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Total 1197 results found since Jan 2013.

Clinicopathological Characteristics, Prognosis, and Correlated Tumor Cell Function of Tropomodulin-3 in Pancreatic Adenocarcinoma
CONCLUSION: Our study shows that TMOD3 may be associated with the progression of PAAD cells, and that it is an independent risk factor for poor pathological features and prognosis of PAAD. It may be helpful as a prognostic indicator of clinical outcomes in PAAD patients.PMID:37563820 | DOI:10.2174/1386207326666230810142646
Source: Combinatorial Chemistry and High Throughput Screening - August 11, 2023 Category: Chemistry Authors: Bin Zhong Dan-Dan Ma Tao Zhang Qi Gong Y I Dong Jian-Xin Zhang Zhong-Hu Li Wei-Dong Jin Source Type: research

Molecules, Vol. 28, Pages 5934: Caspase-1 Regulates the Apoptosis and Pyroptosis Induced by Phthalocyanine Zinc-Mediated Photodynamic Therapy in Breast Cancer MCF-7 Cells
o Chunhui Xia Photodynamic therapy (PDT) is an innovative and perspective antineoplastic therapy. Tetra-α-(4-carboxyphenoxy) phthalocyanine zinc (TαPcZn)-mediated PDT (TαPcZn-PDT) has shown antitumor activity in some tumor cells, but the manner in which caspase-1 is involved in the regulation of apoptosis and pyroptosis in the TαPcZn-PDT-treated breast cancer MCF-7 cells is unclear. Therefore, effects of TαPcZn-PDT on cytotoxicity, cell viability, apoptosis, pyroptosis, cellular reactive oxygen species (ROS), mitochondrial membrane potential (&...
Source: Molecules - August 8, 2023 Category: Chemistry Authors: Chunjie Ma Yu Wang Wei Chen Ting Hou Honglian Zhang Hongguang Zhang Xu Yao Chunhui Xia Tags: Article Source Type: research

Molecules, Vol. 28, Pages 5335: Dendritic Mesoporous Organosilica Nanoparticles with Photosensitizers for Cell Imaging, siRNA Delivery and Protein Loading
In conclusion, DMON are versatile nanoparticles capable of loading siRNA and delivering it into cancer cells, and also loading FVIII protein with good DLC. Due to the presence of tetrasulfide, it was not possible to perform PDT or PCI.
Source: Molecules - July 11, 2023 Category: Chemistry Authors: Haneen Omar Sara Jakimoska Julia Guillot Edreese Alsharaeh Clarence Charnay Fr édérique Cunin Aur élie Bessière Jean-Olivier Durand Laurence Raehm Laure Lichon M élanie Onofre Magali Gary-Bobo Tags: Article Source Type: research

Synthesis and characterization of novel cationic lipid: Efficient siRNA delivery and anticancer activity of survivin-siRNA lipoplexes for the treatment of lung and breast cancers
ChemMedChem. 2023 Jun 12:e202300097. doi: 10.1002/cmdc.202300097. Online ahead of print.ABSTRACTSurvivin has been shown to be widely expressed in most tumor cells, including lung and breast cancers. Due to limited siRNA delivery, it is more challenging to target survivin using knockdown-based techniques. The cationic lipids deliver small interfering RNA (siRNA) and also display inherent anti-cancer activities; therefore, cationic lipid therapies have become very popular for treating malignant cancers. In the current study, we attempted to synthesize a series of acid-containing cationic lipids, anthranilic acid-containing m...
Source: ChemMedChem - June 12, 2023 Category: Chemistry Authors: Sandeep Vaidya Annie Mohod Abhisheik Chowdary Eedara Sai Balaji Andugulapati Srihari Pabbaraja Source Type: research

