An aromatic substance, eugenol induces distinct depressant effects on respiratory activity in different postnatal developmental stages of the rat
Publication date: Available online 14 June 2019Source: Neuroscience ResearchAuthor(s): Sayumi Kotani, Itaru Yazawa, Hiroshi Onimaru, Masahiko IzumizakiAbstractEugenol modulates neuronal activity through actions on voltage-gated ionic channels and/or transient receptor potential channels. We previously suggested that eugenol inhibited cellular (and/or network) mechanisms essential for the maintenance of the respiratory burst activity in a brainstem-spinal cord preparation from newborn rat (postnatal day 0–3). Study of the distinct effects of eugenol in neonatal and later developmental stage rats may offer new informat...
Source: Neuroscience Research - June 14, 2019 Category: Neuroscience Source Type: research

Molecular drivers of human cerebral cortical evolution
Publication date: Available online 5 June 2019Source: Neuroscience ResearchAuthor(s): Ikuo K. SuzukiAbstractOne of the most important questions in human evolutionary biology is how our ancestor has acquired an expanded volume of the cerebral cortex, which may have significantly impacted on improving our cognitive abilities. Recent comparative approaches have identified developmental features unique to the human or hominid cerebral cortex, not shared with other animals including conventional experimental models. In addition, genomic, transcriptomic, and epigenomic signatures associated with human- or hominid-specific proces...
Source: Neuroscience Research - June 7, 2019 Category: Neuroscience Source Type: research

Prelim ii(edi board)
Publication date: July 2019Source: Neuroscience Research, Volume 144Author(s): (Source: Neuroscience Research)
Source: Neuroscience Research - June 1, 2019 Category: Neuroscience Source Type: research

Nax-positive glial cells in the organum vasculosum laminae terminalis produce epoxyeicosatrienoic acids to induce water intake in response to increases in [Na+] in body fluids
Publication date: Available online 28 May 2019Source: Neuroscience ResearchAuthor(s): Hiraki Sakuta, Chia-Hao Lin, Masaki Yamada, Yoshihiro Kita, Suzumi M. Tokuoka, Takao Shimizu, Masaharu NodaAbstractNax is a [Na+] sensor expressed in specific glial cells in the sensory circumventricular organs (sCVOs) in the brain. We recently demonstrated that Nax signals are involved in the control of not only salt intake but also water intake behavior. Our pharmacological experiments suggested that Nax signals led to activation of neurons bearing TRPV4 by using epoxyeicosatrienoic acids (EETs) as gliotransmitters to stimulate water in...
Source: Neuroscience Research - May 30, 2019 Category: Neuroscience Source Type: research

Involvement of the retrosplenial cortex in the processing of the temporal aspect of episodic-like memory in rats
Publication date: Available online 24 May 2019Source: Neuroscience ResearchAuthor(s): Tomohiro Hayashi, Masashi Oguro, Nobuya SatoAbstractTo investigate the effects of retrosplenial cortex (RSC) lesions on episodic-like memory, we used four types of object recognition tasks. What task examined memory of object identities. Where task examined memory of object locations. When task examined memory of the temporal order of presented objects. Episodic task examined the integrated memory of the identity, location, and temporal order of presented objects. Rats with the RSC lesions preferred novel objects in the What and Where tas...
Source: Neuroscience Research - May 26, 2019 Category: Neuroscience Source Type: research

Coffee polyphenols prevent cognitive dysfunction and suppress amyloid β plaques in APP/PS2 transgenic mouse
In conclusion, our results demonstrate that coffee polyphenols prevent cognitive deficits and reduce Aβ plaque deposition via disaggregation of Aβ in the APP/PS2 mouse. (Source: Neuroscience Research)
Source: Neuroscience Research - May 21, 2019 Category: Neuroscience Source Type: research

