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Condition: Cirrhosis

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Total 302 results found since Jan 2013.

Safety of direct oral anticoagulants in patients with mild to moderate cirrhosis: a systematic review and meta-analysis
AbstractTo evaluate major bleeding in cirrhosis with use of traditional anticoagulation or direct oral anticoagulants (DOACs), using a standardized definition. Anticoagulation in patients with cirrhosis is often a clinical conundrum for providers as the necessary balance between thrombotic and bleeding risk is complicated by end organ damage. Recent meta-analyses have sought to evaluate the safety and efficacy of direct oral anticoagulants in patients with liver disease. These recent analyses are limited by various bleeding definitions, broad inclusion criteria, and few indications for anticoagulation. We sought to conduct...
Source: Journal of Thrombosis and Thrombolysis - March 16, 2021 Category: Hematology Source Type: research

Thrombocytopenia-Related Problems in Patients with Concomitant Atrial Fibrillation Requiring Antithrombotic Prevention: A Retrospective Cohort Study
Resumo Baixas doses de edoxabana e enoxaparina s ódica foram objeto de uma comparação retrospectiva implementada com a técnica do escore de propensão a fim de mitigar os efeitos das diferenças nas características clínicas basais de duas coortes e minimizar o risco de viés. Posteriormente, usando um modelo de riscos proporcionais de Cox, a valiou-se a associação de cada tipo de terapia com o risco do composto de morte por todas as causas, acidente vascular cerebral/ataque isquêmico transitório, hospitalizações e ocorrência de sangramentos maiores. Para essa análise, um valor de p< 0,05 foi considerado es...
Source: Arquivos Brasileiros de Cardiologia - October 23, 2020 Category: Cardiology Source Type: research

Temporal Evolution of the iFR (Instantaneous Wave-Free Ratio) Employment Results Analysis
Resumo Baixas doses de edoxabana e enoxaparina s ódica foram objeto de uma comparação retrospectiva implementada com a técnica do escore de propensão a fim de mitigar os efeitos das diferenças nas características clínicas basais de duas coortes e minimizar o risco de viés. Posteriormente, usando um modelo de riscos proporcionais de Cox, a valiou-se a associação de cada tipo de terapia com o risco do composto de morte por todas as causas, acidente vascular cerebral/ataque isquêmico transitório, hospitalizações e ocorrência de sangramentos maiores. Para essa análise, um valor de p< 0,05 foi considerado es...
Source: Arquivos Brasileiros de Cardiologia - October 23, 2020 Category: Cardiology Source Type: research

Update of the Brazilian Guidelines for Valvular Heart Disease – 2020
Resumo Baixas doses de edoxabana e enoxaparina s ódica foram objeto de uma comparação retrospectiva implementada com a técnica do escore de propensão a fim de mitigar os efeitos das diferenças nas características clínicas basais de duas coortes e minimizar o risco de viés. Posteriormente, usando um modelo de riscos proporcionais de Cox, a valiou-se a associação de cada tipo de terapia com o risco do composto de morte por todas as causas, acidente vascular cerebral/ataque isquêmico transitório, hospitalizações e ocorrência de sangramentos maiores. Para essa análise, um valor de p< 0,05 foi considerado es...
Source: Arquivos Brasileiros de Cardiologia - October 23, 2020 Category: Cardiology Source Type: research

Statement – Protocol for the Reconnection of Cardiology Services with Patients During the COVID-19 Pandemic – 2020
Resumo Baixas doses de edoxabana e enoxaparina s ódica foram objeto de uma comparação retrospectiva implementada com a técnica do escore de propensão a fim de mitigar os efeitos das diferenças nas características clínicas basais de duas coortes e minimizar o risco de viés. Posteriormente, usando um modelo de riscos proporcionais de Cox, a valiou-se a associação de cada tipo de terapia com o risco do composto de morte por todas as causas, acidente vascular cerebral/ataque isquêmico transitório, hospitalizações e ocorrência de sangramentos maiores. Para essa análise, um valor de p< 0,05 foi considerado es...
Source: Arquivos Brasileiros de Cardiologia - October 23, 2020 Category: Cardiology Source Type: research

Erratum
Resumo Baixas doses de edoxabana e enoxaparina s ódica foram objeto de uma comparação retrospectiva implementada com a técnica do escore de propensão a fim de mitigar os efeitos das diferenças nas características clínicas basais de duas coortes e minimizar o risco de viés. Posteriormente, usando um modelo de riscos proporcionais de Cox, a valiou-se a associação de cada tipo de terapia com o risco do composto de morte por todas as causas, acidente vascular cerebral/ataque isquêmico transitório, hospitalizações e ocorrência de sangramentos maiores. Para essa análise, um valor de p< 0,05 foi considerado es...
Source: Arquivos Brasileiros de Cardiologia - October 23, 2020 Category: Cardiology Source Type: research

Colchicine: An ancient drug with multiple benefits.
Abstract The history of colchicine dates to ancient Egyptians when it was used for alleviation of swelling and pain. Although its popularity varied throughout the years, colchicine has been a mainstay for the treatment of several diseases, mainly rheumatic and cardiac ones. The mechanism of action of the drug involves several intracellular and extracellular targets, although interaction with tubulin is the most described. Based on several clinical trials and meta-analyses, colchicine is safely recommended as a monotherapy or as an add-on for the treatment and prevention of recurrent pericarditis, postpericardiotom...
Source: Current Pharmaceutical Design - October 23, 2020 Category: Drugs & Pharmacology Authors: El Hasbani G, Jawad A, Uthman I Tags: Curr Pharm Des Source Type: research

