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Specialty: Neuroscience
Condition: Hemorrhagic Stroke

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Total 735 results found since Jan 2013.

Evaluation of Postural Sway in Post-stroke Patients by Dynamic Time Warping Clustering
This study instead evaluates the postural sway features of post-stroke patients using the clustering method of machine learning. First, we collected the stroke patients' multi-variable motion-capture standing-posture data and processed them into t s long data slots. Then, we clustered the t-s data slots into K cluster groups using the dynamic-time-warping partition-around-medoid (DTW-PAM) method. The DTW measures the similarity between two temporal sequences that may vary in speed, whereas PAM identifies the centroids for the DTW clustering method. Finally, we used a post-hoc test and found that the sway amplitudes of mark...
Source: Frontiers in Human Neuroscience - December 3, 2021 Category: Neuroscience Source Type: research

Outcomes in minor stroke patients treated with intravenous thrombolysis
CONCLUSIONS: Intravenous t-PA may be safe and effective in minor stroke (NIHSS ≤ 5) within a 4.5-h window and further randomized controlled trials are warranted.PMID:36942504 | DOI:10.1111/cns.14164
Source: CNS Neuroscience and Therapeutics - March 21, 2023 Category: Neuroscience Authors: Chunmiao Duan Yunyun Xiong Hong-Qiu Gu Shang Wang Kai-Xuan Yang Manjun Hao Xingquan Zhao Xia Meng Yongjun Wang Source Type: research

Candesartan Reduces the Hemorrhage Associated with Delayed Tissue Plasminogen Activator Treatment in Rat Embolic Stroke.
Abstract We have previously reported that angiotensin receptor blockade reduces reperfusion hemorrhage in a suture occlusion model of stroke, despite increasing matrix metalloproteinase (MMP-9) activity. We hypothesized that candesartan will also decrease hemorrhage associated with delayed (6 h) tissue plasminogen activator (tPA) administration after embolic stroke, widening the therapeutic time window of tPA. Adult male Wistar rats were subjected to embolic middle cerebral artery occlusion (eMCAO) and treated with either candesartan (1 mg/kg) alone early at 3 h, delayed tPA (10 mg/kg) alone at 6 h, the combi...
Source: Neurochemical Research - November 6, 2013 Category: Neuroscience Authors: Ishrat T, Pillai B, Ergul A, Hafez S, Fagan SC Tags: Neurochem Res Source Type: research

Intersegmental coordination of gait after hemorrhagic stroke.
Abstract We compared gait using the planar law of intersegmental coordination between 14 hemorrhagic stroke subjects walking at a self-selected normal speed (56 ± 21 cm/s) and 15 age-matched healthy controls walking at a very slow speed (56 ± 19 cm/s). Sagittal plane elevation angles of the thigh, shank, and foot segments were submitted to principal component analysis. Additional outcome measures included the range of elevation angle and timing of peak elevation angle of the thigh, shank, and foot segments. The range of elevation angles at the shank and foot was significantly smaller in the paretic leg tha...
Source: Experimental Brain Research - September 17, 2014 Category: Neuroscience Authors: Chow JW, Stokic DS Tags: Exp Brain Res Source Type: research

Aerobic exercise effects on neuroprotection and brain repair following stroke: A systematic review and perspective
Publication date: October 2014 Source:Neuroscience Research, Volume 87 Author(s): Mark W. Austin , Michelle Ploughman , Lindsay Glynn , Dale Corbett Aerobic exercise (AE) enhances neuroplasticity and improves functional outcome in animal models of stroke, however the optimal parameters (days post-stroke, intensity, mode, and duration) to influence brain repair processes are not known. We searched PubMed, CINAHL, PsychInfo, the Cochrane Library, and the Central Register of Controlled Clinical Trials, using predefined criteria, including all years up to July 2013 (English language only). Clinical studies were included if p...
Source: Neuroscience Research - November 22, 2014 Category: Neuroscience Source Type: research

EP 9. Prevalence, clinical characteristics and long-term course of headache in patients with stroke (multicenter study of DMKG)
Headache in association with stroke is a symptom not at all differentiated and investigated in Germany. According to previous data, it seems to be a common problem, but usually other symptoms of stroke are predominating. Furthermore, the treatment is focused on acute therapy of ischemic stroke followed by rehabilitation. However, headaches in subarachnoid hemorrhage as a special type of stroke represents the leading clinical symptom and thus also be diagnostically significant. Headache in stroke should be classified as symptomatic headache (IHS 6.1 –6.2).
Source: Clinical Neurophysiology - August 5, 2016 Category: Neuroscience Authors: S. Dietrich, A. D üring, D. Rothkirch, F. Filippopulos, O. Eren, T. Dresler, A. Straube, G. Goßrau, T. Kraya Source Type: research

