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Drug: Folic Acid

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Total 203 results found since Jan 2013.

H‐Type hypertension, stroke and diabetes in China: Opportunities for primary prevention / H型高血压,脑卒中和糖尿病:中国人群一级预防的机遇
1969年,McCully 首次发现同型半胱氨酸水平即使轻度升高也可加速动脉粥样硬化的发展,由此提出“同型半胱氨酸‐动脉粥样硬化学说”1。接下来的一些前瞻性队列研究提出,同型半胱氨酸水平每降低3 µmol/L可以使脑卒中风险下降24%2。然而,考察降低同型半胱氨酸治疗对脑卒中影响的一些随机、对照临床研究并未观察到明确的结果3。需要注意的是,流行病学研究与临床试验存在诸多重要的不同之处。一般队列研究多关注相对健康人群,而大多数临床研究入组的则是患有心脑血管疾病...
Source: Journal of Diabetes - November 4, 2015 Category: Endocrinology Authors: Xianhui Qin, Yong Huo Tags: Commentary ‐ by Invitation Only Source Type: research

Effect of folic acid supplementation on risk of new‐onset diabetes in adults with hypertension in China: Findings from the CSPPT
ConclusionsAmong adults with hypertension with no history of stroke and/or MI in China, folic acid supplementation had no significant effect on the risk of new‐onset diabetes. This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes - October 11, 2015 Category: Endocrinology Authors: Xianhui Qin, Jianping Li, Yan Zhang, Dafang Chen, Binyan Wang, Mingli He, Jia Fu, Genfu Tang, Yefeng Cai, Xiuli Shi, Xin Xu, Fan Fan Hou, Xiaobin Wang, Yong Huo Tags: Original Article Source Type: research

H‐type hypertension, stroke and diabetes in China: Opportunities for primary prevention
Abstract In summary, the CSPPT, with its large sample size and unique study design has provided a definitive answer regarding the role of folic acid supplementation in conjunction with anti‐hypertension therapy in the primary prevention of stroke. Further studies are needed to examine the joint effect of anti‐hypertensive treatment and folic acid supplementation on the development or progression of T2DM as well as vascular complications, particularly in populations without folic acid fortification. If these relationships can be established and underlying mechanisms elucidated, the implications for clinical and public h...
Source: Journal of Diabetes - September 1, 2015 Category: Endocrinology Authors: Xianhui Qin, Yong Huo Tags: Original Article Source Type: research

Multidisciplinary approach and anesthetic management of a surgical cancer patient with methylene tetrahydrofolate reductase deficiency: a case report and review of the literature
Conclusions Neoplastic disease and related surgery followed by the administration of chemotherapeutic drugs alter the hemostatic balance in cancer patients. Those suspected of also having a thrombophilic disease require a thorough laboratory diagnostic workup, including a molecular analysis aimed at identifying the genetic mutation responsible for the hyperhomocysteinemia, as indicated. The case described in this report highlights the importance of a multidisciplinary approach that includes expertise in peri-operative anesthesia, surgery, oncology, and hematology.
Source: Journal of Medical Case Reports - August 20, 2015 Category: Journals (General) Source Type: research

Malnutrition and laboratory markers in geriatric patients. A comparison of neurologic-psychiatric, internal and trauma surgical diseases
Conclusions Following Mini Nutritional Assessment, the additional measurement of albumin, cholinesterase and hemoglobin allowed a more precise grading of malnutrition. There were significant differences between the disease groups. A deficit of albumin, cholinesterase and hemoglobin was found more often in multimorbid trauma-surgical and internal patients than in neurologic-psychiatric patients.
Source: The Journal of Nutrition, Health and Aging - August 18, 2015 Category: Nutrition Source Type: research

Efficacy of folic acid in primary prevention of stroke among patients with hypertension in China
After folic acid had been documented to reduce birth defects, the United States mandated folic acid food fortification in grain products in 1996 and implemented the policy by 1998.1 Around this time, controversy surfaced on adverse effects of folic acid, namely its possible role in promoting carcinogenesis. However, data over the next decade failed to provide sufficient evidence to support such a claim.1,2 In addition to decreasing neural tube defects, folic acid supplementation has been hypothesized to decrease the risk of stroke and cardiovascular events; however, among the multiple randomized controlled studies thus far...
Source: Journal of the American Society of Hypertension - August 18, 2015 Category: Cardiology Authors: Sangita Goel, Franz H. Messerli Tags: Commentary Source Type: research

