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Total 481 results found since Jan 2013.

MEK/ERK/1/2 sensitive vascular changes coincide with retinal functional deficit, following transient ophthalmic artery occlusion.
In conclusion, this is the first study to show a beneficial in vivo effect of U0126 on vascular contractility following ischemia in the ophthalmic artery. Coupled with the knowledge obtained from cerebral vasculature, these results point towards a novel therapeutic approach following ischemia-related injuries to the eye. PMID: 30439349 [PubMed - as supplied by publisher]
Source: Experimental Eye Research - November 12, 2018 Category: Opthalmology Authors: Blixt FW, Haanes KA, Ohlsson L, Sörensen KD, Fedulov V, Warfvinge K, Edvinsson L Tags: Exp Eye Res Source Type: research

Endothelial Cell-Specific Inactivation of TSPAN12 (Tetraspanin 12) Reveals Pathological Consequences of Barrier Defects in an Otherwise Intact Vasculature.
Conclusions- This study establishes mice with late endothelial cell-specific loss of Tspan12 as a model to study pathological consequences of BRB impairment in an otherwise intact vasculature. PMID: 30354230 [PubMed - in process]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 26, 2018 Category: Cardiology Authors: Zhang C, Lai MB, Pedler MG, Johnson V, Adams RH, Petrash JM, Chen Z, Junge HJ Tags: Arterioscler Thromb Vasc Biol Source Type: research

Tannins and Vascular Complications of Diabetes: An update
ConclusionThis review focuses on the role of various tannins in prevention and management of diabetic complications like diabetic nephropathy, diabetic neuropathy, diabetic retinopathy and diabetic cardiomyopathy. It will researchers to find some leads for the development of new cost effective therapy using dietary source for the management of diabetic complications.Graphical abstract
Source: Phytomedicine - October 23, 2018 Category: Drugs & Pharmacology Source Type: research

Evaluation of health utility values for diabetic complications, treatment regimens, glycemic control and other subjective symptoms in diabetic patients using the EQ-5D-5L
ConclusionsThe utility decrement related to each diabetic complication varied with its severity and accompanying symptoms. Complex treatment regimens were independently associated with lower utility values. The utility decrement associated with diabetic complication and complex treatment regimens would be overestimated in the analysis without adjustment for glycemic control or other subjective symptoms.
Source: Acta Diabetologica - October 23, 2018 Category: Endocrinology Source Type: research

Bile acids and their effects on diabetes
AbstractDiabetes is a widespread, rapidly increasing metabolic disease that is driven by hyperglycemia. Early glycemic control is of primary importance to avoid vascular complications including development of retinal disorders leading to blindness, end-stage renal disease, and accelerated atherosclerosis with a higher risk of myocardial infarction, stroke and limb amputations. Even after hyperglycemia has been brought under control, “metabolic memory,” a cluster of irreversible metabolic changes that allow diabetes to progress, may persist depending on the duration of hyperglycemia. Manipulation of bile acid (BA) recep...
Source: Frontiers of Medicine - October 10, 2018 Category: General Medicine Source Type: research

Could 2018 Really Be the Year of AI in Medtech?
Has there really been another topic in medtech this year that has generated more attention than Artificial Intelligence? There have been numerous approvals, clearances, and even in some cases praise from regulatory bodies about AI-based medtech. MD+DI has been on the frontlines covering the recent AI boom. That coverage spawned a webinar titled, How Artificial Intelligence Has Changed Everything for Medtech hosted by Dave Saunders CTO and Co-founder of Galen Robotics. In just a few short weeks at MD&M Minneapolis, AI will be discussed in depth at a session titled, Artificial Intelligence (AI): What You Need to Know to ...
Source: MDDI - October 9, 2018 Category: Medical Devices Authors: Omar Ford Tags: Business Digital Health Source Type: news

To Pack or Not to Pack: Inpatient Management of Epistaxis in the Elderly.
Conclusion Nonpacking interventions in the elderly do not appear to be associated with increased morbidity or mortality when compared to nasal packing only but appear to be associated with increased hospital charges and length of stay. Embolization in the elderly results in greater hospital charges but no change in outcome when compared to ligation. PMID: 30270635 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - October 1, 2018 Category: ENT & OMF Authors: Zhou AH, Chung SY, Sylvester MJ, Zaki M, Svider PS, Hsueh WD, Baredes S, Eloy JA Tags: Am J Rhinol Allergy Source Type: research

Attention network plays key role in restoring vision after brain damage
(Institute for Medical Psychology, Otto-v.-Guericke University Magdeburg) About one-third of patients who have suffered a stroke end up with low vision, losing up to half of their visual field. This partial blindness was long considered irreversible, but recent studies have shown that vision training after optic nerve and brain damage can help restore or improve vision. A new study published in the journal Clinical Neurophysiology reports on key mechanisms of vision restoration: attention.
Source: EurekAlert! - Biology - September 4, 2018 Category: Biology Source Type: news

