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High prevalence of primary dyslipidaemia in black South African patients at a tertiary hospital in northern Gauteng, South Africa.
CONCLUSION: A significant burden and a high prevalence of dyslipidaemias were present in adults in whom a monogenic disorder should be considered. The extent and severity of dyslipidaemia justify a special clinic and laboratory to ensure accurate diagnosis with effective intervention for patients and their families. PMID: 27384370 [PubMed - as supplied by publisher]
Source: South African Medical Journal - July 8, 2016 Category: African Health Tags: S Afr Med J Source Type: research

What to Expect When Expecting With Systemic Lupus Erythematosus (SLE): A Population‐Based Study of Maternal and Fetal Outcomes in SLE and Pre‐SLE
ConclusionOur data demonstrate that adverse maternal and fetal outcomes are more common in SLE pregnancies. Furthermore, these unfavorable outcomes are observed in pregnancies occurring prior to the diagnosis of SLE. Thus, the underlying immunologic profile of SLE and alterations preceding clinical SLE may contribute to these pregnancy complications.
Source: Arthritis Care and Research - June 22, 2016 Category: Rheumatology Authors: Elizabeth V. Arkema, Kristin Palmsten, Christopher Sjöwall, Elisabet Svenungsson, Jane E. Salmon, Julia F. Simard Tags: Systemic Lupus Erythematosus Source Type: research

What to Expect When Expecting With Systemic Lupus Erythematosus (SLE): A Population ‐Based Study of Maternal and Fetal Outcomes in SLE and Pre‐SLE
ConclusionOur data demonstrate that adverse maternal and fetal outcomes are more common in SLE pregnancies. Furthermore, these unfavorable outcomes are observed in pregnancies occurring prior to the diagnosis of SLE. Thus, the underlying immunologic profile of SLE and alterations preceding clinical SLE may contribute to these pregnancy complications.
Source: Arthritis Care and Research - June 22, 2016 Category: Rheumatology Authors: Elizabeth V. Arkema, Kristin Palmsten, Christopher Sj öwall, Elisabet Svenungsson, Jane E. Salmon, Julia F. Simard Tags: Systemic Lupus Erythematosus Source Type: research

Post authorization safety study comparing quetiapine to risperidone and olanzapine
ConclusionsQuetiapine was associated with lower EPS, but higher failed suicide attempt rates compared to risperidone. Quetiapine was associated with lower EPS and DM rates compared to olanzapine. The results should be interpreted with caution because of possible channelling and residual confounding. Copyright © 2016 John Wiley & Sons, Ltd.
Source: Human Psychopharmacology: Clinical and Experimental - June 12, 2016 Category: Psychiatry Authors: Edith M. Heintjes, Jetty A. Overbeek, Fernie J. A. Penning‐van Beest, Gunnar Brobert, Ron M. C. Herings Tags: Research Article Source Type: research

Unmasking a Hidden Cause of Persistent Facial Ulceration: The Relevancy of a Neurologic Examination
A 49-year-old woman presented to the Emergency Department of a tertiary medical center for evaluation of chronic facial ulceration. Her past medical history was significant for type II diabetes mellitus, hypothyroidism, antiphospholipid antibody syndrome, venous thromboembolism, and stroke. The patient noted progressive ulceration around the left nasal ala with extension to the left eyebrow and eyelid for 2 years. She had been evaluated for this problem numerous times at outside medical facilities.
Source: The American Journal of Medicine - May 19, 2016 Category: Journals (General) Authors: Kyle W. Mahoney, Jules B. Lipoff, Bennett W. Clark Tags: Diagnostic dilemma Source Type: research

Unmasking a Hidden Cause of Persistent Facial Ulceration The Relevancy of a Neurologic Examination
A 49-year-old woman presented to the emergency room of a tertiary medical center for evaluation of chronic facial ulceration. Her past medical history was significant for type II diabetes mellitus, hypothyroidism, antiphospholipid antibody syndrome, venous thromboembolism, and stroke. The patient noted progressive ulceration around the left nasal ala with extension to the left eyebrow and eyelid for 2 years. She had been evaluated for this problem numerous times at outside medical facilities. Previous treatments included three 6-week courses of intravenous vancomycin, one 6-week course of daptomycin, and one 2-week course of oral acyclovir.
Source: The American Journal of Medicine - May 19, 2016 Category: Journals (General) Authors: Kyle W. Mahoney, Jules B. Lipoff, Bennett W. Clark Tags: Diagnostic Dilemma Source Type: research

Unmasking a Hidden Cause of Persistent Facial Ulceration: The Relevancy of a Neurologic Examination
A 49-year-old woman presented to the Emergency Department of a tertiary medical center for evaluation of chronic facial ulceration. Her past medical history was significant for type II diabetes mellitus, hypothyroidism, antiphospholipid antibody syndrome, venous thromboembolism, and stroke. The patient noted progressive ulceration around the left nasal ala with extension to the left eyebrow and eyelid for 2 years. She had been evaluated for this problem numerous times at outside medical facilities.
Source: The American Journal of Medicine - May 19, 2016 Category: Journals (General) Authors: Kyle W. Mahoney, Jules B. Lipoff, Bennett W. Clark Tags: Diagnostic dilemma Source Type: research

What to expect when expecting with SLE: A population‐based study of maternal and fetal outcomes in SLE and pre‐SLE
Conclusions: Our data demonstrate that adverse maternal and fetal outcomes are more common in SLE pregnancies. Furthermore these unfavourable outcomes are observed in pregnancies occurring prior to the diagnosis of SLE. Thus, the underlying immunologic profile of SLE and alterations preceding clinical SLE may contribute to these pregnancy complications. This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - February 1, 2016 Category: Rheumatology Authors: Elizabeth V. Arkema, Kristin Palmsten, Christopher Sjöwall, Elisabet Svenungsson, Jane E. Salmon, Julia F. Simard Tags: Original Article Source Type: research

