Offspring to Parent LDLT: Narrowing the Gap Between Theory and Evidence
No abstract available (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Letters to the Editor Source Type: research

Significance of Offspring Donors on Long-term Survival in Adult Living Donor Liver Transplantation: Asian Experience
No abstract available (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Letters to the Editor Source Type: research

Response to Assessing Association Between Intraoperative Fluid Balance and the Risk of Acute Kidney Injury After Liver Transplantation: Methodological Issues
No abstract available (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Letters to the Editor Source Type: research

Assessing Association Between Intraoperative Fluid Balance and the Risk of Acute Kidney Injury After Liver Transplantation: Methodological Issues
No abstract available (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Letters to the Editor Source Type: research

Use of Culture to Reach Metabolically Adequate Beta-cell Dose by Combining Donor Islet Cell Isolates for Transplantation in Type 1 Diabetes Patients
Conclusions. Human islet isolates with insufficient beta-cell mass for implantation within 72 hours can be cultured for 96 hours and longer to combine multiple preparations in order to reach the desired beta-cell dose and therefore result in a better metabolic benefit. (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

Recent Trends of Infectious Complications Following Heart Transplantation
Conclusions. A significant reduction in viral, fungal, and Nocardia IEps after heart transplantation was observed, most likely due to advancements in immunosuppression and preventive strategies, including pretransplant infectious diseases screening and antimicrobial prophylaxis. (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

Impaired Exercise Tolerance Early After Heart Transplantation Is Associated With Development of Cardiac Allograft Vasculopathy
Conclusions. Normalized peak VO2 ≤60% and VE/VCO2 ≥34 at 1 year after HTx are associated with the development of CAV. (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

Long-term Outcome in Severe Left Ventricular Primary Graft Dysfunction Post Cardiac Transplantation Supported by Early Use of Extracorporeal Membrane Oxygenation
Background. Severe primary graft dysfunction (PGD) is the leading cause of early death following cardiac transplantation. The early use of venoarterial extracorporeal membrane oxygenation (VA-ECMO) may facilitate graft rescue. However, the additional risks of its use are unknown. Methods. We retrospectively reviewed the medical records of all adult patients who underwent cardiac transplantation from January 2009 to February 2016 at St Vincent’s Hospital, Sydney, to evaluate risk factors for the use of VA-ECMO and related morbidity and long-term survival. Results. One hundred ninety-two transplanted patients w...
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

Association of Alemtuzumab Induction With a Significantly Lower Incidence of GVHD Following Intestinal Transplantation: Results of 445 Consecutive Cases From a Single Center
Conclusions. These results may help advance the current state of knowledge about risk factors for GVHD development following intestinal transplantation. (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

Association of More Intensive Induction With Less Acute Rejection Following Intestinal Transplantation: Results of 445 Consecutive Cases From a Single Center
Background. In intestinal transplantation, acute cellular rejection (ACR) remains a significant challenge to achieving long-term graft survival. It is still not clear which are the most important prognostic factors. Methods. We performed a Cox multivariable analysis of the hazard rates of developing any ACR, severe ACR, and cause-specific graft loss during the first 60 months posttransplant among 445 consecutive intestinal transplant recipients at our institution since 1994. Of particular interest was to determine the prognostic influence of induction type: rabbit antithymocyte globulin (rATG; 2 mg/kg × 5...
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

Pretransplant NT-proBNP, Dialysis Vintage, and Posttransplant Mortality in Kidney Transplant Recipients
Background. End-stage kidney disease and dialysis vintage are characterized by accelerated atherosclerosis, volume overload, and progressive left ventricular hypertrophy, leading to elevated N-terminal probrain natriuretic peptide (NT-proBNP) levels. Pretransplant dialysis vintage is associated with excess mortality after transplantation. We want to study whether pretransplant NT-proBNP is associated with posttransplantation mortality and if it explains the association of dialysis vintage with posttransplantation mortality in kidney transplant recipients (KTR). Methods. We measured plasma NT-proBNP on arrival at the h...
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

