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Total 1197 results found since Jan 2013.
A functional and self-assembling octyl-phosphonium-tagged esculetin as an effective siRNA delivery agent
Chem. Commun., 2021, Accepted Manuscript DOI: 10.1039/D1CC03497A, CommunicationAltab Shaikh, Praveen Neeli, Gajalakshmi Singuru, Sravya Panangipalli, Raj Kumar Banerjee, M. Sridhar Reddy, Rajamannar Thennati, B. Surendar Reddy, Srigiridhar Kotamraju Herein, we document a self-assembling octyl-TPP tagged esculetin (Mito-Esc) as a functional, and as a novel small molecule siRNA delivery vector. While Mito-Esc itself induce selective breast cancer cell death,... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - October 20, 2021 Category: Chemistry Authors: Altab Shaikh Source Type: research
Molecules, Vol. 26, Pages 5635: Orexin-A Regulates Follicular Growth, Proliferation, Cell Cycle and Apoptosis in Mouse Primary Granulosa Cells Via the AKT/ERK Signaling Pathway
This study aimed to explore the expression of OXA and OX1R and their regulatory role in GCs proliferation, cell cycle progression, apoptosis, oocyte maturation, and underlying molecular mechanisms of these processes and elucidate its novel signaling pathway. Western blotting and RT-qPCR showed that OXA and OX1R were expressed during different developmental stages of GCs, and siRNA transfection successfully inhibited the expression of OX1R at the translational and transcriptional levels. Flow cytometry revealed that OX1R knockdown upregulated GCs apoptosis and triggered S-phase arrest in cell cycle progression. RT-qPCR and ...
Source: Molecules - September 16, 2021 Category: Chemistry Authors: Muhammad Safdar Aixin Liang Shahid Ali Rajput Nasir Abbas Muhammad Zubair Aftab Shaukat Aziz ur Rehman Huma Jamil Yan Guo Farman Ullah Ligou Yang Tags: Article Source Type: research
High-throughput Single-cell Mass Spectrometry Reveals Abnormal Lipid Metabolism in Pancreatic Ductal Adenocarcinoma
Angew Chem Int Ed Engl. 2021 Sep 10. doi: 10.1002/anie.202107223. Online ahead of print.ABSTRACTEven populations of clonal cells are heterogeneous, which requires high-throughput analysis methods with single-cell sensitivity. Here, we propose a rapid, label-free single-cell analytical method based on active capillary dielectric barrier discharge ionization mass spectrometry, which can analyze multiple metabolites in single cells at a rate of 38 cells/minute. Multiple cell types (HEK-293T, PANC-1, CFPAC-1, H6c7, HeLa and iBAs) were discriminated successfully. We found that abnormal lipid metabolism occurs in pancreatic canc...
Source: Angewandte Chemie - September 10, 2021 Category: Chemistry Authors: Qinlei Liu Wenjie Ge Tongtong Wang Jiayi Lan Sandra Mart ínez-Jarquín Christian Wolfrum Markus Stoffel Renato Zenobi Source Type: research
Molecules, Vol. 26, Pages 4919: The Inhibitory Effect of Sulforaphane on Bladder Cancer Cell Depends on GSH Depletion-Induced by Nrf2 Translocation
In this study, human bladder cancer T24 cells were used as in vitro model for revealing the inhibitory effect and its potential mechanism of SFN on cell growth. Here, a low dose of SFN (2.5 µM) was shown to promote cell proliferation (5.18–11.84%) and migration in T24 cells, whilst high doses of SFN (>10 µM) inhibited cell growth significantly. The induction effect of SFN on nuclear factor (erythroid-derived 2)-like 2 (Nrf2) expression at both low (2.5 µM) and high dose (10 µM) was characterized by a bell-shaped curve. Nrf2 and glutathione (GSH) might be the underlying mechanism in the effect of SFN on T24...