Spinal CCL1/CCR8 regulates phosphorylation of GluA1-containing AMPA receptor in postoperative pain after tibial fracture and orthopedic surgery in mice
This study examined whether spinal CCL1 is associated with fracture-associated postoperative pain via AMPA receptor.We herein discovered that the tibial fracture with orthopedic surgery initiated and maintained chronic postoperative pain along with spinal up-regulation of CCL1/CCR8 expression and phosphorylation of GluA1-containing AMPA receptor. Central CCL1/CCR8 inhibition impaired mechanical and cold allodynia, and phosphorylated GluA1-containing AMPA receptor in the spinal dorsal horn. Intrathecal injection of GluA1-containing AMPA receptor antagonist NASPM alleviated fracture-related postoperative pain. Also, exogenou...
Source: Neuroscience Research - May 21, 2019 Category: Neuroscience Source Type: research

Video-based assessments of the hind limb stepping in a mouse model of hemi-parkinsonism
Publication date: Available online 16 May 2019Source: Neuroscience ResearchAuthor(s): Masatoshi Ogawa, Yu Zhou, Ryosuke Tsuji, Satoshi Goto, Jiro KasaharaAbstractUnilateral injection of 6-hydroxydopamine (6-OHDA) is commonly used to generate a rodent model of Parkinson’s disease (PD). Although motor deficits of the lower extremities represent one of the major clinical symptoms in PD patients, validated tests for assessing motor impairments of the hind limb in 6-OHDA mice are currently unavailable. We here report the video-based assessments of the asymmetric use of hind limbs in 6-OHDA mice. A significantly decreased ...
Source: Neuroscience Research - May 17, 2019 Category: Neuroscience Source Type: research

Prelim ii(edi board)
Publication date: June 2019Source: Neuroscience Research, Volume 143Author(s): (Source: Neuroscience Research)
Source: Neuroscience Research - May 16, 2019 Category: Neuroscience Source Type: research

Adapting terminology: clarifying prism adaptation vocabulary, concepts, and methods
Publication date: Available online 22 March 2019Source: Neuroscience ResearchAuthor(s): C. Prablanc, F. Panico, L. Fleury, L. Pisella, T. Nijboer, S. Kitazawa, Y. RossettiAbstractWhen individuals are exposed to a constant change of the interplay with their environment, they are able to develop compensatory alterations of visuo-motor coordination in order to counteract the perturbation. Prism adaptation (PA) is a very simple tool that has been used for several decades to investigate adaptive processes. However, the specific terminology used in PA literature has continuously evolved and is still subjected to broad inconsiste...
Source: Neuroscience Research - May 3, 2019 Category: Neuroscience Source Type: research

Genome editing-based approaches for imaging protein localization and dynamics in the mammalian brain
Publication date: Available online 26 April 2019Source: Neuroscience ResearchAuthor(s): Takayasu MikuniAbstractA neuron contains thousands of proteins, each of which mediates neuronal processes at distinct subcellular compartments. Thus, precise mapping of each protein with subcellular resolution in the brain is essential to understand neuronal processes at the molecular level. However, no conventional methods have provided rapid, generalizable, and high-throughput readouts for the subcellular localization of endogenous proteins in the mammalian brain. Recently, new methods based on in vivo genome editing have been develop...
Source: Neuroscience Research - April 27, 2019 Category: Neuroscience Source Type: research

Serotonergic modulation of feeding behavior in Caenorhabditis elegans and other related nematodes
Publication date: Available online 24 April 2019Source: Neuroscience ResearchAuthor(s): Yuuki Ishita, Takahiro Chihara, Misako OkumuraAbstractSerotonin is a conserved neuromodulator that controls feeding behavior in response to environmental inputs in a wide range of species, including the nematode, Caenorhabditis elegans. To understand the detailed mechanism and evolution of serotonergic neuromodulation, the feeding behaviors of C. elegans and related species have been studied intensively because of their simple neural anatomy and genetic manipulability. C. elegans shows patterned movements of a feeding structure called t...
Source: Neuroscience Research - April 25, 2019 Category: Neuroscience Source Type: research