Does a Useful Test Exist to Properly Evaluate the Pathogenicity of Donor-specific Antibodies? Lessons From a Comprehensive Analysis in a Well-studied Single-center Kidney Transplant Cohort
Conclusions. Complement-binding DSA per se were not significantly associated with allograft survival in the entire study sample. Finally, gDSA predicted subsequent graft loss in patients who showed a stable renal function at the day of biopsy. Our data suggest that DSA mean fluorescence intensity and presence of gDSA might provide prognostic information during posttransplant monitoring. (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

The Influence of Antithymocyte Globulin Dose on the Incidence of CMV Infection in High-risk Kidney Transplant Recipients Without Pharmacological Prophylaxis
Conclusions. In our study of high-risk KT recipients without CMV prophylaxis, a single ATG dose decreased the risk of CMV infection without increasing the risk of AR or compromising graft or patient survival. (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

Excess Stroke Deaths in Kidney Transplant Recipients: A Retrospective Population-based Cohort Study Using Data Linkage
Conclusions. Kidney transplant recipients had excess stroke deaths, particularly at younger ages and women. Preexisting cerebrovascular disease was a potentially modifiable risk factor for stroke death, suggesting further studies of secondary stroke prevention for kidney transplant recipients. (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

Kidney Transplant Outcomes in Patients With Adenine Phosphoribosyltransferase Deficiency
Conclusions. Kidney allograft outcomes are good in APRT deficiency patients beginning XOR inhibitor therapy pretransplant. Delay in such treatment is a major cause of premature graft loss in these patients. Increased awareness among clinicians is imperative, promoting early diagnosis of APRT deficiency and pharmacotherapy initiation before kidney transplantation. (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

Five-year Outcomes of Pulmonary Hypertension With and Without Elevated Left Atrial Pressure in Patients Evaluated for Kidney Transplantation
Conclusions. The mortality risk associated with PH among patients with advanced chronic kidney disease appears to differ by etiology. Patients with PH in the absence of eLAP are at high risk of death and in need of focused attention. Future research efforts should investigate potential strategies to improve outcomes for these patients. (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

Surveillance for HCC After Liver Transplantation: Increased Monitoring May Yield Aggressive Treatment Options and Improved Postrecurrence Survival
Background. Currently, no surveillance guidelines for hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) exist. In this retrospective, multicenter study, we have investigated the role of surveillance imaging on postrecurrence outcomes. Methods. Patients with recurrent HCC after LT from 2002 to 2016 were reviewed from 3 transplant centers (University of California San Francisco, Mayo Clinic Florida, and University of Toronto). For this study, we proposed the term cumulative exposure to surveillance (CETS) as a way to define the cumulative sum of all the protected intervals that each surveillance...
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research

Neoadjuvant Chemoradiotherapy and Liver Transplantation for Unresectable Hilar Cholangiocarcinoma: The Irish Experience of the Mayo Protocol
This study reports the experience of the Irish National Liver Transplant Programme with the Mayo Protocol. Methods. All patients diagnosed with unresectable hCCA between 2004 and 2016, who were eligible for the treatment protocol, were prospectively studied. Results. Thirty-seven patients commenced chemoradiotherapy. Of those, 11 were excluded due to disease progression and 26 proceeded to liver transplantation. There were 24 males, the median age was 49, and 88% had underlying primary sclerosing cholangitis. R0 and pathologic complete response rates were 96% and 62%, respectively. Overall median survival was 53 mont...
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research

