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Specialty: Biochemistry
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Total 111164 results found since Jan 2013.
The regulation of RGLG2-VWA by Ca < sup > 2+ < /sup > ions
Biochim Biophys Acta Proteins Proteom. 2023 Sep 19:140966. doi: 10.1016/j.bbapap.2023.140966. Online ahead of print.ABSTRACTRGLG2, an E3 ubiquitin ligase in Arabidopsis thaliana, affects hormone signaling and participates in drought regulation. Here, we determined two crystal structures of RGLG2 VWA domain, representing two conformations, open and closed, respectively. The two structures reveal that Ca2+ ions are allosteric regulators of RGLG2-VWA, which adopts open state when NCBS1(Novel Calcium ions Binding Site 1) binds Ca2+ ions and switches to closed state after Ca2+ ions are removed. This mechanism of allosteric regu...
Source: Biochimica et Biophysica Acta - September 21, 2023 Category: Biochemistry Authors: Mei-Ling Zhang Jia-Xiang Zhang Yan Liang Shi-Cheng Tian Shu-Yang Xie Tong Zhou Qin Wang Source Type: research
Long non-coding RNAs in non-small cell lung cancer: Implications for preventing therapeutic resistance
Biochim Biophys Acta Rev Cancer. 2023 Sep 19:188982. doi: 10.1016/j.bbcan.2023.188982. Online ahead of print.ABSTRACTLung cancer has the highest mortality and morbidity rates among all cancers worldwide. Despite many complex treatment options, including radiotherapy, chemotherapy, targeted drugs, immunotherapy, and combinations of these treatments, efficacy is low in cases of resistance to therapy, metastasis, and advanced disease, contributing to low overall survival. There is a pressing need for the discovery of novel biomarkers and therapeutic targets for the early diagnosis of lung cancer and to determine the efficacy ...
Source: Biochimica et Biophysica Acta - September 21, 2023 Category: Biochemistry Authors: Wenjuan Liu Bingli Zuo Wenting Liu Yanfei Huo Nasha Zhang Ming Yang Source Type: research
Defective insulin-stimulated equilibrative nucleoside transporter-2 activity and altered subcellular transporter distribution drive the loss of adenosine homeostasis in diabetic kidney disease progression
CONCLUSION: Deficient insulin regulation of ENT2 activity contributes to chronically high adenosine levels and glomerular alterations that underline diabetic kidney disease progression.PMID:37734469 | DOI:10.1016/j.bbadis.2023.166890
Source: Biochimica et Biophysica Acta - September 21, 2023 Category: Biochemistry Authors: Raibel Suarez Carolina Villarreal Yessica Nahuelp án Claudia Jara Carlos Oyarz ún Sebasti án Alarcón Montserrat M D íaz-Encarnación Elena Guill én-Gómez Claudia Quezada Rody San Mart ín Source Type: research
Phospholipid dependency of membrane protein insertion by the Sec translocon
Biochim Biophys Acta Biomembr. 2023 Sep 19:184232. doi: 10.1016/j.bbamem.2023.184232. Online ahead of print.ABSTRACTMembrane protein insertion into and translocation across the bacterial cytoplasmic membrane are essential processes facilitated by the Sec translocon. Membrane insertion occurs co-translationally whereby the ribosome nascent chain is targeted to the translocon via signal recognition particle and its receptor FtsY. The phospholipid dependence of membrane protein insertion has remained mostly unknown. Here we assessed in vitro the dependence of the SecA independent insertion of the mannitol permease MtlA into t...
Source: Biochimica et Biophysica Acta - September 21, 2023 Category: Biochemistry Authors: Max J den Uijl Arnold J M Driessen Source Type: research
pH-dependent conformational change within the Lassa virus transmembrane domain elicits efficient membrane fusion
Biochim Biophys Acta Biomembr. 2023 Sep 19:184233. doi: 10.1016/j.bbamem.2023.184233. Online ahead of print.ABSTRACTLassa virus (LASV) is the most prevalent member of the arenavirus family and the causative agent of Lassa fever, a viral hemorrhagic fever. Although there are annual outbreaks in West Africa, and recently isolated cases worldwide, there are no current therapeutics or vaccines, which poses LASV as a significant global public health threat. One of the key steps in LASV infection is the delivery of its genetic material by fusing its viral membrane with the host cell membrane. This process is facilitated by signi...
