The Clinical and Economic Benefit of CMV Matching in Kidney Transplant: A Decision Analysis
Conclusions.
Altering national allocation policy to preferentially offer CMV D– organs to CMV R– recipients could improve survival and lower costs after transplant if appropriately implemented. (Source: Transplantation)
Source: Transplantation - May 29, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Kidney Transplantation After Rescue Allocation—the Eurotransplant Experience: A Retrospective Multicenter Outcome Analysis
Background.
At Eurotransplant (ET), kidneys are transferred to “rescue allocation” (RA), whenever the standard allocation (SA) algorithms Eurotransplant Kidney Allocation System (ETKAS) and Eurotransplant Senior Program (ESP) fail. We analyzed the outcome of RA.
Methods.
Retrospective patient clinical and demographic characteristics association analyses were performed with graft outcomes for 2422 recipients of a deceased donor renal transplantation (DDRT) after RA versus 25 481 after SA from 71 centers across all ET countries from 2006 to 2018.
Results.
Numbers of DDRTs after RA increased over the t...
Source: Transplantation - May 29, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Prevalence and Risk Factors of Post–heart Transplant Tricuspid Regurgitation
Background.
Tricuspid valve regurgitation (TR) is a common sequela immediately after heart transplantation, and its occurrence has decreased after the adoption of the bicaval anastomosis technique. However, the fate of the tricuspid valve in patients undergoing heart transplantation using the bicaval technique is uncertain.
Methods.
We identified patients who underwent orthotopic heart transplantation with bicaval technique at our institution between January 2001 and December 2018. Changes in TR on transthoracic echocardiography from the immediately posttransplantation period until 10 y posttransplant were inves...
Source: Transplantation - May 29, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
The Presence of Donor-specific Antibodies Around the Time of Pancreas Graft Biopsy With Rejection Is Associated With an Increased Risk of Graft Failure
Conclusions.
PTRs with pancreas allograft rejection and concomitant DSA have an increased risk of DCGF. (Source: Transplantation)
Source: Transplantation - May 29, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Classification of Distinct Patterns of Ischemic Cholangiopathy Following DCD Liver Transplantation: Distinct Clinical Courses and Long-term Outcomes From a Multicenter Cohort
Background.
As the number of donation after circulatory death (DCD) liver transplants (LTs) performed in the United States continues to increase annually, there has been interest by policy makers to develop a more robust exception point safety net for patients who develop ischemic cholangiopathy (IC) following DCD LT. As such, there is a need for better understanding of the clinical course and long-term outcomes in patients who develop IC, as well as determining if IC can be classified into distinct categories with distinctly different clinical outcomes.
Methods.
All DCD LT performed at Mayo Clinic Florida, Mayo...
Source: Transplantation - May 29, 2022 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research
Healthcare Resource Utilization After Living Liver Donation: A Retrospective Case–Control Study
Background.
Living liver donation is generally considered safe, but donors may experience short- or long-term complications. The purpose of this study was to assess healthcare resource utilization after liver donation in living liver donors in comparison with the general population.
Methods.
Outpatient or emergency department visits and hospital admissions were compared between living liver donors who underwent hepatic resection for living liver donation between 2004 and 2018 and the matched general population. Healthcare resource utilization data for 5 y after liver donation were collected from the National Hea...
Source: Transplantation - May 29, 2022 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research
Transplantation of Extended Criteria Donor Livers Following Continuous Normothermic Machine Perfusion Without Recooling
Conclusions
Our pilot study revealed a novel technique designed to avoid secondary IRI. This novel technique is shown to have at least a comparable effect on the standard NMP, although more data are needed to show its superiority in the future. (Source: Transplantation)
Source: Transplantation - May 29, 2022 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research
Direct Impact of Human Platelets on the Development of Transplant Arteriosclerosis
Conclusions.
These data demonstrate that an isolated daily application of both in vivo– and in vitro–activated human platelets results in the development of transplant arteriosclerosis in a humanized mouse transplantation model. (Source: Transplantation)
Source: Transplantation - May 29, 2022 Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research
Impact of Red Blood Cells on Function and Metabolism of Porcine Deceased Donor Kidneys During Normothermic Machine Perfusion
Conclusions.
Although the RBC-BSA–supplemented Aqix solution was also able to support metabolism and renal function, a blood-based perfusion solution remains superior. (Source: Transplantation)
Source: Transplantation - May 29, 2022 Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research
Specialized Proresolving Lipid Meditators Agonistic to Formyl Peptide Receptor Type 2 Attenuate Ischemia-reperfusion Injury in Rat Lung
Conclusions.
The level of intrapulmonary endogenous SPMs decreased during lung IRI process and the administration of AT-RvD1 and AT-LXA4 prevented the exacerbation of lung injury via ALX/FPR2. (Source: Transplantation)
Source: Transplantation - May 29, 2022 Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research
New Approaches to Cardiovascular Disease and Its Management in Kidney Transplant Recipients
Cardiovascular events, including ischemic heart disease, heart failure, and arrhythmia, are common complications after kidney transplantation and continue to be leading causes of graft loss. Kidney transplant recipients have both traditional and transplant-specific risk factors for cardiovascular disease. In the general population, modification of cardiovascular risk factors is the best strategy to reduce cardiovascular events; however, studies evaluating the impact of risk modification strategies on cardiovascular outcomes among kidney transplant recipients are limited. Furthermore, there is only minimal guidance on appro...
Source: Transplantation - May 29, 2022 Category: Transplant Surgery Tags: Reviews Source Type: research
Emerging Concepts of Tissue-resident Memory T Cells in Transplantation
In this review, we summarize and discuss recent advances in understanding the characteristics of tissue-resident memory T cells (TRMs) in the context of solid organ transplantation (SOT). We first introduce the traditionally understood noncirculating features of TRMs and the key phenotypic markers that define this population, then provide a detailed discussion of emerging concepts on the recirculation and plasticity of TRM in mice and humans. We comment on the potential heterogeneity of transient, temporary resident, and permanent resident T cells and potential interchangeable phenotypes between TRM and effector T cells in...
Source: Transplantation - May 29, 2022 Category: Transplant Surgery Tags: Reviews Source Type: research
Consensus Statement on Hemostatic Management, Anticoagulation, and Antiplatelet Therapy in Liver Transplantation
Anticoagulation and antiplatelet therapies are increasingly used in liver transplant (LT) candidates and recipients due to cardiovascular comorbidities, portal vein thrombosis, or to manage posttransplant complications. The implementation of the new direct-acting oral anticoagulants and the recently developed antiplatelet drugs is a great challenge for transplant teams worldwide, as their activity must be monitored and their complications managed, in the absence of robust scientific evidence. In this changing and clinically heterogeneous scenario, the Spanish Society of Liver Transplantation and the Spanish Society of Thro...
Source: Transplantation - May 29, 2022 Category: Transplant Surgery Tags: Reviews Source Type: research
Global Estimates of Capacity for Kidney Transplantation in World Countries and Regions
Conclusions.
There are substantial variations in KT incidence, prevalence, availability, accessibility, and quality worldwide, with the lowest rates evident in low- and lower-middle income countries. Understanding these disparities will inform efforts to increase awareness and the adoption of practices that will ensure high-quality KT care is provided around the world. (Source: Transplantation)
Source: Transplantation - May 29, 2022 Category: Transplant Surgery Tags: Reviews Source Type: research
Quantifying CLAD: A Promising Imaging-based Diagnostic Innovation
No abstract available (Source: Transplantation)
Source: Transplantation - May 29, 2022 Category: Transplant Surgery Tags: Commentaries Source Type: research
