Cardiovascular Burden Is High in Pediatric Lung Transplant Recipients
Conclusions.
Pediatric LTx recipients suffer from a high and sustained burden of subclinical cardiovascular damage. In light of improving long-term outcomes, cardiovascular morbidity needs to be addressed. Our analysis identified classical and nonclassical risk factors to be associated with the measures for cardiovascular damage, which could serve as targets for intervention. (Source: Transplantation)
Source: Transplantation - June 27, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Correlation Between Microvascular Inflammation in Endomyocardial Biopsies and Rejection Transcripts, Donor-specific Antibodies, and Graft Dysfunction in Antibody-mediated Rejection
Background.
The pathology-based diagnosis of cardiac antibody-mediated rejection (AMR) relies on the 2013 International Society for Heart and Lung Transplantation Working Formulation, in which microvascular inflammation (MVI) is considered as present or absent regardless of its extent. This work assessed the biological and clinical value of a semiquantitative evaluation of the extent of MVI in endomyocardial biopsies (EMBs).
Methods.
We retrospectively graded the extent of MVI in 291 EMB from 291 patients according to a 4-point scale in which MVI scores of 0, 1, 2, and 3 represented 0%, 1%–10%, 11%–50%, and>...
Source: Transplantation - June 27, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Solid Organ Donation and Transplantation Activity in the Eurotransplant Area During the First Year of COVID-19
Background.
Transplantation activity during the first wave of the coronavirus disease 2019 (COVID-19) pandemic was severely affected worldwide. This retrospective analysis aimed to assess the impact of COVID-19 on organ donations and transplantations in the Eurotransplant region during the first 12 mo of the pandemic. Specifically, we compared donor and transplantation numbers during both waves to determine whether transplant systems adapted to this new reality.
Methods.
All reported organ donations and transplantations from March 1, 2015, to February 28, 2021, were collected from the Eurotransplant Internationa...
Source: Transplantation - June 27, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
SARS-CoV-2 and Liver Transplant: How Has It Behaved in This Sixth Wave?
Conclusions.
In our series, increased transmissibility of the Omicron variant was confirmed, including nosocomial infection, with a lower risk of severe disease in LTRs. These findings could be supported by the universal vaccination of LTRs and less virulence of the Omicron variant. (Source: Transplantation)
Source: Transplantation - June 27, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
A Fourth Dose of COVID-19 Vaccine Does Not Induce Neutralization of the Omicron Variant Among Solid Organ Transplant Recipients With Suboptimal Vaccine Response
Conclusions.
Although a fourth vaccine dose increases anti-spike IgG and neutralizing capacity against many VOCs, some SOTRs may remain at high risk for Omicron infection despite boosting. Thus, additional protective interventions or alternative vaccination strategies should be urgently explored. (Source: Transplantation)
Source: Transplantation - June 27, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Breakthrough Infections Following mRNA SARS-CoV-2 Vaccination in Kidney Transplant Recipients
Conclusions.
COVID-19 severity in KT patients has remained high and has not improved despite receiving 2 doses of the mRNA vaccine. The mRNA-1273 vaccine shows higher clinical effectiveness than BNT162b2 in KT recipients with breakthrough infections. Confirmation of these data will require further research taking into account the new variants and the administration of successive vaccine doses. (Source: Transplantation)
Source: Transplantation - June 27, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
An Analysis of Serological Response and Infection Outcomes Following Oxford-AstraZeneca (AZD1222) and Pfizer-BioNTech (mRNA BNT162b2) SARS-CoV-2 Vaccines in Kidney and Kidney-pancreas Transplants
Background.
Severe acute respiratory syndrome coronavirus 2 is associated with high mortality among transplant recipients. Comparative data that define humoral responses to the Oxford-AstraZeneca (AZ) and BNT162b2 (Pfizer-BioNTech) vaccines are limited.
Methods.
We recruited 920 kidney transplant patients receiving at least 1 dose of severe acute respiratory syndrome coronavirus 2 vaccine, excluding patients with virus pre-exposure. Serological status was determined with the COVID-SeroKlir ELISA (Kantaro-EKF Diagnostics). Patients with a corrected antibody level of (Source: Transplantation)
Source: Transplantation - June 27, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Influence of the ABO Blood Group System on Hepatocellular Carcinoma Recurrence After Liver Transplantation
Conclusions.