Ovarian progesterone suppresses depression and anxiety-like behaviors by increasing the Lactobacillus population of gut microbiota in ovariectomized mice
This study investigated whether progesterone affects depressant and anxious behaviors via gut microbiota. In ovariectomized (OVX) mice, treatment with progesterone improved depressive and anxious behaviors, and gut microbiota composition was significantly changed. In particular, increased Lactobacillus spp. were observed in these mice. Reduction of microbiota by antibiotic treatment abolished the effect of progesterone on depression and anxiety. In addition, administration of Lactobacillus (L.) reuteri that was increased by progesterone also reduced the depressant behavior in OVX mice, and BDNF gene expression was elevated...
Source: Neuroscience Research - April 24, 2019 Category: Neuroscience Source Type: research

Prelim ii(edi board)
Publication date: May 2019Source: Neuroscience Research, Volume 142Author(s): (Source: Neuroscience Research)
Source: Neuroscience Research - April 21, 2019 Category: Neuroscience Source Type: research

Synchronization between overt speech envelope and EEG oscillations during imagined speech
In this study, we hypothesized that neural oscillations during articulatory imagination of speech could also synchronize with the rhythm of speech imagery. To validate the hypothesis, after replacing the imagined speech with overt speech due to the physically unobservable nature of imagined speech, we investigated (1) whether the EEG-based regressed speech envelopes during the imagined speech correlate with the overt speech envelope and (2) whether the imagined EEG can classify speech stimuli with different envelopes imagined by several participants. The variability of the duration of the imagined speech across trials was ...
Source: Neuroscience Research - April 19, 2019 Category: Neuroscience Source Type: research

Reinforcement schedules differentially affect learning in neuronal operant conditioning in rats
Publication date: Available online 16 April 2019Source: Neuroscience ResearchAuthor(s): Kichan Song, Susumu Takahashi, Yoshio SakuraiABSTRACTOperant conditioning of neuronal activity is a core process for better operation of brain-machine interfaces. However, few studies have investigated the role of reinforcement schedules in neuronal operant conditioning, although they are very effective in behavioral operant conditioning. To test the effect of different reinforcement schedules, the authors trained single-neuron activity in the motor cortex using fixed ratio (FR) and variable ratio (VR) schedules in rats. Neuronal firing...
Source: Neuroscience Research - April 18, 2019 Category: Neuroscience Source Type: research

International symposium of Brain/MINDS: From structure to function
Publication date: Available online 16 April 2019Source: Neuroscience ResearchAuthor(s): (Source: Neuroscience Research)
Source: Neuroscience Research - April 18, 2019 Category: Neuroscience Source Type: research

Repetitive transcranial magnetic stimulation ameliorates recognition memory impairment induced by hindlimb unloading in mice associated with BDNF/TrkB signaling
In conclusion, the data suggest that high frequency rTMS may be an effective countermeasure against the learning and memory deficiency, induced by simulated microgravity.Graphical abstractThe effect of 15 Hz rTMS on both Sham mice and HU miceIt shows that the sketch of recognition memory, synaptic plasticity and protein expressions represents the differences between HU mice and HU + rTMS mice. rTMS improves the recognition memory along with synaptic plasticity and increases the expressions of BDNF, TrkB, p-Akt, PSD95, NR2 A and NR2B in HU mice. The purple ‘‘−’’ impl...
Source: Neuroscience Research - April 12, 2019 Category: Neuroscience Source Type: research

Prelim ii(edi board)
Publication date: April 2019Source: Neuroscience Research, Volume 141Author(s): (Source: Neuroscience Research)
Source: Neuroscience Research - April 5, 2019 Category: Neuroscience Source Type: research

Masao Ito (1928–2018)
Publication date: April 2019Source: Neuroscience Research, Volume 141Author(s): (Source: Neuroscience Research)
Source: Neuroscience Research - April 5, 2019 Category: Neuroscience Source Type: research

