Phenyl glycosides from < em > Bacopa monnieri < /em > with their antioxidant and anti-inflammatory activities

This study described the isolation and identification of one new, bacomoside D3 (1), and seven known phenyl glycosides (2 - 8). The structures of isolates were established by analysis of their spectroscopic data or hydrolysis followed by HPLC analysis together with a comparison to those reported in the literature. These compounds were evaluated for antioxidant and anti-inflammatory activities. Among them, compounds 4 and 5 exhibited strong DPPH radical scavenging activity with IC50 values of 9.77 ± 0.08 and 3.50 ± 0.04 µM, respectively. Compounds 2 and 5 significantly inhibited TNF-α production in LPS-stimulated RAW264.7 cells with IC50 values of 40.60 ± 3.05 and 38.19 ± 1.75 µM, respectively. Furthermore, the active compounds could be efficient inhibitors of oxidants by interfering with the DPPH activity in silico study.PMID:37732634 | DOI:10.1080/14786419.2023.2258544

Source: Natural Product Research - September 21, 2023 Category: Biochemistry Authors: Thi Phuong Anh Dinh Le Thi Thuy Nguyen Thi Thuy My Van Thong Nguyen Le Huyen Tram Tuan Anh Nguyen Dao Huy Toan Thu Huong Tran Thu Ha Tran Thanh Bui Van Nguyen Van Bach Source Type: research