The association between immigration status and ineligible stool samples for colorectal cancer screening
ConclusionNon-Western immigrants have more than three times the risk of submitting an ineligible faeces sample for colorectal cancer screening than native Danes. Translation of invitation, information leaflet, and manual into other languages or targeted information for subgroups may help decrease the risk. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 14, 2018 Category: Cancer & Oncology Source Type: research

Characteristics and survival of children with acute leukemia with Down syndrome or other birth defects in New York State
ConclusionAge at leukemia diagnosis was significantly associated with the birth defect status. Comparable survival was observed for ALL children. However, AML children with DS demonstrated superior survival compared to children with other birth defects or no birth defects. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 14, 2018 Category: Cancer & Oncology Source Type: research

Matching the model with the evidence: comparing discrete event simulation and state-transition modeling for time-to-event predictions in a cost-effectiveness analysis of treatment in metastatic colorectal cancer patients
ConclusionDES represents time-to-event data from clinical trials more naturally and accurately than DT-STM when few events are observed per time cycle. As a consequence, DES is expected to yield a more accurate ICER. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 12, 2018 Category: Cancer & Oncology Source Type: research

Prevalence, predictors, causes of treatment refusal and abandonment in children with acute lymphoblastic leukaemia over 18 years in North India. Treatment phase affecting factors: A step towards better focussed counselling
Publication date: December 2018Source: Cancer Epidemiology, Volume 57Author(s): Areesha Alam, Archana KumarAbstractBackgroundTreatment refusal or abandonment are among the major causes of the survival gap between developed and developing countries.MethodsThis retrospective observational study analyzed records of children aged
Source: Cancer Epidemiology - October 11, 2018 Category: Cancer & Oncology Source Type: research

Cancer epidemiology fieldwork in a resource-limited setting: Experience from the western Kenya ESCCAPE esophageal cancer case-control pilot study
ConclusionsExtra attention and funding to train and monitor data quality and biospecimen collection and collaboration of a large group held together by strong leadership are essential. We recommend studies based on regional treatment centres with their more defined catchment areas rather than in the capital cities as referral routes in multi-level health care systems are severely attrition prone. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 7, 2018 Category: Cancer & Oncology Source Type: research

Erratum to “Time trends and short term projections of cancer prevalence in France” [Cancer Epidemiol. 56 (2018) 97–105]
Publication date: Available online 5 October 2018Source: Cancer EpidemiologyAuthor(s): M. Colonna, O. Boussari, A. Cowppli-Bony, P. Delafosse, G. Romain, P. Grosclaude, V. Jooste, French Network of Cancer Registries (FRANCIM) (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 5, 2018 Category: Cancer & Oncology Source Type: research

Three years of colorectal cancer screening in Denmark
ConclusionsCompared to the European Guidelines, all performance indicators were above the acceptable level and close to the desirable level. Based on these findings, the implementation of the National Danish Colorectal Cancer Screening Programme is considered a success and the programme is hopefully in the process of reducing colorectal cancer morbidity and mortality in Denmark.This study provides relevant information for comparisons to other population-based public service colorectal cancer screening programmes as well as for future revisions of guidelines. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 5, 2018 Category: Cancer & Oncology Source Type: research

Comparison of cancer diagnosis recording between the Clinical Practice Research Datalink, Cancer Registry and Hospital Episodes Statistics
ConclusionPatient demographics and the route of diagnosis impact the accuracy of cancer diagnosis in CPRD. Although CPRD provides invaluable primary care data, patients should ideally be identified from the CR to reduce bias. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 4, 2018 Category: Cancer & Oncology Source Type: research

Dietary patterns and colorectal cancer risk in Zimbabwe: A population based case-control study
ConclusionA shift away from protective, traditional African dietary patterns may partly explain the rising incidence of colorectal cancer in sub-Saharan Africa. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 4, 2018 Category: Cancer & Oncology Source Type: research

Variation in geographical treatment intensity affects survival of non-small cell lung cancer patients in England
ConclusionThere was wide geographical variation in the use of curative treatment and a higher frequency of treatment was associated with better survival. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 4, 2018 Category: Cancer & Oncology Source Type: research

