Filtered By:
Procedure: Gastroschisis Repair

This page shows you your search results in order of relevance. This is page number 10.

Order by Relevance | Date

Total 964 results found since Jan 2013.

Abstract 2049: Characterization of a novel BRCA1-EGR1 interaction
The tumor suppressor protein BRCA1 orchestrates DNA repair and cell cycle arrest following DNA damage, with transcriptional regulation integral to these processes. We have identified a novel, DNA-damage responsive, interaction between BRCA1 and the zinc-finger transcription factor EGR1. EGR1 is rapidly and transiently expressed in response to a wide variety of stress stimuli and growth factors, and like BRCA1, decreased expression of EGR1 correlates with tumor formation in mammary cell lines and tissues.The stress response gene, NDRG1, was identified as a transcriptional target of BRCA1 by microarray analysis and subsequen...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Dickson, N. A., Crawford, N. T., Mullan, P. B. Tags: Molecular and Cellular Biology Source Type: research

Abstract 2081: The CCCTC-binding factor (CTCF) functions to downregulate the transcription of MGMT gene in human glioblastoma cells
The O6-methylguanine-DNA methyltransferase (MGMT) gene located at chromosome 10q26 encodes a DNA repair protein that abrogates the therapeutic effects of alkylating agents by preventing the formation of mutagenic lesions or cytotoxic DNA crosslinks. MGMT is highly expressed in human gliomas and its transcriptional regulation has emerged as a major translational focal point in neuro-oncology, because the epigenetic silencing of the MGMT gene which occurs in a subset of these malignancies confers improved treatment responses to both chemo and radiation therapies. While the promoter methylation and its contribution to glioma ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Srivenugopal, K. S., Al-Obaide, M. I. Tags: Molecular and Cellular Biology Source Type: research

Abstract 3024: Lack of CK1{delta} increases DNA damage and genomic instability due to defects in DNA repair and mitotic checkpoints
Casein kinase 1 delta (CK1δ) is a conserved serine/threonine protein kinase that regulates diverse cellular processes including vesicle trafficking and circadian rhythm. We previously reported that CK1δ is a mediator of Wnt-3a-dependent neurite outgrowth (Greer and Rubin, JCB, 2011) and ciliogenesis (Greer et al. MBoC, 2014). Mice that lack Csnk1d exhibit a perinatal lethal phenotype and typically weigh 30-50% less than their wild type littermates, however, the exact causes of death and small size are unknown. We hypothesized that the absence of CK1δ contributes to cellular stresses that adversely affect cell survival. ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Greer, Y. E., Gao, B., Yang, Y., Lipkowitz, S., Rubin, J. S. Tags: Molecular and Cellular Biology Source Type: research

Sirtuin‐6 deficiency exacerbates diabetes‐induced impairment of wound healing
Abstract Delayed wound healing is one of the major complications in diabetes and is characterized by chronic proinflammatory response, and abnormalities in angiogenesis and collagen deposition. Sirtuin family proteins regulate numerous pathophysiological processes, including those involved in promotion of longevity, DNA repair, glycolysis and inflammation. However, the role of sirtuin 6 (SIRT6), a NAD+‐dependent nuclear deacetylase, in wound healing specifically under diabetic condition remains unclear. To analyse the role of SIRT6 in cutaneous wound healing, paired 6‐mm stented wound was created in diabetic db/db mice...
Source: Experimental Dermatology - August 18, 2015 Category: Dermatology Authors: Rajarajan A. Thandavarayan, Venkata Naga Srikanth Garikipati, Darukeshwara Joladarashi, Sahana Suresh Babu, Prince Jeyabal, Suresh K. Verma, Alexander R. Mackie, Mohsin Khan, Somasundaram Arumugam, Kenichi Watanabe, Raj Kishore, Prasanna Krishnamurthy Tags: Original Article Source Type: research

