Effects of ML351 and tissue plasminogen activator combination therapy in a rat model of focal embolic stroke

In conclusion, ML351 and tPA combination therapy is beneficial in ameliorating HT afte r ischemic stroke. This protective effect is probably because of 12/15‐LOX inhibition and suppression of JNK‐mediated microglia/macrophage activation.

Source: Journal of Neurochemistry - February 5, 2021 Category: Neuroscience Authors: Guangsen Cheng, Wei Zhao, Yongjie Xin, Guomin Huang, Yongkang Liu, Zhongliang Li, Meixiao Zhan, Yong Li, Ligong Lu, Klaus Leyen, Yu Liu Tags: ORIGINAL ARTICLE Source Type: research