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Total 22096 results found since Jan 2013.

Patterns of PET-positive residual tissue at interim restaging and risk of treatment failure in advanced-stage Hodgkin's lymphoma: an analysis of the randomized phase III HD18 trial by the German Hodgkin Study Group
CONCLUSION: PET-2-positive residuals of AS-HL are mostly located in the mediastinum, and a majority of patients have few affected regions. The risk of progression was twofold higher in patients with more than two positive regions in PET-2.PMID:37735258 | DOI:10.1007/s00259-023-06431-w
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Justin Ferdinandus Lutz van Heek Katrin Roth Markus Dietlein Hans-Theodor Eich Christian Baues Peter Borchmann Carsten Kobe Source Type: research

Ultrasound-guided ablation techniques for thyroid lesions
Laryngorhinootologie. 2023 Sep 21. doi: 10.1055/a-2144-4132. Online ahead of print.ABSTRACTUltrasound-guided ablation techniques have been increasingly introduced into routine treatment of thyroid lesions as a complement to existing surgical therapies and radioiodine treatment. In cystic or predominantly cystic lesions instillation therapy (ethanol/polidocanol ablation) has yielded good results. Novel thermal ablation techniques, including radiofrequency ablation (RFA), microwave ablation (MWA), laser ablation (LA) and high intensity focused ultrasound (HIFU), induce irreversible cellular effects by locally applying temper...
Source: Nuklearmedizin - September 21, 2023 Category: Radiology Authors: Johannes-Paul Richter Carl-Philip Richter Daniel Gr öner Source Type: research

Improved daily estimates of relative humidity at high resolution across Germany: A random forest approach
Environ Res. 2023 Sep 19:117173. doi: 10.1016/j.envres.2023.117173. Online ahead of print.ABSTRACTThe lack of readily available methods for estimating high-resolution near-surface relative humidity (RH) and the incapability of weather stations to fully capture the spatiotemporal variability can lead to exposure misclassification in studies of environmental epidemiology. We therefore aimed to predict German-wide 1 × 1 km daily mean RH during 2000-2021. RH observations, longitude and latitude, modelled air temperature, precipitation and wind speed as well as remote sensing information on topographic elevation, vegetation, a...
Source: Environmental Research - September 21, 2023 Category: Environmental Health Authors: Nikolaos Nikolaou Laurens M Bouwer Marco Dallavalle Mahyar Valizadeh Massimo Stafoggia Annette Peters Kathrin Wolf Alexandra Schneider Source Type: research

Racism and discrimination in the context of health inequalities-a  narrative review
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2023 Sep 21. doi: 10.1007/s00103-023-03764-7. Online ahead of print.ABSTRACTRacism and discrimination as social determinants of health are becoming increasingly recognised in public health research in Germany. Studies show correlations with physical and mental health and even changes at the cellular level. In addition to the adverse health effects of interpersonal and direct discrimination, the relevance of structural and institutional racism for health inequalities has been little explored. This narrative review synthesises and critically discusses relevant an...
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - September 21, 2023 Category: International Medicine & Public Health Authors: Katja Kajikhina Carmen Koschollek Kayvan Bozorgmehr Navina Sarma Claudia H övener Source Type: research

Individualising the social? The history of insomnia around 1900
J Sleep Res. 2023 Sep 21:e14034. doi: 10.1111/jsr.14034. Online ahead of print.ABSTRACTUsing the example of the fin-de-siècle German Reich, this article outlines how insomnia emerged as a "disease of civilisation" in an industrialising society, defined by time-specific notions, reflecting and strengthening the social norms of the time. Furthermore, it analyses the process of individualisation and flexibilisation that transferred the social struggles and economic demands of modernity onto the subject's body or soul. The history of insomnia around 1900 thus reveals a pattern of thought that shaped the understanding of the i...
Source: Journal of Sleep Research - September 21, 2023 Category: Sleep Medicine Authors: Hannah Ahlheim Source Type: research

Current practice of outpatient rehabilitation services in patients with mobility-impaired paralysis due to stroke or spinal cord injury: a qualitative interview study in Germany
CONCLUSION: Areas of improvement identified focused on: setting rehabilitation goals towards participation, training therapists on evidence-based treatments and shared decision-making, updating the outpatient service catalogue, and implementing coordination actions. Implementation of these recommendations should be evaluated.PMID:37732606 | DOI:10.1080/09638288.2023.2259301
Source: Disability and Rehabilitation - September 21, 2023 Category: Rehabilitation Authors: Tiziana Daniel Tamara Spingler Andreas Hug Norbert Weidner Michel Wensing Charlotte Ullrich Source Type: research

Digital Health Applications in the Area of Mental Health —a Scoping Review
CONCLUSION: Most of the published studies display a high risk of bias, both because of the manufacturers' participation and because of methodological deficiencies. DiGA are an increasingly important therapeutic modality in psychiatry. The available evidence indicates that treatment effects are indeed present, but prospective comparisons with established treatments are still entirely lacking.PMID:37732500 | DOI:10.3238/arztebl.m2023.0208
Source: Deutsches Arzteblatt International - September 21, 2023 Category: General Medicine Authors: Stefanie Schreiter Lea Mascarell-Maricic Orestis Rakitzis Constantin Volkmann Jakob Kaminski Martin Andr é Daniels Source Type: research

