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Total 222 results found since Jan 2013.

A Perfect Match: health, Hippocrates and lifestyle medicine
Amid the frustration and despair associated with rising premiums, healthcare costs and obesity prevalence, is a trend that is slowly infiltrating the healthcare industry. Although some of the most notable trends (in fitness and nutrition) tend to come and go as quickly as a fastball (World Series, anyone?), this particular trend has an immense amount of staying power based on current scientific research. This immense power has little to do with pharmacological interventions and prescription refills and much more to do with our feet, forks, fingers and minds. This trend, as written in a recent article by the influential and...
Source: Healthy Living - The Huffington Post - November 3, 2016 Category: Consumer Health News Source Type: news

Lifestyle factors and prostate-specific antigen (PSA) testing in UK Biobank: Implications for epidemiological research
Conclusions A variety of sociodemographic, lifestyle and health-related characteristics are associated with PSA testing, suggesting that observed associations of some of these traits with risk for prostate cancer in epidemiological studies may be, at least partially, due to detection bias.
Source: Cancer Epidemiology - September 29, 2016 Category: Cancer & Oncology Source Type: research

Subacute Stroke Mimicking Cerebral Metastasis in 68Ga-PSMA-HBED-CC PET/CT
Abstract: A 65-year-old man with disseminated bone metastases of prostate cancer was referred for 68Ga-PSMA-HBED-CC-PET/CT (short PSMA-PET/CT) to exclude visceral metastases before treatment of bone metastases with 223Ra-dichloride. Apart from disseminated bone metastases, PSMA-PET/CT revealed a focal cerebral tracer uptake in the right frontal lobe highly suspicious for cerebral spread. According to patient history, a cerebral infarction occurred 14 days before PSMA imaging in corresponding localization confirmed by MRI scanning. This case demonstrates the possibility of false-positive finding of cerebral metastases in PS...
Source: Clinical Nuclear Medicine - September 8, 2016 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Potential health hazards of eating red meat
Abstract Red meat (beef, veal, pork, lamb and mutton) consumption contributes several important nutrients to the diet, for example essential amino acids, vitamins (including B12) and minerals (including iron and zinc). Processed red meat (ham, sausages, bacon, frankfurters, salami, etc.) undergoes treatment (curing, smoking, salting or the use of chemical preservatives and additives) to improve its shelf life and/or taste. During recent decades, consumption of red meat has been increasing globally, especially in developing countries. At the same time, there has been growing evidence that high consumption of red meat, espec...
Source: Journal of Internal Medicine - August 31, 2016 Category: Internal Medicine Authors: A. Wolk Tags: Review Source Type: research

2016 Alzheimer's disease facts and figures.
This report describes the public health impact of Alzheimer's disease, including incidence and prevalence, mortality rates, costs of care, and the overall impact on caregivers and society. It also examines in detail the financial impact of Alzheimer's on families, including annual costs to families and the difficult decisions families must often make to pay those costs. An estimated 5.4 million Americans have Alzheimer's disease. By mid-century, the number of people living with Alzheimer's disease in the United States is projected to grow to 13.8 million, fueled in large part by the aging baby boom generation. Today, someo...
Source: The Journal of Alzheimers Association - August 30, 2016 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Prostate size, nocturia and the digital rectal examination: a cohort study of 30 500 men
ConclusionsDigital rectal examination is a modestly accurate tool for measuring prostate volume. While DRE posterior surface area represents a statistically significant predictor of nocturia, the magnitude of effect suggests it has limited clinical utility for assessing this condition, particularly in the presence of cardiovascular risk factors.
Source: BJU International - August 22, 2016 Category: Urology & Nephrology Authors: Benjamin V. Stone, Jonathan Shoag, Joshua A. Halpern, Sameer Mittal, Patrick Lewicki, David M. Golombos, Dina Bedretdinova, Bilal Chughtai, Christopher E. Barbieri, Richard K. Lee Tags: Original Article Source Type: research

Safety of long-term exposure to abiraterone acetate in patients with castration-resistant prostate cancer and concomitant cardiovascular risk factors
Conclusions: Long-term abiraterone treatment was well tolerated in mCRPC patients with controlled cardiovascular comorbidities/risk factors, with no apparent worsening of cardiovascular conditions from baseline over an extended observation period.
Source: Therapeutic Advances in Medical Oncology - August 7, 2016 Category: Cancer & Oncology Authors: Verzoni, E., Grassi, P., Ratta, R., Niger, M., De Braud, F., Valdagni, R., Procopio, G. Tags: Original Research Source Type: research

Prostate size, nocturia, and the digital rectal exam: a cohort study of 30,500 men
ConclusionsDRE is a modestly accurate tool for measuring prostate volume. While DRE posterior surface area represents a statistically significant predictor of nocturia, the magnitude of effect suggests it has limited clinical utility for assessing this condition, particularly in the presence of cardiovascular risk factors.This article is protected by copyright. All rights reserved.
Source: BJU International - July 31, 2016 Category: Urology & Nephrology Authors: Benjamin V. Stone, Jonathan Shoag, Joshua A. Halpern, Sameer Mittal, Patrick Lewicki, David M. Golombos, Dina Bedretdinova, Bilal Chughtai, Christopher E. Barbieri, Richard K. Lee Tags: Original Article Source Type: research

