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Specialty: Biochemistry
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Total 111164 results found since Jan 2013.
Inhibition of STIM1 alleviates high glucose-induced proliferation and fibrosis by inducing autophagy in mesangial cells
In this study, we investigated the role of STIM1 in the proliferation and fibrosis in high glucose (HG)-induced HBZY-1 cells. We found that the expression of STIM1 was increased in renal tissues of diabetic rat and HBZY-1 cells stimulated by HG. Downregulation of STIM1-mediated SOCE suppressed hyperglycemic cell proliferation and fibrosis by activating autophagy. In addition, the inhibitory effect of downregulating STIM1 on cells was blocked by autophagy inhibitor Bafilomycin A1 (BafA1). Moreover, this experiment also showed that STIM1 regulated autophagy, cell proliferation and fibrosis via PI3K/AKT/mTOR signal pathway. T...
Source: Molecular and Cellular Biochemistry - September 22, 2023 Category: Biochemistry Authors: Xixi Zeng Anbang Sun Weiyi Cheng Xin Hou Min Zhu Yanhong Liao Source Type: research
Chemical biology tools for protein labelling: insights into cell-cell communication
Biochem J. 2023 Sep 27;480(18):1445-1457. doi: 10.1042/BCJ20220309.ABSTRACTMulticellular organisms require carefully orchestrated communication between and within cell types and tissues, and many unicellular organisms also sense their context and environment, sometimes coordinating their responses. This review highlights contributions from chemical biology in discovering and probing mechanisms of cell-cell communication. We focus on chemical tools for labelling proteins in a cellular context and how these can be applied to decipher the target receptor of a signalling molecule, label a receptor of interest in situ to unders...
Source: The Biochemical Journal - September 21, 2023 Category: Biochemistry Authors: Megan H Wright Source Type: research
Michael D. Waterfield
Biochem J. 2023 Sep 27;480(18):1475-1478. doi: 10.1042/BCJ20230368.NO ABSTRACTPMID:37732645 | DOI:10.1042/BCJ20230368
Source: The Biochemical Journal - September 21, 2023 Category: Biochemistry Authors: Julian Downward Peter J Parker Bart Vanhaesebroeck Source Type: research
Identification of potential inhibitors against E.coli via novel approaches based on deep learning and quantum mechanics-based atomistic investigations
Arch Biochem Biophys. 2023 Sep 19:109761. doi: 10.1016/j.abb.2023.109761. Online ahead of print.ABSTRACTCurrently, drug resistance to commercially available antibiotics is imparting negative consequences to global health, and the development of novel antibiotics in a timely manner is a prime need of the hour. In the current study, an e-pharmacophore model was built using the 3D structure of DNA gyrase in complex with a standard inhibitor. The generated model was subjected to a pharmacophore based virtual screening against 45,257,086 molecules having 223,460,579 conformers available in MCULE database. Pharmacophore based sc...
Source: Archives of Biochemistry and Biophysics - September 21, 2023 Category: Biochemistry Authors: Mubashir Aziz Syeda Abida Ejaz Bshra A Alsfouk Ahlam Sultan Chen Li Source Type: research
Recent advances in chemical synthesis of structural domains of lipopolysaccharides from the commensal gut-associated microbiota
Chembiochem. 2023 Sep 20:e202300552. doi: 10.1002/cbic.202300552. Online ahead of print.ABSTRACTLipopolysaccharides from the commensal gut-associated microbiota are interesting biomolecules for the treatment of various inflammatory diseases. Different from pathogenic lipopolysaccharides, commensal lipopolysaccharides have distinct chemical structures and mediate beneficial homeostasis with the immune system of host. However, the accessibility issues of homogenous and pure commensal lipopolysaccharides hampered the in-depth studies of their functions. In this concept article, we highlight the recent synthesis of lipopolysac...
Source: Chembiochem - September 21, 2023 Category: Biochemistry Authors: Xiufang Wang Guozhi Xiao Source Type: research
Recent advances and future perspective on lignocellulose-based materials as adsorbents in diverse water treatment applications
Int J Biol Macromol. 2023 Sep 19:126984. doi: 10.1016/j.ijbiomac.2023.126984. Online ahead of print.ABSTRACTThe growing shortage of non-renewable resources and the burden of toxic pollutants in water have gradually become stumbling blocks in the path of sustainable human development. To this end, there has been great interest in finding renewable and environmentally friendly materials to promote environmental sustainability and combat harmful pollutants in wastewater. Of the many options, lignocellulose, as an abundant, biocompatible and renewable material, is the most attractive candidate for water remediation due to the ...
