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Integrating Point-of-Care Ultrasonography Into Nephrology Fellowship Training: A Model Curriculum
Publication date: Available online 22 March 2019Source: American Journal of Kidney DiseasesAuthor(s): Abhilash Koratala, Mark S. Segal, Amir Kazory (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - March 24, 2019 Category: Urology & Nephrology Source Type: research

A Pivot Towards Moderating Intravenous Iron Therapy in Hemodialysis
Publication date: Available online 22 March 2019Source: American Journal of Kidney DiseasesAuthor(s): Xiaojuan Li, Abhijit V. Kshirsagar (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - March 24, 2019 Category: Urology & Nephrology Source Type: research

Oxalosis Associated With High-Dose Vitamin C Ingestion in a Peritoneal Dialysis Patient
We report a case of systemic oxalosis involving the eyes and joints due to long-term use of high-dose vitamin C in a patient receiving maintenance peritoneal dialysis (PD). This 76-year-old woman with autosomal dominant polycystic kidney disease underwent living unrelated kidney transplantation 10 years earlier. The transplant failed 6 months before presentation, and she initiated hemodialysis therapy before transitioning to PD therapy 4 months later. During the month before presentation, the patient noted worsening arthralgias and decreased vision. Ophthalmologic examination revealed proliferative retinopathy and calcium ...
Source: American Journal of Kidney Diseases - March 24, 2019 Category: Urology & Nephrology Source Type: research

Erratum Regarding “Renal Disorders in Pregnancy: Core Curriculum 2019” (Am J Kidney Dis. 2019;73[1]:119-130)
Publication date: Available online 22 March 2019Source: American Journal of Kidney DiseasesAuthor(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - March 24, 2019 Category: Urology & Nephrology Source Type: research

Probiotics and CKD Progression: Are Creatinine-Based Estimates of GFR Applicable?
Publication date: Available online 22 March 2019Source: American Journal of Kidney DiseasesAuthor(s): Kenneth D. Lempert (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - March 24, 2019 Category: Urology & Nephrology Source Type: research

Predictors of Net Acid Excretion in the Chronic Renal Insufficiency Cohort (CRIC) Study
Publication date: Available online 22 March 2019Source: American Journal of Kidney DiseasesAuthor(s): Landon Brown, Alison Luciano, Jane Pendergast, Pascale Khairallah, Cheryl A.M. Anderson, James Sondheimer, L. Lee Hamm, Ana C. Ricardo, Panduranga Rao, Mahboob Rahman, Edgar R. Miller, Daohang Sha, Dawei Xie, Harold I. Feldman, John Asplin, Myles Wolf, Julia J. Scialla, Lawrence J. Appel, Harold I. Feldman, Alan S. GoRationale & ObjectiveHigher urine net acid excretion (NAE) is associated with slower chronic kidney disease progression, particularly in patients with diabetes mellitus. To better understand potential mech...
Source: American Journal of Kidney Diseases - March 24, 2019 Category: Urology & Nephrology Source Type: research

Contents
Publication date: April 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 4Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - March 22, 2019 Category: Urology & Nephrology Source Type: research

KDOQI US Commentary on the 2017 ACC/AHA Hypertension Guideline
Publication date: April 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 4Author(s): Holly J. Kramer, Raymond R. Townsend, Karen Griffin, Joseph T. Flynn, Daniel E. Weiner, Michael V. Rocco, Michael J. Choi, Matthew R. Weir, Tara I. Chang, Rajiv Agarwal, Srinivasan BeddhuHypertension is a modifiable risk factor for cardiovascular morbidity and mortality and reduction of elevated blood pressure (BP) remains an important intervention for slowing kidney disease progression. Over the past decade, the most appropriate BP target for initiation and titration of BP-lowering medications has been an area of intense ...
Source: American Journal of Kidney Diseases - March 22, 2019 Category: Urology & Nephrology Source Type: research

Editorial Board
Publication date: April 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 4Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - March 22, 2019 Category: Urology & Nephrology Source Type: research

Masthead
Publication date: April 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 4Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - March 22, 2019 Category: Urology & Nephrology Source Type: research

