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Drug: Folic Acid

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Total 203 results found since Jan 2013.

Folic acid reduces doxorubicin-induced cardiomyopathy by modulating endothelial nitric oxide synthase.
Abstract The use of doxorubicin (DOXO) as a chemotherapeutic drug has been hampered by cardiotoxicity leading to cardiomyopathy and heart failure. Folic acid (FA) is a modulator of endothelial nitric oxide (NO) synthase (eNOS), which in turn is an important player in diseases associated with NO insufficiency or NOS dysregulation, such as pressure overload and myocardial infarction. However, the role of FA in DOXO-induced cardiomyopathy is poorly understood. The aim of this study was to test the hypothesis that FA prevents DOXO-induced cardiomyopathy by modulating eNOS and mitochondrial structure and function. Male...
Source: J Cell Mol Med - June 13, 2017 Category: Molecular Biology Authors: Octavia Y, Kararigas G, de Boer M, Chrifi I, Kietadisorn R, Swinnen M, Duimel H, Verheyen FK, Brandt MM, Fliegner D, Cheng C, Janssens S, Duncker DJ, Moens AL Tags: J Cell Mol Med Source Type: research

B vitamins and cognition in subjects with small vessel disease: A Substudy of VITATOPS, a randomized, placebo-controlled trial
VITAmins TO Prevent Stroke (VITATOPS) study, a randomized, double-blind international multi-centre trial involving 8164 subjects in studying effect of lowering homocysteine level by daily administration of B-vitamins (2mg folic acid, 25mg vitamin B6, and 0.5mg vitamin B12) failed to demonstrate a positive effect of B-vitamins in reducing incidence of major vascular events and global cognition decline as measured by mini-mental state examination (MMSE) score [1,2]. However, assessment of cognition using MMSE alone has its limitations and a full neuropsychological assessment of different cognitive domains will provide more robust evidence.
Source: Journal of the Neurological Sciences - May 30, 2017 Category: Neurology Authors: Simon Kang Seng Ting, Arul Earnest, Huihua Li, Shahul Hameed, Hui Meng Chang, Christopher Li Hsian Chen, Eng-King Tan Tags: Letter to the Editor Source Type: research

B vitamins and cognition in subjects with small vessel disease: An extension study of VITATOPS, a randomized, placebo-controlled trial
VITAmins TO Prevent Stroke (VITATOPS) study, a randomized, double-blind international multi-centre trial involving 8164 subjects in studying effect of lowering homocysteine level by daily administration of B-vitamins (2mg folic acid, 25mg vitamin B6, and 0.5mg vitamin B12) failed to demonstrate a positive effect of B-vitamins in reducing incidence of major vascular events and global cognition decline as measured by mini-mental state examination (MMSE) score [1,2]. However, assessment of cognition using MMSE alone has its limitations and a full neuropsychological assessment of different cognitive domains will provide more robust evidence.
Source: Journal of the Neurological Sciences - May 30, 2017 Category: Neurology Authors: Simon Kang Seng Ting, Arul Earnest, Huihua Li, Shahul Hameed, Hui Meng Chang, Christopher Li Hsian Chen, Eng-King Tan Tags: Letter to the Editor Source Type: research

Swallowing difficulty and nutrient intakes among residents in assisted living facilities in Helsinki
Conclusion Although malnutrition was more common among those with SWD than those without, the daily intakes of energy, protein and micronutrients were similar in these groups, highlighting that the risk of malnutrition and low nutrient intakes commonly occurred in both groups of residents in assisted living facilities.
Source: European Geriatric Medicine - May 11, 2017 Category: Geriatrics Source Type: research

Meta-analysis of folic acid efficacy trials in stroke prevention: Insight into effect modifiers
Conclusions: Folic acid supplementation could reduce the stroke risk in regions without folic acid fortification, particularly in trials using a relatively low dosage of folic acid and with low vitamin B12 levels.
Source: Neurology - May 8, 2017 Category: Neurology Authors: Zhao, M., Wu, G., Li, Y., Wang, X., Hou, F. F., Xu, X., Qin, X., Cai, Y. Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Clinical trials Randomized controlled (CONSORT agreement), All epidemiology ARTICLE Source Type: research

Early Carotid Occlusion After Endarterectomy in a Patient With a Mutation for MTHFR A1298C Polymorphism
Conclusions: Even if the association between homocysteine and carotid restenosis after CEA is unclear, an initial screening before the surgical procedure could be useful to promptly treat this condition and probably reduce the risk of this complication. In the case of homozygous mutation, the selection of patients and the appropriate therapy could reduce the risk of carotid restenosis.
Source: The Neurologist - May 1, 2017 Category: Neurology Tags: Case Report/Case Series Source Type: research

Folic acid therapy reduces the risk of mortality associated with heavy proteinuria among hypertensive patients
Objective: We aimed to evaluate whether proteinuria and estimated glomerular filtration rate (eGFR) levels can modify the efficacy of folic acid therapy on the risk of all-cause mortality among hypertensive patients in the China Stroke Primary Prevention Trial, a randomized, double-blind, and controlled trial. Methods: A total of 20 702 hypertensive patients without a history of major cardiovascular diseases were randomly assigned to a double-blind daily treatment of a single tablet containing 10-mg enalapril and 0.8-mg folic acid (n = 10 348), or 10-mg enalapril alone (n = 10 354). All-cause mortality, a pr...
Source: Journal of Hypertension - April 26, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Kidney Source Type: research