Obituary Philip Majerus
Physician and biochemist who showed small doses of aspirin reduce the risk of heart attack and stroke. Born on July 10, 1936, in Chicago, IL, USA, he died with prostate cancer on June 8, 2016, in University City, MO, USA, aged 79 years.
Source: LANCET - July 29, 2016 Category: Journals (General) Authors: Alison Snyder Tags: Obituary Source Type: research

Cardiovascular risk after androgen deprivation therapy for prostate cancer: an Asian perspective
Abstract Androgen deprivation therapy (ADT) plays an important role in managing prostate cancer. However, ADT may result in major cardiovascular events and potentially lead to fatal consequences. Cardiovascular disease is the leading cause of mortality and it is a very important health condition to look into. Asians and Caucasians differ both physiologically and genetically, and they may have display different cardiovascular profiles. In this article, we reviewed the literature focusing on the cardiovascular risk after ADT for prostate cancer in the Asian population. We would discuss about the pathogenesis of ADT ...
Source: International Urology and Nephrology - June 1, 2016 Category: Urology & Nephrology Source Type: research

Mortality, cardiovascular risk, and androgen deprivation therapy for prostate cancer: A systematic review with direct and network meta-analyses of randomized controlled trials and observational studies
Abstract: Androgen deprivation therapy (ADT) is a cornerstone therapy for advanced prostate cancer (PCa). We hypothesized that cardiovascular (CV) risk is different across the various ADT modalities to compare their effects on CV morbidity and mortality, and all-cause mortality in patients with PCa. To investigate more in depth potential CV risk heterogeneity focusing on coronary (main outcome) and cerebrovascular risk, CV, and overall mortality. We performed a Medline and Embase query, without language restriction, since 1950 up to July 2014. We included randomized controlled trials (RCTs) and observational studies provid...
Source: Medicine - June 1, 2016 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Susceptibility ‐weighted imaging: current status and future directions
Susceptibility‐weighted imaging (SWI) is a method that uses the intrinsic nature of local magnetic fields to enhance image contrast in order to improve the visibility of various susceptibility sources and to facilitate diagnostic interpretation. It is also the precursor to the concept of the use of phase for quantitative susceptibility mapping (QSM). Nowadays, SWI has become a widely used clinical tool to image deoxyhemoglobin in veins, iron deposition in the brain, hemorrhages, microbleeds and calcification. In this article, we review the basics of SWI, including data acquisition, data reconstruction and post‐processi...
Source: NMR in Biomedicine - May 17, 2016 Category: Radiology Authors: Saifeng Liu, Sagar Buch, Yongsheng Chen, Hyun ‐Seok Choi, Yongming Dai, Charbel Habib, Jiani Hu, Joon‐Yong Jung, Yu Luo, David Utriainen, Meiyun Wang, Dongmei Wu, Shuang Xia, E. Mark Haacke Tags: Special issue review article Source Type: research

EPMA-World Congress 2015
Table of contents A1 Predictive and prognostic biomarker panel for targeted application of radioembolisation improving individual outcomes in hepatocellular carcinoma Jella-Andrea Abraham, Olga Golubnitschaja A2 Integrated market access approach amplifying value of “Rx-CDx” Ildar Akhmetov A3 Disaster response: an opportunity to improve global healthcare Russell J. Andrews, Leonidas Quintana A4 USA PPPM: proscriptive, profligate, profiteering medicine-good for 1 % wealthy, not for 99 % unhealthy Russell J. Andrews A5 The role of ...
Source: EPMA Journal - May 8, 2016 Category: Global & Universal Source Type: research

Survival and cardiovascular events in men treated with testosterone replacement therapy: an intention-to-treat observational cohort study
Publication date: Available online 7 May 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Christopher J D Wallis, Kirk Lo, Yuna Lee, Yonah Krakowsky, Alaina Garbens, Raj Satkunasivam, Sender Herschorn, Ronald T Kodama, Patrick Cheung, Steven A Narod, Robert K Nam Background Conflicting evidence exists for the association between testosterone replacement therapy and mortality and cardiovascular events. The US Food and Drug Administration recently cautioned that testosterone replacement therapy might increase risk of heart attack and stroke, based on evidence from studies with short treatment d...
Source: The Lancet Diabetes and Endocrinology - May 7, 2016 Category: Endocrinology Source Type: research

Emerging trends in non-communicable disease mortality in South Africa, 1997 - 2010.
CONCLUSIONS: NCDs contribute to premature mortality in SA, threatening socioeconomic development. While NCD mortality rates have decreased slightly, it is necessary to strengthen prevention and healthcare provision and monitor emerging trends in cause-specific mortality to inform these strategies if the target of 2% annual decline is to be achieved. PMID: 27138667 [PubMed - as supplied by publisher]
Source: South African Medical Journal - May 5, 2016 Category: African Health Tags: S Afr Med J Source Type: research