Nephrotic Syndrome and a Maculopapular Rash
Publication date: April 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 4Author(s): Michael C. van Herwerden, Mark Wijnen, Frank M.M. Smedts, L. Jacobien Ellerbroek, Sebastiaan J. Huisman (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - March 22, 2019 Category: Urology & Nephrology Source Type: research

Hypertension in CKD: Core Curriculum 2019
Publication date: Available online 19 March 2019Source: American Journal of Kidney DiseasesAuthor(s): Elaine Ku, Benjamin J. Lee, Jenny Wei, Matthew R. WeirHypertension and chronic kidney disease (CKD) are closely interlinked pathophysiologic states, such that sustained hypertension can lead to worsening kidney function and progressive decline in kidney function can conversely lead to worsening blood pressure (BP) control. The pathophysiology of hypertension in CKD is complex and is a sequela of multiple factors, including reduced nephron mass, increased sodium retention and extracellular volume expansion, sympathetic nerv...
Source: American Journal of Kidney Diseases - March 21, 2019 Category: Urology & Nephrology Source Type: research

Cost-effectiveness of Pneumococcal Vaccination Among Patients With CKD in the United States
Publication date: Available online 19 March 2019Source: American Journal of Kidney DiseasesAuthor(s): Junichi Ishigami, William V. Padula, Morgan E. Grams, Alexander R. Chang, Bernard Jaar, Ron T. Gansevoort, John F.P. Bridges, Csaba P. Kovesdy, Shinichi Uchida, Josef Coresh, Kunihiro MatsushitaRationale & ObjectivePneumococcal vaccine is recommended for adults 65 years and older and those younger than 65 years with clinical indications (eg, diabetes, lung/heart disease, kidney failure, and nephrotic syndrome). Its cost-effectiveness in less severe chronic kidney disease (CKD) is uncharacterized.Study DesignCost-effect...
Source: American Journal of Kidney Diseases - March 21, 2019 Category: Urology & Nephrology Source Type: research

Erratum Regarding “Comparing Newer GFR Estimating Equations Using Creatinine and Cystatin C to the CKD-EPI Equation in Adults” (Am J Kidney Dis. 2017;70[4]:587-589)
Publication date: Available online 20 March 2019Source: American Journal of Kidney DiseasesAuthor(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - March 21, 2019 Category: Urology & Nephrology Source Type: research

Operationalizing Telehealth for Home Dialysis Patients in the United States
Publication date: Available online 18 March 2019Source: American Journal of Kidney DiseasesAuthor(s): Susie Q. Lew, Neal SikkaUntil January 2019, Medicare beneficiaries requiring maintenance dialysis therapy were eligible for telehealth services only if the originating site was located in a rural area and the patient was situated in an authorized facility. Free-standing dialysis facilities and the patient’s home were clearly restricted sites. Beginning in 2019, new opportunities are available for home dialysis patients in the United States to engage in telehealth; these include existing waivers within End-Stage Renal...
Source: American Journal of Kidney Diseases - March 19, 2019 Category: Urology & Nephrology Source Type: research

Using Human Genetics to Drive Drug Discovery: A Perspective
Publication date: Available online 18 March 2019Source: American Journal of Kidney DiseasesAuthor(s): Caroline S. FoxThe probability of success of developing medicines to treat human disease can be improved by leveraging human genetics. Different types of genetic data and techniques, including genome-wide association, whole-exome sequencing, and whole-genome sequencing, can be used to gain insight into human disease. Layering different types of genetic evidence from Mendelian disease, coding variants, and common variation can bolster support for a genetic target. Human knockouts offer the potential to perform reverse genet...
Source: American Journal of Kidney Diseases - March 19, 2019 Category: Urology & Nephrology Source Type: research

Integrative Point-of-Care Ultrasound Curriculum to Impart Diagnostic Skills Relevant to Nephrology
Publication date: Available online 18 March 2019Source: American Journal of Kidney DiseasesAuthor(s): Surekha Mullangi, Stephen M. Sozio, David B. Hellmann, Carol Martire, Sadichhya Lohani, Paul Segal, Tariq Shafi (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - March 19, 2019 Category: Urology & Nephrology Source Type: research

