Childhood cancer registration in New Zealand: A registry collaboration to asssess and improve data quality
CONCLUSION: With two national registries covering childhood cancers, New Zealand is uniquely positioned to undertake regular cooperative activities to ensure high quality data is available for research and patient care. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - June 11, 2018 Category: Cancer & Oncology Source Type: research

Genetic polymorphisms of Th2 interleukins, history of asthma or eczema and childhood acute lymphoid leukaemia: Findings from the ESCALE study (SFCE)
Conclusion This study provides a new insight into the relationship between allergic symptoms and childhood acute lymphoid leukaemia, by suggesting this inverse association could be limited to children carrying certain genetic polymorphisms. If confirmed, these results could help better understand the biological mechanisms involved in the development of childhood acute lymphoid leukaemia. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - June 6, 2018 Category: Cancer & Oncology Source Type: research

Erratum to “Plasma magnesium is inversely associated with Epstein-Barr virus load in peripheral blood and Burkitt lymphoma in Uganda” [Cancer Epidemiol. 52 (2018) 70–74]
Publication date: Available online 1 June 2018 Source:Cancer Epidemiology Author(s): Juan Ravell, Isaac Otim, Hadijah Nabalende, Ismail D. Legason, Steven J. Reynolds, Martin D. Ogwang, Christopher M. Ndugwa, Vickie Marshall, Denise Whitby, James J. Goedert, Eric A. Engels, Kishor Bhatia, Michael J. Lenardo, Sam M. Mbulaiteye (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - June 1, 2018 Category: Cancer & Oncology Source Type: research

Prevalence of hereditary cancer susceptibility syndromes in children with cancer in a highly consanguineous population
Conclusion Four out of 10 children with cancer fulfilled criteria for HCSS, most often due to consanguinity. This higher than expected prevalence suggests the need to validate consanguinity as a criterion for HCSS in highly consanguineous populations. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 31, 2018 Category: Cancer & Oncology Source Type: research

Trends in thyroid cancer: Retrospective analysis of incidence and survival in Denmark 1980 –2014
Conclusion The incidence of thyroid cancer is rising. This is primarily attributable to an increase in papillary carcinomas. The relative survival has improved significantly in Denmark since 1980. The cause of the increasing incidence remains to be established, but enhanced diagnostic scrutiny and increased iodine intake may be influential. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 28, 2018 Category: Cancer & Oncology Source Type: research

Breast and cervical cancer incidence and mortality trends in Russia 1980 –2013
Conclusion The temporal patterns of breast cancer incidence and mortality in Russia are in line with other countries in Europe, although cervical cancer rates and the risk of occurrence in recent generations is rapidly increasing; these trends underscore the need to place immediate priority in national cervical vaccination and screening programs. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 27, 2018 Category: Cancer & Oncology Source Type: research

A prospective study of cancer survivors and risk of sepsis within the REGARDS cohort
Conclusion In this prospective cohort of community-dwelling adults we observed that cancer survivors had more than a 2.5-fold increased risk of sepsis. Public health efforts should attempt to mitigate sepsis risk by awareness and appropriate treatment (e.g., antibiotic administration) to cancer survivors with suspected infection regardless of the number of years since cancer remission. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 26, 2018 Category: Cancer & Oncology Source Type: research

Avoidable colorectal cancer cases in Denmark – The impact of red and processed meat
Conclusion Decreased red and processed meat consumption could reduce the burden of CRC markedly in Denmark. These results can assist public health planners and help highlight the important role of a modest but realistic reduction in meat consumption in the prevention of CRC. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 26, 2018 Category: Cancer & Oncology Source Type: research

Toenail selenium, genetic variation in selenoenzymes and risk and outcome in glioma
Conclusion The present study offers no support for the hypothesis that selenium plays a role in the onset of glioma or patient outcome. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 26, 2018 Category: Cancer & Oncology Source Type: research

Determinants of cancer treatment and mortality in older cancer patients using a multi-state model: Results from a population-based study (the INCAPAC study)
Conclusion Further studies are necessary to understand the impact of geriatric impairments on treatment administration and to develop clinical practice guidelines. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 26, 2018 Category: Cancer & Oncology Source Type: research

