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Specialty: Biochemistry
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Total 111164 results found since Jan 2013.
Dietary fat and lipid metabolism in the tumor microenvironment
Biochim Biophys Acta Rev Cancer. 2023 Sep 16:188984. doi: 10.1016/j.bbcan.2023.188984. Online ahead of print.ABSTRACTMetabolic reprogramming has been considered a core hallmark of cancer, in which excessive accumulation of lipids promote cancer initiation, progression and metastasis. Lipid metabolism is often considered as the digestion and absorption process of dietary fat, and the ways in which cancer cells utilize lipids are often influenced by the complex interactions within the tumor microenvironment. Among multiple cancer risk factors, obesity has a positive association with multiple cancer types, while diets like ca...
Source: Biochimica et Biophysica Acta - September 18, 2023 Category: Biochemistry Authors: Swagata Goswami Qiming Zhang Cigdem Elif Celik Ethan M Reich Ömer H Yilmaz Source Type: research
Inhibition of PP2A ameliorates intervertebral disc degeneration by reducing annulus fibrosus cells apoptosis via p38/MAPK signal pathway
CONCLUSIONS: This study suggests that the downregulation of PP2 A could reduce AF cell apoptosis and degeneration via the p38/MAPK pathway. It also revealed that the inhibition of PP2 A is expected to be a therapeutic target for IVDD.PMID:37722489 | DOI:10.1016/j.bbadis.2023.166888
Source: Biochimica et Biophysica Acta - September 18, 2023 Category: Biochemistry Authors: Pengfei Zhu Xiexing Wu Li Ni Kai Chen Zhongchen Dong Jiacheng Du Fanchen Kong Yubo Mao Huaqiang Tao Miao Chu Haiqin Mao Huilin Yang Qinbai Liu Minfeng Gan Dechun Geng Source Type: research
KDM5A noncanonically binds antagonists MLL1/2 to mediate gene regulation and promotes epithelial to mesenchymal transition
Biochim Biophys Acta Gene Regul Mech. 2023 Sep 16:194986. doi: 10.1016/j.bbagrm.2023.194986. Online ahead of print.ABSTRACTDifferential expression of genes involved in certain processes is a collaborative outcome of crosstalk between signalling molecules and epigenetic modifiers. In response to environmental stimulus, interplay between transcription factors and epigenetic modifiers together dictates the regulation of genes. MLLs and KDM5A are functionally antagonistic proteins, as one acts as a writer and the other erases the active chromatin mark, i.e., H3K4me3. KDM5A influences the process of EMT by binding to both epith...
Source: Biochimica et Biophysica Acta - September 18, 2023 Category: Biochemistry Authors: R Kirtana Soumen Manna Samir Kumar Patra Source Type: research
Histone mutations in cancer
Biochem Soc Trans. 2023 Sep 18:BST20210567. doi: 10.1042/BST20210567. Online ahead of print.ABSTRACTGenes encoding histone proteins are recurrently mutated in tumor samples, and these mutations may impact nucleosome stability, histone post-translational modification, or chromatin dynamics. The prevalence of histone mutations across diverse cancer types suggest that normal chromatin structure is a barrier to tumorigenesis. Oncohistone mutations disrupt chromatin structure and gene regulatory mechanisms, resulting in aberrant gene expression and the development of cancer phenotypes. Examples of oncohistones include the histo...
Source: Biochemical Society Transactions - September 18, 2023 Category: Biochemistry Authors: Kimberly N Espinoza Pereira Jixiu Shan Jonathan D Licht Richard L Bennett Source Type: research
Insights into the function of cytoglobin
Biochem Soc Trans. 2023 Sep 18:BST20230081. doi: 10.1042/BST20230081. Online ahead of print.ABSTRACTSince its discovery in 2001, the function of cytoglobin has remained elusive. Through extensive in vitro and in vivo research, a range of potential physiological and pathological mechanisms has emerged for this multifunctional member of the hemoglobin family. Currently, over 200 research publications have examined different aspects of cytoglobin structure, redox chemistry and potential roles in cell signalling pathways. This research is wide ranging, but common themes have emerged throughout the research. This review examine...
