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Specialty: Biochemistry
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Total 111164 results found since Jan 2013.
Effects of tetrahydroxy stilbene glycoside derivatives on free radical damage and apoptosis in APP695V717I transgenic mice
Redox Rep. 2023 Dec;28(1):2259246. doi: 10.1080/13510002.2023.2259246. Epub 2023 Sep 20.ABSTRACTMitochondrial dysfunction leading to overproduction of oxygen free radicals is an important event in the development of Alzheimer's disease. Tetrahydroxy stilbene glycoside (TSG) is one of the main effective components of Polygonum multiflorum and has a certain free radical scavenging effect. We synthesized tetrahydroxy stilbene glycoside derivatives (Mito-TSGs) that can cross the mitochondrial membrane and may provide effective protection against Alzheimer's disease. This experiment investigates the protective mechanism of tetr...
Source: Redox Report : communications in free radical research - September 20, 2023 Category: Biochemistry Authors: Jun Qian Yun Li Yanyun Wang Qunying Ye Hongbo Luo Source Type: research
Maternal obstructive sleep apnea aggravates metabolic dysfunction-associated fatty liver disease via HMGB1-TLR4 signaling-mediated endoplasmic reticulum stress in male offspring rats
CONCLUSIONS: These findings indicate that MOSA can exert prolonged adverse effects manifested as metabolic dysfunction in male offspring. Therefore, surveillance and management of OSA during pregnancy may be necessary to prevent and alleviate MAFLD in offspring.PMID:37730152 | DOI:10.1016/j.bbadis.2023.166889
Source: Biochimica et Biophysica Acta - September 20, 2023 Category: Biochemistry Authors: Ruhua Wang Wei Feng Yan Wang Yonghong Jiang Yiguang Lin Xueqing Chen Source Type: research
Conserved residues at the family and subfamily levels determine enzyme activity and substrate binding in glycoside hydrolase family 13
Int J Biol Macromol. 2023 Sep 18:126980. doi: 10.1016/j.ijbiomac.2023.126980. Online ahead of print.ABSTRACTSite-directed mutagenesis is a valuable strategy for modifying enzymes, but the lack of understanding of conserved residues regulating glycosidase function hinders enzyme design. We analyzed 1662 enzyme sequences to identify conserved amino acids in maltohexaose-forming amylase at both family and subfamily levels. Several conserved residues at the family level (G37, P45, R52, Y57, D101, V103, H106, G230, R232, D234, E264, H330, D331, and G360) were found, mutations of which resulted in reduced enzyme activity or inac...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Shixia Xi Xiaofeng Ban Haocun Kong Caiming Li Zhengbiao Gu Zhaofeng Li Source Type: research
Macroporous and ultralight polyethyleneimine-grafted chitosan/nano-TiO < sub > 2 < /sub > foam as a novel adsorbent with antibacterial activity for the efficient U(VI) removal
Int J Biol Macromol. 2023 Sep 18:126966. doi: 10.1016/j.ijbiomac.2023.126966. Online ahead of print.ABSTRACTThe radioactive contamination from the excessive discharge of uranium-containing wastewater seriously threatens environmental safety and human health. Herein, macroporous and ultralight polyethyleneimine-grafted chitosan/nano-TiO2 composite foam (PCT) with antibacterial activity was synthesized, which could quickly remove U(VI) from solution. Among different PCT adsorbents, PCT-2 had the best adsorption performance for U(VI), which could be due to its honeycomb macroporous structures and the presence of abundant amin...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Xianqian Ao Limin Zhou Jieyun Jin Yanlin Liu Jinbo Ouyang Zhirong Liu Hamza Shehzad Source Type: research
The electron beam irradiation of collagen in the dry and gel states: The effect of the dose and water content from the primary to the quaternary levels
Int J Biol Macromol. 2023 Sep 18:126898. doi: 10.1016/j.ijbiomac.2023.126898. Online ahead of print.NO ABSTRACTPMID:37729990 | DOI:10.1016/j.ijbiomac.2023.126898
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Monika Šupová Tom áš Suchý Hynek Chlup Miloslav Šulc Tom áš Kotrč Lucie Šilingová Margit Žaloudková Šárka Rýglová Martin Braun David Chv átil Zden ěk Hrdlička Milan Hou ška Source Type: research
Effect of microwave followed by cooling on structural and digestive properties of pinh ão starch
