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Total 195 results found since Jan 2013.

Visual statistical learning and orthographic awareness in Chinese children with and without developmental dyslexia
This study examined the role of visual statistical learning in reading and writing and its relationship to orthographic awareness in Hong Kong Chinese children with and without developmental dyslexia. Thirty-five 7- to 8-year-old children with developmental dyslexia and 37 chronologically age-matched controls were tested on visual statistical learning, orthographic awareness, nonverbal cognitive ability, Chinese word reading, and word dictation tasks. Visual statistical learning was assessed using a triplet learning paradigm that required children to detect the temporal order of visual stimuli. Orthographic awareness was m...
Source: Research in Developmental Disabilities - July 31, 2019 Category: Disability Source Type: research

23 Stroke outcomes in patients with left ventricular assist device
In conclusion, stroke remains an important cause of morbidity and mortality among Hong Kong patients receiving LVAD therapy.
Source: Heart Asia - April 24, 2019 Category: Cardiology Authors: Wong, K., Cally, H., Au, T. W., Katherine, F. Tags: Keynote Lecture Source Type: research

11 Hospice and palliative care for advanced cardiac diseases in hong kong
Advanced cardiac diseases are common non-cancer conditions that require good palliative care. Palliative Care should embrace both cancer and non-cancer conditions, and is applicable early in the course of illness, in conjunction with other therapies. There is a high prevalence of symptoms and distress in heat failure (HF) necessitating palliative care, which include not just dyspnoea and oedema but also a range of other symptoms that are all sub-optimally controlled at the end of life.1 For patients with HF, palliative care attends to physical, psychological, social and spiritual distress, caring for both patients and fam...
Source: Heart Asia - April 24, 2019 Category: Cardiology Authors: Lo, R. S. Tags: Keynote Lecture Source Type: research

Influence of Combined Transcranial Direct Current Stimulation and Motor Training on Corticospinal Excitability in Children With Unilateral Cerebral Palsy
Conclusion This proof-of-principle study evaluated the influence of cathodal contralesional tDCS on corticospinal excitability in pediatric participants with UCP. A hypothesized decrease in contralesional excitability was noted in participants in the Active+CIMT group, however, the efficacy of tDCS to modulate corticospinal excitability was not statistically different than the Sham+CIMT group. A more detailed understanding of how tDCS impacts M1 neurophysiology will be essential to inform future clinical trials on the optimal dosing parameters, based on individual brain circuitry, to explore the potential functional benef...
Source: Frontiers in Human Neuroscience - April 23, 2019 Category: Neuroscience Source Type: research

Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1 β Deficient Murine Hearts
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health pro...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Shengui Sansheng San Ameliorates Cerebral Energy Deficiency via Citrate Cycle After Ischemic Stroke
Conclusion In summary, SSS extraction significantly ameliorates cerebral energy metabolism via boosting citrate cycle, which mainly embodies the enhancements of blood glucose concentration, glucose and lactate transportation and glucose utilization, as well as the regulations of relative enzymes activities in citrate cycle. These ameliorations ultimately resulted in numerous ATP yield after stroke, which improved neurological function and infarcted volume. Collectively, it suggests that SSS extraction has exerted advantageous effect in the treatment of cerebral ischemia. Ethics Statement All animal operations were accor...
Source: Frontiers in Pharmacology - April 22, 2019 Category: Drugs & Pharmacology Source Type: research

The validity, reliability and clinical utility of a performance-based executive function assessment in people with mild to moderate dementia.
CONCLUSION: Our results indicated that the Chinese Multiple Errands Test is a reliable and valid instrument for assessing executive function in Chinese older people with dementia. PMID: 30990085 [PubMed - as supplied by publisher]
Source: Aging and Mental Health - April 15, 2019 Category: Geriatrics Authors: Lai FH, Dawson D, Yan EW, Ho EC, Tsui JW, Fan SH, Lee AT Tags: Aging Ment Health Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