Source: Molecules - August 13, 2021 Category: Chemistry Authors: Canxia He Luigina P. Buongiorno Wei Wang Jonathan C. Y. Tang Natalizia Miceli Maria Fernanda Taviano Yujuan Shan Yongping Bao Tags: Article Source Type: research
Alnylam and PeptiDream team up on siRNA delivery
Source: Chemical and Engineering News - August 7, 2021 Category: Chemistry Authors: Ryan Cross Source Type: research
Molecules, Vol. 26, Pages 4711: Insulin Receptor Substrate 1 Is Involved in the Phycocyanin-Mediated Antineoplastic Function of Non-Small Cell Lung Cancer Cells
Chengtao Wang
Phycocyanin, derived from marine algae, is known to have noteworthy antineoplastic properties. However, the underlying mechanism involved in phycocyanin-mediated anti-growth function on non-small cell lung cancer (NSCLC) cells is still ambiguous. Here, we investigated the mechanism of action of phycocyanin on H1299, A549, and LTEP-a2 cells. According to the results obtained, insulin receptor substrate 1 (IRS-1) expression was reduced by phycocyanin. Cell phenotype tests showed that siRNA knockdown of IRS-1 expression significantly inhibited the growth, migration, colony formation, but promoted the apoptos...
Source: Molecules - August 4, 2021 Category: Chemistry Authors: Shuai Hao Qiancheng Li Yuanpu Liu Fannian Li Qi Yang Jing Wang Chengtao Wang Tags: Article Source Type: research
Molecules, Vol. 26, Pages 4626: Cholesterol Sequestration from Caveolae/Lipid Rafts Enhances Cationic Liposome-Mediated Nucleic Acid Delivery into Endothelial Cells
In this study, we demonstrated that the transient modulation of caveolae/lipid rafts mediated endocytosis with the cholesterol-sequestrating agents, nystatin, filipin III, and siRNA against Cav-1, which significantly increased the transfection properties of cationic lipid-(2-hydroxy-N-methyl-N,N-bis(2-tetradecanamidoethyl)ethanaminium chloride), namely, amide liposomes in combination with 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) (AD Liposomes) in liver sinusoidal endothelial cells (SK-Hep1). In particular, nystatin was found to be highly effective with 2–3-fold enhanced transfection efficacy when compared wit...
Source: Molecules - July 30, 2021 Category: Chemistry Authors: Santhosh Chandar Maddila Chandrashekhar Voshavar Porkizhi Arjunan Rashmi Prakash Chowath Hari Krishna Reddy Rachamalla Balaji Balakrishnan Poonkuzhali Balasubramanian Rajkumar Banerjee Srujan Marepally Tags: Article Source Type: research
Molecules, Vol. 26, Pages 4537: Trans-( −)-Kusunokinin: A Potential Anticancer Lignan Compound against HER2 in Breast Cancer Cell Lines?
Molecules, Vol. 26, Pages 4537: Trans-(−)-Kusunokinin: A Potential Anticancer Lignan Compound against HER2 in Breast Cancer Cell Lines?
Molecules doi: 10.3390/molecules26154537
Authors:
Rattanaburee
Tanawattanasuntorn
Thongpanchang
Tipmanee
Graidist
Trans-(−)-kusunokinin, an anticancer compound, binds CSF1R with low affinity in breast cancer cells. Therefore, finding an additional possible target of trans-(−)-kusunokinin remains of importance for further development. Here, a computational study was completed followed by indirect proof of specific target proteins using small interfering RNA (siRNA...