Incomplete uptake of EGFR mutation testing and its impact on estimation of mutation prevalence in patients with non-squamous NSCLC: A population-based study in New Zealand
ConclusionThe methods described here allowed a more accurate estimation of the prevalence of EGFR mutation. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - October 4, 2018 Category: Cancer & Oncology Source Type: research

The association between sex and most childhood cancers is not mediated by birthweight
ConclusionSignificant direct effects for sex and numerous childhood cancer types suggests sex-specific factors such as differences in gene expression from the autosomes or the X chromosome, rather than birthweight, may underlie sex differences in tumor risk. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - September 22, 2018 Category: Cancer & Oncology Source Type: research

Title page / Editorial Board
Publication date: October 2018Source: Cancer Epidemiology, Volume 56Author(s): (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - September 21, 2018 Category: Cancer & Oncology Source Type: research

Table of contents
Publication date: October 2018Source: Cancer Epidemiology, Volume 56Author(s): (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - September 21, 2018 Category: Cancer & Oncology Source Type: research

Cancer incidence and all-cause mortality among civilian men and women employed by the Royal Norwegian Navy between 1950 and 2005
ConclusionIn men, we observed a lowered all-cause mortality and an excess of stomach cancer in workshop workers. In women, increased risks of overall cancer, lung cancer and ovarian cancer was seen. An increased risk of bladder cancer and a lowered incidence of brain cancer was observed among female cleaners. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - September 9, 2018 Category: Cancer & Oncology Source Type: research

Skin cancer healthcare impact: A nation-wide assessment of an administrative database
Publication date: October 2018Source: Cancer Epidemiology, Volume 56Author(s): A.F. Duarte, B. Sousa-Pinto, A. Freitas, L. Delgado, A. Costa-Pereira, O. CorreiaAbstractBackgroundSkin cancer is an important health concern, with an increasing incidence worldwide.ObjectiveTo assess the clinical and economic burden of melanoma (MM) and non-melanoma skin cancer (NMSC) at public hospitals in mainland Portugal.MethodsWe used an administrative database containing a registration of all hospitalizations and ambulatory episodes occurred in Portuguese public hospitals between 2011 and 2015. We assessed all episodes with associated dia...
Source: Cancer Epidemiology - September 2, 2018 Category: Cancer & Oncology Source Type: research

Predictive value of the UICC and AJCC 8th edition tumor-nodes-metastasis (TNM) classification for patients treated with radical prostatectomy
ConclusionsCT 1/cT2 and S I/II subgrouping is feasible to predict a different pT-category and a favorable WHO-grade (Gleason-Score) after RP, but failed to predict a different BFS. With the additional information of WHO-grade (Gleason-Score) and PSA, the PSG represents an approach for the prediction of all examined endpoints which is a useful tool to help clinicians to advise their patients. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - September 1, 2018 Category: Cancer & Oncology Source Type: research

EPHA2 sequence variants are associated with susceptibility to Kaposi’s sarcoma-associated herpesvirus infection and Kaposi’s sarcoma prevalence in HIV-infected patients
ConclusionsVariations in the KSHV entry receptor gene EPHA2 affected susceptibility to KSHV infection and KS development in a South African HIV-infected patient cohort. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - September 1, 2018 Category: Cancer & Oncology Source Type: research

Trends in cervical cancer incidence and mortality in Oklahoma and the United States, 1999–2013
ConclusionWomen in Oklahoma had a higher cervical cancer incidence and mortality rate than the US. A disproportionately higher incidence of cervical cancer among AI/AN and API women and deaths among AI/AN and AA women were observed signaling continuing racial disparities. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - September 1, 2018 Category: Cancer & Oncology Source Type: research

Survival of adults with cancers of bone or soft tissue in Europe—Report from the EUROCARE-5 study
Publication date: October 2018Source: Cancer Epidemiology, Volume 56Author(s): Charles A. Stiller, Laura Botta, David H. Brewster, Vincent K.Y. Ho, Anna Maria Frezza, Jeremy Whelan, Paolo G. Casali, Annalisa Trama, Gemma Gatta, the EUROCARE-5 Working GroupAbstractBackgroundFive-year relative survival (RS) of adults with bone and soft-tissue cancers in Europe was still
Source: Cancer Epidemiology - September 1, 2018 Category: Cancer & Oncology Source Type: research

