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Total 1197 results found since Jan 2013.
Wood smoke particulate matter (WSPM2.5) induces pyroptosis through both caspase-1/IL-1 β/IL-18 and ATP/P2Y-dependent mechanisms in human bronchial epithelial cells
In this study, biofuel PM2.5 extracted from wood smoke (WSPM2.5) was used according to our previous publication. A 16-HBE cell line was used as the cell model. Results showed that: Firstly, WSPM2.5 induced significant pyroptosis in 16-HBE cells, reflected by the typical changes including elevated release of lactate dehydrogenase release (LDH) and activated activity and expression of Caspase-1/IL-1β/IL-18 signaling pathway. Then, specific inhibitors for both Caspases (Z-VAD-FMK) and Caspase-1 (VX-765), as well as specific siRNA knockdown of IL-1β all effectively attenuated the WSPM2.5-induced upregulation of downstream in...
Source: Chemosphere - July 19, 2022 Category: Chemistry Authors: Xin Fu Wei Hong Shuyi Li Zhi Chen Wenqu Zhou Jianwei Dai Xiaoliang Deng Hongbin Zhou Bing Li Pixin Ran Source Type: research
L-theanine induces skeletal muscle fiber type transformation by activation of prox1/CaN signaling pathway in C2C12 myotubes
Biol Chem. 2022 Jul 18. doi: 10.1515/hsz-2022-0165. Online ahead of print.ABSTRACTThe aim of this study was to investigate the effect and mechanism of L-theanine (LT) on muscle fiber type transformation in C2C12 myotubes. Our data showed that LT exhibited significantly higher slow oxidative muscle fiber expression and lower glycolytic fibers expression. In addition, LT significantly increased the activities of malate dehydrogenase (MDH) and succinic dehydrogenase (SDH), and decreased lactate dehydrogenase (LDH) activity, the calcineurin (CaN) activity and the protein expressions of nuclear factor of activated T cell 1 (NFA...
Source: Biological Chemistry - July 19, 2022 Category: Chemistry Authors: Xiaoling Chen Man Zhang Gang Jia Hua Zhao Guangmang Liu Zhiqing Huang Source Type: research
Wood smoke particulate matter (WSPM2.5) induces pyroptosis through both caspase-1/IL-1 β/IL-18 and ATP/P2Y-dependent mechanisms in human bronchial epithelial cells
In this study, biofuel PM2.5 extracted from wood smoke (WSPM2.5) was used according to our previous publication. A 16-HBE cell line was used as the cell model. Results showed that: Firstly, WSPM2.5 induced significant pyroptosis in 16-HBE cells, reflected by the typical changes including elevated release of lactate dehydrogenase release (LDH) and activated activity and expression of Caspase-1/IL-1β/IL-18 signaling pathway. Then, specific inhibitors for both Caspases (Z-VAD-FMK) and Caspase-1 (VX-765), as well as specific siRNA knockdown of IL-1β all effectively attenuated the WSPM2.5-induced upregulation of downstream in...
Source: Chemosphere - July 19, 2022 Category: Chemistry Authors: Xin Fu Wei Hong Shuyi Li Zhi Chen Wenqu Zhou Jianwei Dai Xiaoliang Deng Hongbin Zhou Bing Li Pixin Ran Source Type: research
L-theanine induces skeletal muscle fiber type transformation by activation of prox1/CaN signaling pathway in C2C12 myotubes
Biol Chem. 2022 Jul 18. doi: 10.1515/hsz-2022-0165. Online ahead of print.ABSTRACTThe aim of this study was to investigate the effect and mechanism of L-theanine (LT) on muscle fiber type transformation in C2C12 myotubes. Our data showed that LT exhibited significantly higher slow oxidative muscle fiber expression and lower glycolytic fibers expression. In addition, LT significantly increased the activities of malate dehydrogenase (MDH) and succinic dehydrogenase (SDH), and decreased lactate dehydrogenase (LDH) activity, the calcineurin (CaN) activity and the protein expressions of nuclear factor of activated T cell 1 (NFA...
Source: Biological Chemistry - July 19, 2022 Category: Chemistry Authors: Xiaoling Chen Man Zhang Gang Jia Hua Zhao Guangmang Liu Zhiqing Huang Source Type: research
Wood smoke particulate matter (WSPM2.5) induces pyroptosis through both caspase-1/IL-1 β/IL-18 and ATP/P2Y-dependent mechanisms in human bronchial epithelial cells
In this study, biofuel PM2.5 extracted from wood smoke (WSPM2.5) was used according to our previous publication. A 16-HBE cell line was used as the cell model. Results showed that: Firstly, WSPM2.5 induced significant pyroptosis in 16-HBE cells, reflected by the typical changes including elevated release of lactate dehydrogenase release (LDH) and activated activity and expression of Caspase-1/IL-1β/IL-18 signaling pathway. Then, specific inhibitors for both Caspases (Z-VAD-FMK) and Caspase-1 (VX-765), as well as specific siRNA knockdown of IL-1β all effectively attenuated the WSPM2.5-induced upregulation of downstream in...
Source: Chemosphere - July 19, 2022 Category: Chemistry Authors: Xin Fu Wei Hong Shuyi Li Zhi Chen Wenqu Zhou Jianwei Dai Xiaoliang Deng Hongbin Zhou Bing Li Pixin Ran Source Type: research
L-theanine induces skeletal muscle fiber type transformation by activation of prox1/CaN signaling pathway in C2C12 myotubes
Biol Chem. 2022 Jul 18. doi: 10.1515/hsz-2022-0165. Online ahead of print.ABSTRACTThe aim of this study was to investigate the effect and mechanism of L-theanine (LT) on muscle fiber type transformation in C2C12 myotubes. Our data showed that LT exhibited significantly higher slow oxidative muscle fiber expression and lower glycolytic fibers expression. In addition, LT significantly increased the activities of malate dehydrogenase (MDH) and succinic dehydrogenase (SDH), and decreased lactate dehydrogenase (LDH) activity, the calcineurin (CaN) activity and the protein expressions of nuclear factor of activated T cell 1 (NFA...
Source: Biological Chemistry - July 19, 2022 Category: Chemistry Authors: Xiaoling Chen Man Zhang Gang Jia Hua Zhao Guangmang Liu Zhiqing Huang Source Type: research