Source: Molecules - July 27, 2021 Category: Chemistry Authors: Rattanaburee Tanawattanasuntorn Thongpanchang Tipmanee Graidist Tags: Article Source Type: research
Corrigendum to “Multi-targeting siRNA nanoparticles for simultaneous inhibition of PI3K and Rac1 in PTEN-deficient prostate cancer” J. Ind. Eng. Chem. 99 (2021) 196–203
Publication date: Available online 7 July 2021Source: Journal of Industrial and Engineering ChemistryAuthor(s): Min Ju Kim, Hyosuk Kim, Xueliang Gao, Ju Hee Ryu, Yoosoo Yang, Ick Chan Kwon, Thomas M. Roberts, Sun Hwa Kim
Source: Journal of Industrial and Engineering Chemistry - July 8, 2021 Category: Chemistry Source Type: research
Molecules, Vol. 26, Pages 3852: Cytoprotection against Oxidative Stress by Methylnissolin-3-O- β-D-glucopyranoside from Astragalus membranaceus Mainly via the Activation of the Nrf2/HO-1 Pathway
Molecules, Vol. 26, Pages 3852: Cytoprotection against Oxidative Stress by Methylnissolin-3-O-β-D-glucopyranoside from Astragalus membranaceus Mainly via the Activation of the Nrf2/HO-1 Pathway
Molecules doi: 10.3390/molecules26133852
Authors:
Xiaohua Wu
Jian Xu
Yousheng Cai
Yuejun Yang
Yuancai Liu
Shugeng Cao
Astragalus membranaceus is a famous herb found among medicinal and food plants in East and Southeastern Asia. The Nrf2-ARE assay-guided separation of an extract from Jing liqueur led to the identification of a nontoxic Nrf2 activator, methylnissolin-3-O-β-D-glucopyranoside (MNG, a component of A. ...
Source: Molecules - June 24, 2021 Category: Chemistry Authors: Xiaohua Wu Jian Xu Yousheng Cai Yuejun Yang Yuancai Liu Shugeng Cao Tags: Article Source Type: research
Heat-induced manganese-doped magnetic nanocarriers combined with Yap-siRNA for MRI/NIR-guided mild photothermal and gene therapy of hepatocellular carcinoma
Publication date: 15 December 2021Source: Chemical Engineering Journal, Volume 426Author(s): Qian Zhang, Weiyong Zhao, Jin Cheng, Zhoufeng Deng, Ping Zhang, Amin Zhang, Zhi Xu, Shaojun Pan, Xinmei Liao, Daxiang Cui
Source: Chemical Engineering Journal - June 20, 2021 Category: Chemistry Source Type: research
Molecules, Vol. 26, Pages 3591: Quantitative Proteomics and Differential Protein Abundance Analysis after Depletion of Putative mRNA Receptors in the ER Membrane of Human Cells Identifies Novel Aspects of mRNA Targeting to the ER
chard Zimmermann
In human cells, one-third of all polypeptides enter the secretory pathway at the endoplasmic reticulum (ER). The specificity and efficiency of this process are guaranteed by targeting of mRNAs and/or polypeptides to the ER membrane. Cytosolic SRP and its receptor in the ER membrane facilitate the cotranslational targeting of most ribosome-nascent precursor polypeptide chain (RNC) complexes together with the respective mRNAs to the Sec61 complex in the ER membrane. Alternatively, fully synthesized precursor polypeptides are targeted to the ER membrane post-translationally by either the TRC, SND, or PEX1...
Source: Molecules - June 11, 2021 Category: Chemistry Authors: Pratiti Bhadra Stefan Schorr Monika Lerner Duy Nguyen Johanna Dudek Friedrich F örster Volkhard Helms Sven Lang Richard Zimmermann Tags: Article Source Type: research
Tumor targeted delivery of siRNA by a nano-scale quaternary polyplex for cancer treatment
Publication date: 1 December 2021Source: Chemical Engineering Journal, Volume 425Author(s): Chun Wang, Qi Liu, Zhanzhan Zhang, Ying Wang, Yadan Zheng, Jialei Hao, Xinzhi Zhao, Yang Liu, Linqi Shi
Source: Chemical Engineering Journal - June 6, 2021 Category: Chemistry Source Type: research
