Trends in Albuminuria and GFR Among Adolescents in the United States, 1988-2014
Publication date: Available online 14 July 2018Source: American Journal of Kidney DiseasesAuthor(s): Sharon H. Saydah, Hui Xie, Giuseppina Imperatore, Nilka Rios Burrows, Meda E. PavkovRationale & ObjectiveAlbuminuria and low estimated glomerular filtration rate (eGFR) define chronic kidney disease in adults and youth. Different from adults, the burden of abnormal kidney markers among youth in the general United States population is largely unknown.Study DesignSerial cross-sectional national surveys.Setting & ParticipantsAdolescents aged 12 to 18 years participating in the National Health and Nutrition Examination ...
Source: American Journal of Kidney Diseases - July 15, 2018 Category: Urology & Nephrology Source Type: research

Cognitive Changes in Peritoneal Dialysis Patients: A Multicenter Prospective Cohort Study
ConclusionsIn a PD population, global cognitive function declined over 2 years, though some specific cognitive domains improved. Besides well-recognized factors, hypoalbuminemia and depression were also risk factors for cognitive impairment. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 12, 2018 Category: Urology & Nephrology Source Type: research

Associations Between Kidney Disease Measures and Regional Pulse Wave Velocity in a Large Community-Based Cohort: The Atherosclerosis Risk in Communities (ARIC) Study
ConclusionsBoth lower eGFR and higher ACR are independently associated with measures of central arterial stiffness, with stronger associations for ACR over eGFR. Our findings suggest that central arterial stiffness may be an important pathophysiologic phenotype of vascular disease in CKD. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 12, 2018 Category: Urology & Nephrology Source Type: research

Preimplantation Genetic Diagnosis of Autosomal Dominant Polycystic Kidney Disease Applied in China
Publication date: Available online 12 July 2018Source: American Journal of Kidney DiseasesAuthor(s): Chenchen Zhou, Changlin Mei, Cheng Xue (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 12, 2018 Category: Urology & Nephrology Source Type: research

Non–Vitamin K–Dependent Oral Anticoagulants for Nonvalvular Atrial Fibrillation in Patients With CKD: Pragmatic Considerations for the Clinician
Publication date: Available online 2 May 2018Source: American Journal of Kidney DiseasesAuthor(s): Gautam R. Shroff, Rachel Stoecker, Allyson HartManagement of atrial fibrillation (AF) in patients with advanced chronic kidney disease (CKD) poses a complex conundrum because of higher risks for both thromboembolic and bleeding complications compared to the general population. This makes it particularly important for clinicians to carefully weigh the risks versus benefits of anticoagulation therapy to determine the individualized net clinical benefit for every patient. During the past few years, 4 non–vitamin K–de...
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