Int J Biol Macromol. 2023 Sep 18:126981. doi: 10.1016/j.ijbiomac.2023.126981. Online ahead of print.ABSTRACTTo increase its resistant content, native pinhão starch was modified using a microwave (300 W, 90 s) and subsequently cooled at 4 °C for 4, 8, 16, 24, and 72 h. The results demonstrated that all starches exhibited a crystalline structure of type C, with decreased crystallinity after modification. In the modified samples, the ratio of peaks 1047/1022 cm-1 and 995/1022 cm-1, as identified by FTIR, indicated a reduction in the crystalline region and damage to the double helix structure of starch granules. DSC analysis...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Mariane Santos Dorneles Eduarda Silva de Azevedo Caciano Pelayo Zapata Nore ña Source Type: research
Heat sensitive E-helix cut ferritin nanocages for facile and high-efficiency loading of doxorubicin
In this study, we utilized the high-efficiency heat-sensitivity of the multiple channel switch structures of the E-helix-cut ferritin mutant (Ecut-HFn) and Cu2+ assistance to achieve high-efficiency loading of chemotherapeutic drugs in a one-step process at low temperatures. This method features mild reaction conditions (45 °C), high loading efficiency (about 110 doxorubicin (Dox) per Ecut-HFn), and improved protein and Dox recovery rates (with protein recovery rate around 94 % and Dox recovery rate reaching up to 45 %). The prepared ferritin-Dox particles (Ecut-HFn-Cu-Dox) exhibit a uniform size distribution, good stabil...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Haining Xia Huangtao Xu Jiarong Wang Changhao Wang Ruiguo Chen Tongxiang Tao Shuai Xu Jing Zhang Kun Ma Junfeng Wang Source Type: research
Atractylodes macrocephala Koidz polysaccharide improves glycolipid metabolism disorders through activation of aryl hydrocarbon receptor by gut flora-produced tryptophan metabolites
In this study, a heterogeneous acidic heteropolysaccharide with high molecular weight mainly composed of fructose was isolated from Atractylodes macrocephala Koidz (AMP). Supplementation with AMP was shown to improve diet-induced GMD in a rat model, including decreasing the levels of serum triglycerides, total cholesterol, and glucose, and improving hepatic lipidosis and islet cells morphologies. AMP-treated rats also exhibited modified intestinal flora with enrichments of intestinal Lactobacillus and Rothia species, which was accompanied by increased tryptophan metabolites such as indole-3-propionic acid, indole, tryptami...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Ziwen He Jingyan Guo Huiwen Zhang Jingjing Yu Yiqing Zhou Yajun Wang Ting Li Meiqiu Yan Bo Li Yigong Chen Suhong Chen Guiyuan Lv Jie Su Source Type: research
PMN-incorporated multifunctional chitosan hydrogel for postoperative synergistic photothermal melanoma therapy and skin regeneration
In this study, carboxymethyl chitosan, oxidized fucoidan and polyphenol-metal nanoparticle (PMN) of tannic acid capped gold nanoparticles were used to fabricate multifunctional nanocomposite hydrogels through Schiff base reaction. The prepared hydrogel demonstrated outstanding photothermal effect, and the controlled high temperature will rapidly kill melanoma cells as well as bacteria within 10 min. Good injectability, self-healing and adhesion combined with high reactive oxygen species (ROS) scavenging capacity, hemostasis and biocompatibility made this hydrogel platform perfect for the treatment of mice melanoma resectio...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Rong Chang Donghui Zhao Chen Zhang Kaiyue Liu Yuanmeng He Fangxia Guan Minghao Yao Source Type: research
Oyster (Crassostrea gigas) ferritin relieves lead-induced liver oxidative damage via regulating the mitophagy
This study aimed to investigate how oyster ferritin (GF1) attenuates lead-induced oxidative damage to the liver in vitro and in vivo. Animal experiments have confirmed that lead exposure can lead to oxidative damage and lipid peroxidation of the liver, and ferritin can regulate the activity of antioxidant enzymes and alleviate pathological changes in the liver. At the same time, oyster ferritin can regulate the expression of oxidative stress-related genes and reduce the expression of inflammasome-related genes. In addition, lead can induce apoptosis and mitophagy, leading to overproduction of reactive oxygen species and ce...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Han Li Xiaoyu Xia Shuzhen Cheng Jiachen Zang Zhenyu Wang Ming Du Source Type: research
Tough and antibacterial poly(l-lactic acid) composites prepared via blending with the bifunctional macromolecular ionomer