Oxytocin administration modulates rats’ helping behavior depending on social context
In this study, we examined the effect of oxytocin administration on helping behavior in rats. The rats learned to open a door to help a cagemate soaked with water. The rats were divided into Pair and Solo groups. The rats in the Pair group were housed with their cagemates and those in the Solo group were housed individually. The rats in both groups received oxytocin (1.0 mg/kg) or saline injections intraperitoneally for 5 consecutive days before starting the experimental sessions. In the rats injected with oxytocin, the Solo group showed helping behavior faster than those in the Pair group. The results suggest that ...
Source: Neuroscience Research - April 4, 2019 Category: Neuroscience Source Type: research

The motor engram as a dynamic change of the cortical network during early sequence learning: an fMRI study
Publication date: Available online 30 March 2019Source: Neuroscience ResearchAuthor(s): Yuki H. Hamano, Sho K. Sugawara, Takaaki Yoshimoto, Norihiro SadatoAbstractNeural substrates of motor engrams in the human brain are hard to identify because their dormant states are difficult to discriminate. We utilized eigenvector centrality (EC) to measure the network information that accumulates as an engram during learning. To discriminate engrams formed by emphasis on speed or accuracy, we conducted functional MRI on 58 normal volunteers as they performed a sequential finger-tapping task with the non-dominant left hand. Participa...
Source: Neuroscience Research - April 1, 2019 Category: Neuroscience Source Type: research

Dynamics of memory engrams
Publication date: Available online 30 March 2019Source: Neuroscience ResearchAuthor(s): Shogo Takamiya, Shoko Yuki, Junya Hirokawa, Hiroyuki Manabe, Yoshio SakuraiABSTRACTIn this update article, we focus on “memory engrams”, which are traces of long-term memory in the brain, and emphasizes that they are not static but dynamic. We first introduce the major findings in neuroscience and psychology reporting that memory engrams are sometimes diffuse and unstable, indicating that they are dynamically modified processes of consolidation and reconsolidation. Second, we introduce and discuss the concepts of cell assemb...
Source: Neuroscience Research - April 1, 2019 Category: Neuroscience Source Type: research

Revisiting a Theory of Cerebellar Cortex
Publication date: Available online 26 March 2019Source: Neuroscience ResearchAuthor(s): Tadashi Yamazaki, William LennonAbstractLong-term depression at parallel fiber-Purkinje cell synapses plays a principal role in learning in the cerebellum, which acts as a supervised learning machine. Recent experiments demonstrate various forms of synaptic plasticity at different sites within the cerebellum. In this article, we take into consideration synaptic plasticity at parallel fiber-molecular layer interneuron synapses as well as at parallel fiber-Purkinje cell synapses, and propose that the cerebellar cortex performs reinforceme...
Source: Neuroscience Research - March 27, 2019 Category: Neuroscience Source Type: research

Adapting terminology Clarifying prism adaptation vocabulary, concepts, and methods
Publication date: Available online 22 March 2019Source: Neuroscience ResearchAuthor(s): C Prablanc, F Panico, L Fleury, L Pisella, T Nijboer, S Kitazawa, Y RossettiAbstractWhen individuals are exposed to a constant change of the interplay with their environment, they are able to develop compensatory alterations of visuo-motor coordination in order to counteract the perturbation. Prism adaptation (PA) is a very simple tool that has been used for several decades to investigate adaptive processes. However, the specific terminology used in PA literature has continuously evolved and is still subjected to broad inconsistency. Gr...
Source: Neuroscience Research - March 23, 2019 Category: Neuroscience Source Type: research

