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MDS classification is improving in an era of the WHO 2016 criteria of MDS: A population-based analysis among 9159 MDS patients diagnosed in the Netherlands
Conclusion The classification of MDS is improving in the Netherlands. Nevertheless, particular diagnostic and prognostic procedures that are essential for the diagnosis and subsequent treatment decision-making of MDS were not fully utilized in particular patient subsets. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - September 12, 2017 Category: Cancer & Oncology Source Type: research

“Assessing the methodological quality of systematic reviews in radiation oncology: A systematic review”
Conclusions Systematic reviews and meta-analyses may introduce a high risk of bias if applied to inform decision-making based on AMSTAR. We recommend that decision-makers in Radiation Oncology scrutinize the methodological quality of systematic reviews and meta-analyses prior to assessing their utility to inform evidence-based medicine and researchers adhere to methodological standards outlined in validated guidelines when embarking on a systematic review. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - September 12, 2017 Category: Cancer & Oncology Source Type: research

Long-term trends in incidence and survival of penile cancer in France
Conclusion Penile cancer remains rare in France, but survival is still low − probably because of delays in diagnosis and limited improvements in care. International clinical trials are needed to develop care recommendations based on an adequate level of evidence. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - September 9, 2017 Category: Cancer & Oncology Source Type: research

Helicobacter pylori serological biomarkers of gastric cancer risk in the MCC-Spain case-control Study
Conclusions In our population, people seropositive for H. pylori were characterized by two patterns of antibody reactivity against H. pylori proteins: 1) Combined high seroreactivity against several proteins, associated with a lower non-cardia gastric cancer risk, and 2) High seroreactivity against CagA and VacA, associated with an increased risk. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - September 7, 2017 Category: Cancer & Oncology Source Type: research

Calcium channel blockers and breast cancer incidence: An updated systematic review and meta-analysis of the evidence
Publication date: October 2017 Source:Cancer Epidemiology, Volume 50, Part A Author(s): Cameron M. Wright, Rachael E. Moorin, Enayet K. Chowdhury, Bruno H. Stricker, Christopher M. Reid, Christobel M. Saunders, Jeffery D. Hughes Controversy exists regarding the potential association between taking calcium channel blockers (CCBs) and the development of breast cancer. As a positive association would have important public health implications due to the widespread use of CCBs, this study aimed to incorporate new evidence to determine whether an association is likely to exist. We searched MEDLINE, EMBASE and the Cochrane Libra...
Source: Cancer Epidemiology - September 2, 2017 Category: Cancer & Oncology Source Type: research

Association between the neighborhood obesogenic environment and colorectal cancer risk in the Multiethnic Cohort
Conclusion Findings from our large racial/ethnically diverse cohort suggest neighborhood obesogenic characteristics are not strongly associated with the risk of colorectal cancer. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - September 1, 2017 Category: Cancer & Oncology Source Type: research

Clinical epidemiology of tracheal invasion from thyroid cancer in Japanese population: Functional outcomes and effect of aging
Conclusion The peak incidence of tracheal invasion from thyroid cancer was observed at ages of >70years. In addition, conventional surgical management appears to be limited in its ability to reconstruct tracheal defects. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - September 1, 2017 Category: Cancer & Oncology Source Type: research

Is there a socioeconomic variation in survival from renal tumours in children and young people resident in northern England (1968 –2012)?
Conclusions This study did not detect a significant social gradient in renal tumour survival. The identification of tumour stage as a strong predictor of survival irrespective of age, necessitates the development of appropriate public health interventions that target early diagnosis and treatment. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - August 24, 2017 Category: Cancer & Oncology Source Type: research

Risk of second primary cancers among patients with a first primary gastric cancer: A population-based study in North Portugal
Conclusions Patients with a gastric FPC were found to be at increased risk of developing SPC, mainly in digestive organs, when compared to the general population. Close surveillance of these patients may allow early detection of SPC. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - August 23, 2017 Category: Cancer & Oncology Source Type: research