Int J Biol Macromol. 2023 Sep 18:126974. doi: 10.1016/j.ijbiomac.2023.126974. Online ahead of print.ABSTRACTIn order to expand the application of PLLA in the packaging field, improving its toughness and antibacterial activity has been widely concerned. However, seldom researches can simultaneously efficiently improve the toughness and antibacterial activity of PLLA by adding one kind of additions. To address above problems, the bifunctional branched poly(butylene adipate) ionomer additive (b-PBAUi) was synthesized. For b-PBAUi, its branched structure not only increased the plasticizing effect of additive, but also acted as...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Fang Wu Jie Tan Jin-Hui Wu Jun-Chi Zhou Yao Wu Source Type: research
Molecular insights into the structure destabilization effects of ECG and EC on the A β protofilament: An all-atom molecular dynamics simulation study
Int J Biol Macromol. 2023 Sep 18:127002. doi: 10.1016/j.ijbiomac.2023.127002. Online ahead of print.ABSTRACTThe formation of Aβ into amyloid fibrils was closely connected to AD, therefore, the Aβ aggregates were the primary therapeutic targets against AD. Previous studies demonstrated that epicatechin-3-gallate (ECG), which possessed a gallate moiety, exhibited a greater ability to disrupt the preformed Aβ amyloid fibrils than epicatechin (EC), indicating that the gallate moiety was crucial. In the present study, the molecular mechanisms were investigated. Our results demonstrated that ECG had more potent disruptive imp...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Rong-Zu Nie Shan-Shuo Zhang Xiao-Ke Yan Kun Feng Yan-Jing Lao Ya-Ru Bao Source Type: research
Synthesis of phytic acid-modified chitosan and the research of the corrosion inhibition and antibacterial properties
In this study, chitosan (CS) and phytic acid (PA) were employed as raw materials to synthesize a range of chitosan-phytic acid complexes (CP) with different ratios (CS:PA = 12:1, 9:1, 6:1, 3:1, 1:1). The structures and elemental compositions of the compounds were characterized using Fourier-Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy with Energy-Dispersive X-ray Spectroscopy (SEM-EDS). The thermal stability of the synthesized materials was analyzed using a Thermogravimetric Analyzer (TG). Electrochemical testing was conducted to explore the corrosion inhibition effect of the modified inhibitors...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Qing Yin Jiali Liu Zicheng Zhong Yueyuan Zhang Feiran Zhang Mingming Wang Source Type: research
Aminated yeast β-D-glucan for macrophage-targeted delivery of CpG oligodeoxynucleotides and synergistically enhanced cancer immunotherapy
Int J Biol Macromol. 2023 Sep 18:126998. doi: 10.1016/j.ijbiomac.2023.126998. Online ahead of print.ABSTRACTCpG oligodeoxynucleotides (CpG ODNs) activate immune system and show strong potential in cancer immunotherapy. However, therapeutic efficacy of CpG ODNs is hampered due to rapid nuclease degradation and insufficient cellular uptake. Delivery of CpG ODNs into antigen presenting cells (APCs) is vital to enhance their therapeutic efficacy. Herein, we developed a super-convenient yet efficient strategy for macrophage-targeted delivery of CpG ODNs and synergistically enhanced cancer immunotherapy. Aminated yeast β-D-gluc...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Huijie Zhang Zhiqing Wang Shuo Wang Jiawen Zhang Lipeng Qiu Jinghua Chen Source Type: research
Green synthesis of a chlorfenapyr chitosan nanopesticide for maize root application: Reducing environmental pollution and risks to nontarget organisms
Int J Biol Macromol. 2023 Sep 18:126988. doi: 10.1016/j.ijbiomac.2023.126988. Online ahead of print.ABSTRACTChlorfenapyr (CHL) is a pyrrole insecticide with a novel structure that is used to control resistant pests. However, its weak systemic activity limits its application to crop roots. Herein, a novel CHL formulation with improved effective utilization rates and suitability for root application is developed to avoid or reduce contamination caused by pesticide spraying. Accordingly, we prepared CHL@CS/CMCS nanoparticle (NP) suspensions with a particle size of approximately 100 nm using chitosan (CS) and carboxymethyl chi...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Qun Zheng Jiyingzi Wu Wenjuan Yan Shiqi Zhu Xiaoran Miao Ruifei Wang Suqing Huang Dongmei Cheng Peiwen Zhang Zhixiang Zhang Source Type: research