Oversleeping: The Effects and Health Risks of Sleeping Too Much
This article originally appeared on the Amerisleep blog. Rosie Osmun is the Creative Content Manager at Amerisleep, a progressive memory foam mattress brand focused on eco-friendly sleep solutions. Rosie writes more posts on the Amerisleep blog about the science of sleep, eco-friendly living, leading a healthy lifestyle and more. -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.
Source: Healthy Living - The Huffington Post - January 29, 2016 Category: Consumer Health News Source Type: news

De Novo Headache During Pregnancy and Puerperium
Conclusion: De novo headache during pregnancy is relatively common and almost always leads to neurological referral.
Source: The Neurologist - December 28, 2015 Category: Neurology Tags: Review Article Source Type: research

Clinical Reasoning: A 50-year-old man with "elephantiasis" and headache
A 50-year-old man with a medical history of "elephantiasis" of the legs, status post left above the knee amputation with prosthetic limb, and hypothyroidism presented with 1 week of headache and nausea. The headache was continuous, with gradual worsening over the 7 days prior to admission, and he had minimal relief with ibuprofen. On the second day, he developed nausea. He denied any history of headaches, blurred or double vision, numbness, weakness, tingling, loss of balance, vertigo, chest pain, palpitations, or shortness of breath. In the emergency room, he was afebrile with a heart rate of 78 beats per minute and regul...
Source: Neurology - November 23, 2015 Category: Neurology Authors: Yaghi, S., Kitago, T., Elkind, M. S. V. Tags: All Cerebrovascular disease/Stroke, Embolism, Infarction RESIDENT AND FELLOW SECTION Source Type: research

A Probable Life-Saving Switch from Apixaban to Phenprocoumon.
Abstract The direct oral anticoagulants (DOAC) dabigatran, rivaroxaban, and apixaban are increasingly prescribed in atrial fibrillation (AF) patients, although dosage in elderly patients, safety in chronic kidney disease, food- and drug-interactions, laboratory tests for monitoring, and antidote are not clarified. In a 78-year-old man with an acute stroke, paroxysmal AF and sick-sinus-syndrome were detected as he received a DDD-pacemaker and 5 mg apixaban/bid. He had a history of hypertension, hypothyroidism, diabetes mellitus, hyperlipidemia, sleep apnea, lumbar discopathy, and nephropathy. Renal function deterio...
Source: The Heart Surgery Forum - October 30, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Stöllberger C, Finsterer J Tags: Heart Surg Forum Source Type: research

Autism in the Son of a Woman with Mitochondrial Myopathy and Dysautonomia: A Case Report
Conclusion Given emerging evidence that mitochondrial dysfunction, particularly in the electron transport chain needed for cellular energy production, is an underlying pathophysiological mechanism for some varieties of ASD, clinicians should have a high index of suspicion for mitochondrial disease, especially when they encounter a patient with unusual neurological or constitutional symptoms. The prevalence of mitochondrial disease in ASD patients may be as high as five percent, which means that it is not the “zebra”[27] diagnosis that it might be in a non-ASD patient, where prevalence is about 0.01 percent.10 Reference...
Source: Innovations in Clinical Neuroscience - October 9, 2015 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Asperger's syndrome Autism Behavioral and Cognitive Neurology Case Report Current Issue Intellectual Disability Neurologic Systems and Symptoms Pervasive Developmental Disorders ASD autism spectrum disorder dysauton Source Type: research

Multiple intracranial arteritis and hypothyroidism secondary to Streptococcus anginosus infection
A 50-year-old Chinese woman reported a sharp paroxysmal headache and abrupt paralysis of the left leg. She then developed ptosis, blurred vision, diplopia and fever. On admission, a neurological examination revealed right III, IV, VI and left V1 cranial nerve palsy, bilateral upper eyelid oedema and left leg monoplegia (Medical Research Council grade 2/5). In addition, a left Babinski sign and nuchal rigidity were observed. Blood tests revealed elevated white cell count (WCC) and a majority of the cells were neutrophils. Lumbar puncture revealed that the WCC (120x106/μL) and protein level (0.79 g/L) of the cerebros...
Source: Journal of Neurology, Neurosurgery and Psychiatry - August 13, 2015 Category: Neurosurgery Authors: Zhang, C., Xie, B., Shi, F.-D., Hao, J. Tags: Open access, Immunology (including allergy), Meningitis, Brain stem / cerebellum, Cranial nerves, Drugs: CNS (not psychiatric), Headache (including migraine), Infection (neurology), Pain (neurology), Stroke, Hypertension, Ophthalmology, Radiology, Musculo Source Type: research

Post-thrombolysis hemorrhage in a patient with hypothyroidism and acute ischemic stroke: Case report.
Abstract Thrombolytic treatment with intravenous recombinant tissue plasminogen activator (rtPA) is an effective treatment for acute ischemic stroke. However, its effectiveness and risks in patients with hypothyroidism have not been reported. Here, we report the case of hemorrhagic transformation after intravenous rtPA thrombolysis treatment in a patient with acute ischemic stroke and hypothyroidism. An apparent edema formed around the hematoma and progressively worsened. He also developed lung infection, electrolyte imbalance, and abnormal liver and kidney functions, and eventually died within 1 month of symptom ...
Source: Neurologia i Neurochirurgia Polska - July 1, 2015 Category: Neurology Authors: Gu F, Qin J, Chen R, Xu X Tags: Neurol Neurochir Pol Source Type: research