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Condition: Non-alcoholic Fatty Liver Diseases (NAFLD)

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Total 269 results found since Jan 2013.

Mechanism of bariatric and metabolic surgery: beyond surgeons, gastroenterologists and endocrinologists.
Authors: Valentí V, Cienfuegos JA, Becerril Mañas S, Frühbeck G Abstract Bariatric-metabolic surgery is the safest, most effective and long-lasting treatment for obesity and its associated co-morbidities, whether they be metabolic (type 2 diabetes, hyperlipidemia non-alcoholic fatty liver disease) or cardiovascular (myocardial infarction, stroke). Due to the obesity pandemic, bariatric-metabolic surgery is the second most frequent intra-abdominal procedure and the gastroenterologist and the surgeon must be aware of the physiologic changes caused by the anatomic reconfiguration following surgery. Among the mechan...
Source: Revista Espanola de Enfermedades Digestivas - February 23, 2020 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

The predictive value of the hepatorenal index for detection of impaired glucose metabolism in patients with non-alcoholic fatty liver disease
ConclusionUltrasonographically acquired HRI has a significant predictive impact on the detection of prediabetes and diabetes in patients with NAFLD.
Source: Indian Journal of Gastroenterology - March 16, 2020 Category: Gastroenterology Source Type: research

Fatty liver index and development of cardiovascular disease in Koreans without pre-existing myocardial infarction and ischemic stroke: a large population-based study
Despite the known association between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD), whether NAFLD predicts future CVD events, especially CVD mortality, remains uncertain. We evalu...
Source: Cardiovascular Diabetology - May 2, 2020 Category: Cardiology Authors: Jun Hyung Kim, Jin Sil Moon, Seok Joon Byun, Jun Hyeok Lee, Dae Ryong Kang, Ki Chul Sung, Jang Young Kim and Ji Hye Huh Tags: Original investigation Source Type: research

The Association Between Nonalcoholic Fatty Liver Disease and Risk of Cardiovascular Disease, Stroke, and Extra-Hepatic Cancers
Publication date: Available online 20 May 2020Source: Journal of Clinical and Experimental HepatologyAuthor(s): Nicolette Veracruz, Bilal Hameed, Sammy Saab, Robert J. Wong
Source: Journal of Clinical and Experimental Hepatology - May 20, 2020 Category: Gastroenterology Source Type: research

Brief Report: Relationship Between Nonalcoholic Fatty Liver Disease and Cardiovascular Disease in Persons With HIV
Background: Nonalcoholic fatty liver disease (NAFLD) and HIV are independently associated with cardiovascular disease (CVD). However, the factors associated with NAFLD in persons living with HIV (PWH) and whether CVD is more frequent in PWH with NAFLD are currently unknown. Methods: From the Partners HealthCare Research Patient Data Registry, we identified PWH with and without NAFLD between 2010 and 2017. NAFLD was defined using validated histological or radiographic criteria. CVD was defined by an ICD-9 diagnosis of coronary artery disease, myocardial infarction, coronary revascularization, peripheral vascular diseas...
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - June 25, 2020 Category: Infectious Diseases Tags: Clinical Science Source Type: research

Effects of surface-deacetylated chitin nanofibers on non-alcoholic steatohepatitis model rats and their gut microbiota.
Abstract Nonalcoholic steatohepatitis (NASH), a more advanced form of nonalcoholic fatty liver disease (NAFLD), is associated with increased cardiovascular and liver-related mortality. Stroke-prone spontaneously hypertensive rats (SHRSP5/Dmcr) that are fed a high-fat and high-cholesterol diet develop hepatic lesions that are similar to those observed in human NASH pathology. We investigated the hepatic protective and antioxidant effects of surface-deacetylated chitin nanofibers (SDACNFs) that were administered to SHRSP5/Dmcr rats for 8 weeks. The administration of SDACNFs (80 mg/kg/day) resulted in a significa...
Source: International Journal of Biological Macromolecules - July 18, 2020 Category: Biochemistry Authors: Goto M, Iohara D, Michihara A, Ifuku S, Azuma K, Kadowaki D, Maruyama T, Otagiri M, Hirayama F, Anraku M Tags: Int J Biol Macromol Source Type: research

HIIT for post-COVID patients within cardiac rehabilitation: Response to letter to the editor
We thank Li and colleagues for their comments regarding our recent research into the benefits of incorporating high-intensity interval training (HIIT) into cardiac rehabilitation for patients with coronary artery disease (CAD) [1]. In recent years, HIIT has proven popular in the general community and has been studied across a wide array of cardiovascular (CV)-related disorders, such as hypertension [2,3], stroke [4,5], type II diabetes [6] and non-alcoholic fatty liver disease [7]. This is due to compounding, compelling evidence of the efficacy of HIIT on CV outcomes such as reduced blood pressure, lowered body fat, improv...
Source: International Journal of Cardiology - August 29, 2020 Category: Cardiology Authors: Andrew Keech, Kimberley Way, Katie Holgate, Jennifer Fildes, Praveen Indraratna, Jennifer Yu Tags: Letter to the Editor Source Type: research