A methodology for discovering novel brain-relevant peptides: combination of ribosome profiling and peptidomics
In this study, we introduce and validate a new methodology for the discovery of novel peptides derived from mammalian brain. This methodology combines ribosome profiling and mass spectrometry-based peptidomics. Using this framework, we have identified a novel peptide in mouse whole brain whose expression is highest in the basal ganglia, hypothalamus and amygdala. Although its functional role is unknown, it has been previously detected in peripheral tissue as a component of the mRNA decapping complex. Continued discovery and studies of novel regulating peptides in mammalian brain may also provide insight into brain disorder...
Source: Neuroscience Research - March 9, 2019 Category: Neuroscience Source Type: research

Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice
Publication date: Available online 1 March 2019Source: Neuroscience ResearchAuthor(s): Takatoshi Hikida, Makiko Morita, Mahomi Kuroiwa, Tom Macpherson, Takahide Shuto, Naoki Sotogaku, Minae Niwa, Akira Sawa, Akinori NishiABSTRACTDevelopment of drug addictive behaviors is modulated by both genetic and environmental risk factors. However, the molecular mechanisms remain unknown. To address the role of adolescent stress in the development of drug addiction, we combined a transgenic mouse model in which a putative dominant-negative form of DISC1 under expressional control of the prion protein promoter is used as a genetic risk...
Source: Neuroscience Research - March 4, 2019 Category: Neuroscience Source Type: research

Prelim ii(edi board)
Publication date: March 2019Source: Neuroscience Research, Volume 140Author(s): (Source: Neuroscience Research)
Source: Neuroscience Research - February 27, 2019 Category: Neuroscience Source Type: research

Circuits and neural dynamics underlying behavior
Publication date: March 2019Source: Neuroscience Research, Volume 140Author(s): Shigeyoshi Fujisawa, Hokto Kazama (Source: Neuroscience Research)
Source: Neuroscience Research - February 27, 2019 Category: Neuroscience Source Type: research

Postnatal development of the distribution of nitric oxide-producing neurons in the rat corpus callosum
Publication date: Available online 20 February 2019Source: Neuroscience ResearchAuthor(s): Paolo Barbaresi, Emanuela Mensà, Andrea Sagrati, Laura GraciottiAbstractThe postnatal development of nitric oxide (NO)-producing intracallosal neurons was studied in rats by nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry from postnatal day 0 (P0) to P30. NADPH-d-positive neurons (NADPH-d+Ns) were detected already at P0, mainly in the rostral region of the corpus callosum (cc). Their location and the intensity of staining allowed them to be classified as type I NO-producing neurons. At P0, tufts...
Source: Neuroscience Research - February 21, 2019 Category: Neuroscience Source Type: research

Cerebellar transcranial direct current stimulation modulates the effect of cerebellar transcranial magnetic stimulation on the excitability of spinal reflex
This study aimed to investigate whether this facilitation of the spinal motoneuron pool excitability by C-TMS is affected by cerebellar transcranial direct current stimulation (ctDCS) in a polarity-specific manner. Eleven healthy adults participated in this study. The H-reflex was measured from the right soleus muscle by electrical stimulation of the right tibial nerve. The conditioning TMS over the right cerebellum was delivered 110 ms before tibial nerve stimulation. The H-reflex ratio was calculated as conditioned/unconditioned H-reflex amplitude, and measured for pre- or post-anodal, cathodal, or sham right ctDC...
Source: Neuroscience Research - February 20, 2019 Category: Neuroscience Source Type: research

Confocal and multiphoton calcium imaging of the enteric nervous system in anesthetized mice
Publication date: Available online 18 February 2019Source: Neuroscience ResearchAuthor(s): Yuki Motegi, Masaaki Sato, Kazuhide Horiguchi, Masamichi Ohkura, Keiko Gengyo-Ando, Yuji Ikegaya, Yasuyuki Fusamae, Yoshie Hongo, Minoru Suzuki, Koichi Ogawa, Miyako Takaki, Junichi NakaiAbstractMost imaging studies of the enteric nervous system (ENS) that regulates the function of the gastrointestinal tract are so far performed using preparations isolated from animals, thus hindering the understanding of the ENS function in vivo. Here we report a method for imaging the ENS cellular network activity in living mice using a new transge...
Source: Neuroscience Research - February 19, 2019 Category: Neuroscience Source Type: research

