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Diabetes Equates the Rich and the Poor
Diabetes test, Mauritius. Credit: Nasseem Ackbarally/IPSBy Bruno KappaNAIROBI, Nov 12 2021 (IPS) Although for different reasons, diabetes appears to be one of the few cases that put rich and poor societies at equal footing. In either case, diabetes is caused by wrong, dangerous to health nutritional habits. In fact, people in industrialised countries tend to consume the so-called “junk food”, while in poor nations diabetes is caused by malnutrition and undernourishment. And it is a seriously worrying health problem. In fact, globally, an estimated 422 million adults were living with diabetes as of 2014, compared to 108...
Source: IPS Inter Press Service - Health - November 12, 2021 Category: International Medicine & Public Health Authors: Bruno Kappa Tags: Global Headlines Health Source Type: news

Function of selected natural antidiabetic compounds with potential against cancer via modulation of the PI3K/AKT/mTOR cascade
Biomed Pharmacother. 2021 Nov 5:112138. doi: 10.1016/j.biopha.2021.112138. Online ahead of print.ABSTRACTDiabetes mellitus (DM) is a metabolic disorder with growing global incidence, as 387 million people were diagnosed in 2014 with an expected projection of 642 million in 2040. Several complications are associated with DM including heart attack, stroke, kidney failure, blindness, and cancer. The latter is the second leading cause of death worldwide accounting for one in every six deaths, with liver, pancreas, and endometrium cancers are the most abundant among patients with diabetes. Phosphoinositide 3-kinase (PI3K)/prote...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 9, 2021 Category: Drugs & Pharmacology Authors: Agustina Dwi Retno Nurcahyanti Adeline Jap Jullietta Lady Deka Prismawan Farukh Sharopov Rachid Daoud Michael Wink Mansour Sobeh Source Type: research

Efficacy and safety of acupuncture combined with Chinese herbal medicine in the treatment of type 2 diabetes mellitus: A protocol for a systematic review and meta-analysis
This study will generate evidence-based data on the treatment of T2DM with acupuncture combined with Chinese herbal medicine and will provide new ideas and treatment modalities to investigate in future research.
Source: Medicine - October 29, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Novel prenatal diagnosis of protein C deficiency and primary prophylaxis with protein C concentrate
Protein C deficiency (PCD) is a rare inherited thrombophilia with high morbidity and mortality. Protein C plays an important role in the coagulation cascade by inactivating factors V and VIII, which then decreases thrombin production. In the absence of protein C, these pro-coagulant factors proceed unchecked, causing a hypercoagulable state. PCD may manifest with early and severe clinical complications, including purpura fulminans, disseminated intravascular coagulation, vitreal vein thrombosis resulting in blindness, and arterial ischemic stroke [1].
Source: Thrombosis Research - October 19, 2021 Category: Hematology Authors: Alexandra Prosser, Lauren Amos, Mukta Sharma Tags: Full Length Article Source Type: research

Safety of intravenous thrombolysis and mechanical thrombectomy in bilateral posterior cerebral artery territory infarction
CONCLUSION: Even if there is no randomized controlled trial to compare the effectiveness and safety of mechanical thrombectomy (MT) to intravenous thrombolysis in patients with posterior circulation occlusion, the good outcome of this case encourages combined stroke treatments in posterior circulation stroke, even in case of mild but disabling neurological deficits.PMID:34629044 | DOI:10.2174/1574886316666211008140212
Source: Current Drug Safety - October 11, 2021 Category: Drugs & Pharmacology Authors: Maurizio Acampa Francesca Guideri Sandra Bracco Rossana Tassi Carlo Domenichelli Pietro Enea Lazzerini Samuele Cioni Giuseppe Martini Source Type: research

