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Condition: Cirrhosis

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Total 302 results found since Jan 2013.

β-Blocker therapy for cirrhotic cardiomyopathy: a randomized-controlled trial
Background Cirrhotic cardiomyopathy is characterized by an attenuated contractile response to stress. Long-term exposure of β-adrenergic receptors to persistently high levels of catecholamines has been implicated in its pathogenesis. We hypothesized that β-blockade with metoprolol could reverse the changes in heart function and morphology in cirrhotic cardiomyopathy. Patients and methods In this prospective randomized trial, we included 78 patients aged between 18 and 60 years with abnormal cardiac output response under dobutamine stress echocardiography, without primary cardiac disease or a history of alcohol intak...
Source: European Journal of Gastroenterology and Hepatology - July 6, 2018 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Mandatory criteria for the application of variability-based parameters of fluid responsiveness: a prospective study in different groups of ICU patients.
CONCLUSIONS: The applicability of SVV in a predominantly medical ICU is only about 25%-35%. The prevalence of both mandatory criteria decreases over time during the ICU stay. Furthermore, the applicability is particularly low in patients with acute pancreatitis and liver failure. PMID: 29971990 [PubMed - in process]
Source: J Zhejiang Univ Sci ... - July 1, 2018 Category: Science Authors: Huber W, Mayr U, Umgelter A, Franzen M, Reindl W, Schmid RM, Eckel F Tags: J Zhejiang Univ Sci B Source Type: research

Cirrhosis and risk of stroke: A systematic review and meta-analysis
Several studies have reported that cirrhosis may increase the risk of stroke. However, its association is controversial. We conducted a systematic review and meta-analysis to investigate the relationship between cirrhosis and the risk of stroke.
Source: Atherosclerosis - June 21, 2018 Category: Cardiology Authors: Jianping Xiong, Weiyu Xu, Hanchun Huang, Jin Bian, Anqiang Wang, Yi Bai, Jianzhen Lin, Yiyao Xu, Xin Lu, Haitao Zhao Source Type: research

Multifocal stroke with proliferation of small cerebral arteries in hepatopulmonary syndrome
Cirrhosis of the liver has been linked to several changes in risk of cerebrovascular disease and may increase the risk of hemorrhage while reducing the risk of ischemic stroke.1,2 The pathophysiology underlying these changes remains unclear, though intracranial hemorrhage and vascular malformations related to liver disease have been described.1,3 Cirrhosis may be complicated by hepatopulmonary syndrome (HPS), in which distal pulmonary arteries dilate, become tortuous, produce shunt physiology, and often produce arteriovenous (AV) malformations.4
Source: Neurology Clinical Practice - June 11, 2018 Category: Neurology Authors: Younce, J. R., Cross, D. T., Goyal, M. S., Lee, J.-M. Tags: MRI, Other cerebrovascular disease/ Stroke, Gastrointestinal, Arteriovenous malformation Case Source Type: research

Ischaemic stroke in patients with liver cirrhosis
No abstract available
Source: European Journal of Gastroenterology and Hepatology - April 27, 2018 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

IJERPH, Vol. 15, Pages 513: Association between Inflammatory Bowel Disease and Cholelithiasis: A Nationwide Population-Based Cohort Study
g Kao We assessed the subsequent risk of cholelithiasis development in patients with inflammatory bowel diseases (IBDs) such as Crohn’s disease (CD) or ulcerative colitis (UC). We identified 8186 patients who aged ≥20 years and were diagnosed with IBD between 2000 and 2010 as the study cohort. A total of 8186 patients without IBD were selected by frequency-matching according to age, sex, comorbidities, and the index date of diagnosis, and they were identified as the control cohort. To measure the incidence of cholelithiasis, all patients were followed up until the end of 2011. The risk of developing cholelithiasis,...
Source: International Journal of Environmental Research and Public Health - March 14, 2018 Category: Environmental Health Authors: Chien-Hua Chen Cheng-Li Lin Chia-Hung Kao Tags: Article Source Type: research

Ischemic stroke in liver cirrhosis: epidemiology, risk factors, and in-hospital outcomes
Conclusion Ischemic stroke was often observed in patients with cirrhosis, and it significantly increased the in-hospital mortality. The association of inflammation, coagulation disorders, and viral hepatitis with development of ischemic stroke in liver cirrhosis should be further evaluated in prospective cohort studies.
Source: European Journal of Gastroenterology and Hepatology - January 17, 2018 Category: Gastroenterology Tags: Original Articles: Liver Cirrhosis Source Type: research

