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The effect of polymeric binder type and concentration on flow and dissolution properties of SMEDDS loaded mesoporous silica-based granules
This study investigated the effect of six polymeric binders' addition to granulation dispersion (GD) (povidone K30, povidone K90, copovidone, Pharmacoat® 603, Pharmacoat® 615 and MethocelTM K100 Premium LV) on characteristics of produced SMEDDS granules, prepared by wet granulation. By incorporation of polymer in GD, it was possible to produce mesoporous silica-based free-flowing granules, with preserved self-microemulsifying properties, responsible for improved in vitro release of carvedilol. The incorporation of higher molecular weight binders resulted in slower in vitro release, while high binder concentration was rel...
Source: European Journal of Pharmaceutical Sciences - September 14, 2023 Category: Drugs & Pharmacology Authors: Mila Kova čević Alenka Zvonar Pobirk Ilija German Ili ć Source Type: research
Work Participation after Multimodal Rehabilitation due to Cardiovascular Diseases - Representative Analyses using Routine Data of the German Pension Insurance
CONCLUSION: For the first time, representative data on occupational participation following rehabilitation on behalf of the GPI are available for the disease groups considered. The analyses underline the need to focus on occupational perspectives already in medical rehabilitation or directly thereafter.PMID:37709287 | DOI:10.1055/a-2133-2552
Source: Die Rehabilitation - September 14, 2023 Category: Rehabilitation Authors: Marco Streibelt Pia Zollmann Heinz V öller Johannes Falk Annett Salzwedel Source Type: research
The effect of polymeric binder type and concentration on flow and dissolution properties of SMEDDS loaded mesoporous silica-based granules
This study investigated the effect of six polymeric binders' addition to granulation dispersion (GD) (povidone K30, povidone K90, copovidone, Pharmacoat® 603, Pharmacoat® 615 and MethocelTM K100 Premium LV) on characteristics of produced SMEDDS granules, prepared by wet granulation. By incorporation of polymer in GD, it was possible to produce mesoporous silica-based free-flowing granules, with preserved self-microemulsifying properties, responsible for improved in vitro release of carvedilol. The incorporation of higher molecular weight binders resulted in slower in vitro release, while high binder concentration was rel...
Source: European Journal of Pharmaceutical Sciences - September 14, 2023 Category: Drugs & Pharmacology Authors: Mila Kova čević Alenka Zvonar Pobirk Ilija German Ili ć Source Type: research
Is More Always Better? Testing the Addition Bias for German Language Statistics
Cogn Sci. 2023 Sep;47(9):e13339. doi: 10.1111/cogs.13339.ABSTRACTThis replication study aims to investigate a potential bias toward addition in the German language, building upon previous findings of Winter and colleagues who identified a similar bias in English. Our results confirm a bias in word frequencies and binomial expressions, aligning with these previous findings. However, the analysis of distributional semantics based on word vectors did not yield consistent results for German. Furthermore, our study emphasizes the crucial role of selecting appropriate translational equivalents, highlighting the significance of c...
Source: Cognitive Science - September 14, 2023 Category: Neuroscience Authors: Sascha Wolfer Source Type: research
Work Participation after Multimodal Rehabilitation due to Cardiovascular Diseases - Representative Analyses using Routine Data of the German Pension Insurance
CONCLUSION: For the first time, representative data on occupational participation following rehabilitation on behalf of the GPI are available for the disease groups considered. The analyses underline the need to focus on occupational perspectives already in medical rehabilitation or directly thereafter.PMID:37709287 | DOI:10.1055/a-2133-2552
Source: Die Rehabilitation - September 14, 2023 Category: Rehabilitation Authors: Marco Streibelt Pia Zollmann Heinz V öller Johannes Falk Annett Salzwedel Source Type: research
Promoting the systematic use of real-world data and real-world evidence for digital health technologies across Europe: a consensus framework
Health Econ Policy Law. 2023 Sep 14:1-16. doi: 10.1017/S1744133123000208. Online ahead of print.ABSTRACTDespite the acceleration in the use of digital health technologies across different aspects of the healthcare system, the full potential of real-world data (RWD) and real-world evidence (RWE) arising from the technologies is not being utilised in decision-making. We examine current national efforts and future opportunities to systematically use RWD and RWE in decision-making in five countries (Estonia, Finland, Germany, Italy and the United Kingdom), and then develop a framework for promotion of the systematic use of RWD...
