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Specialty: Biochemistry
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Total 111164 results found since Jan 2013.
Remote ischemic preconditioning prevents sarcolemmal-associated proteolysis by MMP-2 inhibition
The objective was to determine if remote ischemic preconditioning (rIPC) preserves membrane-associated cytoskeletal proteins (dystrophin and β-dystroglycan) through the inhibition of metalloproteinase type 2 (MMP-2) activity. A second objective was to describe some of the intracellular signals of the rIPC, that modify mitochondrial function at the early reperfusion. Isolated rat hearts were subjected to 30 min of global ischemia and 120 min of reperfusion (I/R). rIPC was performed by 3 cycles of ischemia/reperfusion in the lower limb (rIPC). rIPC significantly decreased the infarct size, induced Akt/GSK-3 β phosphorylati...
Source: Molecular and Cellular Biochemistry - September 20, 2023 Category: Biochemistry Authors: Eliana P Bin Tamara Zaobornyj Mariana Garces Ver ónica D'Annunzio Bruno Buchholz Timoteo Marchini Pablo Evelson Ricardo J Gelpi Mart ín Donato Source Type: research
Interplay between SUMO1-related SUMOylation and phosphorylation of p65 promotes hepatocellular carcinoma progression
Biochim Biophys Acta Mol Cell Res. 2023 Sep 18:119595. doi: 10.1016/j.bbamcr.2023.119595. Online ahead of print.ABSTRACTThe nuclear factor kappaB (NF-κB) subunit p65, plays an important role in the progression of hepatocellular carcinoma (HCC). Phosphorylation of p65 is considered as an important mechanism for the positive regulation of NF-κB activity. According to our previous data, p65 can be SUMOylated by small ubiquitin-related modifier 1 (SUMO1) protein, and SUMO1 promotes p65 nuclear import and HCC progression. However, the effect of SUMO1-related p65 SUMOylation on NF-κB transcriptional activity and the relations...
Source: Biochimica et Biophysica Acta - September 20, 2023 Category: Biochemistry Authors: Can Jiang Chunyang Zhang Min Dai Fuyan Wang Sa Xu Dan Han Yanyan Wang Yajie Cao Yanyan Liang Ziyu Zhang Lina Yan Yujun Shen Kewu He Yuxian Shen Jun Liu Source Type: research
Protein tyrosine phosphatase 1B is a regulator of alpha-actinin4 in the glomerular podocyte
This study aims to uncover novel substrates of PTP1B in podocytes and validate a leading candidate. To this end, using substrate-trapping and mass spectroscopy, we identified putative substrates of this phosphatase and investigated the actin cross-linking cytoskeletal protein alpha-actinin4. PTP1B and alpha-actinin4 co-localized in murine and human glomeruli and transiently transfected E11 podocyte cells. Additionally, podocyte PTP1B deficiency in vivo and culture was associated with elevated tyrosine phosphorylation of alpha-actinin4. Conversely, reconstitution of the knockdown cells with PTP1B attenuated alpha-actinin4 t...
Source: Biochimica et Biophysica Acta - September 20, 2023 Category: Biochemistry Authors: Ming-Fo Hsu Yoshihiro Ito Jai Prakash Singh Shu-Fang Hsu Alan Wells Kuang-Yu Jen Tzu-Ching Meng Fawaz G Haj Source Type: research
Cisplatin-induced DNA crosslinks trigger neurotoxicity in C. elegans
Biochim Biophys Acta Mol Cell Res. 2023 Sep 18:119591. doi: 10.1016/j.bbamcr.2023.119591. Online ahead of print.ABSTRACTThe anticancer drug cisplatin (CisPt) injures post-mitotic neuronal cells, leading to neuropathy. Furthermore, CisPt triggers cell death in replicating cells. Here, we aim to unravel the relevance of different types of CisPt-induced DNA lesions for evoking neurotoxicity. To this end, we comparatively analyzed wild-type and loss of function mutants of C. elegans lacking key players of specific DNA repair pathways. Deficiency in ercc-1, which is essential for nucleotide excision repair (NER) and interstrand...
