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Specialty: Neuroscience
Condition: Hemorrhagic Stroke

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Total 735 results found since Jan 2013.

Autophagy in Intracerebral Hemorrhage: From Mechanism to Regulation
J Integr Neurosci. 2023 Sep 18;22(5):134. doi: 10.31083/j.jin2205134.ABSTRACTIntracerebral hemorrhage (ICH) is the most lethal type of stroke. Secondary injury from ICH determines the recovery, but there is still a lack of effective treatment. The identification of new therapeutic targets may address the current dilemma. The process of autophagy is mediated through the lysosomal pathway and is used to maintain cell homeostasis. Recent studies have advanced our knowledge of autophagy, and in particular its involvement in cell physiology and pathology. Autophagy involves multiple targets and signaling pathways and occurs in ...
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Jia Zheng Wei Zou Xueping Yu Source Type: research

Functional effects of haemoglobin can be rescued by haptoglobin in an in vitro model of subarachnoid haemorrhage
Subarachnoid haemorrhage causes significant cognitive and functional disability in survivors, and one contributing factor is exposure of neurons to haemoglobin causing cell loss and dysfunction. In this in vitro subarachnoid haemorrhage model, haemolysate application to cultured neurons impairs cytoskeletal integrity. Furthermore, amplitude of AMPA receptor-mediated synaptic currents is reduced by haemolysate, driven by reduction in GluA1 expression. These deficits can be prevented with application of exogenous haptoglobin without off-target effects. These results provide new insight into neuronal dysfunction in haemorrhag...
Source: Journal of Neurochemistry - September 14, 2023 Category: Neuroscience Authors: Hannah Warming, Katrin Deinhardt, Patrick Garland, John More, Diederik Bulters, Ian Galea, Mariana Vargas ‐Caballero Tags: ORIGINAL ARTICLE Source Type: research

Role of artificial intelligence and machine learning in the diagnosis of cerebrovascular disease
ConclusionThe implementation of AI and ML algorithms to supplement clinical practice has conferred a high degree of accuracy, efficiency, and expedited detection in the clinical and radiographic evaluation and management of ischemic and hemorrhagic strokes, AVMs, and aneurysms. Such algorithms have been explored for further purposes of prognostication for these conditions, with promising preliminary results. Further studies should evaluate the longitudinal implementation of such techniques into hospital networks and residency programs to supplement clinical practice, and the extent to which these techniques improve patient...
Source: Frontiers in Human Neuroscience - September 7, 2023 Category: Neuroscience Source Type: research

A modified murine photothrombotic stroke model: a minimally invasive and reproducible cortical and sub-cortical infarct volume and long-term deficits
In conclusion, this modified model helps to understand stroke pathogenesis and minimize the animals' numbers which help to increase the scientific and statistical potential in pre-clinical studies.PMID:37656197 | DOI:10.1007/s00221-023-06696-5
Source: Experimental Brain Research - September 1, 2023 Category: Neuroscience Authors: Mohd Salman Saifudeen Ismael Tauheed Ishrat Source Type: research

Connection between oxidative stress and subcellular organelle in subarachnoid hemorrhage: Novel mechanisms and therapeutic implications
CNS Neurosci Ther. 2023 Jul 5. doi: 10.1111/cns.14348. Online ahead of print.ABSTRACTSpontaneous subarachnoid hemorrhage (SAH) is one of the most devastating forms of stroke, with limited treatment modalities and poor patient outcomes. Previous studies have proposed multiple prognostic factors; however, relative research on treatment has not yet yielded favorable clinical outcomes. Moreover, recent studies have suggested that early brain injury (EBI) occurring within 72 h after SAH may contribute to its poor clinical outcomes. Oxidative stress is recognized as one of the main mechanisms of EBI, which causes damage to vario...
Source: CNS Neuroscience and Therapeutics - July 6, 2023 Category: Neuroscience Authors: Jiahao Zhang Zeyu Zhang Xiaoyu Wang Yibo Liu Qian Yu Kaikai Wang Yuanjian Fang Cameron Lenahan Maohua Chen Sheng Chen Source Type: research

Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke
AbstractPurpose of ReviewThis review aims to provide an overview of neuroinflammation in ischemic and hemorrhagic stroke, including recent findings on the mechanisms and cellular players involved in the inflammatory response to brain injury.Recent FindingsNeuroinflammation is a crucial process following acute ischemic stroke (AIS) and hemorrhagic stroke (HS). In AIS, neuroinflammation is initiated within minutes of the ischemia onset and continues for several days. In HS, neuroinflammation is initiated by blood byproducts in the subarachnoid space and/or brain parenchyma. In both cases, neuroinflammation is characterized b...
Source: Current Neurology and Neuroscience Reports - July 3, 2023 Category: Neuroscience Source Type: research

Toll ‐like receptor 4‐mediated microglial inflammation exacerbates early white matter injury following experimental subarachnoid hemorrhage
In conclusion, microglial inflammation has dual effects on early WMI after experimental SAH. Future explorations on more clinically relevant methods for modulating neuroinflammation are warranted to combat stroke with both WMI and gray matter destruction.
Source: Journal of Neurochemistry - June 13, 2023 Category: Neuroscience Authors: Jianhua Peng, Yuke Xie, Jinwei Pang, Yue Wu, Jian Zhou, Long Gu, Kecheng Guo, Lifang Zhang, Bingqing Xie, Shigang Yin, Xiaochuan Sun, Ligang Chen, Yong Jiang Tags: ORIGINAL ARTICLE Source Type: research

Efficacy and safety of remote ischemic conditioning for acute ischemic stroke: A comprehensive meta-analysis from randomized controlled trials
CONCLUSIONS: RIC could reduce the stroke recurrence and improve patients' prognosis. Intervention on bilateral upper limbs, 5 cycles, and a length of 50 min in each intervention might be an optimal protocol for RIC at present. RIC could be an effective therapy for patients not eligible for reperfusion therapy. RIC would not cause other adverse events except for relatively benign RIC-related adverse events.PMID:37183341 | DOI:10.1111/cns.14240
Source: CNS Neuroscience and Therapeutics - May 15, 2023 Category: Neuroscience Authors: Xiuji Kan Zeya Yan Fei Wang Xinyu Tao Tao Xue Zhouqing Chen Zhong Wang Gang Chen Source Type: research

Mendelian randomization study and meta-analysis exploring the causality of age at menarche and the risk of intracerebral hemorrhage and ischemic stroke
CONCLUSION: AAM and ICH, particularly NLICH, are causally related, but not LICH, IS, or its subtypes in European population.PMID:37170723 | DOI:10.1111/cns.14245
Source: CNS Neuroscience and Therapeutics - May 12, 2023 Category: Neuroscience Authors: Xuelun Zou Leiyun Wang Sai Wang Le Zhang Source Type: research

Endothelial TREM-1 receptor regulates the blood-brain barrier integrity after intracerebral hemorrhage in mice via SYK/ β-catenin signaling
CONCLUSIONS: This study demonstrated that TREM-1 deteriorated BBB permeability via modulating the expression of interendothelial junction molecules after ICH, and this regulation is partly mediated by the SYK/β-catenin signaling pathway.PMID:37170484 | DOI:10.1111/cns.14255
Source: CNS Neuroscience and Therapeutics - May 12, 2023 Category: Neuroscience Authors: Yonglin Xie Wei He Li Ma Reng Ren Shuxu Yang Qin Lu Source Type: research

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