The Use of N-of-1 Trials to Individualize Treatment in Patients With Renal Magnesium Wasting
Publication date: Available online 11 October 2018Source: American Journal of Kidney DiseasesAuthor(s): Anneke P. Bech, Jack F.M. Wetzels, Hans Groenewoud, Tom Nijenhuis (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - October 12, 2018 Category: Urology & Nephrology Source Type: research

Sex Disparities in Risk of Mortality Among Children With ESRD
ConclusionsThe mortality rate was substantially higher for girls than for boys treated with RRT. Access to transplantation was lower for girls than boys, but differences in transplantation access accounted for only a small proportion of the survival differences by sex. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - October 12, 2018 Category: Urology & Nephrology Source Type: research

Kidneys
Publication date: Available online 8 October 2018Source: American Journal of Kidney DiseasesAuthor(s): Sandra Miller (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - October 9, 2018 Category: Urology & Nephrology Source Type: research

CKD Due to a Novel Mitochondrial DNA Mutation: A Case Report
We describe a novel mtDNA mutation in a patient who developed chronic kidney disease. The patient exhibited mitochondrial abnormalities in both muscle and kidney, chronic tubulointerstitial changes, and recurrent episodes of rhabdomyolysis. We outline mechanisms that may underlie the occurrence of chronic kidney disease in the setting of this novel mtDNA mutation. We also underscore the need to consider in relevant kidney diseases the presence of an underlying mitochondrial cytopathy because the latter more commonly exists than is generally recognized. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - October 9, 2018 Category: Urology & Nephrology Source Type: research

The Role of Vitamin D in CKD Stages 3 to 4: Report of a Scientific Workshop Sponsored by the National Kidney Foundation
This article reports on the proceedings from a “controversies conference” on vitamin D in chronic kidney disease that was sponsored by the National Kidney Foundation. The report outlines the deliberations of the 3 work groups that participated in the conference. Until newer measurement methods are widely used, the panel agreed that clinicians should classify 25(OH)D “adequacy” as concentrations> 20 ng/mL without evidence of counter-regulatory hormone activity (ie, elevated parathyroid hormone). The panel also agreed that 25(OH)D concentrations 
Source: American Journal of Kidney Diseases - October 6, 2018 Category: Urology & Nephrology Source Type: research

Urine Acidification After Ammonium Chloride
Publication date: Available online 5 October 2018Source: American Journal of Kidney DiseasesAuthor(s): Anneke P. Bech, Tom Nijenhuis, Jack F.M. Wetzels (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - October 6, 2018 Category: Urology & Nephrology Source Type: research

Where Do the Salt and Water Go? A Case of Profound Hyponatremia
Publication date: Available online 26 September 2018Source: American Journal of Kidney DiseasesAuthor(s): Ignacio Portales-Castillo, Richard H. Sterns, Jonathan Bress, Ruben A. ProanoTreatment of profound hyponatremia is challenging. Severe symptoms mandate correction by 4 to 6 mEq/L within hours, but with risk factors for osmotic demyelination, daily correction should be 
Source: American Journal of Kidney Diseases - October 5, 2018 Category: Urology & Nephrology Source Type: research

Screening for Latent Tuberculosis Infection in Migrants With CKD: A Cost-effectiveness Analysis
Publication date: Available online 28 September 2018Source: American Journal of Kidney DiseasesAuthor(s): Jonathon R. Campbell, James C. Johnston, Lisa A. Ronald, Mohsen Sadatsafavi, Robert F. Balshaw, Victoria J. Cook, Adeera Levin, Fawziah MarraRationale & ObjectiveIn countries with a low tuberculosis (TB) incidence, TB disproportionately affects populations born abroad. TB persists in these populations through reactivation of latent TB infection (LTBI) acquired before immigration. Those with chronic kidney disease (CKD) are at increased risk for reactivation and may benefit from LTBI screening and tre...
Source: American Journal of Kidney Diseases - October 5, 2018 Category: Urology & Nephrology Source Type: research

