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Specialty: Neuroscience
Condition: Hemorrhagic Stroke

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Total 735 results found since Jan 2013.

Proteomic Analysis of Cerebral Cortex Extracts from Sus scrofa with Induced Hemorrhagic Stroke
AbstractCerebrovascular diseases, including stroke and micro stroke, are the main causes of death in contemporary society. Hemorrhagic stroke is the fast emerging defficiency in the brain function resulting from disturbance of blood supply to the brain caused by the rapture of blood vessels (Lopez et al. in Proteomics Clin Appl 6:190 –200,2012). The influence of a model hemorrhagic stroke on white pigs with the change in the protein profile of their cortical samples 24 h and 2 months after the stroke was examined using mass-spectrometric analysis. Different proteins (n = 30) were identified, and their content was ele...
Source: Journal of Molecular Neuroscience - April 26, 2018 Category: Neuroscience Source Type: research

Back to Basics: Adherence With Guidelines for Glucose and Temperature Control in an American Comprehensive Stroke Center Sample
Conclusion: Glucose and temperature control may be overlooked in this era of rapid stroke diagnosis and treatment. Acute stroke nurses are well positioned to assume leadership of glucose and temperature monitoring and treatment.
Source: Journal of Neuroscience Nursing - May 5, 2018 Category: Neuroscience Tags: Article Source Type: research

Autophagy in hemorrhagic stroke: Mechanisms and clinical implications
Publication date: April–May 2018Source: Progress in Neurobiology, Volumes 163–164Author(s): Haiying Li, Jiang Wu, Haitao Shen, Xiyang Yao, Chenglin Liu, S. Pianta, J. Han, C.V. Borlongan, Gang ChenAbstractAccumulating evidence advances the critical role of autophagy in brain pathology after stroke. Investigations employing autophagy induction or inhibition using pharmacological tools or autophagy-related gene knockout mice have recently revealed the biological significance of intact and functional autophagy in stroke. Most of the reported cases attest to a pro-survival role for autophagy in stroke, by facilitating remo...
Source: Progress in Neurobiology - July 5, 2018 Category: Neuroscience Source Type: research

Rosiglitazone ameliorates tissue plasminogen activator-induced brain hemorrhage after stroke.
CONCLUSIONS: RSG treatment protects against BBB damage and ameliorates HT in delayed tPA-treated stroke mice by activating PPAR-γ and favoring microglial polarization toward anti-inflammatory phenotype. PMID: 31756041 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - November 21, 2019 Category: Neuroscience Authors: Li Y, Zhu ZY, Lu BW, Huang TT, Zhang YM, Zhou NY, Xuan W, Chen ZA, Wen DX, Yu WF, Li PY Tags: CNS Neurosci Ther Source Type: research

Effects of ML351 and tissue plasminogen activator combination therapy in a rat model of focal embolic stroke
In conclusion, ML351 and tPA combination therapy is beneficial in ameliorating HT afte r ischemic stroke. This protective effect is probably because of 12/15‐LOX inhibition and suppression of JNK‐mediated microglia/macrophage activation.
Source: Journal of Neurochemistry - February 5, 2021 Category: Neuroscience Authors: Guangsen Cheng, Wei Zhao, Yongjie Xin, Guomin Huang, Yongkang Liu, Zhongliang Li, Meixiao Zhan, Yong Li, Ligong Lu, Klaus Leyen, Yu Liu Tags: ORIGINAL ARTICLE Source Type: research

A Scoping Review of the Incidence, Predictors, and Outcomes of Delirium Among Critically Ill Stroke Patients
CONCLUSIONS: Current findings are limited by heterogenous populations, assessments, and measurement parameters. Detection and management of delirium among critically ill stroke patients requires an approach with specific considerations to the complexities of acute neurological injury and concomitant critical illness.
Source: Journal of Neuroscience Nursing - May 13, 2022 Category: Neuroscience Tags: Articles Source Type: research