Patient characteristics and cancer prevalence in the Danish cancer patient pathway for patients with serious non-specific symptoms and signs of cancer —A nationwide, population-based cohort study
Conclusions The prevalence of cancer in the NSSC-CPP was 11%. The most common cancer diagnosis was breast cancer, hematopoietic and lymphoid cancer and malignant melanoma. A small proportion of patients receiving a non-cancer diagnosis in the NSSC-CPP were diagnosed with cancer in the six months following their NSSC-CPP course. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - August 17, 2017 Category: Cancer & Oncology Source Type: research

Are there regional tendencies toward controversial screening practices? A study of prostate and breast cancer screening in a Medicare population
Conclusions Regional rates of PSA screening rates were independent of screening mammography, thus these practices appear to be driven by different factors. Unlike mammography, PSA screening was associated with local enthusiasm for testing and treatment. Efforts to reduce over-testing should contemplate these practices differently, and future research should examine the factors motivating these screening practices. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - August 17, 2017 Category: Cancer & Oncology Source Type: research

CITRUS, cervical cancer screening trial by randomization of HPV testing intervention for upcoming screening: Design, methods and baseline data of 18,471 women
Conclusions Insights from CITRUS will provide future prospects for cervical cancer screening focused on the use of HPV testing in Japan. Clinical trial registration number: NCT01895517, UMIN000010843, TRIUC1312. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - August 17, 2017 Category: Cancer & Oncology Source Type: research

Time trends for prostate cancer mortality in Brazil and its geographic regions: An age –period–cohort analysis
Conclusion The increase in prostate cancer mortality rates in Brazil and its regions was mainly due to population aging. The differences in mortality rates and APC effects between regions are related to demographic differences and access of health services across the country. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - August 17, 2017 Category: Cancer & Oncology Source Type: research

Sex disparities in cancer incidence in Jiashan County, China, 1995 –2014
Conclusions Our results reveal a male predominance in incidence for a majority of cancers in Jiashan County, Eastern China. Possible explanations for these sex disparities in cancer incidence may include lifestyle factors, particularly smoking. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - August 11, 2017 Category: Cancer & Oncology Source Type: research

Genetic association of telomere length with hepatocellular carcinoma risk: A Mendelian randomization analysis
Conclusions Our results indicated that a genetic background that favors longer or shorter telomere length may increase HBV-related HCC risk—a U-shaped association. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - August 8, 2017 Category: Cancer & Oncology Source Type: research

Clinical characteristics and risk of serious disease in patients referred to a diagnostic centre: A cohort study
Conclusions Patients referred by their GP to the diagnostic centre have high risk of serious disease. A multidisciplinary diagnostic approach is needed to embrace the diagnostic spectrum. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - August 7, 2017 Category: Cancer & Oncology Source Type: research

High-risk family colorectal cancer screening service in Ireland: Critical review of clinical outcomes
Conclusion Male gender and age (>50) were the core identifiable risk factors for neoplasia at screening colonoscopy in this family screening setting. Our results would support less intensive surveillance in younger patients (<50), particularly where index colonoscopy is normal. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - August 5, 2017 Category: Cancer & Oncology Source Type: research

Trends in brain cancer mortality among U.S. Gulf War veterans: 21 year follow-up
Conclusion Results from these analyses suggest that veterans possibly exposed at Khamisiyah experienced different patterns of brain cancer mortality risk compared to the other groups. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - August 5, 2017 Category: Cancer & Oncology Source Type: research

Validity of self-reported cancer history in the health examinees (HEXA) study: A comparison of self-report and cancer registry records
Conclusion The accuracy of self-reported cancer history varied by cancer site and may not be sufficient to ascertain cancer incidence, especially for cervical and bladder cancers. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 30, 2017 Category: Cancer & Oncology Source Type: research

Self-reported shift work, recall bias, and belief about disease causation in a case-control study of breast cancer
Conclusion The association between pre-existing belief about breast cancer risk and reported shift work is likely to be due to exposed individuals believing that exposure increases risk, rather than resulting from recall bias. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 28, 2017 Category: Cancer & Oncology Source Type: research

Descriptive epidemiology of primary malignant and non-malignant central nervous tumors in Spain: Results from the Girona Cancer Registry (1994 –2013)
Conclusion This study presents a comprehensive overview of the epidemiology of malignant and non-malignant CNS primary tumors from the well-established region-wide Girona Cancer Registry (1994–2013). Incidence rates were recovered for all histologies. Survival is still dramatically associated to both age and histological subtype. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 22, 2017 Category: Cancer & Oncology Source Type: research