Homocysteine and Stroke Risk Clinical Sciences
Conclusions—In Chinese hypertensive patients, the effect of homocysteine on the first stroke was significantly modified by the methylenetetrahydrofolate reductase C677T genotype and folic acid supplementation. Such information may help to more precisely predict stroke risk and develop folic acid interventions tailored to individual genetic background and nutritional status.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT00794885.
Source: Stroke - April 24, 2017 Category: Neurology Authors: Min Zhao, Xiaobin Wang, Mingli He, Xianhui Qin, Genfu Tang, Yong Huo, Jianping Li, Jia Fu, Xiao Huang, Xiaoshu Cheng, Binyan Wang, Fan Fan Hou, Ningling Sun, Yefeng Cai Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Relationship Between Nutritional Factors and Hip Bone Density in Individuals with Chronic Stroke
AbstractThe aim of this study was to investigate the relationship between dietary habits and hip bone health in community-dwelling individuals with chronic stroke. The usual dietary intake of 94 individuals with chronic stroke (30 women, mean age: 59.0  years) was assessed by a 3-day food record within a single week. Dual-energy X-ray absorptiometry was used to measure bone mineral density (BMD) at both hips. The results showed that low hip bone mass was found in 59 and 50 of the participants on the affected and unaffected side, respectively. The mean hip BMD was also significantly lower on the affected side than the unaf...
Source: Calcified Tissue International - April 17, 2017 Category: Orthopaedics Source Type: research

Association of Serum Uric Acid with Increased Risk of Cancer among Hypertensive Chinese
This study included 20577 adult hypertensive patients with valid SUA measurements who participated in the China Stroke Primary Prevention Trial where subjects were randomly assigned to receive a double‐blind treatment of either 10mg enalapril (n=10286) or 10.8mg enalapril‐folic acid (n=10291). Subjects were prospectively followed for a median of 4.5 years. Cox proportional hazards models were used to calculate hazards ratios (HR) of cancer risk associated with SUA. A total of 232 participants developed cancer. SUA was independently associated with increased cancer risk in the enalapril group [HR: 1.12, (95% CI: 1.03‐...
Source: International Journal of Cancer - April 10, 2017 Category: Cancer & Oncology Authors: Juan Yang, Yupeng Wang, Qianqian Zhao, Xianglin Zhang, Xiaobin Wang, Xianhui Qin, Rong Zhang, Lin Shen, Xiaodong Jiang, Hua Jiang, Yu Lei, Binyan Wang, Jin Gu, Fan Fan Hou, Yong Huo, Wei Gao, Xiping Xu Tags: Research Article Source Type: research

Folic acid inhibits dedifferentiation of PDGF-BB-induced vascular smooth muscle cells by suppressing mTOR/P70S6K signaling.
CONCLUSION: Folic acid inhibits dedifferentiation of PDGF-BB-induced VSMCs by suppressing mTOR/P70S6K signaling. PMID: 28386356 [PubMed]
Source: American Journal of Translational Research - April 9, 2017 Category: Research Tags: Am J Transl Res Source Type: research

B-vitamin and choline supplementation increases neuroplasticity and recovery after stroke.
Abstract Folates are B-vitamins that play an important role in brain function. Dietary and genetic deficiencies in folate metabolism result in elevated levels of homocysteine which have been linked to increased risk of developing a stroke. Reducing levels of homocysteine before or after a stroke through B-vitamin supplementation has been a focus of many clinical studies, however, the results remain inconsistent. Animal model systems provide a powerful mechanism to study and understand functional impact and mechanisms through which supplementation affects stroke recovery. The aim of this study was to understand the...
Source: Neurobiology of Disease - April 7, 2017 Category: Neurology Authors: Jadavji NM, Emmerson JT, MacFarlane AJ, Willmore WG, Smith PD Tags: Neurobiol Dis Source Type: research

Folic acid therapy reduces serum uric acid in hypertensive patients: a substudy of the China Stroke Primary Prevention Trial (CSPPT) Vitamins, minerals, and phytochemicals
Conclusions: Enalapril–folic acid therapy, compared with enalapril alone, can significantly reduce the magnitude of the increase of UA concentrations in hypertensive adults. This trial was registered at clinicaltrials.gov as NCT00794885.
Source: American Journal of Clinical Nutrition - April 3, 2017 Category: Nutrition Authors: Qin, X., Li, Y., He, M., Tang, G., Yin, D., Liang, M., Wang, B., Nie, J., Huo, Y., Xu, X., Hou, F. F. Tags: Research Need: Role of Nutrition in Health Maintenance, Research Need: Role of Nutrition in Medical Management Vitamins, minerals, and phytochemicals Source Type: research

Markers of early vascular ageing.
CONCLUSIONS: Vascular measurements may better represent the continuum of cardiovascular disease from a young healthy to an aged diseased vessel that is going to produce adverse clinical events. PMID: 28356037 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - March 28, 2017 Category: Drugs & Pharmacology Authors: Kotsis V, Antza C, Doundoulakis I, Stabouli S Tags: Curr Pharm Des Source Type: research

How to Boost Your Stem Cells
A California man named Kris Boesen was completely paralyzed after breaking his neck in a terrible car crash last March. But now he can brush his teeth and hug his family again… He's even started to regain sensation in his legs. And it's all because of a simple procedure he underwent about a month after his accident: stem cell therapy. During Kris' procedure, researchers at the University of Southern California injected 10 million stem cells into his spinal cord. Within two weeks, he could wiggle his fingers. Three months later, he was able to feed himself, write his name and operate his wheelchair. His re...
Source: Al Sears, MD Natural Remedies - March 23, 2017 Category: Complementary Medicine Authors: Al Sears Tags: Anti-Aging Source Type: news