Efficacy and Safety of Direct Oral Anticoagulants in Patients with Atrial Fibrillation and Liver Disease: a Meta-Analysis and Systematic Review
ConclusionsOur findings suggest that DOACs significantly reduce the risk of ischemic stroke, major bleeding, and ICH, with no significant effect on the risk of gastrointestinal bleeding in AF patients with liver disease compared with warfarin.
Source: Cardiovascular Drugs and Therapy - September 2, 2020 Category: Cardiology Source Type: research

No Association between Ischemic Stroke and Portal Vein Thrombosis in Liver Cirrhosis.
Conclusion: Ischemic stroke might not be associated with portal vein thrombosis in liver cirrhosis. PMID: 32714987 [PubMed - in process]
Source: Biomed Res - July 29, 2020 Category: Research Authors: Zheng K, Guo X, Yi F, Wang L, Mancuso A, Qi X Tags: Biomed Res Int Source Type: research

Mortality and morbidity in patients with atrial fibrillation and liver cirrhosis.
CONCLUSION: In subjects with liver cirrhosis, AF is associated with higher rates of inpatient mortality, stroke, and acute kidney injury compared to those who do not have the cardiac arrhythmia. PMID: 32843936 [PubMed]
Source: World Journal of Cardiology - July 25, 2020 Category: Cardiology Authors: Darrat YH, Smer A, Elayi CS, Morales GX, Alqahtani F, Alkhouli M, Catanzaro J, Shah J, Salih M Tags: World J Cardiol Source Type: research

Clustering of functioning and disability profile based on the WHO disability assessment schedule 2.0 - a nationwide databank study.
Conclusion: We converted WHO Disability Assessment Schedule 2.0. functioning domain scores into six-dimensioned radar chart, and demonstrate disability restrictions can be further categorized into clusters according to similarity of functioning impairment. Understanding of disease-related disabilities provides an important basis for designing rehabilitation programs and policies on social welfare and health that reflect the daily-living needs of people according to diagnosis.Implication for RehabilitationThe use of radar charts provided a direct visualization of the scope and severity of disabilities associated with specif...
Source: Disability and Rehabilitation - June 10, 2020 Category: Rehabilitation Authors: Chen CP, Chen YW, Chang KH, Huang SW, Wu CH, Escorpizo R, Stucki G, Liou TH Tags: Disabil Rehabil Source Type: research

Tu1164 HYGIEACARE PREP FOR COLONOSCOPY CONSISTENTLY PROVIDES 97% ADEQUACY, AND IS AGNOSTIC TO PREDICTORS OF POOR ORAL BOWEL PREP
The quality of bowel preparation (BP) before colonoscopy plays a pivotal role in the safety, efficacy and quality of the outcome of colonoscopy. Inadequate BP is evident in more than 25% of all colonoscopies. High-quality BP is critical for detection of precancerous lesions.. Inadequate BP is correlated with patient-specific factors including age, male gender, medications, comorbidities such as chronic constipation, diabetes, gastrointestinal surgery, cirrhosis, stroke, and irritable bowel disease (IBD).
Source: Gastrointestinal Endoscopy - May 31, 2020 Category: Gastroenterology Authors: James A. Underwood, Pradeep Bekal, Orly Levitan, Dawn B. Burleson, David A. Johnson Tags: Poster abstracts Source Type: research

Therapeutic potential of phosphodiesterase inhibitors for endothelial dysfunction-related diseases.
Abstract Cardiovascular diseases (CVD) are considered a major health problem worldwide, being the main cause of mortality in developing and developed countries. Endothelial dysfunction, characterized by a decline in nitric oxide production and/or bioavailability, increased oxidative stress, decreased prostacyclin levels, and a reduction of endothelium-derived hyperpolarizing factor is considered an important prognostic indicator of various CVD. Changes in cyclic nucleotides production and/ or signalling, such as guanosine 3', 5'-monophosphate (cGMP) and adenosine 3', 5'-monophosphate (cAMP), also accompany many va...
Source: Current Pharmaceutical Design - April 2, 2020 Category: Drugs & Pharmacology Authors: Blanco-Rivero J, E Xavier F Tags: Curr Pharm Des Source Type: research

The prevalence and prognostic implications of pre-procedural hyperbilirubinemia in patients undergoing transcatheter aortic valve replacement
AbstractPreoperative hyperbilirubinemia is associated with increased mortality and morbidity after cardiac surgery. However, this clinical significance is unclear with transcatheter aortic valve replacement (TAVR) procedures. The aims of this study were to determine the prevalence and prognostic implications of preoperative elevations of serum total bilirubin on TAVR outcomes. In 611 consecutive patients who underwent an elective TAVR procedure, 576 patients had recorded serum total bilirubin levels. Hyperbilirubinemia was defined as any value of serum total bilirubin  ≥ 1.2 mg/dL obtained within 30-days prior to th...
Source: Heart and Vessels - March 27, 2020 Category: Cardiology Source Type: research

Direct oral anticoagulants and warfarin in patients with cirrhosis: a comparison of outcomes
In conclusion DOACs appear to be a safe alternative to warfarin in patients with mild to moderate cirrhosis. Further studies are warranted to confirm these findings.
Source: Journal of Thrombosis and Thrombolysis - January 7, 2020 Category: Hematology Source Type: research