Source: Biochimica et Biophysica Acta - September 21, 2023 Category: Biochemistry Authors: Patrick M Keating Nicholas P Schifano Xinrui Wei Matthew Y Kong Jinwoo Lee Source Type: research
A comprehensive review on the emerging role of long non-coding RNAs in the regulation of NF- κB signaling in inflammatory lung diseases
This study explores the therapeutic potential of targeting lncRNAs and NF-κB signaling to alleviate inflammation and restore lung function. Understanding the intricate relationship between lncRNAs and NF-κB signaling could offer novel insights into disease mechanisms and identify therapeutic targets. Regulation of lncRNAs and NF-κB signaling holds promise as an effective approach for managing inflammatory lung disorders. This review aims to comprehensively analyze the interaction between lncRNAs and the NF-κB signaling pathway in the context of inflammatory lung diseases. It investigates the functional roles of lncRNAs...
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: Asif Ahmad Bhat Obaid Afzal Neetu Agrawal Riya Thapa Waleed Hassan Almalki Imran Kazmi Sami I Alzarea Abdulmalik Saleh Alfawaz Altamimi Neelima Kukreti Amlan Chakraborty Sachin Kumar Singh Kamal Dua Gaurav Gupta Source Type: research
Synthesis of lignin nanoparticle ‑manganese dioxide complex and its adsorption of methyl orange
Int J Biol Macromol. 2023 Sep 19:127012. doi: 10.1016/j.ijbiomac.2023.127012. Online ahead of print.ABSTRACTLignin nanoparticles (LNPs) were synthesized using the anti-solvent method and subsequently loaded with manganese dioxide (MnO2) via potassium permanganate treatment, resulting in the formation of MnO2@LNPs. An extensive investigation was conducted to elucidate the influence of MnO2@LNPs on the decolorization of methyl orange solution. The LNPs were successfully obtained by adjusting the preparation parameters, yielding particles exhibited an average size ranging from 300 to 600 nm, and the synthesis process exhibite...
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: Tian-Shui Guo Shao-Dong Yang Hua-Min Cui Qiong-Fen Yu Ming-Fei Li Source Type: research
Chitosan-based nanopesticides enhanced anti-fungal activity against strawberry anthracnose as "sugar-coated bombs"
Int J Biol Macromol. 2023 Sep 19:126947. doi: 10.1016/j.ijbiomac.2023.126947. Online ahead of print.ABSTRACTA chitosan-based nanoparticle was prepared using chitosan (CS) and O-carboxymethyl chitosan (O-CMCS). Our study revealed that chitosan/O-carboxymethyl chitosan/tebuconazole nanoparticles (CS/O-CMCS/TBA NPs) exhibited superior antifungal activity, foliar adhesion, and microbial target adhesion performance compared to commercial suspension concentrate (SC). The antifungal activity of CS/O-CMCS/TBA NPs against C. gloeosporioides, with a 3.13-fold increase in efficacy over TBA (SC). We also found that low concentrations ...
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: Jian Wu Jinzhe Chang Jun Liu Jiajian Huang Zixia Song Xiaofeng Xie Liting Wei Jiaxin Xu Suqing Huang Dongmei Cheng Youzhi Li Hanhong Xu Zhixiang Zhang Source Type: research
Recent findings in molecular reactions of E. coli as exposed to alkylated, nano- and ordinary chitosans
Int J Biol Macromol. 2023 Sep 19:127006. doi: 10.1016/j.ijbiomac.2023.127006. Online ahead of print.ABSTRACTThe antibacterial effects of chitosan have been widely studied, but the underlying molecular mechanisms are not fully understood. We investigated the molecular responses of Escherichia coli MG1655 cell, a model gram-negative bacterium, upon exposure to chitosan (Cs), alkylated Cs (AlkCs), and chitosan nanoparticles (CsNPs). Nine target genes involved in relevant signaling pathways (ompF, ompC, ompA, mrcA, mrcB, mgtA, glnA, kdpA, lptA) were selected for analysis. A significant reduction in the expression of mrcA, mgtA...