The Impact of Direct-acting Antivirals on Overall Mortality and Tumoral Recurrence in Patients With Hepatocellular Carcinoma Listed for Liver Transplantation: An International Multicenter Study
Background. There is a lack of data on the use of direct-acting antivirals (DAA) on the risk of death and tumoral recurrence in patients with hepatitis C virus (HCV) and hepatocellular carcinoma (HCC) listed for liver transplantation (LT). We aimed to assess the impact of antiviral treatment on mortality and HCC recurrence patients with HCC-HCV. Methods. This was a retrospective multicenter study of patients with HCC-HCV listed for LT from 2005 to 2015. Patients were divided according to the antiviral treatment received after HCC diagnosis: DAA, interferon (IFN), or no antiviral. Intention-to-treat overall survival an...
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research

Temporal Trends and Outcomes in Liver Transplantation for Recipients With HIV Infection in Europe and United States
Background. We evaluated trends and outcomes of liver transplantation (LT) recipients with/without HIV infection. Methods. LT recipients between 2008 and 2015 from the United Network for Organ Sharing and Organ Procurement and Transplantation Network and European Liver Transplant Registry were included. Trends and characteristics related to survival among LT recipients with HIV infection were determined. Results. Among 73 206 LT patients, 658 (0.9%) were HIV-infected. The proportion of LT HIV-infected did not change over time (P-trend = 0.16). Hepatitis C virus (HCV) as indication for LT decreased significan...
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research

Complement 5 Inhibition Ameliorates Hepatic Ischemia/reperfusion Injury in Mice, Dominantly via the C5a-mediated Cascade
Conclusions. Anti-C5 antibody significantly ameliorated hepatic IRI, predominantly via the C5a-mediated cascade, not only by inhibiting platelet aggregation during the early phase but also by attenuating the activation of infiltrating macrophages/neutrophils and hepatocyte apoptosis in the late phase of reperfusion. Given its efficacy, clinical availability, and controllability, C5-targeted intervention may provide a novel therapeutic strategy against hepatic IRI. (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Original Basic Science—Liver Source Type: research

Brown Adipose Tissue: A Potential Site for Islet Transplantation
Conclusions. BAT remarkably enhances the viability and biological function of the transplanted ectopic islets. Moreover, the anatomical location of BAT lends itself to biopsy, removal, and islet retransplantation, which strongly suggests the BAT as a potential desirable site for islet transplantation in basic and clinical research. (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research

Improvement of Islet Allograft Function Using Cibinetide, an Innate Repair Receptor Ligand
Conclusions. Cibinetide reduced the initial transplantation–related severe inflammation and delayed the subsequent alloreactivity. Cibinetide, in combination with low-dose tacrolimus, could significantly improve long-term graft survival in allogeneic PITx. (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research

Kidney Transplantation in Systemic Amyloidosis
The present review discusses current developments and outcomes of renal transplantation in systemic amyloidosis. Amyloidosis can wreak havoc on the architecture and functioning of the kidneys, leading to end-stage renal disease. In recent years, the available treatments, especially for light-chain amyloidosis but also for several of the underlying inflammatory diseases that cause amyloid A amyloidosis have expanded leading to prolonged survival albeit frequently with renal failure. At the same time, there are also increasing numbers of patients diagnosed with one of the inherited forms of amyloidosis for which currently th...
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Reviews Source Type: research

Memory T Cells in Transplantation: Old Challenges Define New Directions
Immunologic memory is the ability of adaptive immune system to quickly and specifically recognize previously encountered antigens and initiate an effector response. Alloreactive memory cells can mount rapid and robust responses to the transplanted organ resulting in allograft injury. Thus preexisting humoral or cellular memory alloresponses are typically associated with poor graft outcomes in experimental and clinical transplantation. While both B and T lymphocytes exhibit memory responses, this review discusses recent updates on the biology of memory T cells and their relevance to the field of transplantation. Three major...
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Reviews Source Type: research

The Implications of B-lineage Cells in Kidney Allografts
The majority of cells comprising the inflammatory infiltrates in kidney allografts undergoing acute and/or chronic rejection are typically T cells and monocyte/macrophages with B cells, plasma cells, and eosinophils accounting for (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Reviews Source Type: research

