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Medtronic Gives Heart Docs Something to & #039;MARVEL & #039; At
Study results published this week in the Journal of the American College of Cardiology: Clinical Electrophysiology show that an investigational set of algorithms in Medtronic's Micra transcatheter pacing system (TPS) significantly improves synchrony and cardiac function in patients with impaired electrical conduction between the chambers of the heart, a condition called atrioventricular (AV) block.
The results from the MARVEL 2 study are expected to be presented Nov. 16 at the American Heart Association's annual scientific sessions.
Medtronic said that based on positive results from both...
Source: MDDI - November 11, 2019 Category: Medical Devices Authors: Amanda Pedersen Tags: Implants Source Type: news
The burden of health conditions across race and ethnicity for aging Americans: Disability-adjusted life years
The objective of this study was to determine the burden of 10 health conditions across race and ethnicity for a nationally-representative sample of aging Americans.
Data from the 1998 to 2014 waves of the Health and Retirement Study, an ongoing longitudinal-panel study, were analyzed.
Those aged over 50 years who identified as Black, Hispanic, or White were included. There were 5510 Blacks, 3423 Hispanics, and 21,168 Whites in the study.
At each wave, participants reported if they had cancer, chronic obstructive pulmonary disease, congestive heart failure, diabetes, back pain, hypertension, a fractured hip, myocardial i...
Source: Medicine - November 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Understanding the Global Prevalence of Hypertension in Children and Adolescents
Hypertension is a major risk factor for the development of cardiovascular disease morbidity and mortality worldwide. Stroke, heart failure, myocardial infarction, and peripheral arterial disease are all outcomes associated with hypertension in adults. Hypertension is also considered to be a major cause of poorer disability-adjusted life-years. The prevalence of hypertension in adults has been debated in part because the definition of hypertension has changed over time. The association between blood pressure and cardiovascular disease is a continuous one, making the establishment of a cut point for hypertension difficult. H...
Source: JAMA Pediatrics - October 7, 2019 Category: Pediatrics Source Type: research
Hypertensive Heart Failure: Sprinting to the Finish Line to Prevent End-Organ Damage
Hypertension affects a billion individuals globally,1 and with the aging population (79% of men and 85% of women>75 years old have high blood pressure [BP]), this number continues to grow,2,3 and the consequences of hypertension are expected to increase. High BP is second only to cigarette smoking as a preventable cause of death in the United States,4 and uncontrolled hypertension results in heart failure, coronary artery disease, kidney disease, stroke, and aortic dissection.5 Progress over the last few decades has led to better understanding and a new knowledge of this growing worldwide epidemic of high BP.
Source: Heart Failure Clinics - August 29, 2019 Category: Cardiology Authors: Ragavendra R. Baliga, Eduardo Bossone, George L. Bakris Tags: Preface Source Type: research
9824 —Prevention of taxane-induced alopecia and nail toxicity
Introduction: Hidradenitis suppurativa (HS) and psoriasis have been linked to cardiovascular disease. There is currently a deficiency in the literature regarding the prevalence of clinically important cardiovascular diseases that arise in patients with HS in a United States population. We sought to determine the odds of stroke, coronary artery disease (CAD), heart failure (HF), and peripheral artery disease (PAD) in patients with HS compared with patients with psoriasis and controls.
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research
9798 —Hidradenitis suppurativa is associated with increased odds of stroke, coronary artery disease, heart failure, and PAD: A population-based analysis in the United States
Introduction: Hidradenitis suppurativa (HS) and psoriasis has been linked to cardiovascular disease. There is currently a deficiency in the literature regarding the prevalence of clinically important cardiovascular diseases that arise in patients with HS in a United States population. We sought to determine the odds of stroke, coronary artery disease (CAD), heart failure (HF), and peripheral artery disease (PAD) in patients with HS compared with patients with psoriasis and controls.
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research
Medicare's bundled payment model did not change skilled nursing facility discharge patterns.
CONCLUSIONS: Hospital participation in BPCI was not associated with changes in the number of SNF partners or in discharge concentration relative to non-BPCI hospitals. More research is needed to understand how hospitals are responding to bundled payment incentives and specific practices that contribute to improvements in cost and quality.