Source: Biochimica et Biophysica Acta - September 20, 2023 Category: Biochemistry Authors: Fabian Wynen Johannes Krautstrunk Lisa Marie M üller Viktoria Graf Vanessa Brinkmann Gerhard Fritz Source Type: research
Coevolution-based computational approach to detect resistance mechanism of epidermal growth factor receptor
Biochim Biophys Acta Mol Cell Res. 2023 Sep 18:119592. doi: 10.1016/j.bbamcr.2023.119592. Online ahead of print.ABSTRACTTyrosine kinase epidermal growth factor receptor (EGFR) correlates the neoplastic cell metastasis, angiogenesis, neoplastic incursion, and apoptosis. Due to the involvement of EGFR in these biological processes, it becomes a most potent target for treating non-small cell lung cancer (NSCLC). The tyrosine kinase inhibitors (TKI) have endorsed high efficacy and anticipation to patients but unfortunately, within a year of treatment, drug targets develop resistance due to mutations. The present study detected...
Source: Biochimica et Biophysica Acta - September 20, 2023 Category: Biochemistry Authors: Gyan Prakash Rai Asheesh Shanker Source Type: research
Noscapine alleviates unilateral ureteral obstruction-induced inflammation and fibrosis by regulating the TGF β1/Smads signaling pathways
Biochim Biophys Acta Mol Cell Res. 2023 Sep 18:119594. doi: 10.1016/j.bbamcr.2023.119594. Online ahead of print.ABSTRACTRenal fibrosis is a common pathway leading to progressive renal function loss in various forms of chronic kidney disease. Many fibrogenic factors regulate renal fibrosis; two key players are post-injury inflammation and transforming growth factor-β1 (TGF-β1)-induced myofibroblast differentiation. Myofibroblast differentiation is tightly regulated by the microtubule polymerization. Noscapine, an antitussive plant alkaloid, is a potent microtubule-interfering agent previously identified as a potential ant...
Source: Biochimica et Biophysica Acta - September 20, 2023 Category: Biochemistry Authors: Cheng-Chieh Hung Kuan-Hsing Chen Hsiang-Hao Hsu Ming-Yang Chang Yi-Ching Ko Huang-Yu Yang Chih-Wei Yang Source Type: research
Single-cell RNA sequencing atlas of peripheral blood mononuclear cells from subjects with coronary artery disease
CONCLUSIONS: Our study offered a detailed profiling of single-cell RNA sequencing of PBMCs from subjects with CADs and controls. These data provide a line of evidence that the JUN signaling pathway may be a potential diagnostic and therapeutic molecule target for CAD.PMID:37730128 | DOI:10.1016/j.bbamcr.2023.119593
Source: Biochimica et Biophysica Acta - September 20, 2023 Category: Biochemistry Authors: Xiaolong Song Yahong Fu Chengcheng Li Qiaowei Jia Mengmeng Ren Xin Zhang Hengjie Bie Hanxiao Zhou Xiongkang Gan Shu He Yanjun Wang Sheng Zhang Renyou Pan Weixin Sun Haitang Zhou Qimeng Ni Jun Song Qian Zhang Xiumei Chen Enzhi Jia Source Type: research
Quantification of Phytochemicals and Metal Ions as well as the Determination of Volatile Compounds, Antioxidant, Antimicrobial and Antacid Activities of the Mimosa pudica L. Leaf: Exploration of Neglected and Under-Utilized Part
Chem Biodivers. 2023 Sep 20:e202301049. doi: 10.1002/cbdv.202301049. Online ahead of print.ABSTRACTMimosa pudica L. (MP) is well-known plant in traditional medicinal system, especially in India. Unfortunately, leaves of MP are less explored. To determine the food and nutritional value of the neglected part of Mimosa pudica L. (MP), that is MP leaves, phytochemicals and metal ions of MP were quantified by newly developed HPLC and ICPOES-based methods. The content of phytochemicals observed using HPLC analysis for chlorogenic acid, catechin, and epicatechin was 141.823 (±8.171), 666.621 (±11.432), and 293.175 (±12.743) μ...