Effect of Intensive Blood Pressure Lowering on Kidney Tubule Injury: Findings From the ACCORD Trial Study Participants
Publication date: Available online 2 October 2018Source: American Journal of Kidney DiseasesAuthor(s): Girish N. Nadkarni, Kinsuk Chauhan, Veena Rao, Joachim H. Ix, Michael G. Shlipak, Chirag R. Parikh, Steven G. CocaRationale & ObjectiveRandom assignment to intensive blood pressure (BP) lowering (systolic BP 
Source: American Journal of Kidney Diseases - October 5, 2018 Category: Urology & Nephrology Source Type: research

Effects of Intensive Blood Pressure Lowering on Kidney Tubule Injury in CKD: A Longitudinal Subgroup Analysis in SPRINT
Publication date: Available online 2 October 2018Source: American Journal of Kidney DiseasesAuthor(s): Rakesh Malhotra, Timothy Craven, Walter T. Ambrosius, Anthony A. Killeen, William E. Haley, Alfred K. Cheung, Michel Chonchol, Mark Sarnak, Chirag R. Parikh, Michael G. Shlipak, Joachim H. Ix, SPRINT Research GroupBackgroundRandom assignment to the intensive systolic blood pressure (SBP) arm (
Source: American Journal of Kidney Diseases - October 5, 2018 Category: Urology & Nephrology Source Type: research

Psychosocial Health and Lifestyle Behaviors in Young Adults Receiving Renal Replacement Therapy Compared to the General Population: Findings From the SPEAK Study
Publication date: Available online 4 October 2018Source: American Journal of Kidney DiseasesAuthor(s): Alexander J. Hamilton, Fergus J. Caskey, Anna Casula, Yoav Ben-Shlomo, Carol D. InwardRationale & ObjectivePatients in late adolescence and early adulthood receiving renal replacement therapy (RRT) face disruption to normal activities, which affects well-being. We aimed to define psychosocial and lifestyle outcomes for young adults on RRT compared to the general population.Study DesignWe undertook a cross-sectional survey (the SPEAK [Surveying Patients Experiencing Young Adult Kidney Failure] Study) using validated me...
Source: American Journal of Kidney Diseases - October 5, 2018 Category: Urology & Nephrology Source Type: research

Urine Sediment Examination in the Diagnosis and Management of Kidney Disease: Core Curriculum 2019
Publication date: Available online 21 September 2018Source: American Journal of Kidney DiseasesAuthor(s): Corey Cavanaugh, Mark A. PerazellaAutomated urine technology and centralized laboratory testing are becoming the standard for providing urinalysis data to clinicians, including nephrologists. This trend has had the unintended consequence of making examination of urine sediment by nephrologists a relatively rare event. In addition, the nephrology community appears to have lost interest in and forgotten the utility of provider-performed urine microscopy. However, it is critical to remember that urine sediment examination...
Source: American Journal of Kidney Diseases - September 22, 2018 Category: Urology & Nephrology Source Type: research

Using All Longitudinal Data to Define Time to Specified Percentages of Estimated GFR Decline: A Simulation Study
ConclusionsA regression method using all longitudinal eGFR values to estimate time to a percentage decline in eGFR increases accuracy and power over traditional methods, representing a potential improvement in the ability to discover treatment or biomarker effects on kidney disease progression. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - September 22, 2018 Category: Urology & Nephrology Source Type: research

Untangling Mesoamerican Nephropathy
Publication date: October 2018Source: American Journal of Kidney Diseases, Volume 72, Issue 4Author(s): Diego Aguilar-Ramirez, Magdalena Madero (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - September 20, 2018 Category: Urology & Nephrology Source Type: research

The Evaluation of Living Kidney Donors: How Long Is Too Long?
Publication date: October 2018Source: American Journal of Kidney Diseases, Volume 72, Issue 4Author(s): Francis L. Weng, Marie M. Morgievich, Praveen Kandula (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - September 20, 2018 Category: Urology & Nephrology Source Type: research

Duration of Living Kidney Transplant Donor Evaluations: Findings From 2 Multicenter Cohort Studies
ConclusionsThe duration of kidney transplant donor evaluation is variable and can be lengthy. Better understanding of the reasons for a prolonged evaluation may inform quality improvement initiatives to reduce unnecessary delays. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - September 20, 2018 Category: Urology & Nephrology Source Type: research

