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Total 1197 results found since Jan 2013.

Molecules, Vol. 26, Pages 901: Silencing ZEB2 Induces Apoptosis and Reduces Viability in Glioblastoma Cell Lines
Conclusions: In line with previous investigations, our results indicated a critical oncogenic role for ZEB2 overexpression in brain glioma tumors. These properties make ZEB2 an essential molecule for further studies in the treatment of glioma cancer.
Source: Molecules - February 9, 2021 Category: Chemistry Authors: Sahar Safaee Masoumeh Fardi Nima Hemmat Neda Khosravi Afshin Derakhshani Nicola Silvestris Behzad Baradaran Tags: Article Source Type: research

Berberine improves dietary-induced cardiac remodeling by upregulating Kruppel-like factor 4-dependent mitochondrial function.
Authors: Ding L, Li S, Wang F, Xu J, Li S, Wang B, Kou J, Wang Y, Cao W Abstract Multiple studies have showed that berberine protects against heart diseases, including obesityassociated cardiomyopathy. However, it is not fully disclosed the potential molecular mechanisms of berberine on controlling cardiac remodelling. Kruppel-like factor (KLF) 4, identified as a critical transcriptional factor, participates in multiple cardiac injuries. The present study was to explore whether KLF4 determined the cardioprotective benefits of berberine in dietary-induced obese mice. High fat diet-induced obese mice were treated wit...
Source: Biological Chemistry - February 7, 2021 Category: Chemistry Tags: Biol Chem Source Type: research

ASAP PEGylation of Dendronized Gold Nanoparticles Affects Their Interaction with Thrombin and siRNA
The Journal of Physical Chemistry BDOI: 10.1021/acs.jpcb.0c10177
Source: Journal of Physical Chemistry B - January 22, 2021 Category: Chemistry Authors: Elz ̇bieta Pędziwiatr-Werbicka, Micha Gorzkiewicz, Katarzyna Horodecka, Dominika Lach, Andrea Barrios-Gumiel, Javier Sánchez-Nieves, Rafael Gómez, Francisco Javier de la Mata, and Maria Bryszewska Source Type: research

Delivery of siRNA by tailored cell-penetrating urea-based foldamers.
Abstract Cell-penetrating foldamers (CPFs) have recently shown promise as efficient and safe nucleic acid delivery systems. However, the application of CPFs to siRNA transport remains scarce. Here, we report helical CPFs tailored with specific end-groups (pyridylthio- or n-octyl-ureas) as effective molecular systems in combination with helper lipids to intracellularly deliver biologically-relevant siRNA. PMID: 33438700 [PubMed - as supplied by publisher]
Source: Chemical Communications - January 13, 2021 Category: Chemistry Authors: Bornerie M, Brion A, Guichard G, Kichler A, Douat C Tags: Chem Commun (Camb) Source Type: research

ASAP Insight into the Mechanism of Carrier-Mediated Delivery of siRNA in the Cell Membrane Using MD Simulation
LangmuirDOI: 10.1021/acs.langmuir.0c02871
Source: Langmuir - December 28, 2020 Category: Chemistry Authors: Ipsita Basu and Prabal K. Maiti Source Type: research

Tyrosine phosphorylation of the scaffold protein IQGAP1 in the MET pathway alters function Signal Transduction
IQGAP1 is a key scaffold protein that regulates numerous cellular processes and signaling pathways. Analogous to many other cellular proteins, IQGAP1 undergoes post-translational modifications, including phosphorylation. Nevertheless, very little is known about the specific sites of phosphorylation or the effects on IQGAP1 function. Here, using several approaches, including MS, site-directed mutagenesis, siRNA-mediated gene silencing, and chemical inhibitors, we identified the specific tyrosine residues that are phosphorylated on IQGAP1 and evaluated the effect on function. Tyr-172, Tyr-654, Tyr-855, and Tyr-1510 were phos...
Source: Journal of Biological Chemistry - December 25, 2020 Category: Chemistry Authors: Andrew C. Hedman, Dean E. McNulty, Zhigang Li, Laetitia Gorisse, Roland S. Annan, David B. Sacks Tags: Signal Transduction Source Type: research

Delivery of siRNA by tailored cell-penetrating urea-based foldamers
Chem. Commun., 2021, Accepted Manuscript DOI: 10.1039/D0CC06285E, CommunicationM égane Bornerie, Anaïs Brion, Gilles Guichard, Antoine Kichler, Céline Douat Cell-penetrating foldamers (CPFs) have recently shown promises as efficient and safe nucleic acid delivery systems. However applications of CPFs to siRNA transport remain scarce. Here, we report helical CPFs tailored... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - December 21, 2020 Category: Chemistry Authors: M égane Bornerie Source Type: research

Molecules, Vol. 25, Pages 6028: The Antiasthma Medication Ciclesonide Suppresses Breast Cancer Stem Cells through Inhibition of the Glucocorticoid Receptor Signaling-Dependent YAP Pathway
This study focused on investigating the effect of ciclesonide on breast cancer and CSCs and determining its underlying mechanism. Here, we showed that ciclesonide inhibits breast cancer and CSC formation. Similar glucocorticoids—dexamethasone and prednisone—did not inhibit CSC formation. Ciclesonide-induced glucocorticoid receptor (GR) degradation was dependent on ubiquitination. We showed via GR small interfering RNA (siRNA) that GR plays an important role in CSC formation. We showed via western blot and immunofluorescence assays that ciclesonide reduces the nuclear level of GR. The GR antagoni...
Source: Molecules - December 19, 2020 Category: Chemistry Authors: Su-Lim Kim Hack Sun Choi Ji-Hyang Kim Dong-Sun Lee Tags: Article Source Type: research