LDL receptor blockade reduces mortality in a mouse model of ischaemic stroke without improving tissue-type plasminogen activator-induced brain haemorrhage: towards pre-clinical simulation of symptomatic ICH
ConclusionDespite the proven causative relationship between severe HT and neurological deterioration in human stroke, rt-PA-triggered HT in mouse MCAo does not contribute to neurological deficit or simulate sICH. Model limitations, such as the long duration of occlusion required, the type of HT achieved and the timing of deficit assessment may account for this mismatch. Our results further suggest that blockade of LDL receptors improves stroke outcome irrespective of rt-PA, blood –brain barrier breakdown and HT.
Source: Fluids and Barriers of the CNS - November 21, 2017 Category: Neuroscience Source Type: research

Acute reversal of dabigatran with Idarucizumab for intravenous thrombolysis as acute stroke treatment
We describe the case of a 73 year old male with AIS and active dabigatran use. Idarucizumab was administered per an approved medical center protocol and the patient was subsequently treated with IV rt-PA. The patient had a severe stroke with no other contraindications to IV rt-PA other than dabigatran use. The patient was administered Idarucizumab and IV rt-PA was given. Within 24 h of treatment, the patient had minimal stroke deficits. Imaging revealed a right middle cerebral artery patchy infarct. The patient was restarted on dabigatran therapy for his atrial fibrillation and was discharged to a skilled nursing facil...
Source: Journal of Clinical Neuroscience - October 9, 2018 Category: Neuroscience Source Type: research

Iron nanoparticle contrast enhanced microwave imaging for emergent stroke: A pilot study
Publication date: Available online 1 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Joseph S. Hudson, Timothy K. Chung, Benjamin S. Prout, Yasunori Nagahama, Madhavan L. Raghavan, David M. HasanAbstractEmergent stroke is mostly evaluated using hospital based imaging. Quick imaging allows for rapid administration of IV thrombolysis and outcome improvement. Microwave imaging (MI) is an emerging portable imaging modality. Iron oxide nanoparticles are known to interact with microwave frequency electromagnetic radiation. In this manuscript, we provide proof of concept for a novel iron oxide nanoparticle enhance...
Source: Journal of Clinical Neuroscience - November 2, 2018 Category: Neuroscience Source Type: research

Incidence, Implications, and Management of Seizures Following Ischemic and Hemorrhagic Stroke
AbstractPurpose of ReviewIn this review, we summarize the recent literature regarding the incidence and treatment of seizures arising after ischemic and hemorrhagic strokes. Additionally, we identify open questions in guidelines and standard clinical care to aid future studies aiming to improve management of seizures in post-stroke patients.Recent FindingsStudies demonstrate an increasing prevalence of seizures following strokes, probably a consequence of advances in post-stroke management and expanding use of continuous EEG monitoring. Post-stroke seizures are associated with longer hospitalization and increased mortality...
Source: Current Neurology and Neuroscience Reports - May 26, 2019 Category: Neuroscience Source Type: research

Targeting focal ischemic and hemorrhagic stroke neuroprotection: current prospects for local hypothermia
AbstractTherapeutic hypothermia (TH) has applications dating back millennia. In modern history, however, TH saw its importation into medical practice where investigations have demonstrated that TH is efficacious in ischemic insults, notably cardiac arrest and hypoxic-ischemic encephalopathy. As well, studies have been undertaken to investigate whether TH can provide benefit in focal stroke (i.e., focal ischemia and intracerebral hemorrhage). However, clinical studies have encountered various challenges with induction and maintenance of post-stroke TH. Most clinical studies have attempted to use body-wide cooling protocols,...
Source: Journal of Neurochemistry - September 9, 2021 Category: Neuroscience Authors: Lane J. Liddle, Anna C.J. Kalisvaart, Ashley H. Abrahart, Mohammed Almekhlafi, Andrew Demchuk, Frederick Colbourne Tags: REVIEW Source Type: research

Effect of Ginkgolide in Ischemic Stroke patients with large Artery Atherosclerosis: Results from a randomized trial
CONCLUSIONS: Ginkgolide, working as PAF antagonist, may reduce recurrent stroke in AIS with ICAS patients within 72 hours after onset. It might be an optional treatment in moderate-to-severe AIS patients with ICAS. (http://www.chictr.org.cn Number as ChiCTR-IPR-17012310).PMID:34676982 | DOI:10.1111/cns.13742
Source: CNS Neuroscience and Therapeutics - October 22, 2021 Category: Neuroscience Authors: Yi Dong Jingyu Zhang Yanxia Wang Lihong Zhao Runhui Li Chunhua Wei Qingke Bai Lishu Wan Liping Sun Shejun Feng Mingyao You Chun Wang Hongtian Zhang Qing He Ming Yu Qiang Dong GISAA committee Source Type: research