Mayo Clinic Q & amp;A podcast: Cardiometabolic diseases increase COVID-19 risk
An estimated 47 million Americans are living with cardiometabolic diseases, according to the American College of Cardiology. Cardiometabolic diseases are interrelated conditions that include cardiovascular diseases, such as heart disease, stroke, and hypertension, as well as metabolic diseases, such as Type 2 diabetes, obesity and nonalcoholic fatty liver disease. Patients with cardiometabolic diseases have a [...]
Source: News from Mayo Clinic - November 13, 2020 Category: Databases & Libraries Source Type: news

Serum uric acid and diabetes: from pathophysiology to cardiovascular disease.
Abstract Hyperuricemia, has been traditionally related to nephrolithiasis and gout. However, it has also been associated with the development of type 2 diabetes mellitus (T2DM) and cardiometabolic and cardiovascular diseases. Pathophysiologically, elevated serum uric acid (SUA) levels may be associated with abnormal lipid and glucose metabolism. In this narrative review, we consider the associations between hyperuricemia, hyperglycemia, atherosclerosis and thrombosis. Furthermore, we comment on the available evidence linking elevated SUA levels with the incidence and outcomes of coronary heart disease, stroke, per...
Source: Current Pharmaceutical Design - January 4, 2021 Category: Drugs & Pharmacology Authors: Katsiki N, Dimitriadis GD, Mikhailidis DP Tags: Curr Pharm Des Source Type: research

Molecules, Vol. 26, Pages 302: Protective Effects of Polyphenol Enriched Complex Plants Extract on Metabolic Dysfunctions Associated with Obesity and Related Nonalcoholic Fatty Liver Diseases in High Fat Diet-Induced C57BL/6 Mice
Conclusions: The results of this study demonstrated that the herbal complex is an effective herbal formulation in the attenuation of obesity and obesity-induced metabolic dysfunction including NAFLD in HFD-induced mouse model.
Source: Molecules - January 8, 2021 Category: Chemistry Authors: Ahtesham Hussain Jin Sook Cho Jong-Seok Kim Young Ik Lee Tags: Article Source Type: research

Akebia saponin D ameliorates metabolic syndrome (MetS) via remodeling gut microbiota and attenuating intestinal barrier injury
Biomed Pharmacother. 2021 Feb 27;138:111441. doi: 10.1016/j.biopha.2021.111441. Online ahead of print.ABSTRACTMetabolic syndrome (MetS) is a complex, multifactorial disease which lead to an increased risk of cardiovascular disease, type 2 diabetes, and stroke. However, selective, and potent drugs for the treatment of MetS are still lacking. Previous studies have found that Akebia saponin D (ASD) has beneficial effects on metabolic diseases such as obesity, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). Therefore, our study was designed to determine the effect and mechanism of action of ASD against MetS in ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 2, 2021 Category: Drugs & Pharmacology Authors: Song Yang Ting Hu He Liu Ya-Li Lv Wen Zhang Han Li Lingling Xuan Li-Li Gong Li-Hong Liu Source Type: research

Hepatic-Metabolite-Based Intermittent Fasting Enables a Sustained Reduction in Insulin Resistance in Type 2 Diabetes and Metabolic Syndrome
Horm Metab Res DOI: 10.1055/a-1510-8896Insulin resistance is the hallmark of Type 2 Diabetes and is still an unmet medical need. Insulin resistance lies at the crossroads of non-alcoholic fatty liver disease, obesity, weight loss and exercise resistance, heart disease, stroke, depression, and brain health. Insulin resistance is purely nutrition related, with a typical molecular disease food intake pattern. The insulin resistant state is accessible by TyG as the appropriate surrogate marker, which is found to lead the personalized molecular hepatic nutrition system for highly efficient ins...
Source: Hormone and Metabolic Research - June 30, 2021 Category: Endocrinology Authors: Rohner, Markus Heiz, Robert Feldhaus, Simon Bornstein, Stefan R. Tags: Endocrine Care Source Type: research

Nonalcoholic Fatty Liver Disease, Liver Fibrosis and Cardiovascular Disease in the Adult US Population
ConclusionsIn this population-based study, we did not identify an independent association between steatosis and fibrosis and CVD. Large prospective cohort studies are needed to provide a more definitive evidence on this topic.
Source: Frontiers in Endocrinology - July 26, 2021 Category: Endocrinology Source Type: research

Fatty liver and cerebrovascular disease: plausible association and possible mechanisms
Purpose of review Nonalcoholic fatty liver disease (NAFLD) is a common comorbidity and has wide ranging extrahepatic manifestations, including through cardiometabolic pathways. As such, there is growing interest in the impact of NAFLD on cerebrovascular disease and brain health more broadly. In this review, we assess recent research into understanding the association between NAFLD and brain health while highlighting potential clinical implications. Recent findings Mechanistically, NAFLD is characterized by both a proinflammatory and proatherogenic state, which results in vascular inflammation and neurodegenerati...
Source: Current Opinion in Lipidology - December 29, 2021 Category: Lipidology Tags: NUTRITION AND METABOLISM: Edited by Frank M. Sacks and Majken K. Jensen Source Type: research