Hepatocyte nuclear factor 1{beta} suppresses canonical Wnt signaling through transcriptional repression of lymphoid enhancer-binding factor 1 Molecular Bases of Disease
Hepatocyte nuclear factor-1β (HNF-1β) is a tissue-specific transcription factor that is required for normal kidney development and renal epithelial differentiation. Mutations of HNF-1β produce congenital kidney abnormalities and inherited renal tubulopathies. Here, we show that ablation of HNF-1β in mIMCD3 renal epithelial cells results in activation of β-catenin and increased expression of lymphoid enhancer–binding factor 1 (LEF1), a downstream effector in the canonical Wnt signaling pathway. Increased expression and nuclear localization of LEF1 are also observed in cystic kidneys from Hnf1b mutant mice. Expression...
Source: Journal of Biological Chemistry - December 18, 2020 Category: Chemistry Authors: Siu Chiu Chan, Sachin S. Hajarnis, Sophia M. Vrba, Vishal Patel, Peter Igarashi Tags: Gene Regulation Source Type: research

Shear-responsive peptide/siRNA complexes as lung-targeting gene vectors
Publication date: Available online 11 December 2020Source: Chinese Chemical LettersAuthor(s): Dongxiao Yin, Mengjie Zhang, Jiaxin Chen, Yuanyu Huang, Dehai Liang
Source: Chinese Chemical Letters - December 12, 2020 Category: Chemistry Source Type: research

Acid-activatible micelleplex delivering siRNA-PD-L1 for improved cancer immunotherapy of CDK4/6 inhibition
Publication date: Available online 11 December 2020Source: Chinese Chemical LettersAuthor(s): Jing Gao, Hanwu Zhang, Fengqi Zhou, Bo Hou, Meiwan Chen, Zhigang Xie, Haijun Yu
Source: Chinese Chemical Letters - December 12, 2020 Category: Chemistry Source Type: research

Dysregulation of hsa-miR-34a and hsa-miR-449a leads to overexpression of PACS-1 and loss of DNA damage response (DDR) in cervical cancer Cell Biology
We have observed overexpression of PACS-1, a cytosolic sorting protein in primary cervical tumors. Absence of exonic mutations and overexpression at the RNA level suggested a transcriptional and/or posttranscriptional regulation. University of California Santa Cruz genome browser analysis of PACS-1 micro RNAs (miR), revealed two 8-base target sequences at the 3′ terminus for hsa-miR-34a and hsa-miR-449a. Quantitative RT-PCR and Northern blotting studies showed reduced or loss of expression of the two microRNAs in cervical cancer cell lines and primary tumors, indicating dysregulation of these two microRNAs in cervical ca...
Source: Journal of Biological Chemistry - December 11, 2020 Category: Chemistry Authors: Mysore S. Veena, Santanu Raychaudhuri, Saroj K. Basak, Natarajan Venkatesan, Parameet Kumar, Roopa Biswas, Rita Chakrabarti, Jing Lu, Trent Su, Marcus Gallagher-Jones, Marco Morselli, Haiqing Fu, Matteo Pellegrini, Theodore Goldstein, Mirit I. Aladjem, Ma Tags: Molecular Bases of Disease Source Type: research

The 2'-caged-tethered-siRNA shows light-dependent temporal controlled RNAi activity for GFP gene into HEK293T cells.
This report describes the syntheses of bulkier siRNA from 2'-caged-tethered-siRNAs, containing bulkier photolabile protecting group (o-nitrobenzyl) at 2'-position of ribose nucleoside. Importantly, these 2'-caged-siRNAs exhibit the light-dependent RNA interference (RNAi) activity into HEK293T cells for the GFP gene expression. The 2'-caged-siRNAs are synthesized by caging the sense and antisense strand of siRNA. The biochemical evaluations of these caged-siRNAs show that antisense-strand caged-siRNAs decrease RNAi activity temporarily in dark while enhancing RNAi activity, almost like control, after exposure withUV- light....
Source: Bioorganic and Medicinal Chemistry - December 9, 2020 Category: Chemistry Authors: Bollu A, Hassan MK, Dixit M, Sharma NK Tags: Bioorg Med Chem Source Type: research

Cell-selective siRNA delivery using glycosylated dynamic covalent polymers self-assembled in situ by RNA-templating.
Abstract Dynamic covalent libraries enable exploring complex chemical systems from which bioactive assemblies can adaptively emerge through template effects. In this work, we studied dynamic covalent libraries made of complementary bifunctional cationic peptides, yielding a diversity of species from macrocycles to polymers. Although polymers are typically expressed only at high concentration, we found that siRNA act as a template in the formation of dynamic covalent polymers at low concentration in a process guided by electrostatic binding. Using a glycosylated building block, we were able to show that this templa...
Source: Angewandte Chemie - December 8, 2020 Category: Chemistry Authors: Laroui N, Coste M, Su D, Ali L, Bessin Y, Barboiu M, Gary-Bobo M, Bettache N, Ulrich S Tags: Angew Chem Int Ed Engl Source Type: research

A novel polyethyleneimine-decorated FeOOH nanoparticle for efficient siRNA delivery
Publication date: Available online 20 November 2020Source: Chinese Chemical LettersAuthor(s): Shuai Guo, Bei Liu, Mengjie Zhang, Chunhui Li, Xiaoxia Wang, Yuhua Weng, Lele Li, Yuanyu Huang
Source: Chinese Chemical Letters - November 20, 2020 Category: Chemistry Source Type: research