Cognitive Impairment in Non–Dialysis-Dependent CKD and the Transition to Dialysis: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
ConclusionsPredialysis cognitive impairment is associated with a lower likelihood of PD as a first dialysis modality and of venous catheter avoidance at dialysis therapy initiation. Future studies may consider addressing cognitive function when testing strategies to improve patient transitions to dialysis therapy. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - September 20, 2018 Category: Urology & Nephrology Source Type: research

Contents
Publication date: October 2018Source: American Journal of Kidney Diseases, Volume 72, Issue 4Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - September 20, 2018 Category: Urology & Nephrology Source Type: research

Social Determinants of Health: Addressing Unmet Needs in Nephrology
Publication date: October 2018Source: American Journal of Kidney Diseases, Volume 72, Issue 4Author(s): Yoshio N. HallThere is ongoing recognition that a wide array of social, economic, and environmental factors influence individuals’ opportunities to engage in health care and healthy behaviors. Despite spending $34 billion annually on the care of patients with end-stage renal disease, the American public and nephrology community remain remarkably complacent about addressing “upstream” factors that influence the prevention, progression, and treatment of chronic kidney diseases. Recently, a growing number ...
Source: American Journal of Kidney Diseases - September 20, 2018 Category: Urology & Nephrology Source Type: research

Impact of Telehealth Interventions on Processes and Quality of Care for Patients With ESRD
Publication date: October 2018Source: American Journal of Kidney Diseases, Volume 72, Issue 4Author(s): Meaghan Lunney, Raymond Lee, Karen Tang, Natasha Wiebe, Aminu K. Bello, Chandra Thomas, Doreen Rabi, Marcello Tonelli, Matthew T. JamesCaring for patients with end-stage renal disease (ESRD) requiring dialysis is intensive and expensive. Telehealth may improve the access and efficiency of ESRD care. For this perspective, we systematically reviewed studies that examined the effectiveness of telehealth versus or in addition to usual care for ESRD management. 10 studies were identified, including 7 randomized trials and 3 c...
Source: American Journal of Kidney Diseases - September 20, 2018 Category: Urology & Nephrology Source Type: research

Masthead
Publication date: October 2018Source: American Journal of Kidney Diseases, Volume 72, Issue 4Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - September 20, 2018 Category: Urology & Nephrology Source Type: research

Editorial Board
Publication date: October 2018Source: American Journal of Kidney Diseases, Volume 72, Issue 4Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - September 20, 2018 Category: Urology & Nephrology Source Type: research

Fever and Gross Hematuria in Kidney Transplant Recipient
Publication date: October 2018Source: American Journal of Kidney Diseases, Volume 72, Issue 4Author(s): Vaishnavi Pochineni, Parmjeet Randhawa, Chethan Puttarajappa (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - September 20, 2018 Category: Urology & Nephrology Source Type: research

Genetic Testing in Clinical Settings
Publication date: October 2018Source: American Journal of Kidney Diseases, Volume 72, Issue 4Author(s): Nora Franceschini, Amber Frick, Jeffrey B. KoppGenetic testing is used for screening, diagnosis, and prognosis of diseases consistent with a genetic cause and to guide drug therapy to improve drug efficacy and avoid adverse effects (pharmacogenomics). This In Practice review aims to inform about DNA-related genetic test availability, interpretation, and recommended clinical actions based on results using evidence from clinical guidelines, when available. We discuss challenges that limit the widespread use of genetic info...
Source: American Journal of Kidney Diseases - September 20, 2018 Category: Urology & Nephrology Source Type: research

Nephrotic Syndrome With Mutations in NPHS2: The Role of R229Q and Implications for Genetic Counseling
Publication date: Available online 18 September 2018Source: American Journal of Kidney DiseasesAuthor(s): Ilse M. Rood, Jeroen K.J. Deegens, Dorien Lugtenberg, Ernie M.H.F. Bongers, Jack F.M. WetzelsMutations in the NPHS2 gene, which encodes the podocyte slit diaphragm protein podocin, cause autosomal recessive steroid-resistant nephrotic syndrome (Online Mendelian Inheritance in Man [OMIM] #600995). Basic research and clinical studies have provided important insights about genotype-phenotype correlations. This knowledge allows personalized genetic (risk) counseling and should lead to changes in the advice given to patient...
Source: American Journal of Kidney Diseases - September 19, 2018 Category: Urology & Nephrology Source Type: research