Editorial: Efficacy of Folic Acid in Primary Prevention of Stroke Among Patients With Hypertension in China
After folic acid had been documented to reduce birth defects, the United States mandated folic acid food fortification in grain products in 1996 and implemented the policy by 1998. 1 Around this time, controversy surfaced on adverse effects of folic acid, namely its possible role in promoting carcinogenesis. However, data over the next decade failed to provide sufficient evidence to support such a claim.1 Of note, folic acid, in some instances can mask anemia from B12 deficiency and may interact with the therapeutic levels of certain medications.
Source: Journal of the American Society of Hypertension - August 18, 2015 Category: Cardiology Authors: Sangita Goel, Franz H. Messerli Source Type: research

In Chinese adults with hypertension, adding folic acid to enalapril reduced incident stroke.
PMID: 26192588 [PubMed - in process]
Source: Annals of Internal Medicine - July 21, 2015 Category: Internal Medicine Authors: Barer D Tags: Ann Intern Med Source Type: research

Folic Acid for Stroke Prevention: Time to Revisit Vitamin Therapy in Patients With Kidney Disease?
Publication date: Available online 14 July 2015 Source:American Journal of Kidney Diseases Author(s): Andrew A. House , Bradley L. Urquhart
Source: American Journal of Kidney Diseases - July 15, 2015 Category: Urology & Nephrology Source Type: research

Homocysteine, Ischemic Stroke, and Coronary Heart Disease in Hypertensive Patients: A Population-Based, Prospective Cohort Study Clinical Sciences
Conclusions— Hyperhomocysteinemia in Chinese hypertensive patients is significantly associated with IS risk but not coronary heart disease susceptibility, and folic acid supplementation can efficiently reduce tHcy levels.
Source: Stroke - June 22, 2015 Category: Neurology Authors: Han, L., Wu, Q., Wang, C., Hao, Y., Zhao, J., Zhang, L., Fan, R., Liu, Y., Li, R., Chen, Z., Zhang, T., Chen, S., Ma, J., Liu, S., Peng, X., Duan, S. Tags: Myocardial cardiomyopathy disease, Valvular heart disease, Clinical Studies, Acute Cerebral Hemorrhage, Cerebral Venous Thrombosis Clinical Sciences Source Type: research

Supplements That Save Lives And Bucks
I’m sure I don’t have to tell you about the high cost of medical care these days. The fact is that as costs continue to skyrocket, more and more Americans are driven into bankruptcy, because they cannot pay their medical bills. Too often, they even lose their homes. You may have even lost a neighbor to this disturbing trend. It may have even happened to you – although, I certainly hope not. That’s one reason I have always dedicated myself to keeping my patients out of hospitals – which often see patients as cash cows, instead of human beings. And a cornerstone of this philosophy has been based upon pr...
Source: Al Sears, MD Natural Remedies - June 3, 2015 Category: Complementary Medicine Authors: Dr. Al Sears Tags: Nutrition supplements vitamins Source Type: news

Interventions for lowering plasma homocysteine levels in kidney transplant recipients.
CONCLUSIONS: There is no current evidence to support the use of homocysteine lowering therapy for cardiovascular disease prevention in kidney transplant recipients. PMID: 25938479 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - May 4, 2015 Category: Journals (General) Authors: Kang A, Nigwekar SU, Perkovic V, Kulshrestha S, Zoungas S, Navaneethan SD, Cass A, Gallagher MP, Ninomiya T, Strippoli GF, Jardine MJ Tags: Cochrane Database Syst Rev Source Type: research

Combination Folic Acid and Medical Therapy Found to Prevent Stroke in Large Population-Based Trial
No abstract available
Source: Neurology Today - April 16, 2015 Category: Neurology Tags: Features Source Type: research

In Context News in brief
Folic acid can reduce risk of first stroke, according to the results of a double-blind trial. 20 702 people with hypertension without a history of stroke or myocardial infarction enrolled in the China Stroke Primary Prevention Trial were randomly assigned to receive either combined enalapril 10 mg and folic acid 0·8 mg or enalapril 10 mg alone. The trial was terminated early, after a median of 4·5 years, when benefits of the combined treatment were identified: there was a significant reduction in risk of first stroke in the folic acid-enalapril group (hazard ratio 0·79, 95% CI 0·68–0·93) compared with enalapril alone group.
Source: Lancet Neurology - April 13, 2015 Category: Neurology Tags: In Context Source Type: research

Incident Cancer in a Cohort of 3,247 Cancer Diagnosis Free Ischemic Stroke Patients
Conclusions: The annual rate of age-adjusted cancer incidence was higher among ischemic stroke patients compared with those in the general population. The odds of mortality were three folds higher among stroke survivors who developed incident cancer.Cerebrovasc Dis 2015;39:262-268
Source: Cerebrovascular Diseases - April 7, 2015 Category: Neurology Source Type: research