Risk of hospitalization among survivors of childhood and adolescent acute lymphoblastic leukemia compared to siblings and a general population sample
Conclusions Five to ten years after diagnosis is a sensitive time period for hospitalizations in the ALL population. Survivors of childhood ALL require better long-term surveillance. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 20, 2017 Category: Cancer & Oncology Source Type: research

Prediagnostic serum calcium and albumin and ovarian cancer: A nested case-control study in the Norwegian Janus Serum Bank Cohort
Conclusions These data confirm a prospective association between higher serum calcium and ovarian cancer. An association in early, but not late, follow-up suggests that the higher calcium reflects the presence of existing cancer. A positive association with serum albumin is novel and should be interpreted cautiously. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 19, 2017 Category: Cancer & Oncology Source Type: research

Exploration of the possible effect on survival of lead-time associated with implementation of cancer patient pathways among symptomatic first-time cancer patients in Denmark
Conclusion The lead time caused by shorter diagnostic intervals after implementation of Cancer Patient Pathways seems to explain less than 15% of the observed changes in the one-year survival estimates for cancer patients in Denmark. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 15, 2017 Category: Cancer & Oncology Source Type: research

Parental age and childhood cancer risk: A Danish population-based registry study
Conclusion Older parental age was a risk factor for various childhood cancers in Danish children. Further investigation of the biological and social factors that may be contributing to these associations is warranted. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 15, 2017 Category: Cancer & Oncology Source Type: research

Survival after recurrence of stage I –III breast, colorectal, or lung cancer
Conclusions Initial stage predicts survival duration after recurrence, whereas time-to-recurrence usually does not. The impact of biologic characteristics (e.g., grade, hormone-receptor status) on survival duration after recurrence needs further study. Predictors of survival duration after recurrence may help facilitate patient decision-making. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 13, 2017 Category: Cancer & Oncology Source Type: research

Cancer incidence in the AGRICAN cohort study (2005 –2011)
Conclusion We found a decreased incidence for tobacco-related cancers and an increased incidence of prostate cancers, skin melanoma and multiple myeloma. Specific subgroups had a higher cancer incidence related to occupational status and pesticide use. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 12, 2017 Category: Cancer & Oncology Source Type: research

Implementing community-based cervical cancer screening programs using visual inspection with acetic acid in India: A systematic review
The objective of this review was to systematically appraise the existing published literature about community-based cervical cancer screening programs that have used visual inspection methods using acetic acid (VIA) in India. All peer reviewed journal articles till December 2015 were searched per PRISMA guidelines. Articles reporting results from cervical cancer screening programs in community-based settings, conducted in India, and using VIA were included in this review. The search resulted in 20 articles to be included in the review with a total of 313,553 women at 12 unique urban and rural sites across India. Seventeen ...
Source: Cancer Epidemiology - July 11, 2017 Category: Cancer & Oncology Source Type: research

Tumor characteristics and family history in relation to mammographic density and breast cancer: The French E3N cohort
Conclusions The stronger association between mammographic density and breast cancer risk with a family history supports the hypothesis of shared genetic factors responsible for familial aggregation of breast cancer and the heritable component of mammographic density. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - July 9, 2017 Category: Cancer & Oncology Source Type: research

If a picture is worth a thousand words, take a good look at the picture: Survival after liver metastasectomy for colorectal cancer
Publication date: August 2017 Source:Cancer Epidemiology, Volume 49 Author(s): Eva Morris, Tom Treasure Introduction An analysis of NHS data published in by Morris et al. in 2010 is widely used as evidence in support of liver metastasectomy for colorectal cancer and its wider application. Recent evidence concerning better overall survival for patients with metastatic colorectal cancer challenges the notional assumptions about what survival would be without metastasectomy. Earlier detection of metastases for local treatments has not resulted in a survival benefit. Materials and methods The interpretation of its central gra...
Source: Cancer Epidemiology - July 8, 2017 Category: Cancer & Oncology Source Type: research

Sedentary work and the risks of colon and rectal cancer by anatomical sub-site in the Canadian census health and environment cohort (CanCHEC)
Conclusion The two significant findings of this analysis should be followed-up in further investigations with additional information on potential confounders. Null findings for rectal cancer were consistent with other studies. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - June 24, 2017 Category: Cancer & Oncology Source Type: research

