Prediction Model for the Efficacy of Folic Acid Therapy on Hyperhomocysteinaemia based on genetic risk score methods.

Prediction Model for the Efficacy of Folic Acid Therapy on Hyperhomocysteinaemia based on genetic risk score methods. Br J Nutr. 2019 Apr 02;:1-25 Authors: Du B, Zhang C, Yue L, Ren B, Zhao Q, Li D, He Y, Zhang W Abstract No risk assessment tools for the efficacy of folic acid treatment for hyperhomocysteinaemia (HHcy) have been developed. We aimed to use two common genetic risk score (GRS) methods to construct prediction models for the efficacy of folic acid therapy on HHcy, and the best gene-environment prediction model was screened out. A prospective cohort study enrolling 638 HHcy patients was performed. We used logistic regression model to estimate the associations of two GRS methods with the efficacy. Performances were compared using area under the receiver operating characteristic curve (AUC). The simple count genetic risk score (SC-GRS) and weighted genetic risk score (wGRS) were found to be independently associated with the efficacy of folic acid treatment for HHcy. Using the SC-GRS, per risk allele increased with a 1.46-fold increased failure risk (P < 0.001) after adjustment for traditional risk factors including age, sex, body mass index, smoking, alcohol consumption, history of diabetes, history of hypertension, history of hyperlipidemia, history of stroke, and history of coronary heart disease. When used the wGRS, the association was strengthened (OR = 2.08, P < 0.001). Addition of the SC-GRS and wGRS to t...
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research