Single-Cell RNA Sequencing of the Adult Mouse Kidney: From Molecular Cataloging of Cell Types to Disease-Associated Predictions
Publication date: Available online 18 September 2018Source: American Journal of Kidney DiseasesAuthor(s): Nils O. Lindström, Guilherme De Sena Brandine, Andrew Ransick, Andrew P. McMahon (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - September 19, 2018 Category: Urology & Nephrology Source Type: research

MIF Matters: The Macrophage Migration Inhibitory Factor and Kidney Injury
Publication date: Available online 18 September 2018Source: American Journal of Kidney DiseasesAuthor(s): Mark Unruh, Brent Wagner, Kenneth R. Hallows (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - September 19, 2018 Category: Urology & Nephrology Source Type: research

Benefit of Eculizumab Compared to Standard of Care Still Unproven in C3 Glomerulopathy
Publication date: Available online 17 September 2018Source: American Journal of Kidney DiseasesAuthor(s): Caroline Duineveld, Nicole C.A.J. van de Kar, Jack F.M. Wetzels (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - September 17, 2018 Category: Urology & Nephrology Source Type: research

In Reply to ‘Benefit of Eculizumab Compared to Standard of Care Still Unproven in C3 Glomerulopathy’
Publication date: Available online 17 September 2018Source: American Journal of Kidney DiseasesAuthor(s): Moglie Le Quintrec, Véronique Frémeaux-Bacchi, Fadi Fakhouri (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - September 17, 2018 Category: Urology & Nephrology Source Type: research

Kidney Tattoos
Publication date: Available online 13 September 2018Source: American Journal of Kidney DiseasesAuthor(s): Jeffrey S. Berns (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - September 13, 2018 Category: Urology & Nephrology Source Type: research

Use of Renin-Angiotensin System Blockade in Advanced CKD: An NKF-KDOQI Controversies Report
Publication date: Available online 7 September 2018Source: American Journal of Kidney DiseasesAuthor(s): Matthew R. Weir, Jay I. Lakkis, Bernard Jaar, Michael V. Rocco, Michael J. Choi, Holly Mattrix-Kramer, Elaine KuMultiple clinical trials have demonstrated that renin-angiotensin system (RAS) blockade with either angiotensin-converting enzyme inhibitors or angiotensin receptor blockers effectively reduces chronic kidney disease (CKD) progression. However, most clinical trials excluded participants with advanced CKD (ie, estimated glomerular filtration rate [eGFR] 
Source: American Journal of Kidney Diseases - September 8, 2018 Category: Urology & Nephrology Source Type: research

Estimated GFR and Hospital-Acquired Infections Following Major Surgery
Publication date: Available online 7 September 2018Source: American Journal of Kidney DiseasesAuthor(s): Junichi Ishigami, Marco Trevisan, Hong Xu, Josef Coresh, Kunihiro Matsushita, Juan-Jesus CarreroRationale & ObjectiveLow estimated glomerular filtration rate (eGFR) increases infection risk, but its contribution to hospital-acquired infection following major surgery is unknown.Study DesignRetrospective cohort study.Setting & ParticipantsResidents of Stockholm, Sweden, 18 years or older with at least 1 recorded serum creatinine measurement, no recent diagnoses of infection, and hospitalized for orthopedic, abdomi...
Source: American Journal of Kidney Diseases - September 8, 2018 Category: Urology & Nephrology Source Type: research

Transplantation of a Gitelman Syndrome Kidney Ameliorates Hypertension: A Case Report
In conclusion, Gitelman syndrome need not preclude kidney donation and transference of the phenotype may have benefits for the recipient. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - September 8, 2018 Category: Urology & Nephrology Source Type: research

Never Thought I Would
Publication date: Available online 7 September 2018Source: American Journal of Kidney DiseasesAuthor(s): Ellen D. Feld (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - September 8, 2018 Category: Urology & Nephrology Source Type: research