Humoral Alloreactivity in VCA Recipients: Should We Learn From Our Experience?
Initially overlooked in favor of T cell–mediated rejection, the importance of the humoral alloimmune response has progressively emerged. As a result, antibody-mediated rejection is now widely recognized as the main cause of late allograft loss in most (if not all) types of solid-organ transplantation. Over the last 2 decades, vascularized composite allotransplantation (VCA) has appeared for replacing tissue defects in patients for whom no other satisfactory reconstructive options were available. Although it is now clear that VCA recipients can develop donor-specific antibodies, conclusions made in solid organ transpl...
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Reviews Source Type: research

Pulmonary Hypertension and Mortality in Patients Awaiting Kidney Transplant: Cause for Concern and Potential Opportunity
No abstract available (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Commentaries Source Type: research

Induction in Intestinal Transplantation
No abstract available (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Commentaries Source Type: research

Posttransplantation HCC Surveillance: Impact on Outcome or Byproduct of Biology?
No abstract available (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Commentaries Source Type: research

On Poetry and Vascularized Composite Allografting
No abstract available (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: Commentaries Source Type: research

Nomenclature for Kidney Function and Disease: Executive Summary and Glossary From a Kidney Disease: Improving Global Outcomes Consensus Conference
No abstract available (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: In View: Special Articles Source Type: research

Additional Suggestions for Organ Donation During COVID-19 Outbreak
No abstract available (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: In View: Special Articles Source Type: research

Global Transplantation COVID Report March 2020
No abstract available (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: In View: Special Articles Source Type: research

Off-the-shelf EBV-specific T-cell Immunotherapy for EBV-associated PTLD
No abstract available (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: In View: Game Changer Source Type: research

Research Highlights
No abstract available (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: In View: Research Highlights Source Type: research

Kidney Transplant Program for Prisoners: Rewards, Challenges, and Perspectives
No abstract available (Source: Transplantation)
Source: Transplantation - September 24, 2020 Category: Transplant Surgery Tags: In View: Around the World Source Type: research

RE: Spinal Cord Ischemia Post-pancreas Transplant
No abstract available (Source: Transplantation)
Source: Transplantation - August 26, 2020 Category: Transplant Surgery Tags: Letters to the Editor Source Type: research

Novel Use of Normothermic Machine Perfusion of the Liver: A Strategy to Mitigate Unexpected Clinical Events
No abstract available (Source: Transplantation)
Source: Transplantation - August 26, 2020 Category: Transplant Surgery Tags: Letters to the Editor Source Type: research

Spinal Cord Ischemia in Pancreas Transplantation: The UK Experience
Conclusions. Based on these findings, there is approximately a 1:440 risk of SCI in pancreas transplantation. Hypotension appears to be a prominent risk factor. Strategies for mitigating the risk of SCI are discussed, drawing on evidence from thoraco-abdominal aortic aneurysm surgery. The risk of long-term neurological deficit should be discussed with prospective pancreas recipients given the potential impact on posttransplant quality of life. (Source: Transplantation)
Source: Transplantation - August 26, 2020 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

Paneth Cell Alterations During Ischemia-reperfusion, Follow-up, and Graft Rejection After Intestinal Transplantation
Conclusions. This study revealed a transient fall in PC numbers in the early post-ITx period but a permanent reduction in lysozyme intensity following ITx. Further research is needed to determine the potential clinical impact of PC impairment after ITx. (Source: Transplantation)
Source: Transplantation - August 26, 2020 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

Favorable Outcomes of Liver Transplantation from Controlled Circulatory Death Donors Using Normothermic Regional Perfusion Compared to Brain Death Donors
Background. Liver transplantation (LT) from controlled donation after circulatory death (cDCD) was initiated in France in 2015 under a protocol based on the use of normothermic regional perfusion (NRP) before organ procurement. The aim was to compare outcomes following cDCD LT with NRP and donation after brain death (DBD) LT. Methods. This is a multicenter retrospective study comparing cDCD LT with NRP and DBD LT. A case-matched study (1:2) was performed using the variables such as recipient and donor age, indication of LT. Results. A total of 50 patients from the cDCD group were matched to 100 patients from the DB...
Source: Transplantation - August 26, 2020 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research