Intravenous thrombolysis versus antiplatelet therapy in minor stroke patients with large vessel occlusion
CONCLUSION: In patients with minor stroke harboring LVO within 4.5-h time window, intravenous t-PA was associated with higher odds for the excellent functional outcome, as compared with the aspirin alone. Further randomized controlled trials are warranted.PMID:36880290 | DOI:10.1111/cns.14124
Source: CNS Neuroscience and Therapeutics - March 7, 2023 Category: Neuroscience Authors: Chunmiao Duan Yunyun Xiong Hongqiu Gu Shang Wang Kai-Xuan Yang Manjun Hao Xueyan Feng Xingquan Zhao Xia Meng Yongjun Wang Source Type: research

P 78. The prognostic value of motor-evoked potentials in motor recovery and functional outcome after stroke – a systematic review of the literature
Conclusions: TMS may be helpful in prognosis of motor recovery and functional outcome in stroke patients, and may become additional tool in making decision about qualification to rehabilitation ward and length of rehabilitation process. However, further studies are necessary to determine the real value of this method. The interpretation of the results of our review was complicated by methodological variation between the included studies.
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: J. Bembenek, K. Kurczych, M. Karlinski, A. Czlonkowska Tags: Society Proceedings Source Type: research

Low dose tPA plus annexin A2 combination attenuates tPA delayed treatment- associated hemorrhage and improves recovery in rat embolic focal stroke
In conclusion, compared to conventional tPA alone, when treated at delayed 4-hour after stroke, the combination of low-dose tPA plus rA2 therapy provides a safer profile by lowering risk of ICH transformation and improves neurological function recovery after stroke.
Source: Neuroscience Letters - July 10, 2015 Category: Neuroscience Source Type: research

Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation
In this study, we investigated factors that influence the effect of intravenous thrombolysis in these patients. Our results showed that thrombolysis was independently associated with a favorable outcome (P < 0.001) and did not influence the mortality of AF-related ischemic stroke, although it increased the risk of hemorrhage within 24 h after treatment. Risk factors for a poor outcome at admission were: heart failure (P = 0.045); high systolic pressure (P = 0.039); high blood glucose (P = 0.030); and a high National Institutes of Health Stroke Scale (NIHSS) score (P < 0.001). Moreover, high systolic pressur...
Source: Neuroscience Bulletin - March 7, 2016 Category: Neuroscience Source Type: research

Cerebral venous collaterals: a new fort for fighting ischemic stroke?
Publication date: Available online 2 December 2017 Source:Progress in Neurobiology Author(s): Lu-sha Tong, Zhen-ni Guo, Yi-bo Ou, Yan-nan Yu, Xiao-cheng Zhang, Jiping Tang, John H. Zhang, Min Lou Stroke therapy has entered a new era highlighted by the use of endovascular therapy in addition to intravenous thrombolysis. However, the efficacy of current therapeutic regimens might be reduced by their associated adverse events. For example, over-reperfusion and futile recanalization may lead to large infarct, brain swelling, hemorrhagic complication and neurological deterioration. The traditional pathophysiological understand...
Source: Progress in Neurobiology - December 2, 2017 Category: Neuroscience Source Type: research

Patent foramen ovale closure for patients with cryptogenic stroke: A systematic review and comprehensive meta-analysis of 5 randomized controlled trials and 14 observational studies.
CONCLUSIONS: In patients with cryptogenic stroke, PFO closure does appeared to be superior to medical therapy in stroke prevention, with an increased incidence of AF. Male, age <45 years, substantial residual shunt, and the history of ASA are the factors that will predict the benefit when PFO is closed. PMID: 29804325 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - May 27, 2018 Category: Neuroscience Authors: Chen X, Chen SD, Dong Y, Dong Q Tags: CNS Neurosci Ther Source Type: research

EEG patterns and epileptic seizures in acute phase stroke
ConclusionEEG in the acute phase of stroke may help to detect specific patterns, such as PLEDs, that are closely related to early seizures. EEG monitoring should be performed to identify purely electrographic seizures.
Source: Neurophysiologie Clinique - July 5, 2018 Category: Neuroscience Source Type: research