Katzenellenbogen JA, Mineo C, Shaul PW, Stowe AM Tags: Endocrinology Source Type: research

Exploring Active Compounds and Mechanisms of Angong Niuhuang Wan on Ischemic Stroke Based on Network Pharmacology and Molecular Docking
CONCLUSION: In conclusion, the bioinformatics and pharmacological results reveal that counteracting oxidative stress, suppressing inflammation, inhibiting the development of AS, and even protecting neurological function are critical pathways for ANW in the treatment of ischemic stroke. These results may help to elucidate the mechanism of ANW on ischemic stroke for experimental studies and clinical applications.PMID:35388303 | PMC:PMC8977296 | DOI:10.1155/2022/2443615
Source: Evidence-based Complementary and Alternative Medicine - April 7, 2022 Category: Complementary Medicine Authors: Yasu Zhang Xiaomin Liu Junzi Long Xue Cheng Xinyu Wang Xiaodong Feng Source Type: research