Temporal trends in competing mortality from second and subsequent primary cancers, 1980 –2014: An Australian population-based study
Conclusion Competing risk models, but not Cox models, demonstrated temporal increases in SPC-specific mortality. Greater detection of non-fatal first prostate cancers appears to have contributed to this trend. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 26, 2018 Category: Cancer & Oncology Source Type: research

Analysis of incidence, mortality and survival for pancreatic and biliary tract cancers across Europe, with assessment of influence of revised European age standardisation on estimates
Conclusion Poor survival for PC and BTC, together with increasing incidence, indicate that action is required. Countries with higher incidence had higher risk factor frequency, suggesting that prevention initiatives targeting risk factors should be promoted. Improvements in diagnosis and treatment are also required. Our results provide a baseline from which to monitor evolution of the PC/BTC burden in Europe. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 26, 2018 Category: Cancer & Oncology Source Type: research

Has cancer survival improved for older people as for younger people? New South Wales, 1980 –2012
Conclusion The reduction in cancer mortality was smaller in older people, as seen in the USA. Research is needed to achieve the best trade-offs between cancer control and harm avoidance in older people. Multidisciplinary teams have an important contribution to make. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 26, 2018 Category: Cancer & Oncology Source Type: research

Lung cancer incidence trends in Uruguay 1990 –2014: An age-period-cohort analysis
Conclusion Despite observed and predicted reductions in lung cancer incidence in Uruguayan men, rates among women are set to continue to increase, with a large rise in the annual number of female lung cancer diagnoses expected before 2035. There are signals of a diminishing risk among recent generations of women born after 1960. The current analysis provides important baseline information in assessing the future impact of the recent tobacco control initiatives in Uruguay. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 26, 2018 Category: Cancer & Oncology Source Type: research

Review of methodological challenges in comparing the effectiveness of neoadjuvant chemotherapy versus primary debulking surgery for advanced ovarian cancer in the United States
Publication date: August 2018 Source:Cancer Epidemiology, Volume 55 Author(s): Ashley L. Cole, Anna E. Austin, Ryan P. Hickson, Matthew S. Dixon, Emma L. Barber Randomized trials outside the U.S. have found non-inferior survival for neoadjuvant chemotherapy (NACT) versus primary debulking surgery (PDS) for advanced ovarian cancer (AOC). However, these trials reported lower overall survival and lower rates of optimal debulking than U.S. studies, leading to questions about generalizability to U.S. practice, where aggressive debulking is more common. Consequently, comparative effectiveness in the U.S. remains controversial. ...
Source: Cancer Epidemiology - May 26, 2018 Category: Cancer & Oncology Source Type: research

Alcohol intake and gastric cancer: Meta-analyses of published data versus individual participant data pooled analyses (StoP Project)
Conclusion Meta-analyses of the association between alcohol drinking and gastric cancer tended to overestimate the magnitude of the effects, possibly due to publication bias. Additionally, individual participant data pooled analyses yielded more precise estimates for different levels of exposure or cancer subtypes. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 17, 2018 Category: Cancer & Oncology Source Type: research

Effect of African-American race on cancer specific mortality differs according to clear cell vs. non-clear cell histologic subtype in metastatic renal cell carcinoma
Conclusion African-Americans experienced higher CSM in ccmRCC. Conversely, African-Americans experienced lower CSM, when diagnosed with non-ccmRCC. These differences are independent of access to CNT and warrant further study since they may have an impact on efficacy or access to systemic therapies. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 17, 2018 Category: Cancer & Oncology Source Type: research

Neoplasms-associated deaths in HIV-1 infected and non-infected patients in Bahia, Brazil
Conclusion HIV infection is a clear risk fator for development of some malignancies, and is associated with early mortality, compared to general population. The level of CD4+ cells count predicts the type of malignancies causing death in this population. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 17, 2018 Category: Cancer & Oncology Source Type: research

Marital status and survival in patients with rectal cancer: An analysis of the Surveillance, Epidemiology and End Results (SEER) database
Conclusion Our study showed marriage was associated with better outcomes of RC patients, but unmarried RC patients, especially widowed patients,are at greater risk of cancer specific mortality. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 17, 2018 Category: Cancer & Oncology Source Type: research

Gastrointestinal cancer incidence in type 2 diabetes mellitus; results from a large population-based cohort study in the UK
Conclusion In this study, T2DM patients were shown to have higher crude IRs of liver, pancreatic and colon cancer, but not of gastric, biliary, and rectal cancer. Moreover, the lower observed IRs of oesophageal cancer in diabetic patients warrants further investigation. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - May 17, 2018 Category: Cancer & Oncology Source Type: research