PRESERVE: The End or the Beginning of a New Era in Prevention of Contrast-Associated Acute Kidney Injury?
Publication date: Available online 8 May 2018Source: American Journal of Kidney DiseasesAuthor(s): Richard Solomon (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Assessing Nephron Hyperplasia in Fetal Congenital Solitary Functioning Kidneys by Measuring Renal Papilla Number
Publication date: Available online 18 May 2018Source: American Journal of Kidney DiseasesAuthor(s): Rozemarijn Snoek, Roel de Heus, Keetje J. de Mooij, Lou R. Pistorius, Marc R. Lilien, A. Titia Lely, Mireille N. Bekker, Tom P.V.M. de Jong (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Tradeoffs in Vascular Access Selection in Elderly Patients Initiating Hemodialysis With a Catheter
Publication date: Available online 18 May 2018Source: American Journal of Kidney DiseasesAuthor(s): Timmy Lee, Joyce Qian, Mae Thamer, Michael AllonRationale & ObjectiveNational vascular access guidelines recommend placement of arteriovenous fistulas (AVFs) over grafts (AVGs) in hemodialysis patients, but have not been comprehensively assessed in the elderly. We evaluated clinically relevant vascular access outcomes in elderly patients receiving an AVF or AVG after hemodialysis therapy initiation.Study DesignRetrospective cohort study using national administrative data.Settings & PartcipantsClaims data from the US ...
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Cryoglobulinemic Glomerulonephritis Associated With Nodal and Renal Infiltration by T-Cell Lymphoma of T-Follicular Helper Phenotype: A Case Report
We present a unique case of cryoglobulinemic glomerulonephritis associated with nodal and renal infiltration by T-cell lymphoma of T-follicular helper phenotype. The patient presented with transient neurologic symptoms, severe nephritic syndrome with nephrotic-range proteinuria, and acute kidney injury. He had elevated double-stranded DNA levels, low complement levels, detectable cryoglobulin, and detectable immunoglobulin M (IgM) paraprotein. The kidney biopsy showed cryoglobulinemic glomerulonephritis with a membranoproliferative pattern and diffuse interstitial infiltrates on light microscopy; IgM, C3 but weak IgG, C1q,...
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Trends in Left Ventricular Assist Device Implantation and Associated Mortality Among Patients With and Without ESRD
Publication date: Available online 18 May 2018Source: American Journal of Kidney DiseasesAuthor(s): Carl P. Walther, Wolfgang C. Winkelmayer, Anita Deswal, Jingbo Niu, Sankar D. Navaneethan (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Risk of Progression of Nonalbuminuric CKD to End-Stage Kidney Disease in People With Diabetes: The CRIC (Chronic Renal Insufficiency Cohort) Study
Publication date: Available online 18 May 2018Source: American Journal of Kidney DiseasesAuthor(s): Digsu N. Koye, Dianna J. Magliano, Christopher M. Reid, Christopher Jepson, Harold I. Feldman, William H. Herman, Jonathan E. ShawBackgroundReduced glomerular filtration rate (GFR) in the absence of albuminuria is a common manifestation of chronic kidney disease (CKD) in diabetes. However, the frequency with which it progresses to end-stage kidney disease (ESKD) is unknown.Study DesignMulticenter prospective cohort study.Setting & ParticipantsWe included 1,908 participants with diabetes and reduced GFR enr...
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Seizures, Antiepileptic Drugs, and CKD
Publication date: Available online 18 May 2018Source: American Journal of Kidney DiseasesAuthor(s): Victoria Títoff, Heather N. Moury, Igor B. Títoff, Kevin M. KellyThere are 2 major categories of patients with seizures and chronic kidney disease (CKD): patients who develop acute symptomatic seizures in the setting of CKD and patients with epilepsy who at some point develop CKD. The incidence of uremic seizures with kidney failure is ∼10%. These seizures are often nonconvulsive and may mimic uremic encephalopathy. Recognition and management of such situations may be challenging for treating physicians who...
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Evolution of Echocardiographic Measures of Cardiac Disease From CKD to ESRD and Risk of All-Cause Mortality: Findings From the CRIC Study
We examined changes in echocardiographic measures during the transition from CKD to ESRD and their associations with post-ESRD mortality.Study DesignProspective study.Setting & ParticipantsWe studied 417 participants with CKD in the Chronic Renal Insufficiency Cohort (CRIC) who had research echocardiograms during CKD and ESRD.PredictorWe measured change in left ventricular mass index, left ventricular ejection fraction (LVEF), diastolic relaxation (normal, mildly abnormal, and moderately/severely abnormal), left ventricular end-systolic (LVESV), end-diastolic (LVEDV) volume, and left atrial volume from CKD to ESRD.Outc...
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Autosomal Dominant Tubulointerstitial Kidney Disease: Clinical Presentation of Patients With ADTKD-UMOD and ADTKD-MUC1