Perfusate Analysis During Dual Hypothermic Oxygenated Machine Perfusion of Liver Grafts: Correlations With Donor Factors and Early Outcomes
Background. Liver graft viability assessment has long been considered a limit of hypothermic oxygenated machine perfusion (HOPE). Aim of this study was assessing correlations of easily available perfusate parameters (PP) (aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, glucose, lactate, and pH) with graft features and outcome. Methods. In the period October 2018–February 2020, perfusate samples were obtained every 30 minutes during 50 dual-HOPE (D-HOPE) procedures. Correlations of PP with graft factors, 90-day graft loss, early allograft dysfunction (EAD), L-GrAFT score, acute kidney...
Source: Transplantation - August 26, 2020 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research

Clinical Implementation of Prolonged Liver Preservation and Monitoring Through Normothermic Machine Perfusion in Liver Transplantation
Conclusions. NMP in a multidisciplinary approach enables a safe prolongation of liver preservation and overnight organ care. A first field test of NMP indicates safety and benefit of this approach. (Source: Transplantation)
Source: Transplantation - August 26, 2020 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research

Agmatine Attenuates Liver Ischemia Reperfusion Injury by Activating Wnt/β-catenin Signaling in Mice
Conclusions. AGM showed protective effects against LIRI by activating the Wnt/β-catenin signaling pathway. (Source: Transplantation)
Source: Transplantation - August 26, 2020 Category: Transplant Surgery Tags: Original Basic Science—Liver Source Type: research

Metformin Preconditioning Improves Hepatobiliary Function and Reduces Injury in a Rat Model of Normothermic Machine Perfusion and Orthotopic Transplantation
Conclusions. Preconditioning with metformin lowers hepatobiliary injury and improves hepatobiliary function in an in situ and ex situ model of rat donor liver transplantation. (Source: Transplantation)
Source: Transplantation - August 26, 2020 Category: Transplant Surgery Tags: Original Basic Science—Liver Source Type: research

Ex Vivo Lung Perfusion Improves the Inflammatory Signaling Profile of the Porcine Donor Lung Following Transplantation
Conclusions. EVLP alters the inflammatory signaling profile of the donor lung before transplantation, with a global cell survival and antiapoptotic signature. (Source: Transplantation)
Source: Transplantation - August 26, 2020 Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research

Comparing Donor Heart Assessment Strategies During Ex Situ Heart Perfusion to Better Estimate Posttransplant Cardiac Function
Conclusions. Left ventricular functional parameters, especially ventricular work and reserve, provided the best estimation of myocardial performance following transplantation. Furthermore, simple NI estimates of ventricular function proved useful in this setting. Right ventricular and metabolic measurements were limited in their ability to correlate with myocardial recovery. This emphasizes the need for an ESHP platform capable of assessing myocardial contractility and suggests that metabolic parameters alone do not provide a reliable evaluation. (Source: Transplantation)
Source: Transplantation - August 26, 2020 Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research

Prolonged Cold Ischemia Time in Mouse Heart Transplantation Using Supercooling Preservation
Conclusions. Supercooling heart preservation at –8°C greatly prolonged the preservation time and improved the posttransplant outcomes in comparison to conventional 4°C UW preservation. Supercooling preservation is a promising technique for organ preservation. (Source: Transplantation)
Source: Transplantation - August 26, 2020 Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research

Multiple Progressive Thermopreconditioning Improves Cardiac Ischemia/Reperfusion-induced Left Ventricular Contractile Dysfunction and Structural Abnormality in Rat
Conclusions. 3PTP therapies may through Bag3 upregulation alleviate I/R injury-induced left ventricular structural deterioration and dysfunction. (Source: Transplantation)
Source: Transplantation - August 26, 2020 Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research