Partial nephrectomy seems to confer a survival benefit relative to radical nephrectomy in metastatic renal cell carcinoma
Publication date: October 2018Source: Cancer Epidemiology, Volume 56Author(s): Elio Mazzone, Sebastiano Nazzani, Felix Preisser, Zhe Tian, Michele Marchioni, Marco Bandini, Umberto Capitanio, Anil Kapoor, Derya Tilki, Francesco Montorsi, Shahrokh F. Shariat, Fred Saad, Alberto Briganti, Pierre I. KarakiewiczAbstractObjectivePartial nephrectomy (PN) is technically feasible in patients with metastatic renal cell carcinoma (mRCC). We tested the contemporary effect of PN on cancer-specific mortality (CSM), other-cause mortality (OCM) and early postoperative outcomes compared to radical nephrectomy (RN) in mRCC patients.Materia...
Source: Cancer Epidemiology - August 31, 2018 Category: Cancer & Oncology Source Type: research

International testicular cancer incidence rates in children, adolescents and young adults
ConclusionThese differences in incidence rate variations in pediatric and AYA testicular cancer are intriguing and may aid in understanding the different etiologies of testicular cancer by age group. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - August 19, 2018 Category: Cancer & Oncology Source Type: research

Defining low-value PSA testing in a large retrospective cohort: Finding common ground between discordant guidelines
Publication date: October 2018Source: Cancer Epidemiology, Volume 56Author(s): Brock O’Neil, Christopher Martin, Ashley Kapron, Michael Flynn, Kensaku Kawamoto, Kathleen A. CooneyAbstractBackgroundReports of low-value prostate-specific antigen (PSA) testing (testing in which the harms outweigh the benefits) generally employ population level data sources. While such results may be generalizable, they often lack the detail necessary to understand provider clinical decision making and guideline concordance. Using a retrospective study of PSA testing at our institution we intend to characterize the frequency and patterns...
Source: Cancer Epidemiology - August 19, 2018 Category: Cancer & Oncology Source Type: research

Time trends and short term projections of cancer prevalence in France
ConclusionPrevalent cases are numerous in a country such as France, where incidence and survival are high. Due to the sensitivity of prevalence to changes in incidence and survival, we recommend that the results of projections are presented under different scenarios. We propose a robust and flexible prevalence estimate. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - August 18, 2018 Category: Cancer & Oncology Source Type: research

Risk stratification for colorectal neoplasia detection in the Flemish colorectal cancer screening programme
ConclusionA large difference in risk with regard to the detection of colorectal neoplasia was found, based on demographics of the population. For some participants, the chance of finding no anomalies was more than 60%. Including additional variables in a prediction model could further increase discrimination between outcomes and practicality. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - August 14, 2018 Category: Cancer & Oncology Source Type: research

Recommendation to use exact P-values in biomarker discovery research in place of approximate P-values
ConclusionsExact P-values, which correspond to permutation tests with non-parametric rank statistics such as empirical ROC statistics, are preferred over approximate P-values. Approximate P-values can lead to inappropriate biomarker selection rules and incorrect conclusions.ImpactExact P-values in place of approximate P-values in discovery research may improve the yield of biomarkers that validate clinically. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - August 10, 2018 Category: Cancer & Oncology Source Type: research

Associations of coffee, tea and caffeine intake with risk of breast, endometrial and ovarian cancer among Canadian women
ConclusionOur findings suggest that coffee and/or caffeine may be associated with reduced risk of endometrial cancer but, probably, associated increased with risk of breast cancer among premenopausal or normal weight women. However, further studies are needed to confirm our findings. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - August 1, 2018 Category: Cancer & Oncology Source Type: research

Effect of a 12-month exercise intervention on leukocyte telomere length: Results from the ALPHA Trial
ConclusionWe found no evidence to suggest that one year of aerobic exercise alters telomere attrition significantly in healthy postmenopausal women. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - August 1, 2018 Category: Cancer & Oncology Source Type: research