ConclusionsThe main genetic cause of ADTKD in our Spanish cohort is the MUC1 pathogenic mutation c.(428)dupC. Renal survival may be worse in individuals with the MUC1 mutation than in those with UMOD mutations. Clinical presentation does not permit distinguishing between these variants. However, hyperuricemia and gout are more frequent in individuals with ADTKD-UMOD. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Estimating Time to ESRD in Children With CKD
ConclusionsCKD staged by level of eGFR and proteinuria characterizes the timeline of progression and can guide management strategies in children. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Arteriovenous Fistula Maturation in Prevalent Hemodialysis Patients in the United States: A National Study
ConclusionsWe identified numerous associations between AVF maturation and patient-level factors in a recent national sample of US hemodialysis patients. After accounting for these patient factors, we observed substantial differences in AVF maturation across some ESRD networks, indicating a need for additional study of the provider, practice, and regional factors that explain AVF maturation.Graphical Abstract (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Linear and Nonlinear Estimated GFR Slopes in ADPKD Patients Reaching ESRD
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Matei Neagu, Daniel Coca, Albert C.M. Ong (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Impact of Obesity on Modality Longevity, Residual Kidney Function, Peritonitis, and Survival Among Incident Peritoneal Dialysis Patients
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Yoshitsugu Obi, Elani Streja, Rajnish Mehrotra, Matthew B. Rivara, Connie M. Rhee, Melissa Soohoo, Daniel L. Gillen, Wei-Ling Lau, Csaba P. Kovesdy, Kamyar Kalantar-ZadehBackgroundThe prevalence of severe obesity, often considered a contraindication to peritoneal dialysis (PD), has increased over time. However, mortality has decreased more rapidly in the PD population than the hemodialysis (HD) population in the United States. The association between obesity and clinical outcomes among patients with end-stage kidney disease...
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Center Effects and Peritoneal Dialysis Peritonitis Outcomes: Analysis of a National Registry
ConclusionsThese results suggest that center effects contribute substantially to the appreciable variation in PD peritonitis outcomes that exist across PD centers within Australia. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Prognostic Value of High-Sensitivity Versus Conventional Cardiac Troponin T Assays Among Patients With Type 2 Diabetes Mellitus Undergoing Maintenance Hemodialysis
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Till Keller, Christoph Wanner, Vera Krane, Daniel Kraus, Bernd Genser, Hubert Scharnagl, Winfried März, Christiane DrechslerBackgroundMortality is high among patients undergoing hemodialysis for whom cardiac troponin concentration is a strong predictor of outcome. Modern troponin assays allow measurement of very low concentrations.Study DesignUsing data from a randomized controlled trial, a cohort analysis to evaluate the prognostic value of very low cardiac troponin T (TnT) concentrations.Setting & Participants1,2...
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Factors Associated With Withdrawal From Maintenance Dialysis: A Case-Control Analysis
ConclusionsWomen, older patients, and those of white race were more likely to withdraw from dialysis therapy. The period before withdrawal was characterized by higher rates of medical events and higher levels of morbidity. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Validity of a Risk Prediction Equation for CKD After 10 Years of Follow-up in a Japanese Population: The Ibaraki Prefectural Health Study
ConclusionsEstimations of risk for CKD after 10 years of follow-up in a general Japanese population can be achieved with a high level of validity. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Hyperuricemia, Acute and Chronic Kidney Disease, Hypertension, and Cardiovascular Disease: Report of a Scientific Workshop Organized by the National Kidney Foundation
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Richard J. Johnson, George L. Bakris, Claudio Borghi, Michel B. Chonchol, David Feldman, Miguel A. Lanaspa, Tony R. Merriman, Orson W. Moe, David B. Mount, Laura Gabriella Sanchez Lozada, Eli Stahl, Daniel E. Weiner, Glenn M. ChertowUrate is a cause of gout, kidney stones, and acute kidney injury from tumor lysis syndrome, but its relationship to kidney disease, cardiovascular disease, and diabetes remains controversial. A scientific workshop organized by the National Kidney Foundation was held in September 2016 to review c...
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Palliative Care Disincentives in CKD: Changing Policy to Improve CKD Care
This article reviews policies that affect the delivery of palliative care for this population, discusses reforms that could address disincentives to palliative care, identifies quality measurement issues for palliative care for individuals with advanced CKD and ESRD, and considers potential pitfalls in the implementation of new models of integrated palliative care. Reforming health care delivery in ways that remove policy disincentives to palliative care for patients with advanced CKD and ESRD will fill a critical gap in care. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