ABO blood system influences the oncological outcome of recipients undergoing LT for HCC. Its incorporation in the prognostication model of LT for HCC may allow improving the management of LT candidates. (Source: Transplantation)
Source: Transplantation - June 27, 2022 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research
Rising Trend in Waitlisting for Alcoholic Hepatitis With More Favorable Outcomes Than Other High Model for End-stage Liver Disease in the Current Era
Background.
In the appropriate candidate, liver transplantation (LT) is a viable treatment for alcoholic hepatitis (AH). We compared the waitlisting trends and outcomes of AH patients in the context of others with high Model for End-stage Liver Disease (MELD) score.
Methods.
LT listings for AH between January 1, 2008, and June 12, 2020 were identified in the United Network for Organ Sharing database. Temporal trends in listings for AH were assessed. Covariate adjusted competing risks models evaluated waitlist mortality and LT rates between AH candidates and others with listing native MELD ≥30.
Results.
...
Source: Transplantation - June 27, 2022 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research
Survival After Liver Transplantation: An International Comparison Between the United States and the United Kingdom in the Years 2008–2016
Conclusions.
Risk-adjusted mortality in the United States and the United Kingdom was similar in the first 90 d post-LT but better in the United Kingdom thereafter. International comparisons of LT may highlight differences in healthcare delivery and help benchmarking by identifying modifiable factors that can facilitate improved global outcomes in LT. (Source: Transplantation)
Source: Transplantation - June 27, 2022 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research
Shotgun Immunoproteomics for Identification of Nonhuman Leukocyte Antigens Associated With Cellular Dysfunction in Heart Transplant Rejection
Conclusions.
This work demonstrates a novel high-throughput strategy to identify clinically relevant non-HLA from donor endomyocardial biopsy. Such a technique has the potential to improve understanding of longitudinal timing of antigen-specific responses and their cause and effect relationship in graft rejection. (Source: Transplantation)
Source: Transplantation - June 27, 2022 Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research
Luminal Administration of a Water-soluble Carbon Monoxide–releasing Molecule (CORM-3) Mitigates Ischemia/Reperfusion Injury in Rats Following Intestinal Transplantation
Conclusions.
Our study demonstrates that luminally delivered CORM-3 provides beneficial effects in cold-stored rat small intestinal grafts and could be an attractive therapeutic application of CO in the clinical setting of organ preservation and transplantation. (Source: Transplantation)
Source: Transplantation - June 27, 2022 Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research
Activated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression
Conclusions.
AXL activation protects the liver from I/R injury by upregulating SOCS-1 and inhibiting the toll-like receptor 4/myeloid differentiation factor-88/nuclear factor kappa-B signaling axis. Targeting AXL may be a new therapeutic option for ameliorating hepatic I/R injury. (Source: Transplantation)
Source: Transplantation - June 27, 2022 Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research
High Oxygenation During Normothermic Regional Perfusion After Circulatory Death Is Beneficial on Donor Cardiac Function in a Porcine Model
Conclusions.
All hearts weaned from NRP showed acceptable hemodynamic function for transplantation. Hearts exposed to LOX showed more myocardial damage and showed poorer contractile performance than hearts reperfused with high oxygen. (Source: Transplantation)
Source: Transplantation - June 27, 2022 Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research
Current and Potential Applications for Indocyanine Green in Liver Transplantation
Indocyanine green (ICG) is a fluorescent dye taken up and almost exclusively cleared by the liver. Measurement of its clearance and visualization of its fluorescence make it suitable for a number of potential applications in liver transplantation including assessment of liver function and real-time assessment of arterial, venous, and biliary structures. ICG clearance can be used to assess donor graft quality before procurement and graft metabolic function before transplant using normothermic ex vivo machine perfusion. ICG clearance in the post–liver transplantation period is able to predict recipient outcomes with correl...
Source: Transplantation - June 27, 2022 Category: Transplant Surgery Tags: Reviews Source Type: research