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: Weidong Xiao Ran Sun Sihai Hu Chengzhen Meng Bin Xie Mengying Yi Yaoguo Wu Source Type: research
Magnetic xanthan gum-silk fibroin hydrogel: A nanocomposite for biological and hyperthermia applications
Int J Biol Macromol. 2023 Sep 19:127005. doi: 10.1016/j.ijbiomac.2023.127005. Online ahead of print.ABSTRACTA magnetic xanthan hydrogel/silk fibroin nanobiocomposite (XG hydrogel/SF/Fe3O4) was designed, fabricated, and characterized using analyzing methods such as FT-IR, EDX, FE-SEM, XRD, TGA, and VSM to evaluate the exact structure of product nanobiocomposite. The FE-SEM images reveal the presence of spherical shapes exhibiting a narrow size range and homogeneous distribution, measuring between 30 and 35 nm in diameter. The VSM analysis demonstrates the superparamagnetic properties of the XG hydrogel/SF/Fe3O4 nanobiocompo...
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: Hooman Aghamirza Moghim Aliabadi Mohadeseh Forouzandeh-Malati Fereshte Hassanzadeh-Afruzi Ehsan Bahojb Noruzi Fatemeh Ganjali Amir Kashtiaray Milad Salimi Bani Reza Baradaran Eftekhari Reza Eivazzadeh-Keihan Ali Maleki Source Type: research
Network-supported and adaptable binding efficacy for flexible and multi-functionalized chitosan/phenolic carbaldehyde hydrogels
Int J Biol Macromol. 2023 Sep 19:127004. doi: 10.1016/j.ijbiomac.2023.127004. Online ahead of print.ABSTRACTA thoughtful strategy has been intended to control the hydrogel networking to assess the binding efficacy of multifunctional hydrogel. The processing of two distinct network-supported hydrogels has portrayed to express the operating interactions involved during co-existence with solvents, small molecules, biomolecules, etc. Herein, chitosan has separately functionalized in semisynthetic approaches with 4-hydroxyisopthalaldehyde (ChDA) and 2-hydroxybenzene-1,3,5-tricarbaldehyde (ChTA) to construct different gel networ...
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: Shubhankar Ghorai Biswajit Jana Jhuma Ganguly Source Type: research
Phenyl glycosides from < em > Bacopa monnieri < /em > with their antioxidant and anti-inflammatory activities
This study described the isolation and identification of one new, bacomoside D3 (1), and seven known phenyl glycosides (2 - 8). The structures of isolates were established by analysis of their spectroscopic data or hydrolysis followed by HPLC analysis together with a comparison to those reported in the literature. These compounds were evaluated for antioxidant and anti-inflammatory activities. Among them, compounds 4 and 5 exhibited strong DPPH radical scavenging activity with IC50 values of 9.77 ± 0.08 and 3.50 ± 0.04 µM, respectively. Compounds 2 and 5 significantly inhibited TNF-α production in LPS-stimulated RAW264...
Source: Natural Product Research - September 21, 2023 Category: Biochemistry Authors: Thi Phuong Anh Dinh Le Thi Thuy Nguyen Thi Thuy My Van Thong Nguyen Le Huyen Tram Tuan Anh Nguyen Dao Huy Toan Thu Huong Tran Thu Ha Tran Thanh Bui Van Nguyen Van Bach Source Type: research
Biological activities of the aerial and undergound parts of < em > Gymnadenia nigra < /em > Rchb.f. (syn. < em > Nigritella nigra < /em > (L.) Rchb. f.) from the Italian Alps
This study investigated the bioactivity of both aerial (GNAR) and underground (GNUG) parts of Gymnadenia nigra Rchb.f. (syn. Nigritella nigra (L.) Rchb. f.) (Orchidaceae). The obtained data proved interesting when the samples were tested in two adrenocortical cancer cell lines (SW13 and H295R). In particular, the GNAR 80% methanol extract distinctly inhibited their viability after 24 h at a concentration of 1 µg/µL by MTT assay and trypan blue dye exclusion method. Cell morphology evaluation by means Wright's staining also showed significant results, particularly in SW13 cells under the effect of both extracts. GNAR extr...
Source: Natural Product Research - September 21, 2023 Category: Biochemistry Authors: Sara Vitalini Beatrice Rubin Halenya Monticelli Susi Barollo Marco Redaelli Loris Bertazza Caterina Mian Maira Zorzan Stefania Garzoli Marcello Iriti Raffaele Pezzani Source Type: research
Insecticidal activity of extracts of < em > handroanthus impetiginosus < /em > on < em > Plutella xylostella < /em > (Lepidoptera: plutellidae) larvae
Nat Prod Res. 2023 Sep 21:1-8. doi: 10.1080/14786419.2023.2260069. Online ahead of print.ABSTRACTPlutella xylostella is considered the main pest of cabbage in Brazil and the world, causing damage of up to 100%. Thus, this study evaluated the insecticidal activity of extracts obtained from the fruits, seeds, bark, leaves, and flowers of Handroanthus impetiginosus against the diamondback moth, P. xylostella larvae. The seed extract showed the highest mortality (97.0%) compared to the control treatment. The LC50 values indicated that the seed and flower extracts (0.01003 and 0.01288 mg/L respectively) assumed the highest toxi...