Diagnosing cancer in patients with ‘non-alarm’ symptoms: Learning from diagnostic care innovations in Denmark
Publication date: June 2018 Source:Cancer Epidemiology, Volume 54 Author(s): Alice S. Forster, Cristina Renzi, Georgios Lyratzopoulos (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - April 25, 2018 Category: Cancer & Oncology Source Type: research

Bayesian estimates of the incidence of rare cancers in Europe
Conclusion For the first time the Bayesian estimates of IRs and the yearly expected numbers of cases for each rare cancer in each individual European country were calculated. Moreover, the indicator T is useful to convey incidence estimates for exceptionally rare cancers and in small countries; it far exceeds the professional lifespan of a medical doctor. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - April 22, 2018 Category: Cancer & Oncology Source Type: research

Evaluation of racial disparities in pediatric optic pathway glioma incidence: Results from the Surveillance, Epidemiology, and End Results Program, 2000 –2014
Conclusions Incidence of OPGs was highest among White children. This study represents one of the largest to assess differences in OPG susceptibility by race/ethnicity. These findings may inform future studies that seek to evaluate modifying factors for this pediatric tumor including tumorigenesis, treatment, outcome, and long-term late effects. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - April 22, 2018 Category: Cancer & Oncology Source Type: research

Ethnic disparity in breast cancer survival in southern Thai women
Conclusions Our findings confirm previous studies that have shown lower survival rates in Muslim Thai women compared to Buddhist women with breast cancer and offer novel information on subtype distribution. To date, this is the first study assessing clinical subtypes in southern Thailand by religious status. Impact Our findings are critical in providing information on the role of clinical subtype in cancer disparities and provide evidence from the Southeast Asian region for global studies on breast cancer survival. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - April 22, 2018 Category: Cancer & Oncology Source Type: research

Proton pump inhibitors and oesophageal cancer: Flawed methodology and false alarms
Publication date: Available online 17 April 2018 Source:Cancer Epidemiology Author(s): Grigorios I. Leontiadis, Alexander C. Ford, Colin W. Howden (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - April 20, 2018 Category: Cancer & Oncology Source Type: research

Adiposity at different periods of life and risk of adult glioma in a cohort of postmenopausal women
Conclusions Our weak findings regarding the association of adiposity measures with risk of glioma are in agreement the results of several large cohort studies. In view of the available evidence, adiposity is unlikely to represent an important risk factor for glioma. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - April 12, 2018 Category: Cancer & Oncology Source Type: research

Childhood nephroblastoma in Southern and Eastern Europe and the US: Incidence variations and temporal trends by human development index
Conclusions Variations in incidence and time trends across the examined registries, changing male-to-female patterns with advancement in age, and positive associations with the HDI imply a plausible role for environmental and genetic factors in disease etiology, and these need to be explored further. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - April 12, 2018 Category: Cancer & Oncology Source Type: research

PPI use and oesophageal cancer: What if the results are true?
Publication date: Available online 9 April 2018 Source:Cancer Epidemiology Author(s): Nele Brusselaers, Lars Engstrand, Jesper Lagergren (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - April 10, 2018 Category: Cancer & Oncology Source Type: research

The increasing burden of cancer attributable to high body mass index in Brazil
Conclusions Cancer cases attributable to high BMI will reach 29,490, which will be 4.6% of all cancers in Brazil in 2025; the extent will be greater in women (6.2% or 18,837) than in men (3.2% or 15,702). This information is a tool to support policy makers for future cancer prevention strategies in Brazil. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - March 29, 2018 Category: Cancer & Oncology Source Type: research

Changes in the prevalence of comorbidity in the Australian population with cancer, 2007 –2014
Conclusion Comorbidity is more prevalent among the cancer population than the general population without cancer. The prevalence of comorbidity was fairly stable for most but not all comorbidities in the population with cancer over the eight-year study period. Further studies on the impacts of coordinated care models for the management of multi-morbidity experienced by cancer survivors that align with the ‘National Strategic Framework for Chronic Conditions’ are needed. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - March 27, 2018 Category: Cancer & Oncology Source Type: research

