Perfusate Enzymes and Platelets Indicate Early Allograft Dysfunction After Transplantation of Normothermically Preserved Livers
No abstract available (Source: Transplantation)
Source: Transplantation - October 28, 2022 Category: Transplant Surgery Tags: Letters to the Editor Source Type: research
Clinical Outcomes and Effectiveness of Heart Transplantation in Patients With Systemic Light-chain Cardiac Amyloidosis
Conclusions.
Heart transplantation can achieve long-term survival in appropriately selected patients with AL cardiac amyloidosis. (Source: Transplantation)
Source: Transplantation - October 28, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
New-onset Obesity After Lung Transplantation: Incidence, Risk Factors, and Clinical Outcomes
Background.
Lung transplant (LTx) recipients who gain weight after transplantation may experience an upward shift in body mass index (BMI) that places them in the obese category. The incidence, risk factors, and impact on metabolic health and mortality of new-onset obesity have not been documented in the LTx setting.
Methods.
This single-center retrospective study included 564 LTx recipients. Individuals were stratified according to their BMI trajectories from pretransplant evaluation up to 10 y posttransplant. New-onset obesity was defined as a pretransplant BMI 30 kg/m2. The incidence, risk factors, and post...
Source: Transplantation - October 28, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Single Lung Transplant Remains a Viable Option for Patients With Severe Secondary Pulmonary Hypertension
Background.
Although double lung transplant is recommended in patients with severe secondary pulmonary hypertension (SPH), our institutional experiences suggest a role for single lung transplant in these patients. Here, we review our experience prioritizing single lung transplant in patients with SPH to minimize their surgical burden.
Methods.
We conducted a retrospective review of our lung transplant database to identify patients with SPH who underwent single lung transplant. Patients were stratified as either mild SPH (mean pulmonary artery pressure 25–40 mm Hg) or severe SPH (mean pulmonary artery pressur...
Source: Transplantation - October 28, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Secondary Prophylaxis With Inhaled Colistin to Prevent Recurrence of Pseudomonas aeruginosa and Extended-spectrum β-lactamase-producing Enterobacterales Pneumonia in ICU After Lung Transplantation: A Before-and-after Retrospective Cohort Analysis
Conclusions.
Our study suggests a potential benefit of secondary prophylaxis with IC to prevent the recurrence of P aeruginosa or ESBL-PE pneumonia in the intensive care unit after LTx. (Source: Transplantation)
Source: Transplantation - October 28, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Outcomes Following Extrahepatic and Intraportal Pancreatic Islet Transplantation: A Comparative Cohort Study
Background.
Preliminary studies show promise for extrahepatic islet transplantation (ITx). However, clinical comparisons with intraportal ITx outcomes remain limited.
Methods.
This single-center cohort study evaluates patients receiving extrahepatic or intraportal ITx between 1999 and 2018. Primary outcome was stimulated C-peptide level. Secondary outcomes were fasting plasma glucose, BETA-2 scores, and fasting C-peptide level. Multivariable logistic modeling evaluated factors independently associated with a composite variable of early graft failure and primary nonfunction within 60 d of ITx.
Results.
Of ...
Source: Transplantation - October 28, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Survival Benefit in Older Patients Transplanted With Viremic Hepatitis C Positive Kidneys When Compared With High KDPI Kidneys
Conclusions.
Our findings could be used for counseling candidates on the types of kidneys they should consider for transplantation. Also, listing practices for viremic Hep C kidneys need continued re-evaluation. (Source: Transplantation)
Source: Transplantation - October 28, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Assessing the Relationship Between Molecular Rejection and Parenchymal Injury in Heart Transplant Biopsies
Conclusions.
Characterizing heart transplants for their injury state provides new understanding of dysfunction and outcomes and demonstrates the differential impact of T cell–mediated rejection versus AMR on the parenchyma. Slow deterioration from AMR emerges as a major contributor to late dysfunction. (Source: Transplantation)
Source: Transplantation - October 28, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Preliminary Clinical Experience of Molnupiravir to Prevent Progression of COVID-19 in Kidney Transplant Recipients
Conclusions.