Source: Biochemical Society Transactions - September 18, 2023 Category: Biochemistry Authors: Brandon J Reeder Source Type: research
Corrigendum to "pH evaluation in the digestive tract of the pygmy octopus, Paroctopus digueti" Comparative Biochemistry and Physiology, Part B 269 (2024) 110881
Comp Biochem Physiol B Biochem Mol Biol. 2023 Sep 16;269:110897. doi: 10.1016/j.cbpb.2023.110897. Online ahead of print.NO ABSTRACTPMID:37722231 | DOI:10.1016/j.cbpb.2023.110897
Source: Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology. - September 18, 2023 Category: Biochemistry Authors: N Perales-Garc ía D Tovar-Ram írez M G Mart ínez-Morales B P Ceballos-V ázquez D A Corona-Rojas M A Salcedo-Meza A Garrido-Mora F Vega-Villasante H Nolasco-Soria Source Type: research
Circular RNA CSPP1 motivates renal cell carcinoma carcinogenesis and the Warburg effect by targeting RAC1 through microRNA-493-5p
Acta Biochim Pol. 2023 Sep 18;70(3):693-701. doi: 10.18388/abp.2020_6299.ABSTRACTCircular RNAs (circRNAs) take on regulatory roles in renal cell carcinoma (RCC). The research's goal was to figure out circ-CSPP1's role and molecular mechanism in RCC. The results clarified that circ-CSPP1 expression was enhanced in RCC. Down-regulating circ-CSPP1 refrained the proliferation, migration, invasion, and Warburg effect (aerobic glycolysis), but accelerated apoptosis of RCC cells. The luciferase activity assay exhibited that circ-CSPP1 could perform as an endogenous sponge for miR-493-5p. Elevating miR-493-5p repressed RCC progres...
Source: Acta Biochim Pol - September 18, 2023 Category: Biochemistry Authors: Dong Zhang XiaoJie Yang QiDong Luo DeLia Fu HongLiang Li Peng Zhang Chong Tie Source Type: research
circROCK1 Promotes septic myocardial injury through regulating miR-96-5p/OXSR1 axis
CONCLUSION: CircROCK1 promotes myocardial injury in septic mice by regulating the miR-96-5p/OXSR1 axis, and it can be used as a potential target for treating septic myocardial dysfunction.PMID:37721476 | DOI:10.18388/abp.2020_6547
Source: Acta Biochim Pol - September 18, 2023 Category: Biochemistry Authors: ZhiYu He Lingling Xu Xiaojun Zeng Biqing Yang Peiying Liu Dunzheng Han Hao Xue Bihui Luo Source Type: research
HDAC inhibitors: Promising agents for leukemia treatment
Biochem Biophys Res Commun. 2023 Sep 14;680:61-72. doi: 10.1016/j.bbrc.2023.09.023. Online ahead of print.ABSTRACTThe essential role of epigenetic modification in the pathogenesis of a series of cancers have gradually been recognized. Histone deacetylase (HDACs), as well-known epigenetic modulators, are responsible for DNA repair, cell proliferation, differentiation, apoptosis and angiogenesis. Studies have shown that aberrant expression of HDACs is found in many cancer types. Thus, inhibition of HDACs has provided a promising therapeutic approach alternative for these patients. Since HDAC inhibitor (HDACi) vorinostat was ...
Source: Biochemical and Biophysical Research communications - September 18, 2023 Category: Biochemistry Authors: Yun Deng Qian Cheng Jing He Source Type: research
Metabolomic Diversity in Microbial Mats Under Different Environmental Conditions: A Tool to Test Microbial Ecosystem Chemical Change
In this study, microbial mats from a small pond in the Cuatro Cienegas Basin in Coahuila, Mexico, were collected in wet and dry seasons. In addition to these samples, mesocosm experiments from the wet samples were set. These mats are elastic and rise after heavy rainfall by forming gas domes structures known as "Archean domes", by the outgassing of methanogenic bacteria, archaea, and sulfur bacteria. Extracts from all mats and mesocosms were subjected to untargeted mass spectrometry-based metabolomics and molecular networking analysis. Interestingly, each mat showed high chemical diversity that may be explained by the temp...
