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Condition: Cardiomyopathy
Procedure: PET Scan

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Total 24 results found since Jan 2013.

The prognostic role of right ventricular dysfunction in patients with hypertrophic cardiomyopathy
AbstractHypertrophic cardiomyopathy (HCM) primarily affects the left ventricle (LV) sparing the right ventricle (RV) in vast majority of cases. However, several studies employing CMR have revealed that myocardial hypertrophy may also involve the RV. To assess RV size and function in a large prospectively cohort of HCM patients and to evaluate whether these parameters in association with other MR findings can predict cardiac events. Two participating centers prospectively included patients with known or suspected HCM between 2011 and 2017. CMR studies were performed with three different scanners. Outcome measures were a com...
Source: The International Journal of Cardiovascular Imaging - May 5, 2023 Category: Radiology Source Type: research

Cryptogenic stroke and TIA: Suggested diagnostic approach while waiting for evaluation and treatment guidelines
CONCLUSIONS: An individual approach and targeted diagnostics using advanced medical technologies in selected patients, who may benefit from a tailored treatment regimen, can help reveal a probable cause in the majority of strokes and TIAs previously classified as cryptogenic.PMID:35146751 | DOI:10.1111/ane.13590
Source: Atherosclerosis - February 11, 2022 Category: Cardiology Authors: Barbara Ratajczak-Tretel Anna Tancin Lambert Dan Atar Anne Hege Aamodt Source Type: research

Assessing the pharmacokinetics and metabolism of 18FLMI1195 in clinical imaging populations
Conclusions: These preliminary results suggest notable differences in the clearance and metabolic profiles of [18F]LMI1195 dependent on the given disease pathology. Radiotracer parent fraction can be equally measured by column-switching HPLC or SPE. These findings offer an important consideration for estimation of myocardial sympathetic nerve density using [18F]LMI1195 in patients suffering from cardiovascular disease. Support: Heart & Stroke Foundation of Canada/CANet ERLI (Rotstein) References: [1] Zelt, J. G. E. et al. J. Nucl. Cardiol. 2019, 26 (6), 2151-2153. [2] Sinusas, A. J. et al. J. Nucl. Med. 2014, 55 (9), 1...
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Mair, B., Al Haddad, R., Zelt, J., Dinelle, K., Quigley, S., Beanlands, R., DeKemp, R., Rotstein, B. Tags: Clinical Science (Poster Session) Source Type: research

Outcome of patients receiving a continuous flow left ventricular assist device - a retrospective single center study.
Conclusions. Survival rates were good, although one third of patients were bridged with temporary circulatory support. We report a high level of freedom from pump thrombosis, fatal stroke, and driveline infection. PMID: 32292078 [PubMed - as supplied by publisher]
Source: Scandinavian Cardiovascular Journal - April 16, 2020 Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats
Conclusion Principal findings of this work are that abnormal Ca2+ transient amplitude, contractile dysfunction; and impaired relaxation of MetS cardiomyocytes underlies intrinsic dysfunctional RyR2 and SERCA pump. Abnormal activity of RyRs was evidenced by its decreased ability to bind [3H]-ryanodine. Although the MetS condition does not modify RyR2 protein expression, its phosphorylation at Ser2814 is decreased, which impairs its capacity for activation during ECC. The dysfunctional RyRs, together with a decreased activity of SERCA pump due to decreased Thr17-PLN phosphorylation suggest a downregulation of CaMKII in MetS...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research

Age-Dependence of Flow Homeostasis in the Left Ventricle
Conclusions: In average, blood spends 1 to 3 beats inside the LV with very low shear stress rates. The apical region is the most prone to blood stasis, particularly in mid-aged adults. The washout of blood in the normal LV is age-dependent due to physiological changes in the degree of apical penetration of the filling waves. Introduction Cardioembolic stroke is a major source of mortality and disability worldwide and blood stasis one of its major determinants (Adams et al., 1986). Left ventricular (LV) function has evolved to maximize mechanical efficiency and ensure organ perfusion at a low cost of energy and fill...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