Appearance and modulation of a reactive temporal-lobe 8–10-Hz tau-rhythm
In this study, we sought to characterize its emergence and auditory reactivity. Using a 306-channel MEG on 26 right-handed participants, we delivered six-second-long, natural, monaural sounds with pleasant, unpleasant, or neutral emotional valence. In eight participants, a clear, sound-related bilateral suppression of 8–10 Hz tau-rhythm occurred in the temporal areas, close to the source of the 100-ms auditory response. Moreover, these eight “tau subjects” exhibited significantly larger temporal-lobe theta-band (4–8 Hz) power over the entire experimental period compared to the remainin...
Source: Neuroscience Research - February 13, 2019 Category: Neuroscience Source Type: research

Internal structure of the rat subiculum characterized by diverse immunoreactivities and septotemporal differences
Publication date: Available online 13 February 2019Source: Neuroscience ResearchAuthor(s): Yoshihisa Ishihara, Takaichi Fukuda, Fumi SatoAbstractThe subiculum is one of output structures of the hippocampal formation and plays a pivotal role in learning and memory. Because its morphological features are less investigated than those of the hippocampus proper, we explored the internal structure of the rat subiculum using immunohistochemistry. The septal subiculum comprised one region, whereas the temporal subiculum consisted of two subregions, the distal subiculum (Sub1) and proximal subiculum (Sub2). The Sub2 contained four ...
Source: Neuroscience Research - February 13, 2019 Category: Neuroscience Source Type: research

Left, right, or bilateral amygdala activation? How effects of smoothing and motion correction on ultra-high field, high-resolution functional magnetic resonance imaging (fMRI) data alter inferences
Publication date: Available online 11 February 2019Source: Neuroscience ResearchAuthor(s): Jerry E. Murphy, Julio A. Yanes, Lauren A.J. Kirby, Meredith A. Reid, Jennifer L. RobinsonAbstractGiven the amygdala’s role in survival mechanisms, and its pivotal contributions to psychological processes, it is no surprise that it is one of the most well-studied brain regions. One of the common methods for understanding the functional role of the amygdala is the use of functional magnetic resonance imaging (fMRI). However, fMRI tends to be acquired using resolutions that are not optimal for smaller brain structures. Furthermor...
Source: Neuroscience Research - February 12, 2019 Category: Neuroscience Source Type: research

miR-1933-3p is upregulated in skeletal muscles of MuSK+ EAMG mice and affects Impa1 and Mrpl27
This study elucidated the intracellular miRNA profile in the omohyoid muscle of mice with MuSK + EAMG. The levels of eleven mouse miRNAs were elevated and two mouse miRNAs were reduced in muscles of MuSK + EAMG mice. Transient expression of miR-1933-3p and miR-1930-5p in mouse muscle (C2C12) cells revealed several downregulated genes, out of which five had predicted binding sites for miR-1933-3p. The mRNA expression of mitochondrial ribosomal protein L27 (Mrpl27) and Inositol monophosphatase I (Impa1) was reduced in miR-1933-3p transfected C2C12 cells compared to control cells (p =&thinsp...
Source: Neuroscience Research - February 12, 2019 Category: Neuroscience Source Type: research

Prelim ii(edi board)
Publication date: February 2019Source: Neuroscience Research, Volume 139Author(s): (Source: Neuroscience Research)
Source: Neuroscience Research - February 7, 2019 Category: Neuroscience Source Type: research

Mechanism of neuroaxonal degeneration: from molecular signaling to therapeutic applications
Publication date: February 2019Source: Neuroscience Research, Volume 139Author(s): Toshiyuki Araki, Toshihide Yamashita (Source: Neuroscience Research)
Source: Neuroscience Research - February 7, 2019 Category: Neuroscience Source Type: research

daf-16/FOXO isoform b in AIY neurons is involved in low preference for Bifidobacterium infantis in Caenorhabditis elegans
In conclusion, C. elegans showed a low preference for B. infantis, and daf-16b in AIY interneurons and daf-18 had roles in leaving B. infantis. (Source: Neuroscience Research)
Source: Neuroscience Research - February 5, 2019 Category: Neuroscience Source Type: research