Identifying Important Outcomes for Young People With CKD and Their Caregivers: A Nominal Group Technique Study
ConclusionsKidney function, infection, survival, and growth were the highest priorities for patients with CKD and their caregivers. Young people with CKD also prioritized highly the outcomes that directly affected their lifestyle and sense of normality, while caregiver’s highest priorities concerned the long-term health of their child, current health problems, and the financial and family burdens of caring for a child with CKD. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - March 16, 2019 Category: Urology & Nephrology Source Type: research

Ethical and Policy Considerations for Genomic Testing in Pediatric Research: The Path Toward Disclosing Individual Research Results
Publication date: Available online 14 March 2019Source: American Journal of Kidney DiseasesAuthor(s): Craig S. Wong, Amy J. Kogon, Bradley A. Warady, Susan L. Furth, John D. Lantos, Benjamin S. WilfondDNA is now commonly collected in clinical research either for immediate genomic analyses or stored for future studies. Many genomic studies were previously designed without awareness of the ethical issues that might arise regarding the disclosure of genomic test results. At the start of the Chronic Kidney Disease in Children (CKiD) Cohort Study in 2004, we did not foresee the advent of genomic technology or the associated eth...
Source: American Journal of Kidney Diseases - March 15, 2019 Category: Urology & Nephrology Source Type: research

NUP Nephropathy: When Defective Pores Cause Leaky Glomeruli
Publication date: Available online 12 March 2019Source: American Journal of Kidney DiseasesAuthor(s): Beata S. Lipska-Ziętkiewicz, Franz Schaefer (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - March 13, 2019 Category: Urology & Nephrology Source Type: research

Anti-LRP2 Nephropathy With Abundant IgG4-Positive Plasma Cells: A Case Report
We present a rare case of anti-LRP2 nephropathy/anti–brush border antibody disease and describe the novel feature of abundant IgG4-positive interstitial plasma cells. Along with the combination of TBM deposits, tubulointerstitial nephritis (TIN), and segmental glomerular subepithelial immune deposits seen in both entities, this newly described feature adds to the morphologic overlap with IgG4-related TIN. Identification of large TBM deposits using light microscopy and IgG staining of apical aspects of proximal tubules using immunofluorescence microscopy can point to the correct diagnosis of anti-LRP2 nephropathy and ...
Source: American Journal of Kidney Diseases - March 13, 2019 Category: Urology & Nephrology Source Type: research

Urinary Concentration Ability: Time to Bring the Tubules to the Table
Publication date: Available online 12 March 2019Source: American Journal of Kidney DiseasesAuthor(s): Ke Wang, Bryan Kestenbaum (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - March 13, 2019 Category: Urology & Nephrology Source Type: research

CKD Progression: Teasing Out Contributions of Elements in the Human Exposome
Publication date: Available online 12 March 2019Source: American Journal of Kidney DiseasesAuthor(s): Neil R. Powe (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - March 13, 2019 Category: Urology & Nephrology Source Type: research

An Ex Vivo Test of Complement Activation on Endothelium for Individualized Eculizumab Therapy in Hemolytic Uremic Syndrome
ConclusionsThe C5b-9 endothelial deposition assay may represent an advance in our ability to monitor aHUS activity and individualize therapy. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - March 7, 2019 Category: Urology & Nephrology Source Type: research

Estimated GFR at Dialysis Initiation and Mortality in Children and Adolescents
The objective of this study was to evaluate the mortality risk associated with eGFR at dialysis therapy initiation in children and adolescents with kidney failure.Study DesignRetrospective cohort study.Setting & Participants9,963 incident dialysis patients aged 1 to 17 years in the US Renal Data System registry (1995-2016).PredictoreGFRs at dialysis therapy initiation calculated using the pediatric-specific bedside Schwartz equation (
Source: American Journal of Kidney Diseases - March 4, 2019 Category: Urology & Nephrology Source Type: research

In Reply to ‘TREX1 Mutation Causing Autosomal Dominant Thrombotic Microangiopathy and CKD Is in Fact a Case of RVCL-S Presenting With Renal Features’
Publication date: Available online 4 March 2019Source: American Journal of Kidney DiseasesAuthor(s): Ashima Gulati, Neera Dahl (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - March 4, 2019 Category: Urology & Nephrology Source Type: research