Sequential matched analysis of racial disparities in breast cancer hospitalization outcomes among African American and White patients
Conclusion African American women experienced higher odds of inpatient mortality and longer length of stay compared with White women even after accounting for differences in demographics, presentation and treatment characteristics. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - June 16, 2017 Category: Cancer & Oncology Source Type: research

Socioeconomic measures influence survival in osteosarcoma: an analysis of the National Cancer Data Base
Conclusion Treating providers should be aware that some of their patients may have challenges unrelated to their diagnosis that make timely presentation, adherence to treatment, and continued close surveillance difficult. This investigation suggests that socioeconomic variables influence overall survival for osteosarcoma in the United States, although not as dramatically as established tumor- and treatment-related risk factors. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - June 10, 2017 Category: Cancer & Oncology Source Type: research

Pollution and regional variations of lung cancer mortality in the United States
Conclusion We observed a belt of counties with high lung mortality ranging from eastern Oklahoma through central Appalachia; these counties were characterized by higher pollution, a more rural population, lower socioeconomic status and poorer access to healthcare. To mitigate the burden of lung cancer mortality in the US, both urban and rural areas should consider minimizing air pollution. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - June 10, 2017 Category: Cancer & Oncology Source Type: research

Potential impact of the Affordable Care Act's preventive services provision on breast cancer stage: A preliminary assessment
We examined: 1) whether a shift in breast cancer stage occurred, and 2) the impact of the provision on racial/ethnic disparities in stage. Materials and methods Data from the National Cancer Database were used. The pre- and post-PSP periods were identified as 2007–2009 and 2011–2013, respectively. Proportion differences (PDs) and 95% confidence Intervals (CIs) were calculated. Results All three racial/ethnic groups experienced a statistically significant shift toward Stage I breast cancer. Pre-PSP, the black:white disparity in Stage I cancer was −9.5 (95% CI: −8.9, −10.4) and the Latina:white ...
Source: Cancer Epidemiology - June 10, 2017 Category: Cancer & Oncology Source Type: research

Clinical outcomes of female breast cancer according to BRCA mutation status
Conclusions BRCAm carriers may have a better prognosis than BRCAwt women. However, limited testing conducted mainly during follow-up, yielded low numbers for precise estimations, and may be attributable to selection bias. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - June 9, 2017 Category: Cancer & Oncology Source Type: research

Management of advanced ovarian cancer in South West Wales − a comparison between primary debulking surgery and primary chemotherapy treatment strategies in an unselected, consecutive patient cohort
Conclusion This retrospective study of an unselected, consecutive cohort of women with AOC in South West Wales shows comparable survival outcomes with recently published trials, despite the relatively advanced age and poor performance status of our patient cohort. Over the seven-year study period, our data also demonstrated a non-significant trend towards improved survival following primary surgery in patients who achieved maximal cytoreduction. Our future aim therefore is to examine and develop the role of extended surgery in these patients. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - June 8, 2017 Category: Cancer & Oncology Source Type: research

The completeness and timeliness of cancer registration and the implications for measuring cancer burden
Conclusion The estimated completeness levels for the NICR are comparable to other high quality cancer registries internationally. While data timeliness has little impact on incidence estimates, delays in registration may have implications for specific research studies into incidence and survival. This means that improvements in the timeliness of reporting should be a target for all registries but not at the expense of completeness. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - June 8, 2017 Category: Cancer & Oncology Source Type: research

Incidence and mortality of pancreatic cancer on a rapid rise in Taiwan, 1999 –2012
Conclusion The incidence and mortality of pancreatic cancer have been rapidly rising and presumably will continue to rise in Taiwan. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - June 8, 2017 Category: Cancer & Oncology Source Type: research

Colorectal cancer metastatic disease progression in Australia: A population-based analysis
Conclusions An understanding of the variation in risk of metastatic progression is useful for planning health service requirements, and can help inform decisions about treatment and follow-up for colorectal cancer patients. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - June 7, 2017 Category: Cancer & Oncology Source Type: research