TNFR2 knockdown triggers apoptosis-induced proliferation in primarily cultured Schwann cells
In this study, we used small interfering RNA to knock down the expression of TNFR1 and TNFR2 in primarily cultured Schwann cells, respectively and observed its effects on apoptosis and proliferation. The downregulation of TNFR1 or TNFR2 resulted in a remarkable decrease of cell viability and dramatically increased the apoptosis of Schwann cells. In contrast, the cell apoptosis induced by the knockdown of TNFR2, but not TNFR1, promoted the Schwann cell proliferation. Together, these observations indicated that Schwann cells can undergo AiP, and TNFR2 knockdown triggers the process. Additionally, we established the sciatic n...
Source: Neuroscience Research - February 5, 2019 Category: Neuroscience Source Type: research

Regulation of cortical blood flow responses by the nucleus basalis of Meynert during nociceptive processing
The objective of this study was to investigate the contribution of NBM to CBF responses evoked by nociceptive electrical stimuli and how it may be affected by systemic MAP. CBF was recorded in isoflurane-anesthetized rats (n = 8) using laser speckle contrast imaging, in two conditions (intact vs left NBM lesion). Electrical stimulation was applied to the sciatic nerve. Sciatic stimulation produced intensity dependent increases in MAP (p 
Source: Neuroscience Research - January 31, 2019 Category: Neuroscience Source Type: research

The effect of loss of the glucose-monitoring neurons in the anterior cingulate cortex: physiologic challenges induce complex feeding-metabolic alterations after local streptozotocin microinjection in rats
Publication date: Available online 24 January 2019Source: Neuroscience ResearchAuthor(s): Edina Hormay, Bettina László, István Szabó, Tamás Ollmann, Bernadett Nagy, László Péczely, Kitti Mintál, Zoltán KarádiAbstractThe anterior cingulate cortex (ACC) is interrelated to limbic structures, parts of the central glucose-monitoring (GM) network. GM neurons, postulated to exist here, are hypothesised to participate in regulatory functions, such as the central control of feeding and metabolism. In the present experiments, GM neurons were identified and ...
Source: Neuroscience Research - January 25, 2019 Category: Neuroscience Source Type: research

Regional and temporal regulation and role of somatostatin receptor subtypes in the mouse brain following systemic kainate-induced acute seizures
Publication date: Available online 25 January 2019Source: Neuroscience ResearchAuthor(s): Chizuru Iwasawa, Minoru Narita, Hideki TamuraAbstractSomatostatin reduces neuronal excitability via somatostatin receptors (Sst1-Sst5) and inhibits seizure activity. However, the expression status of the Sst subtypes in epileptic mice and their role in the antiepileptic effects of somatostatin remain unclear. Here, we show that the Sst subtypes are regulated differently by epileptic neuronal activity in mice. Systemic kainate injection rapidly and transiently elevated the Sst2 and Sst3 mRNA and reduced Sst1 and Sst4 mRNA in the hippoc...
Source: Neuroscience Research - January 25, 2019 Category: Neuroscience Source Type: research

Uridine treatment prevents REM sleep deprivation-induced learning and memory impairment
Publication date: Available online 24 January 2019Source: Neuroscience ResearchAuthor(s): Busra Ocalan, Aysen Cakir, Cansu Koc, Guldal Gulec Suyen, Nevzat KahveciABSTRACTPrevious studies have shown that sleep plays an important role in cognitive functions and sleep deprivation impairs learning and memory. Uridine is the main pyrimidine nucleoside found in human blood circulation and has beneficial effects on cognitive functions. The aim of the present study was to investigate the effects of uridine administration on learning and memory impairment in sleep-deprived rats. Flower pot method was used to induce REM sleep depriv...
Source: Neuroscience Research - January 24, 2019 Category: Neuroscience Source Type: research