Source: Natural Product Research - September 21, 2023 Category: Biochemistry Authors: Andriely B Silva Daniel L Montagnini Albert Katchborian-Neto Jo ão V Andrade Hallana A Manuquian Pedro S S R Cavallari Samarah G Almeida Enes P Barbosa Wilson R Cunha Marisi G Soares Mario F C Santos M árcio L A Silva Alessandra M Vacari Source Type: research
A new benzophenone derivative from < em > Aspergillus fumigatus < /em > WJ-131
Nat Prod Res. 2023 Sep 21:1-10. doi: 10.1080/14786419.2023.2260071. Online ahead of print.ABSTRACTA new benzophenone derivative, 8'-hydroxymonomethylsulochrin (1), together with eighteen known compounds (2-19) were produced by the endophytic fungus Aspergillus fumigatus WJ-131, isolated from the stem of Gardenia jasminoides. The structure of 1 was determined by extensive spectroscopic analysis and X-ray crystallography. Under the condition of concentration of 20.0 μM, the splenic lymphocytes proliferation rates of compounds 1 and 7 induced by LPS were 39.4% and 38.1% (LPS, the splenic lymphocytes cell proliferation rates ...
Source: Natural Product Research - September 21, 2023 Category: Biochemistry Authors: Jia-Qi Liu Sheng-Qi Zhang Xiu-Hong Wu Shuai-Xing Liu Rui-Dang Yang Liang Deng Le Cai Source Type: research
Network pharmacology and molecular docking to scientifically validate the potential mechanism of Lonicerae japonicae flos in the clinical treatment of COVID-19
Nat Prod Res. 2023 Sep 21:1-8. doi: 10.1080/14786419.2023.2260070. Online ahead of print.ABSTRACTUsing network pharmacology and molecular docking, we predicted the potential mechanisms of Lonicerae japonicae flos (LJF) therapy for COVID-19. A total of 493 component-related targets and 6,233 COVID-19-related genes were identified, and 267 core genes with overlapping of the two types of genes were identified. The target AKT1, CASP3, IL1B, IL6, PTGS2, TNF and JUN were the hub genes in PPI network according to MCODE score. Component-Target analysis showed the close relationship between targets and components. The results of fu...
Source: Natural Product Research - September 21, 2023 Category: Biochemistry Authors: Yisheng Huang Yan Fang Huanhuan Jie Hongbiao Yang Wen Zhou Yijian Chen Baolin Zhong Source Type: research
A new anthraquinone derivative from the marine fish-derived fungus < em > Alternaria < /em > sp. X112
Nat Prod Res. 2023 Sep 21:1-6. doi: 10.1080/14786419.2023.2258540. Online ahead of print.ABSTRACTA new anthraquinone, altermodinacid A (1), and five known derivatives, pachybasic acid (2), emodic acid (3), emodin (4), phomarin (5), and 1,7-dihydroxy-3-methylanthracene-9,10-dione (6), were discovered from a halotolerant fungus Alternaria sp. X112 isolated from a marine fish Gadus macrocephalus. Their structures were determined by analysing MS and NMR data. The cytotoxic effect, antiagricultural pathogens activity, antibacterial activity and quorum sensing inhibitory potential of new compound 1 were evaluated.PMID:37732591 |...
Source: Natural Product Research - September 21, 2023 Category: Biochemistry Authors: Xiaoyuan Xu Gang Li Rao Fu Hongxiang Lou Xiaoping Peng Source Type: research
Phytoremediation of Heavy Metal Contaminated Soil Using Bidens pilosa: Effect of Varying Concentrations of Sophorolipids
Appl Biochem Biotechnol. 2023 Sep 21. doi: 10.1007/s12010-023-04684-7. Online ahead of print.ABSTRACTThe current study investigates the impact of biosurfactant (sophorolipids, SL) concentrations (0.1 to 1 g kg-1) on the removal of cadmium (29 mg kg-1) from soil using Bidens pilosa. The results showed that increasing concentrations of SL increased the plant biomass. The dry weight of plants was 0.87 g, 0.77 g, 0.65 g, 0.85 g, 0.91 g, 0.92 g, 1.06 g in control, SL0 (No SL), SL1 (0.1 g kg-1), SL2 (0.25 g kg-1), SL3 (0.5 g kg-1), SL4 (0.75 g kg-1), and SL5 (1 g kg-1), respectively. It was observed that root length was higher i...
Source: Applied Biochemistry and Biotechnology - September 21, 2023 Category: Biochemistry Authors: Vijendra Shah Pooja Dani Achlesh Daverey Source Type: research
