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Triiodothyronine Aggravates Global Cerebral Ischemia-Reperfusion Injury in Mice
In this study, we examined the effect of T3 administration on DNA fragmentation induced by neuronal death and the activation of inflammatory cells such as astrocytes and microglia in the hippocampus following GCI. The content of nucleosomes generated by DNA fragmentation in the hippocampus was increased by GCI and further increased by T3 administration. The protein expression levels of glial fibrillary acidic protein (GFAP), an astrocytic marker, and Ionized calcium binding adaptor protein 1 (Iba1), a microglial marker, in the hippocampus were also increased by GCI and further increased by T3 administration. The levels of ...
Source: Biological and Pharmaceutical Bulletin - December 2, 2021 Category: Drugs & Pharmacology Authors: Masaru Doshi Shiro Watanabe Yujin Natori Makoto Hosoyamada Yutaka Hirashima-Akae Source Type: research
