Filtered By:
Condition: Liver Disease

This page shows you your search results in order of relevance. This is page number 11.

Order by Relevance | Date

Total 328 results found since Jan 2013.

Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway
Publication date: Available online 5 July 2018Source: Redox BiologyAuthor(s): Xiao-Juan Zhao, Han-Wen Yu, Yan-Zi Yang, Wen-Yuan Wu, Tian-Yu Chen, Ke-Ke Jia, Lin-Lin Kang, Rui-Qing Jiao, Ling-Dong KongAbstractOxidative stress is a critical factor in nonalcoholic fatty liver disease pathogenesis. MicroRNA-200a (miR-200a) is reported to target Kelch-like ECH-associated protein 1 (Keap1), which regulates nuclear factor erythroid 2-related factor 2 (Nrf2) anti-oxidant pathway. Polydatin (3,4′,5-trihydroxy-stilbene-3-β-D-glucoside), a polyphenol found in the rhizome of Polygonum cuspidatum, have anti-oxidative, anti-inflammat...
Source: Redox Biology - July 6, 2018 Category: Biology Source Type: research

High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease
Publication date: July 2018Source: Redox Biology, Volume 17Author(s): Firas Alhasson, Ratanesh Kumar Seth, Sutapa Sarkar, Diana A. Kimono, Muayad S. Albadrani, Diptadip Dattaroy, Varun Chandrashekaran, Geoffrey I. Scott, Samir Raychoudhury, Mitzi Nagarkatti, Prakash Nagarkatti, Anna Mae Diehl, Saurabh ChatterjeeAbstractHigh circulatory insulin and leptin followed by underlying inflammation are often ascribed to the ectopic manifestations in non-alcoholic fatty liver disease (NAFLD) but the exact molecular pathways remain unclear. We have shown previously that CYP2E1-mediated oxidative stress and circulating leptin in NAFLD...
Source: Redox Biology - July 11, 2018 Category: Biology Source Type: research

Activation of the CXCL16/CXCR6 pathway promotes lipid deposition in fatty livers of apolipoprotein E knockout mice and HepG2 cells.
This study aimed to investigate the role of CXC chemokine ligand 16 (CXCL16) and its receptor CXC chemokine receptor 6 (CXCR6) in NAFLD under inflammation. We used IL-1β stimulation in human hepatoblastoma cell line (HepG2) for in vitro studies and casein injection in apolipoprotein E knockout mice in vivo to induce inflammatory stress. The effects of inflammation on cholesterol accumulation were examined by histochemical staining and a quantitative intracellular cholesterol assay. The gene and protein expression of molecules involved in CXCL16/CXCR6 pathway and extracellular matrix (ECM) were examined by real-time polyme...
Source: American Journal of Translational Research - July 19, 2018 Category: Research Tags: Am J Transl Res Source Type: research

Periostin promotes liver fibrogenesis by activating lysyl oxidase in hepatic stellate cells Molecular Bases of Disease
Liver fibrosis arises from dysregulated wound healing due to persistent inflammatory hepatic injury. Periostin is a nonstructural extracellular matrix protein that promotes organ fibrosis in adults. Here, we sought to identify the molecular mechanisms in periostin-mediated hepatic fibrosis. Hepatic fibrosis in periostin−/− mice was attenuated as evidenced by significantly reduced collagen fibril density and liver stiffness compared with those in WT controls. A single dose of carbon tetrachloride caused similar acute liver injury in periostin−/− and WT littermates, and we did not detect significant differences in tr...
Source: Journal of Biological Chemistry - August 17, 2018 Category: Chemistry Authors: Pradeep Kumar, Tekla Smith, Reben Raeman, Daniel M. Chopyk, Hannah Brink, Yunshan Liu, Todd Sulchek, Frank A. Anania Tags: Cell Biology Source Type: research

Yangonin protects against non-alcoholic fatty liver disease through farnesoid X receptor
ConclusionsYangonin protects against NAFLD due to its activation of FXR signalling to inhibit hepatic lipogenesis and gluconeogenesis, and to promote lipid metabolism and glycogen synthesis, as well as insulin sensitivity.Graphical abstract
Source: Phytomedicine - September 5, 2018 Category: Drugs & Pharmacology Source Type: research

Genipin Reverses HFD-Induced Liver Damage and Inhibits UCP2-Mediated Pyroptosis in Mice
Conclusion: GNP reverses HFD-induced liver damage and inhibits UCP2-mediated pyroptosis. Thus, GNP may serve as a potential therapeutic candidate for NAFLD.Cell Physiol Biochem 2018;49:1885 –1897
Source: Cellular Physiology and Biochemistry - September 20, 2018 Category: Cytology Source Type: research

Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces hepatic steatosis and endoplasmic reticulum stress by inducing nuclear factor erythroid-derived 2-related factor 2 nuclear translocation.
Abstract Activation of endoplasmic reticulum (ER) stress is involved in the development of nonalcoholic fatty liver disease. Glucagon-like peptide-1 (GLP-1) has been reported to reduce hepatic steatosis, but the underlying mechanism has not been fully elucidated. Here, we investigated whether exendin-4 (EX-4), a GLP-1 receptor analogue, improves hepatic steatosis through ER stress reduction. Furthermore, we explored which ER stress pathway is involved in this process, with a focus on the protein kinase RNA-like ER kinase (PERK)-nuclear factor erythroid-derived 2-related factor 2 (Nrf2) pathway. EX-4 treatment redu...
Source: Toxicology and Applied Pharmacology - September 22, 2018 Category: Toxicology Authors: Yoo J, Cho IJ, Jeong IK, Ahn KJ, Chung HY, Hwang YC Tags: Toxicol Appl Pharmacol Source Type: research

