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Total 1197 results found since Jan 2013.

An Insight on RNA Based Therapeutics and Vaccines: Challenges and Opportunities
This article emphasizes the potential of RNA based drugs and the major barriers associated with the development of RNA therapeutics. Additionally, the role of RNA based vaccines and their challenges in advancing this promising vaccine platform for the prevention of infectious diseases have been discussed.PMID:34792013 | DOI:10.2174/1568026621666211118095451
Source: Current Topics in Medicinal Chemistry - November 18, 2021 Category: Chemistry Authors: Kanisht Batra Sushila Maan Anju Sehrawat Source Type: research

PCSK9 as a new player in cancer: New opportunity or red herring?
Curr Med Chem. 2021 Nov 15. doi: 10.2174/0929867328666211115122324. Online ahead of print.ABSTRACTInitially described as a factor involved in liver regeneration and neuronal differentiation, proprotein convertase subtilisin/kexin type 9 (PCSK9) has become one of the key regulators of low-density lipoprotein cholesterol. Besides that, a number of studies have suggested PCSK9 may play a role in cancer biology. This is particularly true for gastroenteric (gastric and liver cancers) and lung cancers, where higher PCSK9 levels were associated with the increased ability of the tumor to develop and give metastasis as well as with...
Source: Current Medicinal Chemistry - November 16, 2021 Category: Chemistry Authors: Aldo Bonaventura Alessandra Vecchi é Massimiliano Ruscica Francesco Grossi Francesco Dentali Source Type: research

4-Thiofuranoid Glycal: Versatile Glycosyl Donor for the Selective Synthesis of -anomer of 4'-thionucleoside and its biological activities
Curr Med Chem. 2021 Nov 15. doi: 10.2174/0929867328666211115121434. Online ahead of print.ABSTRACTThe first highly diastereoselective synthesis of -anomers of 4'-thionucleosides has been carried out by means of electrophilic glycosidation utilizing 3,5-O-(di-t-butylsilylene) (DTBS)-4-thiofuranoid glycal as a glycosyl donor. The resulting glycosides were transformed into ribo-, 2'-deoxy- and arabinofuranosyl nucleosides through a chemical transformation of the 2'-substituent. The additive Pummerer reaction of the glycal S-oxide gave 1,2-di-O-acetyl-3,5-O-DTBS-4-thioribofuranose. The utility of the DTBS-protected 4-thiori...
Source: Current Medicinal Chemistry - November 16, 2021 Category: Chemistry Authors: Kazuhiro Haraguchi Hiroki Kumamoto Hiromichi Tanaka Source Type: research

PCSK9 as a new player in cancer: New opportunity or red herring?
Curr Med Chem. 2021 Nov 15. doi: 10.2174/0929867328666211115122324. Online ahead of print.ABSTRACTInitially described as a factor involved in liver regeneration and neuronal differentiation, proprotein convertase subtilisin/kexin type 9 (PCSK9) has become one of the key regulators of low-density lipoprotein cholesterol. Besides that, a number of studies have suggested PCSK9 may play a role in cancer biology. This is particularly true for gastroenteric (gastric and liver cancers) and lung cancers, where higher PCSK9 levels were associated with the increased ability of the tumor to develop and give metastasis as well as with...
Source: Current Medicinal Chemistry - November 16, 2021 Category: Chemistry Authors: Aldo Bonaventura Alessandra Vecchi é Massimiliano Ruscica Francesco Grossi Francesco Dentali Source Type: research

4-Thiofuranoid Glycal: Versatile Glycosyl Donor for the Selective Synthesis of -anomer of 4'-thionucleoside and its biological activities
Curr Med Chem. 2021 Nov 15. doi: 10.2174/0929867328666211115121434. Online ahead of print.ABSTRACTThe first highly diastereoselective synthesis of -anomers of 4'-thionucleosides has been carried out by means of electrophilic glycosidation utilizing 3,5-O-(di-t-butylsilylene) (DTBS)-4-thiofuranoid glycal as a glycosyl donor. The resulting glycosides were transformed into ribo-, 2'-deoxy- and arabinofuranosyl nucleosides through a chemical transformation of the 2'-substituent. The additive Pummerer reaction of the glycal S-oxide gave 1,2-di-O-acetyl-3,5-O-DTBS-4-thioribofuranose. The utility of the DTBS-protected 4-thiori...
Source: Current Medicinal Chemistry - November 16, 2021 Category: Chemistry Authors: Kazuhiro Haraguchi Hiroki Kumamoto Hiromichi Tanaka Source Type: research

Potential inhibitors and plant based technology: An alternative approach to treat corona virus
Bioorg Chem. 2021 Nov 1;117:105460. doi: 10.1016/j.bioorg.2021.105460. Online ahead of print.ABSTRACTThe current pneumonia outbreak, which began in early December 2019 near Wuhan City, Hubei Province, China, is caused by a novel corona virus (CoV) known as '2019-nCoV' or '2019 novel corona virus or COVID-19' by the World Health Organization (WHO). Vaccines are available to prevent corona virus contagious infection or to reduce the viral load in body but virus is continuously mutating itself to infect people at severity. In this critical scenario this review provide a compiled study for techniques and tools that can be used...
Source: Bioorganic Chemistry - November 11, 2021 Category: Chemistry Authors: Sachin Sharma Chetana Suvalka None Bharti Manoj Joshi Ayush Bahuguna Source Type: research

A functional and self-assembling octyl-phosphonium-tagged esculetin as an effective siRNA delivery agent
Chem. Commun., 2021, Advance Article DOI: 10.1039/D1CC03497A, CommunicationAltab Shaikh, Praveen Kumar Neeli, Gajalakshmi Singuru, Sravya Panangipalli, Rajkumar Banerjee, Sridhar Reddy Maddi, Rajamannar Thennati, Surendar Reddy Bathula, Srigiridhar Kotamraju Herein, we describe the self-assembling ability of an amphiphilic phosphonium cationic lipid to form nanoparticles and deliver MnSOD siRNA into MDA-MB-231 cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - November 11, 2021 Category: Chemistry Authors: Altab Shaikh Source Type: research

Molecules, Vol. 26, Pages 6552: Size and Structure of Empty and Filled Nanocontainer Based on Peptide Dendrimer with Histidine Spacers at Different pH
A. Markelov Novel peptide dendrimer with Lys-2His repeating units was recently synthesized, studied by NMR (Molecules, 2019, 24, 2481) and tested as a nanocontainer for siRNA delivery (Int. J. Mol. Sci., 2020, 21, 3138). Histidine amino acid residues were inserted in the spacers of this dendrimer. Increase of their charge with a pH decrease turns a surface-charged dendrimer into a volume-charged one and should change all properties. In this paper, the molecular dynamics simulation method was applied to compare the properties of the dendrimer in water with explicit counterions at two different pHs (at normal pH with neu...
Source: Molecules - October 29, 2021 Category: Chemistry Authors: Valeriy V. Bezrodnyi Sofia E. Mikhtaniuk Oleg V. Shavykin Igor M. Neelov Nadezhda N. Sheveleva Denis A. Markelov Tags: Article Source Type: research