A cross-sectional survey of general practice health workers ’ perceptions of their provision of culturally competent services to ethnic minority people with diabetes
Diabetes is the fourth most common cause of death globally [1]. It is a lifelong disease, with serious health complications (such as blindness, coronary vascular disease, kidney failure, nerve damage, stroke and lower limb amputation) and significantly reduces life expectancy [2]. The ageing populations and rising levels of obesity across the world would suggest diabetes is a major challenge in global public health. Ethnic minority groups (population subgroups with an ethnic origin different from that of the majority population of the host country), are susceptible to diabetes due to physiological, environmental and lifest...
Source: Primary Care Diabetes - August 22, 2018 Category: Primary Care Authors: Peter Zeh, Ann-Marie Cannaby, Harbinder K. Sandhu, Jane Warwick, Jackie A. Sturt Tags: Original research Source Type: research

Pearce Bailey: The "Fifth Horseman" and the National Institute for Neurological Diseases and Blindness.
Authors: Burkholder DB Abstract Pearce Bailey (1902-1976) had an active career focused on the growth and development of neurology as a specialty in the post-World War II era. He was a founding member of the American Academy of Neurology (AAN) and its second president from 1951 to 1953. In 1951, he was also appointed as the first director of the National Institute for Neurological Diseases and Blindness (NINDB), which is now the National Institute of Neurological Disorders and Stroke. Known as an excellent politician, Bailey's role at the NINDB helped bolster the AAN in its early days. Prominent neurologists in the ...
Source: Journal of the History of the Neurosciences - August 19, 2018 Category: Neuroscience Tags: J Hist Neurosci Source Type: research

Abe Baker: Visionary and organizational leader of the American Academy of Neurology.
Authors: Lanska DJ Abstract American neurologist and neuropathologist Abraham Bert (Abe) Baker (1908-1988) was instrumental in founding the American Academy of Neurology and served as a catalyst for the emergence of neurology as a strong, independent medical discipline in the United States in the second half of the twentieth century. Baker served as the first president of the Academy from 1948 to 1951. He was also instrumental in garnering support for the National Institute of Neurological Diseases and Blindness, which was founded in 1950 and later evolved into the National Institute of Neurological Disorders and S...
Source: Journal of the History of the Neurosciences - August 19, 2018 Category: Neuroscience Tags: J Hist Neurosci Source Type: research

The development of diabetes complications in GP-centered healthcare.
CONCLUSIONS: The results of the present study indicate that GP-centered healthcare is associated with a delay in the occurrence of serious diabetes complications and reduces the risk of diabetes complications. This may be because GP-centered care is associated with improved coordination of care. PMID: 30020751 [PubMed - in process]
Source: The American Journal of Managed Care - July 1, 2018 Category: Health Management Authors: Karimova K, Uhlmann L, Hammer M, Guethlin C, Gerlach FM, Beyer M Tags: Am J Manag Care Source Type: research

Health Tip: 4 Steps to Manage Diabetes
-- Every year, 1.7 million people in the United States are diagnosed with diabetes, the U.S. National Institutes of Health says. Left untreated, diabetes can lead to heart disease, stroke, kidney disease, blindness and other health problems, the...
Source: Drugs.com - Daily MedNews - June 14, 2018 Category: General Medicine Source Type: news

The Diabetes Self-management educational programs and their integration in the usual care: a systematic literature review
One of the public health challenges worldwide is diabetes mellitus (DM). It is the fifth leading cause of death in high-income countries, and rapidly becoming an epidemic in low and middle-income countries. The global number of adult people suffering from diabetes in 2014 was estimated at 422 million, and this number is expected to rise to 592 million by 2035, while 175 million people remain undiagnosed [1]. Diabetes care is expensive and the condition can lead to serious complications such as kidney failure, myocardial infarction, stroke, blindness and limb amputation [2].
Source: Health Policy - June 13, 2018 Category: Health Management Authors: Emmanuel Kumah, Giulia Sciolli, Maria Laura Toraldo, Anna Maria Murante Source Type: research

Preparation And Evaluation Of Eudragit Coated Chitosan Microparticles For Oral Insulin Delivery
Objectives Diabetes mellitus was known in relic and vestiges at present a global and ascalating health problem with millions of cases being diagnosed daily. Diabetes can affect numerous parts of the body and is associated with solemn complications, such as heart disease and stroke, blindness, kidney failure, and lower-limb amputation. Some complications, particularly micro vascular (e.g., eye, kidney, and nerve) disease, can be reduced with good glucose control.
Source: Pancreatology - June 1, 2018 Category: Gastroenterology Authors: Aakanchha Jain, S.A.U.R.A.B.H. Bhargav, S.O.U.R.A.B.H. JAIN Tags: 5. Diabetes and the pancreas Source Type: research