Using electronic health records to develop and validate a machine-learning tool to predict type 2 diabetes outcomes: a study protocol
Introduction Type 2 diabetes mellitus (T2DM) is a major cause of blindness, kidney failure, myocardial infarction, stroke and lower limb amputation. We are still unable, however, to accurately predict or identify which patients are at a higher risk of deterioration. Most risk stratification tools do not account for novel factors such as sociodemographic determinants, self-management ability or access to healthcare. Additionally, most tools are based in clinical trials, with limited external generalisability. Objective The aim of this work is to design and validate a machine learning-based tool to identify patients with T2...
Source: BMJ Open - July 30, 2021 Category: General Medicine Authors: Neves, A. L., Pereira Rodrigues, P., Mulla, A., Glampson, B., Willis, T., Darzi, A., Mayer, E. Tags: Open access, Health informatics Source Type: research

Threatening Blindness in a Child With Typical Hemolytic Uremic Syndrome
Hemolytic uremic syndrome (HUS) is the most common cause of acute kidney failure in children younger than five years. Central nervous system involvement occurs in 15% of patients, with clinical manifestations including confusion, coma, seizures, stroke, and cortical blindness. Ocular involvement in children with HUS is rare, but retinal and choroidal hemorrhages as well as ischemic retinopathy due to thrombotic microangiopathic lesions have been documented.
Source: Pediatric Neurology - June 24, 2021 Category: Neurology Authors: Ana ïs Corgier-Pattberg, Marie Beylerian, Stephanie Clave, Mathilde Cailliez, Benoit Testud, Beatrice Desnous Tags: Short Communication Source Type: research

Threatening blindness in a child with typical haemolytic uremic syndrome
Hemolytic uremic syndrome (HUS) is the most common cause of acute kidney failure in children under five years of age, following a gastrointestinal infection with Shiga toxin-producing Escherichia coli (STEC) and characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury (1). Central Nervous System (CNS) involvements are seen in 15% of cases, with clinical manifestations ranging from obnubilation to coma, seizures, stroke, and cortical blindness (2).
Source: Pediatric Neurology - June 24, 2021 Category: Neurology Authors: Ana ïs Corgier-Pattberg, Marie Beylerian, Stephanie Clave, Mathilde Cailliez, Benoit Testud, Beatrice Desnous Tags: Short Communication Source Type: research

Contrast-Induced Encephalopathy after Cerebral Angiogram: A Case Series and Review of Literature
We present 4 individual cases of CIE who presented with stroke-mimic symptoms following surgery with localized iodixanol or ioversol injection. We outline a clinical timeline of all patients, showing that CIE follows a general pattern of delayed onset, worsening symptomology, and ultimately full recovery. All patients received IV hydration, corticosteroids, or both as part of their treatment protocol.Case Rep Neurol 2021;13:405 –413
Source: Case Reports in Neurology - June 18, 2021 Category: Neurology Source Type: research

Concordance between sudomotor disorder and the clinical diagnosis of diabetic peripheral neuropathy, according to various clinical guidelines
In 2017, according to the International Diabetes Federation, 425 million people worldwide, or 8.8% of all adults aged 20 –79 years, were living with diabetes mellitus (DM), about four times more than in 1980. Regrettably, this figure is expected to increase to about 642 million by 2040 [1]. DM is the seventh leading cause of death and provokes many debilitating, detrimental consequences, including organ failure, hea rt disease, stroke, blindness and lower-extremity amputations [2].
Source: Primary Care Diabetes - June 6, 2021 Category: Primary Care Authors: Esther Chicharro-Luna, Ana Belen Ortega-Avila, Aranza Requena-Mart ínez, Gabriel Gijon Nogueron Tags: Original research Source Type: research

An Anatomical Guide to the Terminal Facial Artery: Lumen Diameter and Associated Anatomy Relevant to Dermatologic Procedures
CONCLUSION The large-caliber lumen diameter of the terminal FA creates the potential for intra-arterial injection with commonly used filler needles and blunt-tipped cannulas at all points in its course in the nasolabial fold and midface.
Source: Dermatologic Surgery - June 1, 2021 Category: Dermatology Tags: Original Article Source Type: research