Filtered By:
Specialty: Chemistry

This page shows you your search results in order of date. This is page number 11.

Order by Relevance | Date

Total 1197 results found since Jan 2013.

Effects of long noncoding RNA AK093407 on the biological behavior of colon cancer cells and the underlying mechanism
CONCLUSION: These results showed that knockdown of AK093407 could inhibit colon cancer cell proliferation, induce apoptosis and cell cycle arrest, influence the expression of vital factors in mitochondrial apoptosis pathway and cell cycle regulatory pathway, and may negatively regulate JAK/STAT3 through down-regulating p-Stat3.PMID:35400339 | DOI:10.2174/1386207325666220408092028
Source: Combinatorial Chemistry and High Throughput Screening - April 11, 2022 Category: Chemistry Authors: Zhao Xuerong Sun Ao Wang Jianping Zheng Xin Tian Duoduo Wang Mingjuan Xiao Lijun Zhao Enhong Zheng-Guo Cui Source Type: research

Chemical Modifications in Nucleic Acids for Therapeutic and Diagnostic Applications
Chem Rec. 2022 Apr;22(4):e202100270. doi: 10.1002/tcr.202100270. Epub 2021 Dec 8.ABSTRACTThe last decade has witnessed the blooming of nucleic acids for therapeutic and diagnostic applications. In the present article, we describe the most important results from our group in this area covering the international context that surrounded this research. These include the study of modifications at the terminal and internal positions of siRNA duplexes to enhance nuclease resistance, increase loading of the antisense strand to RISC and avoid side effects such as activation of immune response and sense strand misloading. Then, we d...
Source: Chemical Record - April 7, 2022 Category: Chemistry Authors: Carme F àbrega Anna Avi ñó Ramon Eritja Source Type: research

Molecules, Vol. 27, Pages 2082: Inhibition of Metastatic Hepatocarcinoma by Combined Chemotherapy with Silencing VEGF/VEGFR2 Genes through a GalNAc-Modified Integrated Therapeutic System
Jing Hu Hepatocellular carcinoma (HCC) is a highly malignant tumor related to high mortality and is still lacking a satisfactory cure. Tumor metastasis is currently a major challenge of cancer treatment, which is highly related to angiogenesis. The vascular endothelial growth factor (VEGF)/VEGFR signaling pathway is thus becoming an attractive therapeutic target. Moreover, chemotherapy combined with gene therapy shows great synergistic potential in cancer treatment with the promise of nanomaterials. In this work, a formulation containing 5-FU and siRNA against the VEGF/VEGFR signaling pathway into N-acetyl-galactosam...
Source: Molecules - March 24, 2022 Category: Chemistry Authors: Xunan Li Xiang Wang Nian Liu Qiuyu Wang Jing Hu Tags: Article Source Type: research

Glutathione-Responsive Heterogeneous Metal-Organic Framework Hybrids for Photodynamic-Gene Synergetic Cell Apoptosis
Chemistry. 2022 Mar 20. doi: 10.1002/chem.202200305. Online ahead of print.ABSTRACTIntracellular excessive glutathione (GSH) consumes the cytotoxic 1 O 2 significantly, restricting the development and efficacy of 1 O 2 -mediated photodynamic therapy (PDT). To face with this challenge, herein a heterogeneous metal-organic framework (MOF) nanohybrid was sequentially fabricated with porous coordination network-typed MOF as the core and photosensitizer, and Cu II -centered zeolitic imidazolate framework-67 as shell encapsulating cyanine 3-labelled siRNA. Upon internalized by cells and activated by GSH, the outer shell dissocia...
Source: Chemistry - March 21, 2022 Category: Chemistry Authors: Jintong Liu Bernardino J C órdova Wong Tianrui Liu Hong Yang Lin Yao Ye Jianping Lei Source Type: research