Incident Type 2 Diabetes Among Individuals With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study
ConclusionsThe T2DM incidence rate among individuals with CKD is markedly higher than in the general population, supporting the need for greater vigilance in this population. Measures of glycemic control and family history of DM were independently associated with incident T2DM. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - September 1, 2018 Category: Urology & Nephrology Source Type: research

Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial
ConclusionsCompared to placebo, febuxostat did not mitigate the decline in kidney function among patients with stage 3 CKD and asymptomatic hyperuricemia.FundingFunded by Teijin Pharma Limited.Trial RegistrationRegistered at the UMIN (University Hospital Medical Information Network) Clinical Trials Registry with study number UMIN000008343. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - September 1, 2018 Category: Urology & Nephrology Source Type: research

Maintenance of Certification, Self-regulation, and the Decline of Physician Autonomy
Publication date: Available online 27 August 2018Source: American Journal of Kidney DiseasesAuthor(s): Tod Ibrahim (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - August 27, 2018 Category: Urology & Nephrology Source Type: research

Transforming the American Board of Internal Medicine (ABIM) and Maintenance of Certification (MOC)
Publication date: Available online 27 August 2018Source: American Journal of Kidney DiseasesAuthor(s): Samir Nangia (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - August 27, 2018 Category: Urology & Nephrology Source Type: research

The Role for Protein Restriction in Addition to Renin-Angiotensin-Aldosterone System Inhibitors in the Management of CKD
Publication date: Available online 24 August 2018Source: American Journal of Kidney DiseasesAuthor(s): Laetitia Koppe, Denis FouqueIn experimental studies a low-protein diet (LPD) and renin-angiotensin-aldosterone system (RAAS) inhibitors are both reported to slow the progression of chronic kidney disease (CKD) and reduce proteinuria. RAAS activity contributes to increased blood pressure, fluid retention, and positive sodium balance, but also to kidney damage by enhancing glomerular capillary filtration pressure and synthesis of profibrotic molecules such as transforming growth factor β. It has been well established t...
Source: American Journal of Kidney Diseases - August 25, 2018 Category: Urology & Nephrology Source Type: research

The Validity of Drug Effects on Proteinuria, Albuminuria, Serum Creatinine, and Estimated GFR as Surrogate End Points for ESKD: A Systematic Review
ConclusionsThe association between antihypertensive drug effects on doubling of serum creatinine level and albuminuria or proteinuria with ESKD in treatment trials is not sufficiently certain to enable the confident use of these markers to guide clinical or regulatory decision making. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - August 25, 2018 Category: Urology & Nephrology Source Type: research

Risk of ESRD and Mortality in Kidney and Bladder Stone Formers
ConclusionsThe higher risk for ESRD in recurrent symptomatic compared with incident symptomatic kidney stone formers suggests that stone events are associated with kidney injury. The clinical indication for imaging in asymptomatic stone formers, the correct diagnosis in miscoded stone formers, and the cause of a bladder outlet obstruction in bladder stone formers may explain the higher risk for ESRD or death in these groups. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - August 25, 2018 Category: Urology & Nephrology Source Type: research

Optimized Reference Intervals for Plasma Free Metanephrines in Patients With CKD
Publication date: Available online 23 August 2018Source: American Journal of Kidney DiseasesAuthor(s): Christina Pamporaki, Aleksander Prejbisz, Robert Małecki, Frank Pistrosch, Mirko Peitzsch, Steffen Bishoff, Petra Mueller, Iris Meyer, Doreen Reimann, Katarzyna Hanus, Andrzej Januszewicz, Stefan R. Bornstein, Simon Parmentier, Carola Kunath, Jacques W.M. Lenders, Graeme Eisenhofer, Jens Passauer (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - August 25, 2018 Category: Urology & Nephrology Source Type: research

