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Drug: Folic Acid
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Total 203 results found since Jan 2013.
A Novel Homozygous Non-sense Mutation in the Catalytic Domain of MTHFR Causes Severe 5,10-Methylenetetrahydrofolate Reductase Deficiency
Conclusion: We identified a novel non-sense mutation in MTHFR gene in a single Egyptian family with severe MTHFR deficiency. The present investigation is clinically important, as it adds to the growing list of MTHFR mutations, which might help in genetic counseling of families of affected children and proper genotype-phenotype correlation.
Background
Severe 5,10-Methylenetetrahydrofolate reductase (MTHFR; OMIM 236250) deficiency is a rare inborn error of metabolism and inherited in an autosomal recessive fashion. It is a very common disorder of folate metabolism and is clinically characterized with low plasma methion...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research
Prediction Model for the Efficacy of Folic Acid Therapy on Hyperhomocysteinaemia based on genetic risk score methods.
Abstract
No risk assessment tools for the efficacy of folic acid treatment for hyperhomocysteinaemia (HHcy) have been developed. We aimed to use two common genetic risk score (GRS) methods to construct prediction models for the efficacy of folic acid therapy on HHcy, and the best gene-environment prediction model was screened out. A prospective cohort study enrolling 638 HHcy patients was performed. We used logistic regression model to estimate the associations of two GRS methods with the efficacy. Performances were compared using area under the receiver operating characteristic curve (AUC). The simple count genet...
Source: The British Journal of Nutrition - April 1, 2019 Category: Nutrition Authors: Du B, Zhang C, Yue L, Ren B, Zhao Q, Li D, He Y, Zhang W Tags: Br J Nutr Source Type: research
The modifying effect of the MTHFR genotype on the association between folic acid supplementation and pulse wave velocity: Findings from the CSPPT
ConclusionIn a subgroup of Chinese hypertensive patients who had received 5 ‐year antihypertensive therapy, increases in folate status were associated with higher reductions in PWV, and individuals with the CC genotype showed greatest PWV response to folic acid supplementation.
Source: Cardiovascular Therapeutics - January 28, 2019 Category: Cardiology Authors: Xin Yang,
Minghua Zhang,
Rensheng Song,
Changfu Liu,
Yong Huo,
Geng Qian Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Plasma retinol and the risk of first stroke in hypertensive adults: a nested case-control study.
Conclusions: Our data showed a significant inverse association between plasma retinol and the risk of first stroke among Chinese hypertensive adults. This study was registered at clinicaltrials.gov as NCT00794885.
PMID: 30624586 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - January 9, 2019 Category: Nutrition Authors: Yu Y, Zhang H, Song Y, Lin T, Zhou Z, Guo H, Liu L, Wang B, Liu C, Li J, Zhang Y, Huo Y, Wang C, Wang X, Hou FF, Qin X, Xu X Tags: Am J Clin Nutr Source Type: research
The modifying effect of the MTHFR genotype on the association between folic acid supplementation and pulse wave velocity: Findings from the CSPPT
ConclusionIn a subgroup of Chinese hypertensive patients who had received 5 ‐year antihypertensive therapy, increases in folate status were associated with higher reductions in PWV, and individuals with the CC genotype showed greatest PWV response to folic acid supplementation.
Source: Cardiovascular Therapeutics - November 20, 2018 Category: Cardiology Authors: Xin Yang,
Minghua Zhang,
Rensheng Song,
Changfu Liu,
Yong Huo,
Geng Qian Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Review: Folic acid may reduce risk for CVD and stroke, and B-vitamin complex may reduce risk for stroke.
PMID: 30326088 [PubMed - in process]
Source: Annals of Internal Medicine - October 16, 2018 Category: Internal Medicine Authors: Aung K, Htay T Tags: Ann Intern Med Source Type: research
Folic Acid Exerts Post-Ischemic Neuroprotection In Vitro Through HIF-1 α Stabilization
AbstractThe constant failure of single-target drug therapies for ischemic stroke necessitates the development of novel pleiotropic pharmacological treatment approaches, to effectively combat the aftermath of this devastating disorder. The major objective of our study involves a multi-target drug repurposing strategy to stabilize hypoxia-inducible factor-1 α (HIF-1α) via a structure-based screening approach to simultaneously inhibit its regulatory proteins, PHD2, FIH, and pVHL. Out of 1424 Food and Drug Administration (FDA)-approved drugs that were screened, folic acid (FA) emerged as the top hit and its binding potential...
Source: Molecular Neurobiology - October 5, 2018 Category: Neurology Source Type: research
A genetic deficiency in folic acid metabolism impairs recovery after ischemic stroke.
Abstract
Stroke is a leading cause of disability and death world-wide and nutrition is a modifiable risk factor for stroke. Metheylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in the metabolism of folic acid, a B-vitamin. In humans, a polymorphism in MTHFR (677C→T) is linked to increased risk of stroke, but the mechanisms remain unknown. The Mthfr+/- mice mimic a phenotype described in humans at bp677. Using this mouse model, the aim of this study was to investigate the impact of MTHFR deficiency on stroke outcome. Male Mthfr+/- and wildtype littermate control mice were aged (~1.5-year-old) and tr...
Source: Experimental Neurology - July 25, 2018 Category: Neurology Authors: Jadavji NM, Emmerson JT, Shanmugalingam U, MacFarlane AJ, Willmore WG, Smith PD Tags: Exp Neurol Source Type: research
The current status of homocysteine as a risk factor for cardiovascular disease: a mini review.
Authors: Chrysant SG, Chrysant GS
Abstract
INTRODUCTION: Hyperhomocysteinemia has been considered as a risk factor for systemic atherosclerosis, cardiovascular disease (CVD) and stroke and many epidemiologic and case-controlled studies have demonstrated its association with these complications. In addition, treatment of hyperhomocysteinemia with folic acid ± B vitamins prevents the development of atherosclerosis, CVD and strokes. However, subsequent prospective, randomized, placebo- controlled trials have not shown an association of high homocysteine levels or their lowering with treatment with the incidence of at...
Source: Expert Review of Cardiovascular Therapy - July 8, 2018 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research
A True Hematologic Emergency
BY GREGORY TAYLOR, DO, & JACKLYN MCPARLANE, DOA 33-year-old woman with a past medical history of sickle cell SS presented to the emergency department with chest pain, difficulty breathing, and a cough for two days. Her chest pain was diffuse, without radiation, and partially reproducible. Her cough was nonproductive, and she also reported fever and chills.The patient noted this was different from her normal back and leg pain from past sickle cell crises. She was following up with a sickle cell specialist, and was compliant with her hydroxyurea treatment.Her temperature was 102.8°F, blood pressure was 94/60 mm...
Source: The Case Files - June 26, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: research
Supplements Won't Prevent Heart Disease: Study
There was one exception, researchers said. A more recent clinical trial in China found that folic acid supplements helped curb participants' risk of stroke.
Source: WebMD Health - May 29, 2018 Category: Consumer Health News Source Type: news
Most vitamin, mineral supplements not shown to lower heart disease risk
(American College of Cardiology) Current research does not show enough evidence that vitamin or mineral supplements are beneficial for preventing or treating heart disease, with the exception of folic acid for reducing stroke risk, according to a review article published in the Journal of the American College of Cardiology. Current recommendations to adopt healthy diets that are heavy in plant-based foods from which these vitamins are derived naturally should be reinforced.
Source: EurekAlert! - Medicine and Health - May 28, 2018 Category: International Medicine & Public Health Source Type: news