DKK1 is a potential novel mediator of cisplatin-refractoriness in non-small cell lung cancer cell lines
Conclusions: We identified DKK1 as a possible marker of a cisplatin-refractory phenotype and as a potential novel therapeutic target to improve platinum response of NSCLC cells.
Source: BMC Cancer - September 9, 2015 Category: Cancer & Oncology Authors: Hogir SalimDali ZongPetra HåågMetka NovakBirgitta MörkRolf LewensohnLovisa LundholmKristina Viktorsson Source Type: research

Cardiomyocyte A Disintegrin And Metalloproteinase 17 (ADAM17) Is Essential in Post-Myocardial Infarction Repair by Regulating Angiogenesis Original Articles
Conclusions— This study highlights the key role of cardiomyocyte ADAM17 in post-MI recovery by regulating VEGFR2 transcription and angiogenesis, thereby limiting left ventricular dilation and dysfunction. Therefore, ADAM17 upregulation, within the physiological range, could provide protective effects in ischemic cardiomyopathy.
Source: Circulation: Heart Failure - September 15, 2015 Category: Cardiology Authors: Fan, D., Takawale, A., Shen, M., Wang, W., Wang, X., Basu, R., Oudit, G. Y., Kassiri, Z. Tags: Other heart failure, Angiogenesis, Cell signalling/signal transduction, Gene expression, Acute myocardial infarction Original Articles Source Type: research

CD44 Influences Fibroblast Behaviors Via Modulation of Cell–Cell and Cell–Matrix Interactions, Affecting Survivin and Hippo Pathways
CD44 has been studied in a wide variety of cell types, in a diverse array of cell behaviors and in a diverse range of signaling pathways. We now document a role for CD44 in mediating fibroblast behaviors via regulation of N‐cadherin, extracellular matrix expression, Survivin and the Hippo pathway. Here, we report our findings on the roles of CD44 in modulating proliferation, apoptosis, migration and invasion of murine wild‐type (WT‐FB) and CD44 knockout dermal fibroblasts (CD44KO‐FB). As we have documented in microvascular endothelial cells lacking CD44, we found persistent increased proliferation, reduced activati...
Source: Journal of Cellular Physiology - November 23, 2015 Category: Cytology Authors: Masayuki Tsuneki, Joseph A. Madri Tags: Original Research Article Source Type: research

Inhibition of Oct 3/4 mitigates the cardiac progenitor-derived myocardial repair in infarcted myocardium
Conclusion: Our results indicate that CSCs-derived cardiac regeneration improves the restoration of cardiac function and is mediated through Oct 3/4.
Source: Stem Cell Research and Therapy - December 24, 2015 Category: Stem Cells Authors: Yu ZhaoJianfeng DuYoufang ChenYaoliang TangGangjian QinGuorong LvShougang ZhuangTing Zhao Source Type: research

Efficient, Low-Cost Nucleofection of Passaged Chondrocytes
This study identifies a cost-effective, efficient method of nonviral nucleofection of bovine-passaged chondrocytes using known buffer formulations. Human-passaged chondrocytes could also be successfully nucleofected in 1M buffer. Thus this method should facilitate cost-efficient gene targeting of cells used for articular cartilage repair in a research setting.
Source: Cartilage - February 7, 2016 Category: Orthopaedics Authors: Parreno, J., Delve, E., Andrejevic, K., Paez-Parent, S., Wu, P.-h., Kandel, R. Tags: Articles Source Type: research

Inhibition of AXUD1 attenuates compression-dependent apoptosis of cementoblasts
Conclusions Compression-induced apoptosis of HPCBs is mediated by AXUD1 via a JNK-dependent pathway. Clinical relevance AXUD1-dependent apoptosis of human cementoblasts might contribute to an impaired repair of root resorptions during orthodontic tooth movement. Further studies are needed to develop treatment strategies aiming to minimize root resorption during orthodontic tooth movement.
Source: Clinical Oral Investigations - February 19, 2016 Category: Dentistry Source Type: research