Source: Chemistry and Biodiversity - September 18, 2023 Category: Biochemistry Authors: Jhoselinne Buenrostro-Mu ñoz Scott A Jarmusch Valeria Souza Anah í Martínez-Cárdenas Carlos A Fajardo-Hern ández Itzel R Yeverino Luis E Eguiarte Mario Figueroa Source Type: research
Injectable and Self-Adaptive Gel Scaffold Based on Heparin Microspheres for Adipogenesis of Human Adipose-Derived Stem Cells
Biomacromolecules. 2023 Sep 18. doi: 10.1021/acs.biomac.3c00348. Online ahead of print.ABSTRACTAn injectable and self-adaptive heparin microsphere-based cell scaffold was developed to achieve adipose regeneration. Simultaneously, the cell scaffold exhibited a dynamic architecture, self-regulated glucose levels, sustained insulin delivery, and steady viscoelastic properties for adipogenesis. The dynamic cell scaffold is cross-linked by the boronate-diol interaction among heparin-based microspheres, which have boronate and maltose groups. Because of the boronate-maltose ester bonds, the gelatinous complex would be partially ...
Source: Biomacromolecules - September 18, 2023 Category: Biochemistry Authors: Xinyue Zhai Xinwei Tao Yuqian Wu Kesun Jin Huaping Tan Tianle Zhou Yong Chen Source Type: research
Continuous-Flow Microreactor Accelerates Molecular Collisions for Lignin Depolymerization to Phenolic Monomers and Oligomers
In this study, we developed a continuous-flow microreactor for depolymerization of lignin into monomeric and oligomeric compounds. The yields of monomers and oligomers can be adjusted by varying the temperature, pressure, residence time, NaOH dosage, and solvent. Under optimized conditions, the lignin conversion rate was 77.73 wt %, and the monomer yield was 13.26 wt %, with 77.81% being phenolic compounds. In addition, comparative characterizations on the raw lignin and products demonstrated that the oil products were mainly composed of phenolic tetramers and trimers, and the effective cleavage of the β-O-4 linkage of S-...
Source: Biomacromolecules - September 18, 2023 Category: Biochemistry Authors: Pengfei Lian Shuangjie Liu Zihao Ma Yongying Wang Ying Han Guangwei Sun Xing Wang Source Type: research
Polysaccharide-Based Double-Network Hydrogels: Polysaccharide Effect, Strengthening Mechanisms, and Applications
Biomacromolecules. 2023 Sep 17. doi: 10.1021/acs.biomac.3c00765. Online ahead of print.ABSTRACTPolysaccharides are carbohydrate polymers that are major components of plants, animals, and microorganisms, with unique properties. Biological hydrogels are polymeric networks that imbibe and retain large amounts of water and are the major components of living organisms. The mechanical properties of hydrogels are critical for their functionality and applications. Since synthetic polymeric double-network (DN) hydrogels possess unique network structures with high and tunable mechanical properties, many natural functional polysaccha...
Source: Biomacromolecules - September 18, 2023 Category: Biochemistry Authors: Pengguang Wang Qingyu Liao Hongbin Zhang Source Type: research
S100a9 inhibits Atg9a transcription and participates in suppression of autophagy in cardiomyocytes induced by β < sub > 1 < /sub > -adrenoceptor autoantibodies
CONCLUSION: Our research showed that β1-AAs increased S100a9 expression in cardiomyocytes and that S100a9 interacted with HIF-1α, which prevented HIF-1α from entering the nucleus normally, thus inhibiting the transcription of Atg9a. This resulted in autophagy inhibition and cardiac dysfunction.PMID:37723445 | PMC:PMC10506287 | DOI:10.1186/s11658-023-00486-1
Source: Cellular and Molecular Biology Letters - September 18, 2023 Category: Biochemistry Authors: Xiaoyan Zhi Shu Shi Yang Li Mingxia Ma Yaolin Long Chen Li Haihu Hao Huirong Liu Xiaohui Wang Li Wang Source Type: research
The emerging functions of mini zinc finger (MIF) microproteins in seed plants: A minireview
Biochimie. 2023 Sep 16:S0300-9084(23)00243-2. doi: 10.1016/j.biochi.2023.09.016. Online ahead of print.ABSTRACTMini zinc fingers constitute a class of microproteins that appeared early in evolution and expanded in seeds plants. In this review, the phylogenetic history, the functions and the mode of action of MIFs in plants are reported and discussed. It appears that mini zinc finger microproteins play an important role in the control of plant development. They are involved in the control of cell division and expansion and in the switch between the determinate/indeterminate state of the meristems. They are involved in the r...
Source: Biochimie - September 18, 2023 Category: Biochemistry Authors: Marie Rose Ndella Thiaw Pascal Gantet Source Type: research
