Improvement of Mineral and Bone Disorders After Renal Transplantation
Conclusions.
Renal transplantation improved bone and mineral abnormalities. The pretransplant period determines the severity of calcification. (Source: Transplantation)
Source: Transplantation - May 1, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Prediction of Liver Transplant Rejection With a Biologically Relevant Gene Expression Signature
Background.
Noninvasive biomarkers distinguishing early immune activation before acute rejection (AR) could more objectively inform immunosuppression management in liver transplant recipients (LTRs). We previously reported a genomic profile distinguishing LTR with AR versus stable graft function. This current study includes key phenotypes with other causes of graft dysfunction and uses a novel random forest approach to augment the specificity of predicting and diagnosing AR.
Methods.
Gene expression results in LTRs with AR versus non-AR (combination of other causes of graft dysfunction and normal function) were ...
Source: Transplantation - May 1, 2022 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research
Induction Therapy With Antithymocyte Globulin and Delayed Calcineurin Inhibitor Initiation for Renal Protection in Liver Transplantation: A Multicenter Randomized Controlled Phase II-B Trial
Conclusions.
Although the use of induction rATG and concurrent CNI deferral in this study did not demonstrate a significant difference in delta creatinine at 1 y, these results indicate a potential role for rATG in preserving early kidney function, especially when considered with CNI deferral beyond 10 d or lower target tacrolimus levels, with acceptable safety and treatment efficacy. (Source: Transplantation)
Source: Transplantation - May 1, 2022 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research
Liver Transplant Center Size and the Impact on Clinical Outcomes and Resource Utilization
Background.
Prior studies suggest that transplant center volume is associated with liver transplantation (LT) outcomes. We compared patient characteristics and waitlist outcomes among transplant centers in the United States with different volumes.
Methods.
Data for adult waitlisted candidates and LT recipients in the United States between 2008 and 2017 were extracted from the Scientific Registry of Transplant Recipients database. Transplant centers were categorized by transplants/year into tertiles: low-volume centers (LVCs; 55 transplantations/y). Patient characteristics, waitlist outcomes, and factors associat...
Source: Transplantation - May 1, 2022 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research
Challenging the Ex Vivo Lung Perfusion Procedure With Continuous Dialysis in a Pig Model
Conclusions.
Management of EVLP perfusate by periodic replacement and continuous dialysis has no significant effect on the lung function nor on the gene expression profiles ex vivo. These results suggest that the accumulation of dialyzable cell products does not significantly alter the lung cell response during EVLP, a finding that may have impact on EVLP management in the clinic. (Source: Transplantation)
Source: Transplantation - May 1, 2022 Category: Transplant Surgery Tags: Original Basic Science Source Type: research
