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Procedure: Gastroschisis Repair

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Total 964 results found since Jan 2013.

DUOX1 is Required for Airway Epithelial Cell Migration and Bronchiolar Re-Epithelialization Following Injury.
Abstract The respiratory epithelium plays a critical role in innate defenses against airborne pathogens and pollutants, and alterations in epithelial homeostasis and repair mechanisms are thought to contribute to chronic lung diseases associated with airway remodeling. Previous studies have implicated the NADPH oxidase dual oxidase 1 (DUOX1) in redox signaling pathways involved in in vitro epithelial wound responses to infection and injury. However, the importance of epithelial DUOX1 in in vivo epithelial repair pathways has not yet been established. Using siRNA silencing of DUOX1 expression, we now show its criti...
Source: American Journal of Respiratory Cell and Molecular Biology - December 13, 2012 Category: Molecular Biology Authors: Gorissen SH, Hristova M, Habibovic A, Sipsey LM, Spiess PC, Janssen-Heininger YM, van der Vliet A Tags: Am J Respir Cell Mol Biol Source Type: research

Metformin-mediated downregulation of p38 mitogen-activated protein kinase-dependent excision repair cross-complementing 1 decreases DNA repair capacity and sensitizes human lung cancer cells to paclitaxel.
Abstract Metformin, an extensively used and well-tolerated drug for treating individuals with type 2 diabetes, has recently gained significant attention as an anticancer drug. On the other hand, paclitaxel (Taxol) is a new antineoplastic drug that has shown promise in the treatment of non-small cell lung cancer (NSCLC). High expression levels of excision repair cross-complementary 1 (ERCC1) in cancers have been positively associated with the DNA repair capacity and a poor prognosis in NSCLC patients treated with platinum-containing chemotherapy. In this current study, paclitaxel was found to increase phosphorylati...
Source: Biochemical Pharmacology - December 7, 2012 Category: Drugs & Pharmacology Authors: Tseng SC, Huang YC, Chen HJ, Chiu HC, Huang YJ, Wo TY, Weng SH, Lin YW Tags: Biochem Pharmacol Source Type: research

Wnt3a/β-catenin increases proliferation in heart valve interstitial cells
Conclusion: Wnt3a/β-catenin signaling pathway is an important regulator of proliferation in adult VICs.
Source: Cardiovascular Pathology - August 13, 2012 Category: Cardiology Authors: Songyi Xu, Avrum I. Gotlieb Tags: Original Articles Source Type: research

Thy-1 knockdown retards wound repair in mouse skin
Conclusion: These data suggest that blocking Thy-1 at wound areas using siRNA reduces repair and affects the re-epithelialization and over-expression of TGF-β1 of the wound during the skin healing process.
Source: Journal of Dermatological Science - January 11, 2013 Category: Dermatology Authors: Min-Jung Lee, Jeong-Oh Shin, Han-Sung Jung Tags: Regular articles Source Type: research

Secreted protein acidic and rich in cysteine (SPARC) is upregulated by transforming growth factor (TGF)-ß and is required for TGF-ß-induced hydrogen peroxide production in fibroblasts
Conclusions: The results presented in this study suggest that SPARC plays a role in epithelial damage in the IPF lung via enhanced H2O2 production from fibroblasts activated by TGF-β. Therefore, SPARC inhibition may prevent epithelial injury in IPF lung and represent a potential therapeutic approach for IPF.
Source: Fibrogenesis and Tissue Repair - March 21, 2013 Category: Biomedical Science Authors: Saiko ShibataJunichi Ishiyama Source Type: research

Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2
Conclusions Notch-1 mediates VEGF/Ang2-induced angiogenesis and EC invasion in inflammatory arthritis.
Source: Annals of the Rheumatic Diseases - May 10, 2013 Category: Rheumatology Authors: Gao, W., Sweeney, C., Walsh, C., Rooney, P., McCormick, J., Veale, D. J., Fearon, U. Tags: Open access, Immunology (including allergy), Pathology, Radiology, Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis, Surgical diagnostic tests, Clinical diagnostic tests Basic and translational research Source Type: research

Transcription Factors Runx1 to 3 Are Expressed in the Lacrimal Gland Epithelium and Are Involved in Regulation of Gland Morphogenesis and Regeneration Cornea
Conclusions. Runx1 and 2 are new markers of the LG epithelial lineage and Runx factors are important for normal LG morphogenesis and regeneration.
Source: Investigative Ophthalmology - May 1, 2013 Category: Opthalmology Authors: Voronov, D., Gromova, A., Liu, D., Zoukhri, D., Medvinsky, A., Meech, R., Makarenkova, H. P. Tags: Cornea Source Type: research

A novel hydroxysuberamide derivative potentiates MG132‐mediated anticancer activity against human hormone refractory prostate cancers—the role of histone deacetylase and endoplasmic reticulum stress
CONCLUSIONSThe data suggest that WJ25591 inhibited HDAC activity, leading to cell‐cycle arrest and inhibition of DNA repair. Caspase cascades are subsequently triggered to execute cell apoptosis. MG‐132 dramatically sensitizes WJ25591‐mediated apoptosis, at least partly, through ER stress response. The data also reveal that combination of HDAC inhibitors and proteasome inhibitors may be a potential strategy against hormone‐refractory prostate cancers. Prostate © 2013 Wiley Periodicals, Inc.
Source: The Prostate - June 28, 2013 Category: Urology & Nephrology Authors: Yi‐Cheng Chen, Wei‐Jan Huang, Jui‐Ling Hsu, Chia‐Chun Yu, Wei‐Ting Wang, Jih‐Hwa Guh Tags: Original Article Source Type: research