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: Vasighe Sadat Mirbagheri Alireza Alishahi Gholamreza Ahmadian Seyyed Hamidreza Hashemi Petroudi Seyed Mahdi Ojagh Gianfranco Romanazzi Source Type: research
Microalgal-based macro-hollow loofah fiber bio-composite for methylene blue removal: A promising step for a green adsorbent
According to this study, the loofah sponge with or without algal biofilm attachment could be applied as a low-cost efficient bio-sorbent for methylene blue removal from water. However, the loofah sponge's ability for biosorption was dramatically increased by the bio-attachment of microalgae, making it a more potent bio-sorbent. Likewise, this study offers insights into the variables influencing the biosorption capacity of loofah sponges and bio-attached loofah sponges, which could be beneficial for enhancing the biosorption processes.PMID:37734521 | DOI:10.1016/j.ijbiomac.2023.127009
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: Reda M Moghazy Rehab H Mahmoud Source Type: research
CALB1: A novel antiviral factor in chicken ileal mucus
In conclusion, we isolated and identified CALB1 from chicken intestinal mucus, which suppressed replication of avian viruses by regulating cellular calcium-ion homeostasis and autophagy.PMID:37734520 | DOI:10.1016/j.ijbiomac.2023.127007
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: Danqing Lu Yang Wu Mei Fu Yaotang Wu Zhisheng Wang Jian Lin Qian Yang Source Type: research
Hemicelluloses hydrogel: Synthesis, characterization, and application in dye removal
Int J Biol Macromol. 2023 Sep 19:127010. doi: 10.1016/j.ijbiomac.2023.127010. Online ahead of print.ABSTRACTNovel materials using biowaste as adsorbents in wastewater treatment have been allocated considerable interest. Herein, we present the synthesis of different hydrogels of crosslinked polyacrylamide in presence of hemicelluloses with/ without bentonite, using a soft reaction condition. The structure of new hydrogels was characterized by spectroscopic, thermal and microscopic experiments. The semi-interpenetrated network with hemicelluloses: 10 %; acrylamide 79 %; bentonite 10 %; N,N,N',N'-tetramethylethylenediamine: 1...
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: C A Rodr íguez-Ramírez Joana E Tasqu é Nancy Lis Garcia Norma B D'Accorso Source Type: research
Tough, recyclable and biocompatible carrageenan-modified polyvinyl alcohol ionic hydrogel with physical cross-linked for multimodal sensing
Int J Biol Macromol. 2023 Sep 19:126954. doi: 10.1016/j.ijbiomac.2023.126954. Online ahead of print.ABSTRACTBiocompatibility hydrogel conductors are considered as sustainable bio-electronic materials for the application of wearable sensors and implantable devices. However, they mostly face the limitations of mismatched mechanical properties with skin tissue and the difficulty of recycling. In this regard, here, a biocompatible, tough, reusable sensor based on physical crosslinked polyvinyl alcohol (PVA) ionic hydrogel modified with ι-carrageenan (ι-CG) helical network was reported. Through simulating the ion transport an...
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: Lingjun Zeng Bo Liu Lijie Duan Guanghui Gao Source Type: research
Modeling and investigation of swelling kinetics of sodium carboxymethyl cellulose/starch/citric acid superabsorbent polymer
Int J Biol Macromol. 2023 Sep 19:127013. doi: 10.1016/j.ijbiomac.2023.127013. Online ahead of print.ABSTRACTCrosslinked hydrophilic polymers with high water absorption rates are known as superabsorbent polymers (SAPs). Most commercial superabsorbent polymers are made with acrylic acid, which is difficult to biodegrade. So, in this investigation, carboxymethyl cellulose (CMC) was utilized as a significant component in the synthesis of polysaccharide-based SAPs. Citric acid (CA) and starch were chosen as crosslinking agents because they are more eco-friendly, non-toxic, and biodegradable than traditional crosslinking agents....
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: Cheera Prasad Seo Young Park Jai Sung Lee Jae Jun Park Yeonju Jang Sung Woo Lee Byoung-Min Lee You-Ree Nam A Karteek Rao Hyeong Yeol Choi Source Type: research
Linc00657 promoted pyroptosis in THP-1-derived macrophages and exacerbated atherosclerosis via the miR-106b-5p/TXNIP/NLRP3 axis
This study was designed to investigate the effects and underlying mechanisms of linc00657 in atherogenesis. The results showed that ox-LDL treatment significantly induced pyroptosis in human THP-1-derived macrophages. The secretion levels of LDH and pro-inflammatory factors were markedly enhanced, and the integrity of plasma membranes was disrupted in ox-LDL-treated THP-1-derived macrophages. These effects were significantly compensated after transfection with linc00657 siRNA and became more evident by linc00657 overexpression. Moreover, the effects of linc00657 overexpression on pyroptosis of THP-1-derived macrophages can...
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: Yin Liang Xiao-Dan Xu Xi Xu Yang-Bo Cai Zi-Xian Zhu Lin Zhu Kun Ren Source Type: research