Innovations in Wearable and Implantable Artificial Kidneys
Publication date: Available online 23 August 2018Source: American Journal of Kidney DiseasesAuthor(s): Megha Salani, Shuvo Roy, William H. FissellMore than 2 million people worldwide receive treatment for end-stage renal disease (ESRD). Current modalities of renal replacement therapy include in-center hemodialysis, peritoneal dialysis, home hemodialysis, and kidney transplantation. Patient survival has gradually increased during the past 2 decades and efforts continue to improve mortality and quality of life for patients with ESRD. Developments in sorbent technology, nanotechnology, and cell culture techniques provide prom...
Source: American Journal of Kidney Diseases - August 25, 2018 Category: Urology & Nephrology Source Type: research

Emerging Concepts in Hematopoietic Stem Cell Transplantation–Associated Renal Thrombotic Microangiopathy and Prospects for New Treatments
Publication date: Available online 23 August 2018Source: American Journal of Kidney DiseasesAuthor(s): Rimda Wanchoo, Ruthee L. Bayer, Claude Bassil, Kenar D. JhaveriThrombotic microangiopathy associated with hematopoietic stem cell transplantation (HSCT-TMA) is a well-recognized complication of HSCT that has a high risk for death. Even in patients who survive, HSCT-TMA is associated with long-term morbidity and chronic organ injury. HSCT-TMA is a multisystem disease that often affects the kidneys. Renal manifestations of HSCT-TMA include reduced glomerular filtration rate, proteinuria, and hypertension. Understanding of t...
Source: American Journal of Kidney Diseases - August 25, 2018 Category: Urology & Nephrology Source Type: research

Missed Hemodialysis Treatments: International Variation, Predictors, and Outcomes in the Dialysis Outcomes and Practice Patterns Study (DOPPS)
Publication date: Available online 23 August 2018Source: American Journal of Kidney DiseasesAuthor(s): Issa Al Salmi, Maria Larkina, Mia Wang, Lalita Subramanian, Hal Morgenstern, Stefan H. Jacobson, Raymond Hakim, Francesca Tentori, Rajiv Saran, Takashi Akiba, Natalia A. Tomilina, Friedrich K. Port, Bruce M. Robinson, Ronald L. PisoniRationale & ObjectiveMissed hemodialysis (HD) treatments not due to hospitalization have been associated with poor clinical outcomes and related in part to treatment nonadherence. Using data from the Dialysis Outcomes and Practice Patterns Study (DOPPS) phase 5 (2012-2015), we report find...
Source: American Journal of Kidney Diseases - August 25, 2018 Category: Urology & Nephrology Source Type: research

Editorial Board
Publication date: September 2018Source: American Journal of Kidney Diseases, Volume 72, Issue 3Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - August 22, 2018 Category: Urology & Nephrology Source Type: research

The Interpretation of Congophilia in Tissue Biopsies: Caution Required
Publication date: September 2018Source: American Journal of Kidney Diseases, Volume 72, Issue 3Author(s): Maria M. Picken (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - August 22, 2018 Category: Urology & Nephrology Source Type: research

Heterogeneity in Outcomes Among β-Blockers Elucidated by Intradialytic Data
Publication date: September 2018Source: American Journal of Kidney Diseases, Volume 72, Issue 3Author(s): Chandan Vangala, Wolfgang C. Winkelmayer (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - August 22, 2018 Category: Urology & Nephrology Source Type: research

A Comparative Study of Carvedilol Versus Metoprolol Initiation and 1-Year Mortality Among Individuals Receiving Maintenance Hemodialysis
ConclusionsRelative to metoprolol initiation, carvedilol initiation was associated with higher 1-year all-cause and cardiovascular mortality. One potential mechanism for these findings may be the increased occurrence of intradialytic hypotension after carvedilol (vs metoprolol) initiation.Graphical Abstract (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - August 22, 2018 Category: Urology & Nephrology Source Type: research

Brain Magnetic Resonance Imaging Findings in Children and Young Adults With CKD
ConclusionsCKD in children and young adults may be associated with lower GM and higher WM volumes in some ROIs. Differences were relatively subtle in the CKD group as a whole, but were more prominent in recipients of a kidney transplant. However, neurocognitive performance was not explained by differences in brain ROI volumes, suggesting a functional rather than structural basis for neurocognitive impairment in CKD. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - August 22, 2018 Category: Urology & Nephrology Source Type: research