CRISPR Gene Editing in the Kidney
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Nelly M. Cruz, Benjamin S. FreedmanCRISPR is a nuclease guidance system that enables rapid and efficient gene editing of specific DNA sequences within genomes. We review applications of CRISPR for the study and treatment of kidney disease. CRISPR enables functional experiments in cell lines and model organisms to validate candidate genes arising from genetic studies. CRISPR has furthermore been used to establish the first models of genetic disease in human kidney organoids derived from pluripotent stem cells. These gene-edi...
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Update on Diabetic Nephropathy: Core Curriculum 2018
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Kausik Umanath, Julia B. LewisDiabetic kidney disease and diabetic nephropathy are the leading cause of end-stage kidney disease in the United States and most developed countries. Diabetes accounts for 30% to 50% of the incident cases of end-stage kidney disease in the United States. Although this represents a significant public health concern, it is important to note that only 30% to 40% of patients with diabetes develop diabetic nephropathy. Specific treatment of patients with diabetic nephropathy can be divided into 4 ma...
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

High-Output Cardiac Failure and Coronary Steal With an Arteriovenous Fistula
We present a 78-year-old man with end-stage renal disease and concomitant coronary artery disease previously requiring coronary artery bypass grafting including a left internal mammary graft to the left anterior descending artery, ischemic cardiomyopathy with left ventricular systolic dysfunction, and severe aortic stenosis who developed hypotension unresponsive to medical therapy after recent angioplasty of his ipsilateral arteriovenous fistula for high-grade outflow stenosis. This case highlights the long-term effects of dialysis access on the cardiovascular system, with special emphasis on complications such as hig...
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

The Clinical and Immunologic Features of Patients With Combined Anti-GBM Disease and Castleman Disease
In this study, we report 3 patients with this combination. They had immunologic features similar to patients with classic anti-GBM disease. Sera from the 3 patients recognized the noncollagenous (NC) domain of the α3 chain of type IV collagen (α3(IV)NC1) and its 2 major epitopes, EA and EB. All 4 immunogloblin G (IgG) subclasses against α3(IV)NC1 were detectable, with predominance of IgG1. In one patient with lymph node biopsy specimens available, sporadic plasma cells producing α3(IV)NC1-IgG were found, suggesting a causal relationship between the 2 diseases. One patient, who achieved remission wit...
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Low Birth Weight: Intrauterine Growth Restriction or Prematurity?
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Judith Kooiman, Fieke Terstappen, A. Titia Lely (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

In Reply to ‘Low Birth Weight: Intrauterine Growth Restriction or Prematurity?’
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Johan G. Eriksson, Eero Kajantie, Clive Osmond (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Thoracic Ultrasound Artifacts: Still a Matter of Discussion
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Marco Sperandeo, Maria Giulia Tinti, Vincenzo Carnevale (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

In Reply to ‘Thoracic Ultrasound Artifacts: Still a Matter of Discussion’
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Adrian Covic, Luminita Voroneanu, Dimitrie Siriopol (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Artificial Intelligence Can Predict GFR Decline During the Course of ADPKD
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Olivier Niel, Charlotte Boussard, Paul Bastard (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

In Reply to ‘Artificial Intelligence Can Predict GFR Decline During the Course of ADPKD’ and ‘Linear and Nonlinear Estimated GFR Slopes in ADPKD Patients Reaching ESRD’
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Godela M. Brosnahan, Charity G. Moore, Kaleab Z. Abebe (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Rhabdomyolysis-Associated Acute Kidney Injury
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Pasquale Esposito, Luca Estienne, Nicoletta Serpieri, Dario Ronchi, Giacomo P. Comi, Maurizio Moggio, Lorenzo Peverelli, Stefania Bianzina, Teresa Rampino (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Contents
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Editorial Board
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Masthead
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Erratum Regarding “Low-Sodium Versus Standard-Sodium Peritoneal Dialysis Solution in Hypertensive Patients: A Randomized Controlled Trial” (Am J Kidney Dis. 2016;67[5]:753-761)
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

