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Total 1197 results found since Jan 2013.

L-theanine induces skeletal muscle fiber type transformation by activation of prox1/CaN signaling pathway in C2C12 myotubes
Biol Chem. 2022 Jul 18. doi: 10.1515/hsz-2022-0165. Online ahead of print.ABSTRACTThe aim of this study was to investigate the effect and mechanism of L-theanine (LT) on muscle fiber type transformation in C2C12 myotubes. Our data showed that LT exhibited significantly higher slow oxidative muscle fiber expression and lower glycolytic fibers expression. In addition, LT significantly increased the activities of malate dehydrogenase (MDH) and succinic dehydrogenase (SDH), and decreased lactate dehydrogenase (LDH) activity, the calcineurin (CaN) activity and the protein expressions of nuclear factor of activated T cell 1 (NFA...
Source: Biological Chemistry - July 19, 2022 Category: Chemistry Authors: Xiaoling Chen Man Zhang Gang Jia Hua Zhao Guangmang Liu Zhiqing Huang Source Type: research

Penehyclidine hydrochloride protects Rat cardiomyocytes from ischemia-reperfusion injury by platelet-derived growth factor-B
CONCLUSION: PHC pretreatment can protect cardiomyocytes from the decrease of cell activity and the increase of apoptosis caused by reperfusion through up-regulating PDGF-B to activate PI3K pathway. Our study indicates that PHC is a potential drug to protect cells from reperfusion injury and PDGF-B is a potential target for preventing MI-R injury.PMID:35838232 | DOI:10.2174/1386207325666220715090505
Source: Combinatorial Chemistry and High Throughput Screening - July 15, 2022 Category: Chemistry Authors: Yan Lu Congna Zi Liang Zhang Boqun Cui Ling Li Jun Ma Source Type: research

Suppression of SARS-CoV-2 Replication with Stabilized and Click-Chemistry Modified siRNAs
Angew Chem Int Ed Engl. 2022 Jul 8. doi: 10.1002/anie.202204556. Online ahead of print.ABSTRACTTThe emergence of more transmissible or aggressive variants of SARS-CoV-2 requires the development of antiviral medication that is quickly adjustable to evolving viral escape mutations. Here we report the synthesis of chemically stabilized small interfering RNA (siRNA) against SARS-CoV-2. The siRNA can be further modified with receptor ligands such as peptides using Cu(I)-catalysed click-chemistry. We demonstrate that optimized siRNAs can reduce viral loads and virus-induced cytotoxicity by up to five orders of magnitude in cell ...
Source: Angewandte Chemie - July 8, 2022 Category: Chemistry Authors: Franziska R Traube Marcel Stern Annika J T ölke Martina Rudelius Ernesto Mej ías-Pérez Nada Raddaoui Beate M K ümmerer C éline Douat Filipp Streshnev Manuel Albanese Paul R Wratil Yasmin V G ärtner Milda Nainyt ė Grazia Giorgio Stylianos Michalakis Source Type: research

Molecules, Vol. 27, Pages 4377: Tetrazine-Induced Bioorthogonal Activation of Vitamin E-Modified siRNA for Gene Silencing
Xinjing Tang The temporal activation of siRNA provides a valuable strategy for the regulation of siRNA activity and conditional gene silencing. The bioorthogonal bond-cleavage reaction of benzonorbonadiene and tetrazine is a promising trigger in siRNA temporal activation. Here, we developed a new method for the bio-orthogonal chemical activation of siRNA based on the tetrazine-induced bond-cleavage reaction. Small-molecule activatable caged siRNAs were developed with the 5′-vitamin E-benzonobonadiene-modified antisense strand targeting the green fluorescent protein (GFP) gene and the mitotic kinesin-5 ...
Source: Molecules - July 8, 2022 Category: Chemistry Authors: Xueli Zhang Amu Gubu Jianfei Xu Ning Yan Wenbo Su Di Feng Qian Wang Xinjing Tang Tags: Article Source Type: research