TREX1 Mutation Causing Autosomal Dominant Thrombotic Microangiopathy and CKD Is in Fact a Case of RVCL-S Presenting With Renal Features
Publication date: Available online 4 March 2019Source: American Journal of Kidney DiseasesAuthor(s): Irene de Boer, Arn M.J.M. van den Maagdenberg, Gisela M. Terwindt (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - March 4, 2019 Category: Urology & Nephrology Source Type: research

Transcriptomics of Human Arteriovenous Fistula Failure: Genes Associated With Nonmaturation
This study compares the RNA expression of pre-access (native) veins and AVFs with distinct maturation outcomes.Study DesignCase-control study.Setting & Participants64 patients undergoing 2-stage AVF surgeries at a single center. 19 native veins and 19 AVF samples were analyzed using RNA sequencing (RNA-seq). 58 native veins were studied using real-time polymerase chain reaction; 45, using immunohistochemistry; and 19, using Western blot analysis.PredictorRNA expression in native veins and AVFs.OutcomeAnatomic nonmaturation, defined as an AVF that never achieved an internal diameter ≥ 6 mm.Analytical Approa...
Source: American Journal of Kidney Diseases - March 1, 2019 Category: Urology & Nephrology Source Type: research

Comparing Seizure Risk Between Peritoneal Dialysis and Hemodialysis
Publication date: Available online 27 February 2019Source: American Journal of Kidney DiseasesAuthor(s): Thiago J.M. Gonçalves, Rosa M.A. Moysés, Fernando M. Coelho, Rosilene M. Elias (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - March 1, 2019 Category: Urology & Nephrology Source Type: research

Prevalence and Risk Factors for CKD Among Brickmaking Workers in La Paz Centro, Nicaragua
Publication date: Available online 27 February 2019Source: American Journal of Kidney DiseasesAuthor(s): Lyanne Gallo-Ruiz, Caryn M. Sennett, Mauricio Sánchez-Delgado, Ana García-Urbina, Tania Gámez-Altamirano, Komal Basra, Rebecca L. Laws, Juan José Amador, Damaris Lopez-Pilarte, Yorghos Tripodis, Daniel R. Brooks, Michael D. McClean, Joseph Kupferman, David Friedman, Aurora Aragón, Marvin González-Quiroz, Madeleine K. ScammellRationale & ObjectiveIn Central America, there is a high prevalence of chronic kidney disease (CKD) of nontraditional etiology often observed among agri...
Source: American Journal of Kidney Diseases - March 1, 2019 Category: Urology & Nephrology Source Type: research

Mineralocorticoid Antagonism and Vascular Function in Early Autosomal Dominant Polycystic Kidney Disease: A Randomized Controlled Trial
Conclusions24 weeks of aldosterone antagonism reduced systolic blood pressure without changing vascular function in patients with early-stage ADPKD.FundingNIDDK, NIH National Center for Advancing Translational Sciences, and the Zell Family Foundation.Trial RegistrationRegistered at ClinicalTrials.gov with study number NCT01853553. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - February 23, 2019 Category: Urology & Nephrology Source Type: research

Progressive Decline in Estimated GFR in Patients With Sickle Cell Disease: An Observational Cohort Study
Publication date: Available online 21 February 2019Source: American Journal of Kidney DiseasesAuthor(s): Vimal K. Derebail, Emily J. Ciccone, Qingning Zhou, R. Rosina Kilgore, Jianwen Cai, Kenneth I. AtagaRationale & ObjectiveProgression of chronic kidney disease (CKD) in sickle cell disease (SCD) and its risk factors remain poorly defined. We identified characteristics associated with CKD as well as decline in estimated glomerular filtration rate (eGFR) and presence of proteinuria over time in adults with SCD.Study DesignRetrospective observational study.Setting & ParticipantsPatients with SCD 18 years or older in...
Source: American Journal of Kidney Diseases - February 22, 2019 Category: Urology & Nephrology Source Type: research

