Long-term and Short-term Outcomes of Solid Organ Transplantation From Donors With a Positive SARS-CoV-2 Test
No abstract available (Source: Transplantation)
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Letters to the Editor Source Type: research
How Did the Omicron Surge Affect Kidney Transplant Recipients Compared With a Cohort From the General Population?
No abstract available (Source: Transplantation)
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Letters to the Editor Source Type: research
Trends in COVID-19 Mortality Among Solid Organ Transplant Recipients: Implications for Prevention
No abstract available (Source: Transplantation)
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Letters to the Editor Source Type: research
Donor-derived Cell-free DNA Shows High Sensitivity for the Diagnosis of Pancreas Graft Rejection in Simultaneous Pancreas-kidney Transplantation
Conclusions.
dd-cfDNA measurement through a simple noninvasive blood test could be incorporated into clinical practice to help inform graft management in SPKTx patients. (Source: Transplantation)
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Hemodynamic Effects of High-dose Levothyroxine and Methylprednisolone in Brain-dead Potential Organ Donors
Conclusions.
High-dose methylprednisolone alone or in combination with levothyroxine allowed for significant reduction in vasopressor support in organ donors. Levothyroxine alone offered no advantage in reducing vasopressor support. Organ yield, transplantation rates, and recipient outcomes were not adversely affected. (Source: Transplantation)
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
The Pathological and Clinical Diversity of Acute Vascular Rejection in Kidney Transplantation
Background.
Vascular rejection (VR) is characterized by arteritis, steroid resistance, and increased graft loss but is poorly described using modern diagnostics.
Methods.
We screened 3715 consecutive biopsies and retrospectively evaluated clinical and histological phenotypes of VR (n = 100) against rejection without arteritis (v0REJ, n = 540) and normal controls (n = 1108).
Results.
Biopsy sample size affected the likelihood of arterial sampling, VR diagnosis, and final Banff v scores (P (Source: Transplantation)
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Predictors of Hypertension Development 1 Year After Heart Transplantation
Conclusions.
Blood pressures increase during the first year after HTx, with female donor sex as a strong predictor of recipient hypertension development. The underlying mechanism seems to be enhanced peripheral vasoconstriction caused by attenuated cardiovascular homeostasis capabilities. Further studies are needed to confirm the results. (Source: Transplantation)
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
International Survey of Clinical Monitoring Practices in Pancreas and Islet Transplantation
Conclusions.
This international survey identifies common immunologic and metabolic monitoring strategies utilized for protocol and for cause following pancreas and islet transplantation. In the absence of any formal studies to assess the efficacy of immunologic and metabolic testing to detect early allograft dysfunction, it can serve as a guidance document for developing monitoring algorithms following beta-cell replacement. (Source: Transplantation)
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Ex Vivo Normothermic Perfusion of Human Upper Limbs
Background.
Ischemia-reperfusion injury remains a primary concern in upper extremity transplantation. Ex vivo normothermic perfusion (EVNP) enables near-physiological organ preservation, avoiding the deleterious effects of hypoxia and cooling. We investigated the effectiveness of human limb EVNP compared with static cold storage (SCS).
Methods.
Twenty human upper extremities were procured. Ten were perfused at 38 °C with an oxygenated red blood cell–based solution, and contralateral limbs served as SCS control (4 °C). EVNP was terminated with systolic arterial pressure ≥115 mm Hg, compartment fullness, o...
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
An Assessment of Ineligible Donor Use in Solid Organ Transplant
Conclusions.
Ineligible donor use can provide significant survival benefit for patients who would otherwise never receive a transplant. Methods to reduce regional heterogeneity in ineligible donor use could increase the number of transplants and improve outcomes for waiting patients. (Source: Transplantation)
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Outcomes of SARS-CoV-2 Infection in Unvaccinated Compared With Vaccinated Solid Organ Transplant Recipients: A Propensity Matched Cohort Study
Background.
Solid organ transplant (SOT) recipients are at high risk for complications from coronavirus disease 2019 (COVID-19). Vaccination may mitigate this risk; however, immunogenicity appears to be significantly impaired, with reports of increased risk of breakthrough infection. It is unknown if vaccine breakthrough infections are milder or as severe as infections in unvaccinated patients.
Methods.
We performed a multicenter matched cohort study between March 2020 and September 2021 to assess influence of COVID-19 vaccination on outcomes of COVID-19 infection. Treatment characteristics and disease severity ...
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Enhanced Humoral Immune Response After COVID-19 Vaccination in Elderly Kidney Transplant Recipients on Everolimus Versus Mycophenolate Mofetil–containing Immunosuppressive Regimens
Background.
Elderly kidney transplant recipients (KTRs) represent almost one third of the total kidney transplant population. These patients have a very high coronavirus disease 2019 (COVID-19)–related mortality, whereas their response to COVID-19 vaccination is impaired. Finding ways to improve the COVID-19 vaccination response in this vulnerable population is of uttermost importance.
Methods.
In the OPTIMIZE trial, we randomly assign elderly KTRs to an immunosuppressive regimen with standard-exposure calcineurin inhibitor (CNI), mycophenolate mofetil, and prednisolone or an adapted regimen with low dose CNI,...
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Preferences for Risks and Benefits of Islet Cell Transplantation for Persons With Type 1 Diabetes With History of Episodes of Severe Hypoglycemia: A Discrete-Choice Experiment to Inform Regulatory Decisions
Background.
The advisory panel for US Food and Drug Administration (FDA) recently endorsed pancreatic islet cell transplantation (ICT) therapy for suboptimally controlled type 1 diabetes (T1D), and FDA approval is under consideration. An important part of regulatory approval includes the patient perspective, through discrete choice. We developed a discrete-choice instrument and used it to determine how 90 people with T1D weigh the risks and benefits of ICT to inform regulatory decisions.
Methods.
Sawtooth software created a random, full-profile, balanced-overlap experimental design for a measure with 8 attribute...
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Perioperative Delta Sodium and Post–Liver Transplant Neurological Complications in Liver Transplant Recipients
Conclusions.
Adult LT recipients with higher perioperative delta sodium shifts displayed a higher risk of post-LT CNS complications, even after adjusting for pre-LT sodium. LT recipients, even those with pre-LT hyponatremia, may benefit from maintenance of stable serum sodium levels to minimize post-LT CNS complications. (Source: Transplantation)
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research
The Landscape of Nondirected Living Liver Donation in the United States
Background.
Living donor liver transplants (LDLTs) including those from nondirected donors (NDDs) have increased during the past decade, and center-level variations in LDLTs have not yet been described. We sought to quantify changes in the volume of NDD transplants over time and variation in NDD volume between transplant centers. We further examined characteristics of living liver donors and identified factors potentially associated with receiving an NDD liver transplant.
Methods.
Using Scientific Registry of Transplant Recipients data between March 01, 2002, and December 31, 2020, we compared 173 NDDs with 5704...
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research