Prostate-specific antigen (PSA) as a possible biomarker in non-prostatic cancer: A review
Publication date: June 2018 Source:Cancer Epidemiology, Volume 54 Author(s): Diana Cristina Pérez-Ibave, Carlos Horacio Burciaga-Flores, Miguel-Ángel Elizondo-Riojas Prostate-specific antigen (PSA) is a serine protease produced by epithelial prostatic cells and its main function is to liquefy seminal coagulum. Currently, PSA is a biomarker for the diagnosis and screening of prostate cancer and it was the first cancer biomarker approved by the FDA. The quantity and serum isoforms of male PSA, allows distinguishing between carcinoma and benign inflammatory disease of the prostate. Initially, it was thought tha...
Source: Cancer Epidemiology - March 26, 2018 Category: Cancer & Oncology Source Type: research

Social inequalities in quality of life in a cohort of women diagnosed with breast cancer in Barcelona (DAMA Cohort)
Conclusions The QoL of women diagnosed with breast cancer is closely linked to both their social and economic status, and to their stage of disease progression. It is necessary to explore interventions that focus on the social determinants of health in order to mitigate their effects on breast cancer survivors’ QoL. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - March 22, 2018 Category: Cancer & Oncology Source Type: research

Prevalence and age-wise distribution of Human Papillomavirus type 16/18 infections among hospital screened women of a peri-urban area in West Bengal: Impact of socio-demographic factors
Conclusions Our study highlights the need for HPV16/18-based screening of cervical cancers in India considering the immense socio-cultural and genetic diversity at the population level. Graphical abstract (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - March 21, 2018 Category: Cancer & Oncology Source Type: research

Circulating inflammatory proteins and gallbladder cancer: Potential for risk stratification to improve prioritization for cholecystectomy in high-risk regions
Conclusion These results highlight the strong associations of inflammatory proteins with GBC risk and their potential clinical utility. Larger studies are needed to identify the most effective combinations of inflammatory proteins for detecting early GBC and precursor lesions. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - March 17, 2018 Category: Cancer & Oncology Source Type: research

Survival differences in childhood and young adult acute myeloid leukemia: A cross-national study using US and England data
Conclusions Similar to the population trend, mortality risk across sex, age at diagnosis, and most AML subtypes was lower in England. Survival outcome for AML with and without maturation in England was better than the population trend, while that for AML inv(16) was worse. Our findings suggest that future etiologic and policy research may uncover the underlying mechanisms and contribute to closing these morality gaps. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - March 17, 2018 Category: Cancer & Oncology Source Type: research

Breast cancer in Portugal: Temporal trends and age-specific incidence by geographic regions
Conclusion The variant patterns observed could be due to a combination of different screening practices and/or exposure to risk factors across regions. Disease heterogeneity among younger and older women may also explain part of the differences in age-specific rates. These results justify continued monitoring of breast cancer incidence by region. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - March 14, 2018 Category: Cancer & Oncology Source Type: research

Patterns of pathologically confirmed metastasis to bone in Near East population
Conclusion The patterns of pathologically confirmed metastasis to skeletal sites in Near East population showed a special distribution, and variation was even observed between the 2 studied centers. Understanding the biologic variations of the primary tumors in our population may further explain the variation in patterns of metastasis. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - March 10, 2018 Category: Cancer & Oncology Source Type: research

Frequency and distribution of primary site among gender minority cancer patients: An analysis of U.S. national surveillance data
Conclusion The proportions of certain primary sites and categories of malignancies among transgender and DSD cancer patients are different from the proportions observed for male or female patients. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - March 10, 2018 Category: Cancer & Oncology Source Type: research

Does body mass index and adult height influence cancer incidence among Chinese living with incident type 2 diabetes?
Conclusion In this sample of participants living with newly diagnosed T2D, cancer incidence was higher among those who were taller, but also lower among those with higher BMI. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - March 6, 2018 Category: Cancer & Oncology Source Type: research

Hereditary association between testicular cancer and familial ovarian cancer: A Familial Ovarian Cancer Registry study
Conclusion These observations provide compelling preliminary evidence for a familial association between ovarian and testicular cancers Future studies should be designed to further investigate this association and evaluate X-linkage. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - February 28, 2018 Category: Cancer & Oncology Source Type: research