Manganese-enhanced magnetic resonance imaging of the spinal cord in rats with formalin-induced pain
Publication date: Available online 24 January 2019Source: Neuroscience ResearchAuthor(s): Myeounghoon Cha, Kyuhong Lee, Jun Sik Won, Bae Hwan LeeAbstractManganese-enhanced magnetic resonance imaging (MEMRI) is based on neuronal activity-dependent manganese uptake, and provides information about nervous system function. However, systematic studies of pain processing using MEMRI are rare, and few investigations of pain using MEMRI have been performed in the spinal cord. Herein, we investigated the pain dependence of manganese ions administered in the rat spinal cord. MnCl2 was administered into the spinal cord via an intrath...
Source: Neuroscience Research - January 24, 2019 Category: Neuroscience Source Type: research

Sex differential effect of dexmedetomidine on fear memory extinction and anxiety behavior in adolescent rats
Publication date: Available online 24 January 2019Source: Neuroscience ResearchAuthor(s): Minji Jang, Taesub Jung, Sung-Hoon Kim, Jihyun NohAbstractExposure to stressful stimuli, including fear and anxiety, modulates the central noradrenergic system. Dexmedetomidine is a commonly used α2-adrenoreceptor agonist. Because the effect of fear acquisition varies between sexes, the present study was designed to investigate sex-related differences in the effects of dexmedetomidine on fear memory and anxiety-like behavior. We conducted a fear test and an elevated plus maze test in 6 to 8-week-old male and female rats. Two dos...
Source: Neuroscience Research - January 24, 2019 Category: Neuroscience Source Type: research

Prelim ii(edi board)
Publication date: January 2019Source: Neuroscience Research, Volume 138Author(s): (Source: Neuroscience Research)
Source: Neuroscience Research - January 20, 2019 Category: Neuroscience Source Type: research

Timing and shaping mechanisms of neural development
Publication date: January 2019Source: Neuroscience Research, Volume 138Author(s): Ryoichiro Kageyama, Kazunori Nakajima (Source: Neuroscience Research)
Source: Neuroscience Research - January 20, 2019 Category: Neuroscience Source Type: research

Monocytes exposed to plasma from patients with Alzheimer’s disease undergo metabolic reprogramming
Publication date: Available online 12 January 2019Source: Neuroscience ResearchAuthor(s): Hannah Wolfe, Virginia Mela Rivas, Aedin M. Minogue, Anne-Marie Miller, Chris McGuigan, Laura Williams, Deirdre Lohan, Brian A. Lawlor, Marina A. LynchAbstractThe search for a blood-based biomarker that identifies Alzheimer’s disease (AD) and can replace current invasive and expensive diagnostic tests, continues. The most extensively-examined peripheral marker is β-amyloid (Aβ) but the results are inconsistent across studies and do not reflect the changes that take place in the brain. Several studies have assessed poss...
Source: Neuroscience Research - January 12, 2019 Category: Neuroscience Source Type: research

Improving working memory and pain inhibition in older persons using transcranial direct current stimulation
Publication date: Available online 4 January 2019Source: Neuroscience ResearchAuthor(s): Zoha Deldar, Nabi Rustamov, Isabelle Blanchette, Mathieu PichéAbstractThe aim of the present study was to examine whether transcranial Direct Current Stimulation (tDCS) could enhance working memory and pain inhibition in older persons. Fifteen volunteers (7 women, 8 men; mean ± SD: 64 ± 4.4 y.o.) participated in two tDCS sessions during which an n-back task was performed with two levels of working memory load, while painful stimulation was delivered at the ankle. The experiment included ...
Source: Neuroscience Research - January 5, 2019 Category: Neuroscience Source Type: research