Source: Chemistry and Biodiversity - September 20, 2023 Category: Biochemistry Authors: Ms Yashika Gandhi Shyam Baboo Prasad Vijay Kumar Hemant Soni Hemant Rawat Sujeet K Mishra Jyotika Grewal Simranjeet Singh Vaibhav Charde Akhil Gupta Sudhanshu Kumar Jha Gagandeep Singh Smriti Tandon Akshada Mrkute Praveen C Ramamurthy Ch Venkata Narasimha Source Type: research
Maresin-1 prevents blood-spinal cord barrier disruption associated with TRPV4 elevation in the experimental model of spinal cord injury
Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Sep 18:159395. doi: 10.1016/j.bbalip.2023.159395. Online ahead of print.ABSTRACTRecently, we reported the TRPV4 ion channel activation and its association with secondary damage after spinal cord injury (SCI). TRPV4 activation is linked with blood-spinal cord barrier (BSCB) disruption, endothelial damage, and inflammation after SCI. Specialized pro-resolving mediators (SPM) are endogenous lipid mediators released for inflammation resolution. Studies suggest that SPM could act as an endogenous antagonist of ion channels directly or indirectly at the plasma membrane. Herein, we ...
Source: Biochimica et Biophysica Acta - September 20, 2023 Category: Biochemistry Authors: Zarna Pathak Tarang Jadav Abhishek Roy Manjeet Chopra Nidhi Singh Pinaki Sengupta Hemant Kumar Source Type: research
Polysaccharide-Based Composite Hydrogel with Hierarchical Microstructure for Enhanced Vascularization and Skull Regeneration
Biomacromolecules. 2023 Sep 20. doi: 10.1021/acs.biomac.3c00655. Online ahead of print.ABSTRACTCritical-size skull defects caused by trauma, infection, and tumor resection raise great demands for efficient bone substitutes. Herein, a hybrid cross-linked hierarchical microporous hydrogel scaffold (PHCLS) was successfully assembled by a multistep procedure, which involved (i) the preparation of poly(lactic-co-glycolic)/nanohydroxyapatite (PLGA-HAP) porous microspheres, (ii) embedding the spheres in a solution of dopamine-modified hyaluronic acid and collagen I (Col I) and cross-linking via dopamine polyphenols binding to (i)...
Source: Biomacromolecules - September 20, 2023 Category: Biochemistry Authors: Gonggong Lu Xiang Li Peilei Wang Xing Li Yuxiang Wang Jiayi Zhu Alfredo Ronca Ugo D'Amora Wenke Liu Xuhui Hui Source Type: research
Visible Light-Prompted Regioselective Synthesis of Novel 5-Aroyl/hetaroyl-2',4-dimethyl-2,4'-bithiazoles as DNA- and BSA-Targeting Agents
Biomacromolecules. 2023 Sep 20. doi: 10.1021/acs.biomac.3c00554. Online ahead of print.ABSTRACTOrganic transformations mediated by visible light have gained popularity in recent years as they are green, renewable, inexpensive, and clean and yield excellent products. The present study describes cyclo-condensation of 2-methylthiazole-4-carbothioamide with differently substituted α-bromo-1,3-diketones achieved by utilizing a white light-emitting diode (LED) (9W) to accomplish the regioselective synthesis of novel 5-aroyl/hetaroyl-2',4-dimethyl-2,4'-bithiazole derivatives as DNA/bovine serum albumin (BSA)-targeting agents. Th...