Molecules, Vol. 28, Pages 4569: The Transport and Uptake of Resveratrol Mediated via Glucose Transporter 1 and Its Antioxidant Effect in Caco-2 Cells
This study investigated the role of resveratrol in the uptake, transport, and alleviation of H2O2-induced oxidative damage in Caco-2 cells. In the Caco-2 cell transport model, it was observed that the uptake and transport of resveratrol (10, 20, 40, and 80 μM) were time dependent and concentration dependent. Different temperatures (37 °C vs. 4 °C) could significantly affect the uptake and transportation of resveratrol. The apical to basolateral transport of resveratrol was markedly reduced by STF-31, a GLUT1 inhibitor, and siRNA intervention. Furthermore, resveratrol pretreatment (80 &...
Source: Molecules - June 6, 2023 Category: Chemistry Authors: Zhen-Dong Zhang Qi Tao Li-Xia Bai Zhe Qin Xi-Wang Liu Shi-Hong Li Ya-Jun Yang Wen-Bo Ge Jian-Yong Li Tags: Article Source Type: research

Molecules, Vol. 28, Pages 4204: Triggering RNA Interference by Photoreduction under Red Light Irradiation
khir RNA interference (RNAi) using small interfering RNAs (siRNAs) is a powerful tool to target any protein of interest and is becoming more suitable for in vivo applications due to recent developments in RNA delivery systems. To exploit RNAi for cancer treatment, it is desirable to increase its selectivity, e.g., by a prodrug approach to activate the siRNAs upon external triggering, e.g., by using light. Red light is especially well suited for in vivo applications due to its low toxicity and higher tissue penetration. Known molecular (not nanoparticle-based) red-light-activatable siRNA prodrugs rely on singlet oxygen ...
Source: Molecules - May 20, 2023 Category: Chemistry Authors: Jennifer R ühle Insa Klemt Andriy Mokhir Tags: Article Source Type: research

Advances in chitosan-based drug delivery systems in melanoma: A narrative review
Curr Med Chem. 2023 May 18. doi: 10.2174/0929867330666230518143654. Online ahead of print.ABSTRACTMelanoma accounts for the minority of skin cancer cases. However, it has the highest mortality rate among the subtypes of skin cancer. At the early stages of the disease, patients show a good prognosis after the surgery, but developing metastases leads to a remarkable drop in patients' 5-year survival rate. Despite the advances made in the therapeutic approaches to this disease, melanoma treatment is still facing several obstacles. Systemic toxicity, water insolubility, instability, lack of proper biodistribution, inadequate c...
Source: Current Medicinal Chemistry - May 19, 2023 Category: Chemistry Authors: Parisa Maleki Dana Jamal Hallajzadeh Zatollah Asemi Mohammad Ali Mansournia Bahman Yousefi Source Type: research

Synthesis and characterization of novel (S)-5'-C-aminopropyl-2'-fluorouridine modified oligonucleotides as therapeutic siRNAs
In this study, we designed and synthesized (S)-5'-C-aminopropyl-2'-fluorouridine (5'-AP-2'-FU) and evaluated the properties of siRNAs containing this analog. A comparative thermodynamic study revealed the enhanced thermal stability of double-stranded RNAs (dsRNAs) containing 5'-AP-2'-FU in a position-specific manner, whereas (S)-5'-C-aminopropyl-2'-O-methyluridine (5'-AP-2'-MoU)-modified dsRNAs exhibited lower melting temperatures. This improved thermal stability of RNA duplexes is attributed to favorable entropy loss, which induces the duplex into an N-type (C3'-endo) conformation and enhances duplex binding in this case....
Source: Bioorganic and Medicinal Chemistry - May 17, 2023 Category: Chemistry Authors: Hitotaka Sato Akash Chandela Yoshihito Ueno Source Type: research

Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex
Chem Commun (Camb). 2023 May 5. doi: 10.1039/d3cc01143g. Online ahead of print.ABSTRACTTo ensure specificity of small interfering RNAs (siRNAs), the antisense strand must be selected by the RNA-induced silencing complex (RISC). We have previously demonstrated that a 5'-morpholino-modified nucleotide at the 5'-end of the sense strand inhibits its interaction with RISC ensuring selection of the desired antisense strand. To improve this antagonizing binding property even further, a new set of morpholino-based analogues, Mo2 and Mo3, and a piperidine analogue, Pip, were designed based on the known structure of Argonaute2, the ...
Source: Chemical Communications - May 5, 2023 Category: Chemistry Authors: Dhrubajyoti Datta Christopher S Theile Kelly Wassarman June Qin Tim Racie Karyn Schmidt Yongfeng Jiang Rachel Sigel Maja M Janas Martin Egli Muthiah Manoharan Source Type: research