International Variations in Peritoneal Dialysis Utilization and Implications for Practice
Publication date: Available online 22 February 2019Source: American Journal of Kidney DiseasesAuthor(s): Victoria Briggs, Simon Davies, Martin WilkieIn many countries, the use of peritoneal dialysis (PD) remains low despite arguments that support its greater use, including dialysis treatment away from hospital settings, avoidance of central venous catheters, and potential health economic advantages. Training patients to manage aspects of their own care has the potential to enhance health literacy and increase patient involvement, independence, quality of life, and cost-effectiveness of care. Complex reasons underlie the va...
Source: American Journal of Kidney Diseases - February 22, 2019 Category: Urology & Nephrology Source Type: research

Renal Hemodynamic Function and RAAS Activation Over the Natural History of Type 1 Diabetes
Publication date: Available online 22 February 2019Source: American Journal of Kidney DiseasesAuthor(s): Yuliya Lytvyn, Petter Bjornstad, Julie A. Lovshin, Genevieve Boulet, Mohammed A. Farooqi, Vesta Lai, Josephine Tse, Leslie Cham, Leif E. Lovblom, Alanna Weisman, Hillary A. Keenan, Michael H. Brent, Narinder Paul, Vera Bril, Andrew Advani, Etienne Sochett, Bruce A. Perkins, David Z.I. CherneyRationale & ObjectiveThe renin-angiotensin-aldosterone system (RAAS) is associated with renal and cardiovascular disease in diabetes. Unfortunately, early RAAS blockade in patients with type 1 diabetes mellitus (T1DM) does not p...
Source: American Journal of Kidney Diseases - February 22, 2019 Category: Urology & Nephrology Source Type: research

2018 USRDS Annual Data Report: Executive Summary
Publication date: March 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 3, Supplement 1Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - February 22, 2019 Category: Urology & Nephrology Source Type: research

Chapter 1: CKD in the General Population
Publication date: March 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 3, Supplement 1Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - February 22, 2019 Category: Urology & Nephrology Source Type: research

Chapter 2: Identification and Care of Patients with CKD
Publication date: March 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 3, Supplement 1Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - February 22, 2019 Category: Urology & Nephrology Source Type: research

Chapter 3: Morbidity and Mortality in Patients with CKD
Publication date: March 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 3, Supplement 1Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - February 22, 2019 Category: Urology & Nephrology Source Type: research

Chapter 4: Cardiovascular Disease in Patients with CKD
Publication date: March 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 3, Supplement 1Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - February 22, 2019 Category: Urology & Nephrology Source Type: research

Chapter 5: Acute Kidney Injury
Publication date: March 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 3, Supplement 1Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - February 22, 2019 Category: Urology & Nephrology Source Type: research

Chapter 6: CKD among Children and Adolescents
Publication date: March 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 3, Supplement 1Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - February 22, 2019 Category: Urology & Nephrology Source Type: research

Chapter 7: Healthcare Expenditures for Persons with CKD
Publication date: March 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 3, Supplement 1Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - February 22, 2019 Category: Urology & Nephrology Source Type: research

Chapter 8: Prescription Drug Coverage in Patients with CKD
Publication date: March 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 3, Supplement 1Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - February 22, 2019 Category: Urology & Nephrology Source Type: research

Contents
Publication date: March 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 3Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - February 22, 2019 Category: Urology & Nephrology Source Type: research

Volume 1: CKD Analytical Methods
Publication date: March 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 3, Supplement 1Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - February 22, 2019 Category: Urology & Nephrology Source Type: research

Chapter 1: Incidence, Prevalence, Patient Characteristics, and Treatment Modalities
Publication date: March 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 3, Supplement 1Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - February 22, 2019 Category: Urology & Nephrology Source Type: research

Chapter 2: Clinical Indicators and Preventive Care
Publication date: March 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 3, Supplement 1Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - February 22, 2019 Category: Urology & Nephrology Source Type: research

Chapter 3: Vascular Access
Publication date: March 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 3, Supplement 1Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - February 22, 2019 Category: Urology & Nephrology Source Type: research

Chapter 4: Hospitalizations, Readmissions, Emergency Department Visits, and Observation Stays
Publication date: March 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 3, Supplement 1Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - February 22, 2019 Category: Urology & Nephrology Source Type: research

Chapter 5: Mortality
Publication date: March 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 3, Supplement 1Author(s): (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - February 22, 2019 Category: Urology & Nephrology Source Type: research