PMID: 31318505 [PubMed - in process]
Source: The American Journal of Managed Care - June 30, 2019 Category: Health Management Authors: Zhu JM, Navathe A, Yuan Y, Dykstra S, Werner RM Tags: Am J Manag Care Source Type: research
Accountability Assessment of Health Improvements in the United States Associated with Reduced Coal Emissions Between 2005 and 2012
Conclusions:
The direct analyses of emissions reductions estimate substantial health benefits via coal power plant emission and PM2.5 concentration reductions. Differing responses associated with changes in the two exposure metrics underscore the importance of isolating source-specific impacts from those due to total PM2.5 exposure.
Source: Epidemiology - June 6, 2019 Category: Epidemiology Tags: Air Pollution Source Type: research
Hospital participation in clinical trials for patients with acute myocardial infarction: Results from the National Cardiovascular Data Registry
ConclusionsHospitals are becoming less likely to engage in clinical trials for patients with MI. Patients admitted to hospitals that participated in clinical trials more often received guideline-adherent care and had better long-term outcomes.
Source: American Heart Journal - May 26, 2019 Category: Cardiology Source Type: research
Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats
Conclusion
Principal findings of this work are that abnormal Ca2+ transient amplitude, contractile dysfunction; and impaired relaxation of MetS cardiomyocytes underlies intrinsic dysfunctional RyR2 and SERCA pump. Abnormal activity of RyRs was evidenced by its decreased ability to bind [3H]-ryanodine. Although the MetS condition does not modify RyR2 protein expression, its phosphorylation at Ser2814 is decreased, which impairs its capacity for activation during ECC. The dysfunctional RyRs, together with a decreased activity of SERCA pump due to decreased Thr17-PLN phosphorylation suggest a downregulation of CaMKII in MetS...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research
Age-Dependence of Flow Homeostasis in the Left Ventricle
Conclusions: In average, blood spends 1 to 3 beats inside the LV with very low shear stress rates. The apical region is the most prone to blood stasis, particularly in mid-aged adults. The washout of blood in the normal LV is age-dependent due to physiological changes in the degree of apical penetration of the filling waves.
Introduction
Cardioembolic stroke is a major source of mortality and disability worldwide and blood stasis one of its major determinants (Adams et al., 1986). Left ventricular (LV) function has evolved to maximize mechanical efficiency and ensure organ perfusion at a low cost of energy and fill...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research
Harnessing the Four Elements for Mental Health
DiscussionAs detailed above, the “elements” in both a classical and a contemporary sense have effects on our mental health and are potentially modifiable aspects that can be harnessed as therapeutic interventions. The most robust interventional evidence currently available shows tentative support for several use of the elements via horticultural and nature-exposure therapy, green exercise/physical activity, sauna and heat therapy, balneotherapy, and breathing exercises. It should be noted that, in many cases, these interventions were not studied in definitive diagnosed psychiatric disorders and thus it is pre...
Source: Frontiers in Psychiatry - April 23, 2019 Category: Psychiatry Source Type: research
Combination of Dexmedetomidine and Ketamine for Magnetic Resonance Imaging Sedation
Conclusions: The efficacy of DEX–KET sedation was comparable to that of midazolam for MRI examination. DEX–KET was related to shorter scan time and lower occurrence of complications compared to midazolam.
Introduction
Neurocritically ill patients often require brain magnetic resonance imaging (MRI) in addition to conventional neurological evaluations. Brain MRI can reveal structural lesions with a high sensitivity due to its excellent spatial resolution and enhanced soft tissue contrast (1–3). To acquire MRI images, patients' cooperation is imperative. However, keeping patients with ...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research
Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1 β Deficient Murine Hearts
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis.
Introduction
Atrial arrhythmias constitute a major public health pro...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research
Effect of Warfarin on Ischemic Stroke, Bleeding, and Mortality in Patients with Atrial Fibrillation Receiving Peritoneal Dialysis
ConclusionThere is no significant association between warfarin treatment with risks of mortality, ischemic stroke or bleeding in patients with atrial fibrillation receiving peritoneal dialysis.
Source: American Journal of Cardiovascular Drugs - April 22, 2019 Category: Cardiology Source Type: research