Source: Health Economics, Policy, and Law - September 14, 2023 Category: Health Management Authors: Divya Srivastava Cornelia Henschke Lotta Virtanen Eno-Martin Lotman Rocco Friebel Vittoria Ardito Francesco Petracca Source Type: research
Navigating carbon emissions in G-7 economies: a quantile regression analysis of environmental-economic interplay
This study employs panel data from 1990 to 2020 for the G-7 countries (Canada, France, Germany, Italy, Japan, the UK, and the USA) and employs the examination of heterogeneous slope coefficients and cross-sectional dependence tests as preliminary steps before conducting cointegration analysis and second-generation unit-root tests. This study employs the method of movement quantile regression (MMQR) to analyze long-run and short-run relationships. The findings from the MMQR model indicate that economic growth and imports have a negative impact on consumption-based CO2 (CCO2) emissions, which worsens at higher quantiles. On ...
Source: Environmental Science and Pollution Research International - September 14, 2023 Category: Environmental Health Authors: Bowen Luo Arshad Ahmad Khan Xiaoming Wu Hongxia Li Source Type: research
Promoting the systematic use of real-world data and real-world evidence for digital health technologies across Europe: a consensus framework
Health Econ Policy Law. 2023 Sep 14:1-16. doi: 10.1017/S1744133123000208. Online ahead of print.ABSTRACTDespite the acceleration in the use of digital health technologies across different aspects of the healthcare system, the full potential of real-world data (RWD) and real-world evidence (RWE) arising from the technologies is not being utilised in decision-making. We examine current national efforts and future opportunities to systematically use RWD and RWE in decision-making in five countries (Estonia, Finland, Germany, Italy and the United Kingdom), and then develop a framework for promotion of the systematic use of RWD...
Source: Health Economics, Policy, and Law - September 14, 2023 Category: Health Management Authors: Divya Srivastava Cornelia Henschke Lotta Virtanen Eno-Martin Lotman Rocco Friebel Vittoria Ardito Francesco Petracca Source Type: research
Association between Expanded Disability Status Scale score and dietary antioxidant capacity in patients with multiple sclerosis
Braz J Med Biol Res. 2023 Sep 8;56:e12776. doi: 10.1590/1414-431X2023e12776. eCollection 2023.ABSTRACTMultiple sclerosis (MS), a neuroinflammation that results in neurodegeneration, is the most prevalent central nervous system inflammatory disease in young people. A diet rich in antioxidants is known to decrease the production/activity of pro-inflammatory cytokines and have a positive impact on the prognosis of MS. The purpose of this study was to assess if dietary antioxidant capacity is related to Expanded Disability Status Scale (EDSS) scores in patients with MS. Patients with MS (n=220; 137 women and 83 men) were asked...
Source: Braz J Med Biol Res - September 13, 2023 Category: Research Authors: S Mungan I Guzel B C Demirdogen Source Type: research
Relaxing radial retinal incisions for the treatment of persistent macular holes
CONCLUSION: The results of this limited case series suggest that radial retinal incisions of the rim in persistent macula holes after initial surgery with ILM peeling increase the success rate of macula hole closure and results in a relevant increase in BCVA. However, as the number of eyes included in this series is limited, the results must be confirmed in a study with a larger sample size.PMID:37700600 | DOI:10.1177/11206721231201662
Source: European Journal of Ophthalmology - September 13, 2023 Category: Opthalmology Authors: Camenzind-Zuche Hanna Janeschitz-Kriegl Lucas Hasler Pascal Pr ünte Christian Source Type: research