Which indicators of early cancer diagnosis from population-based data sources are associated with short-term mortality and survival?
Publication date: Available online 25 July 2018Source: Cancer EpidemiologyAuthor(s): Patrick Muller, Sarah Walters, Michel P. Coleman, Laura WoodsAbstractBackgroundA key component of recent English cancer policy is the monitoring of trends in early diagnosis of cancer. Early diagnosis can be defined by the disease stage at diagnosis or by other indicators derived from electronic health records. We evaluate the association between different early diagnosis indicators and survival, and discuss the implementation of the indicators in surveillance of early diagnosis.MethodsWe searched the PubMed database and grey literature to...
Source: Cancer Epidemiology - July 26, 2018 Category: Cancer & Oncology Source Type: research

Incidence of prostate cancer and net survival by grade in a geriatric population: A population-based study in a French administrative entity from 1991 to 2013
ConclusionThe epidemiology of prostate cancers among men aged ≥75 include a decrease of incidence and mortality rates from 2003, an important proportion of high grade cancers and a relatively good prognosis except for high grade cancers. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 24, 2018 Category: Cancer & Oncology Source Type: research

Incidence and mortality risk for respiratory tract cancer in the city of São Paulo, Brazil: Bayesian analysis of the association with traffic density
ConclusionOur findings support the hypothesis that residing in areas with high traffic density is associated with increased respiratory tract cancer incidence and mortality risk in the city of São Paulo. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 24, 2018 Category: Cancer & Oncology Source Type: research

Corrigendum to “The burden of HPV associated cancers in two regions in Nigeria 2012–2014” [Cancer Epidemiol. (2016) 91–97]
Publication date: Available online 20 July 2018Source: Cancer EpidemiologyAuthor(s): E.E. Jedy-Agba, E.O. Dareng, S.N. Adebamowo, M. Odutola, E.A. Oga, F. Igbinoba, T. Otu, E. Ezeome, F. Bray, R. Hassan, C.A. Adebamowo (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Title page / Editorial Board
Publication date: August 2018Source: Cancer Epidemiology, Volume 55Author(s): (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Table of contents
Publication date: August 2018Source: Cancer Epidemiology, Volume 55Author(s): (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Testicular cancer among US men aged 50 years and older
ConclusionGiven the distinct time-trends and age-specific patterns of testicular cancer in men aged ≥50 years, additional investigation of risk factors for these tumors is warranted. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Breast and cervical cancer incidence and mortality trends in Russia 1980–2013
ConclusionThe temporal patterns of breast cancer incidence and mortality in Russia are in line with other countries in Europe, although cervical cancer rates and the risk of occurrence in recent generations is rapidly increasing; these trends underscore the need to place immediate priority in national cervical vaccination and screening programs. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Trends in thyroid cancer: Retrospective analysis of incidence and survival in Denmark 1980–2014
ConclusionThe incidence of thyroid cancer is rising. This is primarily attributable to an increase in papillary carcinomas. The relative survival has improved significantly in Denmark since 1980. The cause of the increasing incidence remains to be established, but enhanced diagnostic scrutiny and increased iodine intake may be influential. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Anxiety and depression in women with breast cancer: Social and clinical determinants and influence of the social network and social support (DAMA cohort)
DiscussionOur results show that women long period of cancer survival have high prevalences of anxiety than depression, and this prevalence of anxiety is higher than the general population. In addition, we found inequalities between social classes and the isolation and social support are worse too in low social class. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Epidemiology of multiple myeloma in Taiwan, a population based study
Publication date: August 2018Source: Cancer Epidemiology, Volume 55Author(s): Chao-Hsiun Tang, Hung-Yi Liu, Hsin-An Hou, Hong Qiu, Kuan-Chih Huang, Sarah Siggins, Lee Anne Rothwell, Yanfang LiuAbstractBackgroundAlthough the incidence of multiple myeloma (MM) in Asia is lower than in Western countries, it is steadily increasing. However, limited data are available that describe the epidemiology of MM in Asia.MethodsWe conducted a retrospective cohort study using the Taiwan National Healthcare Insurance Research database to estimate the disease burden and clinical characteristics of patients with MM in Taiwan. All newly diag...
Source: Cancer Epidemiology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Consultation frequency in general practice before cancer diagnosis in relation to the patient’s usual consultation pattern: A population-based study
ConclusionPatients with cancer begin to increase their consultation frequency in general practice before a cancer diagnosis independently of their usual consultation frequency. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Epidemiological surveillance of mesothelioma mortality in Italy.
Publication date: August 2018Source: Cancer Epidemiology, Volume 55Author(s): Lucia Fazzo, Giada Minelli, Marco De Santis, Caterina Bruno, Amerigo Zona, Susanna Conti, Pietro CombaAbstractBackgroundMalignant mesothelioma (MM) is causally linked to asbestos exposure with an estimated etiological fraction of 80% or more.MethodsStandardized rates of all mesothelioma (C45, ICD-10) and malignant pleural mesothelioma (C45.0, ICD-10) mortality in Italy were computed at national and regional levels, for the period 2003–2014. Standardized Mortality Ratios (SMRs, with 95% Confidence Intervals) were calculated for each of the 8...
Source: Cancer Epidemiology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Prevalence of hereditary cancer susceptibility syndromes in children with cancer in a highly consanguineous population
ConclusionFour out of 10 children with cancer fulfilled criteria for HCSS, most often due to consanguinity. This higher than expected prevalence suggests the need to validate consanguinity as a criterion for HCSS in highly consanguineous populations. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Genetic polymorphisms of Th2 interleukins, history of asthma or eczema and childhood acute lymphoid leukaemia: Findings from the ESCALE study (SFCE)
ConclusionThis study provides a new insight into the relationship between allergic symptoms and childhood acute lymphoid leukaemia, by suggesting this inverse association could be limited to children carrying certain genetic polymorphisms. If confirmed, these results could help better understand the biological mechanisms involved in the development of childhood acute lymphoid leukaemia. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Risk of high-grade serous ovarian cancer associated with pelvic inflammatory disease, parity and breast cancer
ConclusionsOur finding of an increased risk of HGSC associated with PID lends support to the hypothesis that inflammatory processes may be involved in the etiology of HGSC. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 20, 2018 Category: Cancer & Oncology Source Type: research