Molecules, Vol. 27, Pages 1990: Dihydrohomoplantagin and Homoplantaginin, Major Flavonoid Glycosides from Salvia plebeia R. Br. Inhibit oxLDL-Induced Endothelial Cell Injury and Restrict Atherosclerosis via Activating Nrf2 Anti-Oxidation Signal Pathway
In this study, we evaluated the effect of homoplantaginin and its derivative dihydrohomoplantagin on oxLDL-induced endothelial cell injury and atherosclerosis in apoE-/- mice. Our results showedthat both dihydrohomoplantagin and homoplantaginin inhibited apoptosis and the increased level of ICAM-1 and VCAM-1 in oxLDL-stimulated HUVECs and the plaque endothelium of apoE-/- mice. Additionally, both of them restricted atherosclerosis development of apoE-/- mice. Mechanistic studies showed that oxLDL-induced the increase in ROS production, phosphorylation of ERK and nuclear translocation of NF-κB in HUVECs was si...
Source: Molecules - March 19, 2022 Category: Chemistry Authors: Ning Meng Kai Chen Yanhong Wang Jiarong Hou Wenhui Chu Shan Xie Fengying Yang Chunhui Sun Tags: Article Source Type: research

Strategies for improving the safety and RNAi efficacy of noncovalent peptide/siRNA nanocomplexes
Adv Colloid Interface Sci. 2022 Mar 9;302:102638. doi: 10.1016/j.cis.2022.102638. Online ahead of print.ABSTRACTIn the past decades, the striking development of cationic polypeptides and cell-penetrating peptides (CPPs) tailored for small interfering RNA (siRNA) delivery has been fuelled by the conception of nuclear acid therapy and precision medicine. Owing to their amino acid compositions, inherent secondary structures as well as diverse geometrical shapes, peptides or peptide-containing polymers exhibit good biodegradability, high flexibility, and bio-functional diversity as nonviral siRNA vectors. Also, a variety of no...
Source: Advances in Colloid and Interface Science - March 17, 2022 Category: Chemistry Authors: Jun Wang Guang Chen Nan Liu Xiaoxia Han Feng Zhao Lei Zhang P Chen Source Type: research

Reactive oxygen species-responsive RNA interference
Chem Commun (Camb). 2022 Mar 17. doi: 10.1039/d2cc00651k. Online ahead of print.ABSTRACTDue to oxidative instability, arylboronic acids are not compatible with the solid-phase synthesis of nucleic acids. We solved this problem and, based on these findings, developed siRNA prodrugs activated in the presence of reactive oxygen species (ROS) in vivo. These prodrugs can be used for specific targeting of ROS-rich cancer cells.PMID:35297916 | DOI:10.1039/d2cc00651k
Source: Chemical Communications - March 17, 2022 Category: Chemistry Authors: Jennifer R ühle Insa Klemt Tatiana Abakumova Olga Sergeeva Polina Vetosheva Timofei Zatsepin Andriy Mokhir Source Type: research

Molecules, Vol. 27, Pages 1936: A Comprehensive Computational Investigation into the Conserved Virulent Proteins of Shigella species Unveils Potential Small-Interfering RNA Candidates as a New Therapeutic Strategy against Shigellosis
In this study, we analyzed 264 conserved sequences from 15 different conserved virulence genes of Shigella sp., through extensive rational validation using a plethora of first-generation and second-generation computational algorithms for siRNA designing. Fifty-eight siRNA candidates were obtained by using the first-generation algorithms, out of which only 38 siRNA candidates complied with the second-generation rules of siRNA designing. Further computational validation showed that 16 siRNA candidates were found to have a substantial functional efficiency, out of which 11 siRNA candidates were found to be non-immunogenic. Fi...
Source: Molecules - March 17, 2022 Category: Chemistry Authors: Parag Palit Farhana Tasnim Chowdhury Namrata Baruah Bonoshree Sarkar Sadia Noor Mou Mehnaz Kamal Towfida Jahan Siddiqua Zannatun Noor Tahmeed Ahmed Tags: Article Source Type: research