Our study suggests that KTRs with SARS-CoV-2 infection under treatment with molnupiravir have a good clinical evolution with a probable lower risk for hospitalization and no adverse effects. At the renal level, molnupiravir was well tolerated, with no evidence of nephrotoxicity secondary to the drug nor interactions with the immunosuppressive therapy. (Source: Transplantation)
Source: Transplantation - October 28, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Trends, Social Context, and Transplant Implications of Obesity Among Incident Dialysis Patients in the United States
This study aimed to examine trends and the social context of obesity among United States dialysis patients and implications for kidney transplant access.
Methods.
We performed a retrospective cohort study of 1 084 816 adults who initiated dialysis between January 2007 and December 2016 using the United States Renal Data System data. We estimated national body mass index (BMI) trends and 1-y cumulative incidence of waitlisting and death without waitlisting by BMI category ( (Source: Transplantation)
Source: Transplantation - October 28, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Clinical Effectiveness of SARS-CoV-2 Vaccination in Renal Transplant Recipients. Antibody Levels Impact in Pneumonia and Death
Conclusions.
Vaccinated RTRs who achieve at least a low antibody titer (>20 AU/mL) had better results in terms of pneumonia and mortality than unvaccinated RTRs. Antibody titer>100 AU/mL associate with even better results than patients with lower antibody titers. (Source: Transplantation)
Source: Transplantation - October 28, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Paired Exchange Living Donor Liver Transplantation: A Nine-year Experience From North India
Conclusions.
Our experience suggests that with careful attention to ethical and logistical issues, the LPE program can expand the living donor liver pool and facilitate a greater number of living donor liver transplantations. (Source: Transplantation)
Source: Transplantation - October 28, 2022 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research
Recipient and Center Factors Associated With Immunosuppression Practice Beyond the First Year After Liver Transplantation and Impact on Outcomes
Background.
Immunosuppression is a critical aspect of post-transplant management, yet practices at intermediate and late time points after liver transplantation (LT) are poorly characterized.
Methods.
A retrospective cohort of 11 326 adult first LT alone recipients between 2007 and 2016 was identified by linking United Network for Organ Sharing transplant data to Medicare administrative claims. The immunosuppression regimen was obtained from Medicare billing claims. Factors associated with calcineurin inhibitor (CNI) monotherapy at 1-, 3-, and 5-y post-LT were investigated using mixed-effects logistic regressi...
Source: Transplantation - October 28, 2022 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research
Time-varying Comparison of All-cause Mortality After Liver Transplantation Between Recipients With and Without Hepatocellular Carcinoma: A Population-based Cohort Study Using the United Kingdom Liver Transplant Registry
Background.
Accurately identifying time-varying differences in the hazard of all-cause mortality after liver transplantation (LT) between recipients with and without hepatocellular carcinoma (HCC) may inform patient selection and organ allocation policies as well as post-LT surveillance protocols.
Methods.
A UK population-based study was carried out using 9586 LT recipients. The time-varying association between HCC and post-LT all-cause mortality was estimated using an adjusted flexible parametric model (FPM) and expressed as hazard ratios (HRs). Differences in this association by transplant year were then inves...
Source: Transplantation - October 28, 2022 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research
Activation of the Aryl Hydrocarbon Receptor Ameliorates Acute Rejection of Rat Liver Transplantation by Regulating Treg Proliferation and PD-1 Expression
Conclusions.
Our results indicated that AhR activation might reduce the occurrence of rat acute rejection by increasing the proportion of Treg and the expression of PD-1. (Source: Transplantation)
Source: Transplantation - October 28, 2022 Category: Transplant Surgery Tags: Original Basic Science Source Type: research