Transcription Factor p63 Regulates Key Genes and Wound Repair in Human Airway Epithelial Basal Cells.
Conclusions: ΔNp63α is the major isoform expressed in basal pHAEC and is essential for epithelial wound repair. The role of ΔNp63α in epithelial barrier integrity requires further study to understand its role in health and disease. PMID: 23837456 [PubMed - as supplied by publisher]
Source: Am J Respir Cell Mol... - July 9, 2013 Category: Respiratory Medicine Authors: Warner SM, Hackett TL, Shaheen F, Hallstrand TS, Kicic A, Stick SM, Knight DA Tags: Am J Respir Cell Mol Biol Source Type: research

Hypoxia Inhibits Cellular Senescence to Restore the Therapeutic Potential of Old Human Endothelial Progenitor Cells via the Hypoxia-Inducible Factor-1α-TWIST-p21 Axis.
CONCLUSIONS: This study introduces ex vivo expansion protocols involving hypoxic preconditioning that are suitable for efficiently expanding old EPCs without senescence through modulation of the hypoxia-induced hypoxia-inducible factor-1α-TWIST-p21 axis. In addition, the expanded cells are shown to be useful for therapeutic vasculogenesis. PMID: 23928864 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 8, 2013 Category: Cardiology Authors: Lee SH, Lee JH, Yoo SY, Hur J, Kim HS, Kwon SM Tags: Arterioscler Thromb Vasc Biol Source Type: research

Gene Expression Profiling for Analysis Acquired Oxaliplatin Resistant Factors in Human Gastric Carcinoma TSGH-S3 Cells: the Role of IL-6 Signaling and Nrf2/AKR1C Axis Identification.
Abstract Oxaliplatin treatment is a mainstay of treatment for advanced gastrointestinal tract cancer, but the underlying mechanisms of acquired oxaliplatin resistance remain largely obscured. We previously demonstrated that increased DNA repair capacity and copper-transporting ATPase 1 (ATP7A) level contributed to oxaliplatin resistance in the human gastric carcinoma cell line TSGH-S3 (S3). In the present study, we applied gene array technology to identify additional resistance factors in S3 cells. We found that interleukin-6 (IL-6), aldo-keto reductase 1C1 (AKR1C1), and AKR1C3 are the top 3 upregulated genes in S...
Source: Biochemical Pharmacology - August 8, 2013 Category: Drugs & Pharmacology Authors: Chen CC, Chu CB, Liu KJ, Huang CY, Chang JY, Pan WY, Chen HH, Cheng YH, Lee KD, Chen MF, Kuo CC, Chen LT Tags: Biochem Pharmacol Source Type: research

Inhibition of Four-and-a-Half LIM Domain Protein 2 Increases Survival, Migratory Capacity and Paracrine Function of Human Early Outgrowth Cells Through Activation of the Sphingosine Kinase-1 Pathway: Implications for Endothelial Regeneration.
Conclusions: Our findings suggest that FHL2 negatively regulates EOC survival, migration and paracrine function. FHL2 inhibition in EOCs reduces apoptosis and enhances survival and migratory capacity of both EOCs and surrounding ECs by activation of the SK-1/S1P pathway, resulting in improvement of endothelial regeneration. PMID: 24084691 [PubMed - as supplied by publisher]
Source: Circulation Research - October 1, 2013 Category: Cardiology Authors: Ebrahimian T, Arfa O, Simeone S, Lemarie CA, Lehoux S, Wassmann S Tags: Circ Res Source Type: research

Proinflammatory Cytokines Induce Stromelysin-1–mediated Cell Proliferation in Dental Pulp Fibroblast-like Cells
Conclusions: Our results showed that proinflammatory cytokine-induced stromelysin-1 regulates cell proliferation and anti-apoptosis in DPFCs in addition to their better documented destructive role in inflammation.
Source: Journal of Endodontics - October 28, 2013 Category: Dentistry Authors: Hideyuki Yamaguchi, Nobuaki Ozeki, Rie Kawai, Tsuyoshi Tanaka, Taiki Hiyama, Kazuhiko Nakata, Makio Mogi, Hiroshi Nakamura Tags: Biology Source Type: research

Reduced migration of MLH1 deficient colon cancer cells depends on SPTAN1
Conclusions: These data suggest that SPTAN1 levels decreased in concordance with MLH1 reduction and impaired cellular mobility in MLH1 deficient colon cancer cells. Therefore, aggressiveness of MLH1-positive CRC might be related to SPTAN1.
Source: Molecular Cancer - January 24, 2014 Category: Cancer & Oncology Authors: Inga HinrichsenBenjamin ErnstFranziska NuberSandra PassmannDieter SchäferVerena SteinkeNicolaus FriedrichsGuido PlotzStefan ZeuzemAngela Brieger Source Type: research

Downregulation of Rad51 participates in OTA-induced DNA double-strand breaks in GES-1 cells in vitro.
Abstract Ochratoxin A (OTA), a mycotoxin produced by ubiquitous Aspergilli, is carcinogenic, teratogenic, and nephrotoxic in both humans and animals. Our previous study found that OTA induced DNA double-strand breaks (DSBs) and resulted in G2 phase arrest in human gastric epithelium immortalized (GES-1) cells. DSBs can cause genomic instability, mutations, and neoplastic transformations, and improper repair of DSBs may lead to the development of cancer. Rad51 is a key protein in the homologous recombination (HR) pathway of DSBs repair. The roles of Rad51 in the repair of DNA damage vary in response to different ty...
Source: Toxicology Letters - February 10, 2014 Category: Toxicology Authors: Lian H, Cui J, Wang Y, Liu J, Wang J, Shen H, Xing L, Wang J, Yan X, Zhang X Tags: Toxicol Lett Source Type: research