Evaluation of data quality at the National Cancer Registry of Ukraine
Conclusion While timely reporting of national data reflects the advantages of a mandatory data collection system, a low DCO% and observed age-specific declines suggest possible underreporting of incidence and mortality data, particularly at older ages. Overall, the evaluation indicates that the data are reasonably comparable and thus may be used to describe the magnitude of the cancer burden in Ukraine. Given its central role in monitoring and evaluation of cancer control activities, ensuring the sustainability of NCRU operations throughout the process of healthcare system reform is of utmost importance. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - February 23, 2018 Category: Cancer & Oncology Source Type: research

Impact of metformin on gastric adenocarcinoma survival: A Belgian population based study
Conclusion In the first population based study of metformin use in gastric cancer adenocarcinoma patients with previous diabetes, our findings suggest that metformin use might improve overall mortality. However, no such association was found for cancer-specific survival. Additional studies in other populations are required. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - February 23, 2018 Category: Cancer & Oncology Source Type: research

Maintenance proton pump inhibition therapy and risk of oesophageal cancer
Conclusion In conclusion, the long term use of PPIs is associated with increased risk of oesophageal adenocarcinoma in the absence of other risk factors. Long term use of PPIs should be addressed with caution. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - February 23, 2018 Category: Cancer & Oncology Source Type: research

Incidence of malignant lymphoma in adolescents and young adults in the 58 counties of California with varying synthetic turf field density
Conclusion Our findings in the state with the greatest number of such fields and a large, diverse patient population are consistent with those of a prior study observing no association between individual-level exposures to turf fields and cancer incidence. Avoidance of synthetic turf fields for fear of increased cancer risk is not warranted. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - February 23, 2018 Category: Cancer & Oncology Source Type: research

Disparity in breast cancer mortality by age and geography in 10 racially diverse US cities
Conclusions While the mortality rate for breast cancer is lower among younger women, the NHB:NHW disparities, as measured by rate ratios, are most pronounced in these age groups. Given the absence of available data regarding incidence, stage and subtypes, further research is necessary and such research is important, given the possible policy implications of these results with respect to screening guidelines and coverage for mammography and breast cancer treatment in particular for younger NHB women. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - February 23, 2018 Category: Cancer & Oncology Source Type: research

Incidence of haematological malignancies, Eastern Cape Province; South Africa, 2004 –2013
Conclusion Haematological malignancies in the Eastern Cape Province show disparities in gender and pathology-specific incidence patterns. The present study suggest that haematological malignancies are not uncommon in this region and the incidence rate of at least one rare subtype, APL, is comparable with some European populations. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - February 18, 2018 Category: Cancer & Oncology Source Type: research

Beasley ’s 1981 paper: The power of a well-designed cohort study to drive liver cancer research and prevention
Publication date: Available online 13 February 2018 Source:Cancer Epidemiology Author(s): Jill Koshiol, Zhiwei Liu, Thomas R. O’Brien, Allan Hildesheim The 1981 Lancet paper by Beasley et al., “Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22707 men in Taiwan” is a seminal publication that clearly demonstrated that chronic infection with hepatitis B virus (HBV), as measured by seropositivity for the hepatitis B surface antigen (HBsAg), preceded the development of hepatocellular carcinoma (HCC). In doing so, this study paved the way for liver cancer prevention efforts through the ...
Source: Cancer Epidemiology - February 14, 2018 Category: Cancer & Oncology Source Type: research

Exploring determinants of care-seeking behaviour of oral cancer patients in India: A qualitative content analysis
Conclusion The care-seeking path among oral cancer patients is complex, customised, and influenced by multiple patient-related and system-related factors. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - February 11, 2018 Category: Cancer & Oncology Source Type: research

Chemotherapy is administered to a minority of hospitalized patients with diffuse large B-cell lymphoma and is associated with less likelihood of death during hospitalization
Conclusion We identified socio-demographics and clinical characteristics associated with inpatient chemotherapy in DLBCL patients. Chemotherapy is associated with lower odds of death during hospitalization, suggesting that most chemotherapy is given appropriately to non-critically ill patients. Clinical acuity is a stronger predictor of death than socio-demographics. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - February 11, 2018 Category: Cancer & Oncology Source Type: research

Development and validation of a prognostic index for survival in non-small cell lung cancer: Results from a Tunisian cohort study
Conclusions This novel and simple prognostic tool could predict survival more accurately in patients with NSCLC. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - February 7, 2018 Category: Cancer & Oncology Source Type: research