YiQiFuMai Powder Injection Attenuates Coronary Artery Ligation-Induced Heart Failure Through Improving Mitochondrial Function via Regulating ROS Generation and CaMKII Signaling Pathways
This study was carried out in accordance with the recommendations of “Guide for the Care and Use of Laboratory Animals, National Institutes of Health.” The protocol was approved by the “China Pharmaceutical University.” Surgical Preparation The mice were anesthetized with chloral hydrate (4% chloral hydrate, ip). The HF model was induced by CAL as previously reported (Gao et al., 2010). Successful ligation of the coronary artery was confirmed by the occurrence of ST-segment elevation in electrocardiogram. Sham operated mice were performed the same process except left CAL. After ligation, the h...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

Cerebral pontine infarctions during pregnancy – A case report and review of the literature
Publication date: Available online 23 January 2019Source: Case Reports in Women's HealthAuthor(s): Jenna Kaye Wildman, Bassam H. RimawiAbstractCerebrovascular disease is not uncommon during pregnancy as a result of either venous or arterial occlusion, or a hemorrhagic event, resulting in ischemia. Pregnancy may alter the prognosis of these neurologic disorders, with increased risks of morbidity and mortality for the mother and the developing fetus. Etiologies of stroke during pregnancy and the postpartum period include preeclampsia, eclampsia, HELLP syndrome, posterior reversible encephalopathy syndrome (PRES), amniotic fl...
Source: Case Reports in Womens Health - January 24, 2019 Category: OBGYN Source Type: research

Muscle Mass and Mortality After Cardiac Transplantation
Conclusions Muscle mass is an independent predictor of mortality and major morbidity after OHT. Further research is needed to determine whether frail OHT patients with low PMA may benefit from muscle-building interventions to improve outcomes.
Source: Transplantation - November 22, 2018 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

Atherosclerosis and cardiovascular involvement in celiac disease: the role of autoimmunity and inflammation.
CONCLUSIONS: On the basis of the reported association among CD, AS and CV diseases, we suggest to perform a more detailed CV risk assessment in all CD patients than what is currently being achieved in clinical practice, in order to scan and treat modifiable CV risk factors in these patients. In particular, we suggest to resort to instrumental techniques to detect AS in the subclinical stage, in order to prevent AS development and CV diseases in CD patients. PMID: 29243787 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - December 17, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Adverse cardiac events in out ‐patients initiating clozapine treatment: a nationwide register‐based study
ConclusionCardiac adverse effects in Danish out‐patients initiating clozapine treatment are extremely rare and these rates appear to be comparable to those observed for other antipsychotic drugs.
Source: Acta Psychiatrica Scandinavica - October 24, 2017 Category: Psychiatry Authors: C. Rohde, C. Polcwiartek, K. Kragholm, B. H. Ebdrup, D. Siskind, J. Nielsen Tags: Original article Source Type: research

'Exercise pill' could potentially help people with heart failure
Conclusion The protein hCT1 caused heart muscles to grow in a more healthy way in rodents with heart failure. When treatment stopped, the heart went back to its original condition – something that does not happen when the heart grows in a dysfunctional way. There is currently no cure for heart failure and treatment is only available for keeping symptoms under control. Therefore, this very promising early-stage research with potential for developing a drug for people with heart failure, has huge implications. However, it is important to remember that as this is experimental laboratory research, there are many more stage...
Source: NHS News Feed - August 9, 2017 Category: Consumer Health News Tags: Heart/lungs Source Type: news

Role of quantitative myocardial positron emission tomography for risk stratification in patients with hypertrophic cardiomyopathy: a 2016 reappraisal
ConclusionsDip-MBF confirms its role as potent predictor of outcome in HCM. However, the threshold for prediction in a contemporary cohort is higher than that reported in earlier studies. Dip-MBF impairment in the lateral wall, possibly reflecting diffuse disease extending to non-hypertrophic regions, is a sensitive predictor of mortality in HCM.
Source: European Journal of Nuclear Medicine and Molecular Imaging - November 3, 2016 Category: Nuclear Medicine Source Type: research