HBV infection and extra-hepatic cancers in adolescents and 20s: A retrospective study in China
ConclusionHBV infection is a risk factor for diverse extra-hepatic cancers in adolescents and 20s. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Benzene exposure at workplace and risk of colorectal cancer in four Nordic countries
ConclusionThis study showed an association between workplace benzene exposure and colorectal cancer. The risk was restricted to ascending and transversal colon, and was the strongest among women. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Hormonal contraceptive use and smoking as risk factors for high-grade cervical intraepithelial neoplasia in unvaccinated women aged 30–44 years: A case-control study in New South Wales, Australia
Publication date: August 2018Source: Cancer Epidemiology, Volume 55Author(s): Huilan Xu, Sam Egger, Louiza S Velentzis, Dianne L O’Connell, Emily Banks, Jessica Darlington-Brown, Karen Canfell, Freddy SitasAbstractBackgroundHuman papillomavirus (HPV) vaccines protect against HPV types 16/18, but do not eliminate the need to detect pre-cancerous lesions. Australian women vaccinated as teenage girls are now entering their mid-thirties. Since other oncogenic HPV types have been shown to be more prevalent in women ≥30 years old, understanding high grade cervical lesions in older women is still important. Hormonal cont...
Source: Cancer Epidemiology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Domperidone use and risk of primary liver cancer in the Clinical Practice Research Datalink
ConclusionDomperidone use was not associated with decreased liver cancer risk among all study participants. Among women, an increased risk at highest levels of exposure warrants further study. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 20, 2018 Category: Cancer & Oncology Source Type: research

Intake of folate and other nutrients related to one-carbon metabolism and risk of cutaneous melanoma among US women and men
ConclusionsWe found some evidence that higher intake of folate from food only was associated with a modest increased risk of cutaneous melanoma. However, since other factors related to dietary folate intake may account for the observed association, our findings warrant further investigation. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 20, 2018 Category: Cancer & Oncology Source Type: research

The scientific impact and value of large, NCI-sponsored randomized phase III cancer chemoprevention trials
ConclusionBased on these criteria, the scientific impact of large phase III cancer chemoprevention trials was very high in absolute terms, and as good as or better than that of treatment trials after accounting for expenditure. For appropriate scientific questions, large chemoprevention trials provide a good scientific return on investment for federal funding agencies.Graphical abstract (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 20, 2018 Category: Cancer & Oncology Source Type: research