Source: Biomacromolecules - September 20, 2023 Category: Biochemistry Authors: Ranjana Aggarwal Naman Jain Gyan Prakash Dubey Snigdha Singh Ramesh Chandra Source Type: research
Assessment of the Alga < em > Cladophora glomerata < /em > as a Source for Cellulose Nanocrystals
Biomacromolecules. 2023 Sep 20. doi: 10.1021/acs.biomac.3c00380. Online ahead of print.ABSTRACTNanocellulose is isolated from cellulosic fibers and exhibits many properties that macroscale cellulose lacks. Cellulose nanocrystals (CNCs) are a subcategory of nanocellulose made of stiff, rodlike, and highly crystalline nanoparticles. Algae of the order Cladophorales are the source of the longest cellulosic nanocrystals, but manufacturing these CNCs is not well-studied. So far, most publications have focused on the applications of this material, with the basic manufacturing parameters and material properties receiving little a...
Source: Biomacromolecules - September 20, 2023 Category: Biochemistry Authors: Karl Mihhels Neptun Yousefi Jaanika Blomster Iina Solala Laleh Solhi Eero Kontturi Source Type: research
Applications and Challenges of Bacteriostatic Aptamers in the Treatment of Common Pathogenic Bacteria Infections
Biomacromolecules. 2023 Sep 20. doi: 10.1021/acs.biomac.3c00634. Online ahead of print.ABSTRACTThe continuous evolution and spread of common pathogenic bacteria is a major challenge in diagnosis and treatment with current biotechnology and modern molecular medicine. To confront this challenge, scientists urgently need to find alternatives for traditional antimicrobial agents. Various bacteriostatic aptamers obtained through SELEX screening are one of the most promising strategies. These bacteriostatic aptamers can reduce bacterial infection by blocking bacterial toxin infiltration, inhibiting biofilm formation, preventing ...
Source: Biomacromolecules - September 20, 2023 Category: Biochemistry Authors: Diandian Li Yuan Su Jie Li Rong Liu Bing Fang Jingjing He Wentao Xu Longjiao Zhu Source Type: research
A single amino acid substitution alters the vanillylamine synthesis activity of Capsicum pAMT
Biochem Biophys Res Commun. 2023 Sep 10;680:86-92. doi: 10.1016/j.bbrc.2023.09.011. Online ahead of print.ABSTRACTSome Capsicum synthesize a unique pungent alkaloid called capsaicin in their fruits. In the synthetic pathway of capsaicin, vanillylamine is produced from vanillin in a reaction catalyzed by a putative aminotransferase (pAMT). Therefore, the capsaicinoids content in the fruits is thought to partially depend on the characteristics of pAMT. Comparing Yume-matsuri (yume), C. annuum variety, and red habanero (RH), C. chinense variety, the vanillylamine synthesis activity of the placental extract was higher in yume ...
Source: Biochemical and Biophysical Research communications - September 20, 2023 Category: Biochemistry Authors: Kaori Sano Saika Nakasato Koji Nagata Kenji Kobata Source Type: research
Development and atomic structure of a new fluorescence-based sensor to probe heme transfer in bacterial pathogens
J Inorg Biochem. 2023 Sep 12;249:112368. doi: 10.1016/j.jinorgbio.2023.112368. Online ahead of print.ABSTRACTHeme is the most abundant source of iron in the human body and is actively scavenged by bacterial pathogens during infections. Corynebacterium diphtheriae and other species of actinobacteria scavenge heme using cell wall associated and secreted proteins that contain Conserved Region (CR) domains. Here we report the development of a fluorescent sensor to measure heme transfer from the C-terminal CR domain within the HtaA protein (CR2) to other hemoproteins within the heme-uptake system. The sensor contains the CR2 do...
Source: Journal of Inorganic Biochemistry - September 20, 2023 Category: Biochemistry Authors: Brendan J Mahoney Andrew K Goring Yueying Wang Poojita Dasika Anqi Zhou Emmitt Grossbard Duilio Cascio Joseph A Loo Robert T Clubb Source Type: research