Abstract IA06: Spatial systems biology of cancer
International efforts have now defined the genomic landscapes of most major human cancer types. The genomic landscape of breast cancer is particularly well described in several recent publications. The high level view of this disease suggests a remarkable level of inter- and intra-tumor heterogeneity, the presence of a few recurrent and many rare genomic aberrations and substantial genomic and epigenomic heterogeneity. The challenge now is to understand how these aberrations and tumor extrinsic influences from the microenvironment collaborate to deregulate aspects of cell differentiation, proliferation, apoptosis, DNA repa...
Source: Molecular Cancer Research - February 29, 2016 Category: Cancer & Oncology Authors: Gray, J. Tags: Genomics - Sporadic and Hereditary: Oral Presentations - Invited Abstracts Source Type: research

Id: 140: klotho, an anti-aging molecule, regulates alveolar epithelial cell mtdna damage and apoptosis
Conclusions Our data demonstrate a crucial role for AEC AKT signaling in mediating the mtDNA damage protective effects of Klotho. Given the importance of AEC aging and apoptosis in pulmonary fibrosis, we reason that Klotho/AKT axis is an innovative therapeutic target for preventing common lung diseases of aging (i.e. IPF, COPD, lung cancer, etc.) for which more effective management regimens are clearly needed. Funding NIH-RO1 ES020357-01A1 (DK) and VA Merit (DK).
Source: Journal of Investigative Medicine - March 21, 2016 Category: Research Authors: Kim, S., Cheresh, P., Jablonski, R., Kamp, D., Eren, M., Vaughan, D. Tags: Pulmonary/Critical Care Source Type: research

Mesenchymal stem cells ameliorate inflammatory cytokine-induced impairment of AT-II cells through a keratinocyte growth factor-dependent PI3K/Akt/mTOR signaling pathway.
Authors: Li J, Huang S, Zhang J, Feng C, Gao D, Yao B, Wu X, Fu X Abstract Lung epithelium restoration subsequent to injury is of concern in association with the outcomes of diverse inflammatory lung diseases. Previous studies have demonstrated that mesenchymal stem cells (MSCs) may promote epithelial repair subsequent to inflammatory injury, however the mechanism that mediates this effect remains unclear. The current study examined the role of MSCs in alveolar type II epithelial cell (AT‑II cell) restoration subsequent to an inflammatory insult. AT‑II cells were firstly exposed to inflammatory cytokines incl...
Source: Molecular Medicine Reports - April 3, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Runx2/DICER/miRNA Pathway in Regulating Osteogenesis
In conclusion, our results suggest that DICER is specifically regulated by osteogenic master gene Runx2 that binds to the DICER promoter. Consequently, DICER cleaves precursors of miR‐335‐5p and miR‐17‐92 cluster to form mature miRNAs, which target and decrease the Dickkopf‐related protein 1 (DKK1) and proapoptotic factor BIM levels, respectively, leading to an enhanced Wnt/β‐catenin signaling pathway. These intriguing results reveal a central mechanism underlying lineage‐specific regulation by a Runx2/DICER/miRNAs cascade during osteogenic differentiation and bone development. Our study also suggests a pote...
Source: Journal of Cellular Physiology - April 11, 2016 Category: Cytology Authors: Leilei Zheng, Qisheng Tu, Shu Meng, Lan Zhang, Liming Yu, Jinlin Song, Yun Hu, Lei Sui, Jin Zhang, Michel Dard, Jessica Cheng, Dana Murray, Jane Lian, Gary Stein, Jake Chen Tags: Original Research Article Source Type: research

DNA Repair Genes ERCC1 and BRCA1 Expression in Non-Small Cell Lung Cancer Chemotherapy Drug Resistance.
CONCLUSIONS ERCC1 and BRCA1 were overexpressed in NSCLC drug-resistant cells, and they regulated lung cancer occurrence and development through the phosphorylating PI3K/AKT signaling pathway. PMID: 27289442 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - June 13, 2016 Category: Research Tags: Med Sci Monit Source Type: research