Disparities in the Use of Older Donation After Circulatory Death Liver Allografts in the United States Versus the United Kingdom
This study aimed to assess the differences between the United States and the United Kingdom in the characteristics and posttransplant survival of patients who received donation after circulatory death (DCD) liver allografts from donors aged>60 y.
Methods.
Data were collected from the UK Transplant Registry and the United Network for Organ Sharing databases. Cohorts were dichotomized into donor age subgroups (donor>60 y [D>60]; donor ≤60 y [D ≤60]). Study period: January 1, 2001, to December 31, 2015.
Results.
1157 DCD LTs were performed in the United Kingdom versus 3394 in the United States. Only 13.8% of...
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Original Clinical Science—Liver Source Type: research
DAMPs Released From Injured Renal Tubular Epithelial Cells Activate Innate Immune Signals in Healthy Renal Tubular Epithelial Cells
Conclusions.
This is the first study to our knowledge to show that endogenous DAMPs released from injured RTECs directly activate PRR signaling in healthy RTECs. These findings provide new insights directed to therapeutics for renal IRI. (Source: Transplantation)
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Original Basic Science Source Type: research
Novel Ex-Vivo Thrombolytic Reconditioning of Kidneys Retrieved 4 to 5 Hours After Circulatory Death
Background.
Due to organ shortage, many patients do not receive donor organs. The present novel thrombolytic technique utilizes organs from donors with uncontrolled donation after circulatory deaths (uDCD), with up to 4–5 h warm ischemia, without advanced cardiopulmonary resuscitation (aCPR) or extracorporeal circulation (EC) after death.
Methods.
The study group of pigs (n = 21) underwent simulated circulatory death. After 2 h, an ice slush was inserted into the abdomen. Kidneys were retrieved 4.5 h after death. Lys-plasminogen, antithrombin-III (ATIII), and alteplase (tPA) were injected through the ren...
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Original Basic Science Source Type: research
Delivering siRNA Compounds During HOPE to Modulate Organ Function: A Proof-of-concept Study in a Rat Liver Transplant Model
Conclusions.
FAS inhibition through siRNA therapy decreases the severity of IRI after LT in a SCS protocol; however the association of siRNA therapy with a HOPE perfusion model is very challenging. Future studies using better designed siRNA compounds and appropriate doses are required to prove the siRNA therapy effectiveness during liver HOPE liver perfusion. (Source: Transplantation)
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Original Basic Science Source Type: research
Shifting Clinical Trial Endpoints in Kidney Transplantation: The Rise of Composite Endpoints and Machine Learning to Refine Prognostication
This article reviews how outcomes measurements have evolved in the past 2 decades in the setting of increased data collection and summarizes recent advances in outcomes measurements pertaining to clinical, histopathological, and immune outcomes. Finally, we discuss the use of composite endpoints and Bayesian concepts, specifically focusing on the integrative box risk prediction score, in conjunction with machine learning to refine prognostication. (Source: Transplantation)
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Reviews Source Type: research
The Impact of Donor and Recipient Genetic Variation on Outcomes After Solid Organ Transplantation: A Scoping Review and Future Perspectives
At the outset of solid organ transplantation, genetic variation between donors and recipients was recognized as a major player in mechanisms such as allograft tolerance and rejection. Genome-wide association studies have been very successful in identifying novel variant-trait associations, but have been difficult to perform in the field of solid organ transplantation due to complex covariates, era effects, and poor statistical power for detecting donor-recipient interactions. To overcome a lack of statistical power, consortia such as the International Genetics and Translational Research in Transplantation Network have been...
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Reviews Source Type: research
Solving the Conundrum of Eosinophils in Alloimmunity
Eosinophils are bone-marrow-derived granulocytes known for their ability to facilitate clearance of parasitic infections and their association with asthma and other inflammatory diseases. The purpose of this review is to discuss the currently available human observational and animal experimental data linking eosinophils to the immunologic response in solid organ transplantation. First, we present observational human studies that demonstrate a link between transplantation and eosinophils yet were unable to define the exact role of this cell population. Next, we describe published experimental models and demonstrate a define...
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Reviews Source Type: research
Update on COVID-19 Therapeutics for Solid Organ Transplant Recipients, Including the Omicron Surge
Major changes have occurred in therapeutics for coronavirus-19 (COVID-19) infection over the past 12–18 mo, most notably in early outpatient therapy. In most cases, solid organ transplant recipients were not included in the original clinical trials of these agents, so studies of real-world outcomes have been important in building our understanding of their utility. This review examines what is known about clinical outcomes in solid organ transplant recipients with newer therapies. SARS-CoV-2 monoclonal antibodies for early treatment or prophylaxis have likely prevented many hospitalizations and deaths. In addition, conva...
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Reviews Source Type: research
Substantial Missed Transplant Opportunity From Underutilization of Donors Not Meeting OPTN Eligible Death Definition
No abstract available (Source: Transplantation)
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Commentaries Source Type: research
Starting at the Source: Donor Research, Done Right
No abstract available (Source: Transplantation)
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Commentaries Source Type: research
Some Like It Hot—A Commentary to Ex Vivo Normothermic Perfusion of Human Upper Limbs
No abstract available (Source: Transplantation)
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Commentaries Source Type: research
So Shines a Good Deed in a Weary World
No abstract available (Source: Transplantation)
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: Commentaries Source Type: research
Deconstructing Silos of Knowledge Around Lung Transplantation to Support Patients: A Patient-specific Search of Scientific Registry of Transplant Recipients Data
No abstract available (Source: Transplantation)
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: In View: Expert Insight Source Type: research
Clearing the Antigenic Slate of Donor Organs Using Ex Vivo Perfusion
No abstract available (Source: Transplantation)
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: In View: Game Changer Source Type: research
Research Highlights
No abstract available (Source: Transplantation)
Source: Transplantation - August 1, 2022 Category: Transplant Surgery Tags: In View: Research Highlights Source Type: research