A Novel Regulatory Role of Apoptosis Antagonizing Transcription Factor in the Pathogenesis of NAFLD and HCC
Conclusion AATF drives NAFLD and hepatocarcinogenesis, offering a potential target for therapeutic intervention.This article is protected by copyright. All rights reserved.
Source: Hepatology - November 5, 2018 Category: Internal Medicine Authors: Divya P. Kumar, Prasanna K. Santhekadur, Mulugeta Seneshaw, Faridoddin Mirshahi, Cora Uram Tuculescu, Arun J. Sanyal Tags: Original Article Source Type: research

Xanthatin induces apoptosis by activating endoplasmic reticulum stress in hepatoma cells.
Abstract Hepatocellular carcinoma (HCC) has high incidence and mortality in patients with chronic liver diseases worldwide. However, there are limited chemotherapeutic agents for HCC in clinic. Xanthatin, a natural sesquiterpene lactone, has significant antitumor activity against a variety of cancers, but little is known about its effects on HCC and the underlying mechanism. Here, we evaluated the antitumor effects of xanthatin on human hepatoma cells. We found that xanthatin caused morphological changes and reduced cell viability in three HCC cell lines in concentration- and time-dependent manners. Xanthatin at 1...
Source: European Journal of Pharmacology - October 30, 2018 Category: Drugs & Pharmacology Authors: Shi TL, Zhang L, Yu JS, Cheng QR, Liu J, Shen YJ, Feng XJ, Shen YX Tags: Eur J Pharmacol Source Type: research

Effects of microRNA ‐217 on proliferation, apoptosis, and autophagy of hepatocytes in rat models of CCL4‐induced liver injury by targeting NAT2
This study aims to explore the effects of miR ‐217 targeting NAT2 on hepatocyte proliferation, apoptosis, and autophagy following carbon tetrachloride (CCL4)‐induced liver injury. Rat models of CCL4‐induced liver injury were established. Healthy Wistar rats were randomized into the normal, blank, negative control (NC), microRNA‐217 (miR ‐217) mimic, miR‐217 inhibitor, small interfering RNA (siRNA)‐N‐acetyltransferase 2 (NAT2), and miR‐217 inhibitor + siRNA‐NAT2 groups. NAT2 activity was evaluated with reversed‐phase high‐performance liquid chromatographic method. Immunohistochemistry was used t...
Source: Journal of Cellular Physiology - November 11, 2018 Category: Cytology Authors: Cheng ‐Liang Yang, Xiao‐Li Zheng, Ke Ye, Ya‐Nan Sun, Yu‐Fei Lu, Hong Ge, Hui Liu Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Repin1 deficiency in liver tissue alleviates NAFLD progression in mice
This study provides evidence that loss of Repin1 in the liver attenuates NAFLD progression, most likely by reducing fat accumulation and alleviating chronic tissue inflammation. Thus, modulating Repin1 expression may become a novel strategy and potential tool to inhibit NAFLD progression.Graphical abstract
Source: Journal of Advanced Research - November 23, 2018 Category: Research Source Type: research

Effects of sera of rats fed with Huganqingzhi tablets on endoplasmic reticulum stress in a HepG2 cell model of nonalcoholic fatty liver disease.
CONCLUSIONS: HGT serum can effectively prevent FFAs-induced steatosis in HepG2 cells by alleviating ER stress, in which PKC-δ may act as an important target. PMID: 30514673 [PubMed - in process]
Source: Journal of Southern Medical University - November 30, 2018 Category: Universities & Medical Training Authors: Yang M, Chen Z, Xiao C, Tang W, Zhou B Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBP α-SIRT1 pathway.
This study aimed to evaluate female adult offspring induced by prenatal caffeine exposure (PCE) are susceptible to non-alcoholic fatty liver disease (NAFLD) and to explore the underlying programming mechanisms. Pregnant rats were intragastrically administered caffeine (30, 60, and 120 mg/kg.d) on gestational day (GD) 9-20. The female adult offspring were randomly divided into three groups: offspring without or with chronic stress during postnatal week (PW) 10-12 and PW28 offspring. Results showed that PW28 PCE female offspring had a higher hepatic triglyceride content and Kleiner scores, accompanied by elevated serum cor...
Source: Toxicology - February 15, 2019 Category: Toxicology Authors: Hu S, Xia L, Luo H, Xu Y, Yu H, Xu D, Wang H Tags: Toxicology Source Type: research

NLRC4 inflammasome activation regulated by TNF- α promotes inflammatory responses in nonalcoholic fatty liver disease.
In this study, we used NLRC4-targeting siRNA and an NLRC4-encoding plasmid to demonstrate that the increases in IL-18 and IL-1β are mainly attributable to the activation of the NLR family CARD domain-containing protein 4 (NLRC4) inflammasome, which stimulates cellular pyroptosis. NLRC4 inflammasome activation is regulated by TNF-α and accompanies the translocation of NLRC4 from the cytoplasm into the mitochondria, but the specific mechanism is unclear. In summary, the increase in TNF-α during NAFLD promotes the activation of the NLRC4 inflammasome, which increases the production of IL-18 and IL-1β and triggers pyroptos...
Source: Biochemical and Biophysical Research communications - February 25, 2019 Category: Biochemistry Authors: Chen Y, Ma K Tags: Biochem Biophys Res Commun Source Type: research