Synthetic cannabinoids in hair —Prevalence of use in abstinence control programs for driver's license regranting in Germany
Synthetic cannabinoids (SCs) have steadily increased on the drug market but are rarely analyzed in abstinence control programs for driver's license regranting. Between March 2020 and March 2021, hair samples from this collective were retrospectively screened for SCs by liquid chromatography –tandem mass spectrometry (LC–MS/MS) analysis, and those testing positive were additionally screened by liquid chromatography-high resolution time of flight mass spectrometry (LC-qTOF/MS). AbstractAlthough the use, structural variety, and prevalence of synthetic cannabinoids (SCs) have steadily increased on the drug market, they are...
Source: Drug Testing and Analysis - September 21, 2023 Category: Drugs & Pharmacology Authors: Johannes Kutzler, Aldo Eliano Polettini, Sergej Bleicher, Christoph Sauer, Wolfgang Schultis, Merja A. Neukamm, Volker Auw ärter Tags: RESEARCH ARTICLE Source Type: research

Health of people with selected citizenships in Germany: prevalence of non-communicable diseases and associated social as well as migration-related factors
DISCUSSION: Given the importance of subjective sense of belonging to the society in Germany and self-reported experience of discrimination for the health outcomes studied, the results point to health inequalities among people with selected citizenships that may indicate mechanisms of social exclusion.PMID:37728772 | DOI:10.1007/s00103-023-03767-4
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - September 20, 2023 Category: International Medicine & Public Health Authors: Susanne Bartig Marleen Bug Carmen Koschollek Katja Kajikhina Miriam Blume Manuel Siegert Christin Heidemann Lena Walther Hannelore Neuhauser Claudia H övener Source Type: research

Exploring experiences of times without care and encounters in dementia: protocol for a living and adaptive evidence map
Introduction Individuals with dementia spend most of the day without care, without encounters, and usually without activity. Although this has been proven in studies, there is a knowledge gap on how individuals with dementia experience these periods of time. Such knowledge would be highly relevant for health professionals and relatives to develop adequate strategies for dealing with these periods of time. The FreiZeit study aims to reconstruct periods of time without care and encounters from the perspective of individuals with dementia and formal and informal carers. The specific objective of this review is to provide a co...
Source: BMJ Open - September 20, 2023 Category: General Medicine Authors: Hirt, J., Adlbrecht, L., Maurer, C., Beer, T. Tags: Open access, Public health Source Type: research

Global Bibliometric Analysis of Leishmaniasis Literature for the Last 20 Years and Investigating the Contribution of T ürkiye
CONCLUSION: The number of publications, especially in endemic areas, was found to be limited other than Brazil. Studies in this area should be supported to ensure the eradication of the disease.PMID:37724362 | DOI:10.4274/tpd.galenos.2023.76376
Source: Turkish Society for Parasitology - September 19, 2023 Category: Parasitology Authors: Sevil Alkan O ğuz Evlice Mustafa Serhat Şahinoğlu Source Type: research

Ranitidine Use and Incident Cancer in a Multinational Cohort
CONCLUSIONS AND RELEVANCE: In this cohort study, ranitidine use was not associated with an increased risk of cancer compared with the use of other H2RAs. Further research is needed on the long-term association of ranitidine with cancer development.PMID:37725377 | DOI:10.1001/jamanetworkopen.2023.33495
Source: Cancer Control - September 19, 2023 Category: Cancer & Oncology Authors: Seng Chan You Seung In Seo Thomas Falconer Chen Yanover Talita Duarte-Salles Sarah Seager Jose D Posada Nigam H Shah Phung-Anh Nguyen Yeesuk Kim Jason C Hsu Mui Van Zandt Min-Huei Hsu Hang Lak Lee Heejoo Ko Woon Geon Shin Nicole Pratt Rae Woong Park Chris Source Type: research

Axial length elongation profiles from 3 to 6 years in an Asian paediatric population: the Growing Up in Singapore Towards Healthy Outcomes birth cohort study (GUSTO)
CONCLUSION: In this preschool cohort, AL elongates at an average length of 0.80 mm from 3 to 6 years, with myopes demonstrating the greatest elongation. The differences in 95th percentile limits for AL elongation between myopes, emmetropes and hyperopes can be valuable information in identifying myopia development in preschool children.PMID:37726156 | DOI:10.1136/bjo-2023-323906
Source: The British Journal of Ophthalmology - September 19, 2023 Category: Opthalmology Authors: David Ziyou Chen Charlene Wong Janice Sing Harn Lam Chen-Hsin Sun Yien Lai Victor Teck Chang Koh Yap-Seng Chong Seang-Mei Saw Yih-Chung Tham Cheryl Ngo Source Type: research

Silicone hydrogel versus hydrogel soft contact lenses for differences in patient-reported eye comfort and safety
CONCLUSIONS: The overall evidence for a difference between all included silicone hydrogel and hydrogel SCLs was of very low certainty, with most trials at high overall risk of bias. The majority of studies did not assess comfort using a validated instrument. There was insufficient evidence to support recommending one SCL material over the other. For extended wear, hydrogel SCL may have a lower risk of adverse events at 52 weeks compared to silicon hydrogel. Future well-designed trials are needed to generate high certainty evidence to further clarify differences in SCL material comfort and safety.PMID:37724689 | PMC:PMC1050...
Source: Cochrane Database of Systematic Reviews - September 19, 2023 Category: General Medicine Authors: Kristina Haworth Darian Travis Louis Leslie Daniel Fuller Andrew D Pucker Source Type: research