Impact of comorbidity on survival by tumour location: Breast, colorectal and lung cancer (2000 –2014)
Conclusions Comorbidity is a significant predictor of overall survival in cancer patients; however, it has a stronger impact on survival in breast cancer than in colorectal and lung cancer. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - June 4, 2017 Category: Cancer & Oncology Source Type: research

Miscalculations can lead to misinterpretation of the results
Publication date: Available online 30 May 2017 Source:Cancer Epidemiology Author(s): Leena Derwish (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 31, 2017 Category: Cancer & Oncology Source Type: research

Incidence and survival of childhood cancer in the French islands of Reunion and Mayotte (2005 –2011)
Publication date: August 2017 Source:Cancer Epidemiology, Volume 49 Author(s): J. Ramiandrisoa, M. Jehanne, F. Sauvat, Y. Reguerre, A. Chamouine, E. Chirpaz The aim of this study is to describe childhood cancer incidence and survival in the French islands of Reunion and Mayotte for the period 2005–2011. Data were taken from the population-based Cancer Registry of Reunion Island. All incident cases of malignant tumours and benign tumours of the Central Nervous System diagnosed between 2005 and 2011 in children under the age of 15 and living in Reunion or Mayotte were included. A total of 236 cases were registered (17...
Source: Cancer Epidemiology - May 31, 2017 Category: Cancer & Oncology Source Type: research

Risk stratification of women with false-positive test results in mammography screening based on mammographic morphology and density: A case control study
Conclusion All four methods, capturing either mammographic morphology or density, could segregate women with FP-screening results according to their risk of future breast cancer − using already available screening mammograms. Our findings need validation on digital mammograms, but may inform potential future risk stratification and tailored screening strategies (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 28, 2017 Category: Cancer & Oncology Source Type: research

Association of TP53 codon 72 and CDH1 genetic polymorphisms with colorectal cancer risk in Bangladeshi population
In conclusion, heterozygosity and mutant homozygosity as well as the combination of both TP53 Arg72Pro and CDH1 rs16260 polymorphisms are responsible to increase the risk of colorectal cancer development in Bangladeshi population. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 27, 2017 Category: Cancer & Oncology Source Type: research

Typical and atypical presenting symptoms of breast cancer and their associations with diagnostic intervals: Evidence from a national audit of cancer diagnosis
Conclusions About 1 in 6 women with breast cancer present with a large spectrum of symptoms other than breast lump. Women who present with non-lump breast symptoms tend to delay seeking help. Further emphasis of breast symptoms other than breast lump in symptom awareness campaigns is warranted. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 24, 2017 Category: Cancer & Oncology Source Type: research

Risk factors for patient-reported errors during cancer follow-up: Results from a national survey in Denmark
Conclusion Workflows related to handling of test results, referrals, bookings and medical records have to be improved. Introduction of one particular healthcare professional responsible for the patients’ follow-up may result in fewer patient-reported errors however interventions are needed to examine this. Patients prone to errors should be subject to particular attention. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 23, 2017 Category: Cancer & Oncology Source Type: research

Racial differences in colorectal cancer survival at a safety net hospital
Conclusions Despite presumed equal access to healthcare and socioeconomic status within a safety-net hospital system, our results reinforce findings from previous studies showing lower colorectal cancer survival in Black patients, and also point to the importance of investigating other factors such as genetic and pathologic differences. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 22, 2017 Category: Cancer & Oncology Source Type: research

The association of lifetime physical inactivity with bladder and renal cancer risk: A hospital-based case-control analysis
Conclusions In this case-control study, we observed evidence of a positive association between renal and bladder cancer with lifetime recreational physical inactivity. These data add to the growing body of evidence suggesting that physical inactivity may be an important independent risk factor for cancer. However, additional studies using a larger sample and prospectively collected data are needed to substantiate the current findings. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 19, 2017 Category: Cancer & Oncology Source Type: research

Modelling lung cancer mortality rates from smoking prevalence: Fill in the gap
Conclusion The time series of prevalence of tobacco smoking explains the mortality from lung cancer with a distance (or gap) of around 30 years. According to the lagged smoking prevalence, the lung cancer mortality among men is declining while in women continues to rise (maximum expected in 2026). (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 19, 2017 Category: Cancer & Oncology Source Type: research