New predictive model for acute gastrointestinal bleeding in patients taking oral anticoagulants: A cohort study
ConclusionsGastrointestinal bleeding increased the risk of subsequent mortality during follow‐up of anticoagulated patients, highlighting the importance of prevention. The study developed a new scoring model for acute GI bleeding risk based on five factors (no‐proton pump inhibitor use, chronic kidney disease, chronic obstructive pulmonary disease, history of peptic ulcer disease, and liver cirrhosis), which was superior to the HAS‐BLED score.
Source: Journal of Gastroenterology and Hepatology - December 28, 2017 Category: Gastroenterology Authors: Akira Shimomura, Naoyoshi Nagata, Takuro Shimbo, Toshiyuki Sakurai, Shiori Moriyasu, Hidetaka Okubo, Kazuhiro Watanabe, Chizu Yokoi, Junichi Akiyama, Naomi Uemura Tags: Gastroenterology Source Type: research

Chronic diseases and socioeconomic inequalities in quality of life among Brazilian adults: findings from a population-based study in Southern Brazil
ConclusionsThe occurrence of long-lasting chronic diseases is associated with inequalities in QoL (physical and psychological domains), with stronger adverse effects among older adults, blacks and individuals with lower income or educational levels.
Source: The European Journal of Public Health - December 25, 2017 Category: General Medicine Source Type: research

Ischemic stroke in liver cirrhosis: epidemiology, risk factors, and in-hospital outcomes
Conclusion Ischemic stroke was often observed in patients with cirrhosis, and it significantly increased the in-hospital mortality. The association of inflammation, coagulation disorders, and viral hepatitis with development of ischemic stroke in liver cirrhosis should be further evaluated in prospective cohort studies.
Source: European Journal of Gastroenterology and Hepatology - December 22, 2017 Category: Gastroenterology Tags: Original Articles: Liver Cirrhosis Source Type: research

Developing a New Score: How Machine Learning Improves Risk Prediction
Composite risk scores have been used for decades to identify disease risk and health status in the general population. However, current approaches often fail to identify people who would benefit from intervention or recommend unnecessary intervention. Machine learning promises to improve accuracy, ensuring targeted treatment for patients that need it and reducing unnecessary intervention. Framingham Risk Score, the gold standard for predicting the likelihood of heart disease, predicts hospitalizations with about 56% accuracy. It uses factors such as age, gender, smoking, cholesterol levels, and systolic blood pressure to...
Source: MDDI - November 17, 2017 Category: Medical Devices Authors: Heather R. Johnson Tags: R & D Source Type: news

Prognostic value of viral eradication for major adverse cardiovascular events in hepatitis C cirrhotic patients
Conclusion In patients with compensated HCV-related cirrhosis, Asian ethnic origin, arterial hypertension, smoking and low serum albumin are independent predictive factors of cardiovascular events, while a sustained virological response is associated with a decreased rate of cardiovascular events.
Source: American Heart Journal - November 9, 2017 Category: Cardiology Source Type: research

Transjugular intrahepatic portosystemic shunt: impact on systemic haemodynamics and renal and cardiac function in patients with cirrhosis.
CONCLUSIONS: TIPS increases CBV by increasing CO and SV, whereas HR is initially unaltered. These results indicate an inability to increase the heart rate in response to a hemodynamic challenge that only partially increases CBV after TIPS. These changes, however, are sufficient for improving renal function. PMID: 29074483 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - October 26, 2017 Category: Physiology Authors: Busk TM, Bendtsen F, Poulsen JH, Clemmesen JO, Larsen FS, Goetze JP, Iversen JS, Jensen MT, Møgelvang R, Pedersen EB, Bech JN, Møller S Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Mechanism for Temporal Changes in Exercise Capacity After Fontan Palliation: Role of Doppler Echocardiography
Conclusions Overall there was a temporal decline in peak V̇O2 that correlated with decline in Doppler SVI. In the patients who had Fontan conversion operation, there was a temporal improvement in peak V̇O2 that correlated with improvement in chronotropic index.
Source: American Heart Journal - October 22, 2017 Category: Cardiology Source Type: research

Role of Doppler Echocardiography for Cardiac Output Assessment in Fontan Patients
Conclusion Doppler SVI correlated with CMRI SVI in patients with systemic LV and systemic RV. The association between output measures (SVI and CI) and FAD were seen only in single LV patients (single RV patients not assessed for this outcome due to small numbers). An association between low Doppler CI and Fontan failure was suggested in a small number of single LV patients.
Source: American Heart Journal - September 22, 2017 Category: Cardiology Source Type: research