The Relationship of Quantitative Retinal Capillary Network to Kidney Function in Type 2 Diabetes
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Carol Y. Cheung, Fangyao Tang, Danny S. Ng, Raymond Wong, Jerry Lok, Zihan Sun, Tiffany Tso, Alexander Lam, Marten Brelén, Kelvin K. Chong, Andrea O. Luk, Juliana C. Chan, Tien Y. Wong, Clement C. Tham (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Cryptographic Protocols to Facilitate Decision Making in Kidney Paired Donation
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Lyndsay S. Baines, Rahul M. Jindal (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

In Reply to ‘Attempts to Change the Globally Accepted Term, CKDu, to KDUCAL, NUCAL, or CINAC Are Inappropriate’
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Srinivas Subramanian, Muhammad M. Javaid (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Attempts to Change the Globally Accepted Term, CKDu, to KDUCAL, NUCAL, or CINAC Are Inappropriate
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Sunil Wimalawansa, Oliver Ileperuma, C.S. Weeraratna (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Tolvaptan for the Syndrome of Inappropriate Secretion of Antidiuretic Hormone: Is the Dose Too High?
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Richard H. Sterns (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

More Realistic Estimation of Time to ESRD in Children
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Guido Filler, Christopher W. McIntyre (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Altered Prostaglandin Signaling as a Cause of Thiazide-Induced Hyponatremia
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Biff F. Palmer, Deborah J. Clegg (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Rapidity of Correction of Hyponatremia Due to Syndrome of Inappropriate Secretion of Antidiuretic Hormone Following Tolvaptan
Publication date: June 2018Source: American Journal of Kidney Diseases, Volume 71, Issue 6Author(s): Jesse H. Morris, Nicole M. Bohm, Branden D. Nemecek, Rachel Crawford, Denise Kelley, Bhavna Bhasin, Paul J. Nietert, Juan Carlos Q. VelezBackgroundTolvaptan effectively corrects hyponatremia due to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH), but undesired overcorrection can occur. We hypothesized that pretherapy parameters can predict the rapidity of response to tolvaptan in SIADH.Study DesignMulticenter historical cohort study.Setting & ParticipantsAdults with SIADH or congestive heart fail...
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Bioelectrical Impedance Analysis Measures and Clinical Outcomes in CKD
Publication date: Available online 6 June 2018Source: American Journal of Kidney DiseasesAuthor(s): Nisha Bansal, Leila R. Zelnick, Jonathan Himmelfarb, Glenn M. ChertowRationale & ObjectiveBioelectrical impedance analysis (BIA) provides a noninvasive assessment of body composition. BIA measures of cell integrity (phase angle) and hydration (vector length) have been associated with mortality among patients receiving dialysis. Whether these measures are associated with clinical outcomes in patients with chronic kidney disease (CKD) is unknown.Study DesignObservational study.Settings & ParticipantsWe studied 3,751 pa...
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Serum Calcitriol Concentrations and Kidney Function Decline, Heart Failure, and Mortality in Elderly Community-Living Adults: The Health, Aging, and Body Composition Study
ConclusionsLower calcitriol concentrations are independently associated with kidney function decline in community-living older adults. Future studies will be needed to clarify whether these associations reflect lower calcitriol concentrations resulting from abnormal kidney tubule dysfunction or direct mechanisms relating lower calcitriol concentrations to more rapid loss of kidney function. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research

Clinical Course of a Patient With Kidney Failure Due to Isolated Bilateral Renal Extramedullary Plasmacytomas
We report the case of a 69-year-old man who developed chronic kidney disease stage 4 between 2009 and 2012. Precipitous kidney failure, anorexia, fatigue, and flank pain necessitated clinical follow-up that ultimately led to thorough imaging and bilateral kidney biopsy. Protein electrophoresis, immunohistochemistry, and immunofluorescence were all consistent with bilateral renal extramedullary plasmacytomas. Treatment recommendations are often limited to prior case successes; however, chemotherapy, radiation, and surgery are the mainstay of treatment. Although surgery or combined therapy provides the best results for patie...
Source: American Journal of Kidney Diseases - July 11, 2018 Category: Urology & Nephrology Source Type: research