An Evaluation of Personal Cooling Systems for Reducing Thermal Strain Whilst Working in Chemical/Biological Protective Clothing
Conclusion: The IV, PCM, and SLIV produced lower heart rate, mean skin, rectal and mean body temperatures in addition to improved work times compared to control. The WS did not improve work times possibly as a result of the cooling capacity of the suit abating, and magnifying thermal insulation. Considering the added time and resources required to implement combination cooling in the form of ice slurry and ice vest (SLIV), there was no significant additive effect for perception, cardiovascular strain, rectal temperature and total trial time relative to the phase change vest or ice vest alone. This may be a product of a &#x...
Source: Frontiers in Physiology - April 11, 2019 Category: Physiology Source Type: research

6-Bromoindirubin-3 ′-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver
In this study, we aimed to investigate the anti-aging effect, and molecular mechanism, of the novel anti-aging drug 6BIO on naturally aged mouse liver. Rapamycin, a well-known promising anti-aging drug that delays aging through mTOR-dependent autophagy (Zhou and Ye, 2018), was used as the positive control in the study. To our knowledge, this is the first study to demonstrate the effects of 6BIO treatment in models of natural aging. Our results indicated that 6BIO ameliorates the decline of liver function with age, including lipid metabolism disorder, and attenuates hepatocyte senescence in aged mice, as revealed by altera...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

Grain size units of Chinese handwriting: development and disorder.
Abstract The current study investigated the grain size of writing units used by children in copying Chinese characters using handwriting measures. In Experiment 1, 31 Grade 1 and 31 Grade 5 children studying in mainstream schools in Hong Kong were invited to copy 36 pseudo-characters on an Android tablet. The pseudo-characters were constructed by combining, in their legal positions, radicals that contain two logographemes. The pseudo-characters contain only high frequency radicals in one condition and only low frequency radicals in the other condition. Linear mixed effect modeling was used to analyze the significa...
Source: Clinical Linguistics and Phonetics - April 1, 2019 Category: Speech-Language Pathology Authors: Lau DK Tags: Clin Linguist Phon Source Type: research

Mirror therapy with bilateral arm training for hemiplegic upper extremity motor functions in patients with chronic stroke.
PMID: 30792371 [PubMed - in process]
Source: Hong Kong Med J - February 1, 2019 Category: General Medicine Authors: Fong KN, Ting KH, Chan CC, Li LS Tags: Hong Kong Med J Source Type: research

Ekso Bionics Steps Up to Develop Exoskeleton Market in Asia
China is expected to have 30 million stroke patients by 2030, and many of those patients will have some degree of disability. And yet, the stroke and spinal cord rehabilitation industry in China is not as developed as it is in the United States. A new joint venture between Ekso Bionics, Zhejiang Youchuang Venture Capital Investment (ZYVC) and Zhejiang Silicon Paradise Asset Management Group could change that. "This joint venture is a transformative opportunity both for Ekso Bionics and for the millions of Chinese stroke and spinal cord injury patients who currently have limited access to advanced rehabilitation...
Source: MDDI - January 30, 2019 Category: Medical Devices Authors: MDDI Staff Tags: Orthopedics Source Type: news

Influence of ultra-endurance exercise on alveolar-capillary recruitment and lung diffusion
Conclusion: The data suggest a transient decrease in DLco following ultraendurance exercise is related to pulmonary de-recruitment; however, alveolar-capillary recruitment during low-intensity exercise remains relatively preserved.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Stewart, G., Fermoyle, C., Wheatley, C., Ziegler, B., Johnson, B. Tags: Clinical respiratory physiology, exercise and functional imaging Source Type: research

Hong Kong ’s PolyU develops robotic arm for stroke patients to facilitate mobile rehabilitation
The Hong Kong Polytechnic University (PolyU) yesterday announced the development of a robotic arm to facilitate self-help and upper-limb mobile rehabilitation for stroke patients. The robotic arm, called “mobile exo-neuro-musculo-skeleton”, is the first-of-its-kind integration of exo-skeleton, soft robot and exo-nerve stimulation technologies.
Source: mobihealthnews - November 1, 2018 Category: Information Technology Source Type: news