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Condition: Liver Disease
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Total 328 results found since Jan 2013.
GSE223652 Hepatocyte mARC1 Promotes Fatty Liver Disease
ConclusionsCollectively, our findings from human genetics, and in vitro and in vivo hepatocyte-specific mARC1 knockdown support the potential efficacy of hepatocyte-specific targeting of mARC1 for treatment of NAFLD.
Source: GEO: Gene Expression Omnibus - April 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Quercetin and Allopurinol Reduce Liver Thioredoxin‐Interacting Protein to Improve Inflammation and Lipid Accumulation in Diabetic Rats
Conclusions and ImplicationsThese results demonstrate that hepatic TXNIP inhibition by quercetin and allopurinol contributes to the improvement of liver inflammation and lipid accumulation under hyperglycemia condition. Therefore, quercetin and allopurinol targeting hepatic TXNIP may have therapeutic application to prevent type 1 diabetes‐associated NAFLD.
Source: British Journal of Pharmacology - May 3, 2013 Category: Drugs & Pharmacology Authors: Wei Wang, Chuang Wang, Xiao‐Qin Ding, Ying Pan, Ting‐Ting Gu, Ming‐Xing Wang, Yang‐Liu Liu, Fu‐Meng Wang, Shui‐Juan Wang, Ling‐Dong Kong Tags: Research Paper Source Type: research
Quercetin and allopurinol reduce liver thioredoxin‐interacting protein to alleviate inflammation and lipid accumulation in diabetic rats
Conclusions and ImplicationsInhibition of hepatic TXNIP by quercetin and allopurinol contributes to the reduction in liver inflammation and lipid accumulation under hyperglycaemic conditions. The targeting of hepatic TXNIP by quercetin and allopurinol may have therapeutic implications for prevention of type 1 diabetes‐associated NAFLD.
Source: British Journal of Pharmacology - June 21, 2013 Category: Drugs & Pharmacology Authors: Wei Wang, Chuang Wang, Xiao‐Qin Ding, Ying Pan, Ting‐Ting Gu, Ming‐Xing Wang, Yang‐Liu Liu, Fu‐Meng Wang, Shui‐Juan Wang, Ling‐Dong Kong Tags: Research Paper Source Type: research
Ceacam1 Null Deletion Causes Vascular Alterations in Large Vessels.
Abstract
Carcinoembryonic antigen-related cell adhesion molecule1 (CEACAM1) promotes hepatic insulin clearance and endothelial survival. However, its role in the morphology of macrovessels remains unknown. Mice lacking Ceacam1 (Cc1(-/-)) exhibit hyperinsulinemia, which causes insulin resistance and fatty liver. With increasing evidence of an association between hyperinsulinemia, fatty liver disease and atherosclerosis, we investigated whether Cc1(-/-) exhibit vascular lesions in atherogenic-prone aortae. Histological analysis revealed impaired endothelial integrity with restricted fat deposition and aortic plaque-...
Source: American Journal of Physiology. Endocrinology and Metabolism - June 25, 2013 Category: Physiology Authors: Najjar SM, Ledford KJ, Abdallah SL, Paus A, Russo L, Kaw MK, Ramakrishnan S, Muturi HT, Raphael CK, Lester SG, Heinrich G, Pierre SV, Benndorf R, Kleff V, Jaffa AA, Levy E, Vazquez G, Goldberg IJ, Beauchemin N, Scalia R, Ergün S Tags: Am J Physiol Endocrinol Metab Source Type: research
Salvianolic acid A preconditioning confers protection against concanavalin A-induced liver injury through SIRT1-mediated repression of p66shc in mice.
Abstract
Salvianolic acid A (SalA) is a phenolic carboxylic acid derivative extracted from Salvia miltiorrhiza. It has many biological and pharmaceutical activities. The purpose of this study was to investigate the effect of SalA on concanavalin A (ConA)-induced acute hepatic injury in Kunming mice and to explore the role of SIRT1 in such an effect. The results showed that in vivo pretreatment with SalA significantly reduced ConA-induced elevation in serum alanine transaminase (ALT) and aspartate transaminase (AST) activities and decreased levels of the hepatotoxic cytokines such as interferon-gamma (IFN-γ) and t...
Source: Toxicology and Applied Pharmacology - August 28, 2013 Category: Toxicology Authors: Xu X, Hu Y, Zhai X, Lin M, Chen Z, Tian X, Zhang F, Gao D, Ma X, Lv L, Yao J Tags: Toxicol Appl Pharmacol Source Type: research
Ceacam1 deletion causes vascular alterations in large vessels
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes hepatic insulin clearance and endothelial survival. However, its role in the morphology of macrovessels remains unknown. Mice lacking Ceacam1 (Cc1–/–) exhibit hyperinsulinemia, which causes insulin resistance and fatty liver. With increasing evidence of an association among hyperinsulinemia, fatty liver disease, and atherosclerosis, we investigated whether Cc1–/– exhibited vascular lesions in atherogenic-prone aortae. Histological analysis revealed impaired endothelial integrity with restricted fat deposition and aortic pla...
Source: AJP: Endocrinology and Metabolism - August 15, 2013 Category: Endocrinology Authors: Najjar, S. M., Ledford, K. J., Abdallah, S. L., Paus, A., Russo, L., Kaw, M. K., Ramakrishnan, S. K., Muturi, H. T., Raphael, C. K., Lester, S. G., Heinrich, G., Pierre, S. V., Benndorf, R., Kleff, V., Jaffa, A. A., Levy, E., Vazquez, G., Goldberg, I. J., Tags: Articles Source Type: research
Smad6 suppresses the growth and self‐renewal of hepatic progenitor cells
Abstract
Activation of hepatic progenitor cells (HPCs) is commonly observed in chronic liver disease and Wnt/β‐catenin signaling plays a crucial role in the expansion of HPCs. However, the molecular mechanisms that regulate the activation of Wnt/β‐catenin signaling in the liver, especially in HPCs, remain largely elusive. Here we reported that ectopic expression of Smad6 suppressed the proliferation and self‐renewal of WB‐F344 cells, a HPC cell line. Mechanistically, we found that Smad6 inhibited Wnt/β‐catenin signaling through promoting the interaction of C‐terminal binding protein (CtBP) with β‐catenin/...
Source: Journal of Cellular Physiology - October 8, 2013 Category: Cytology Authors: Ze‐yang Ding, Hui‐fang Liang, Guan‐nan Jin, Wei‐xun Chen, Wei Wang, Pran K. Datta, Ming‐zhi Zhang, Bixiang Zhang, Xiao‐ping Chen Tags: Original Research Article Source Type: research
Keratin 8 is involved in hepatitis B virus replication
This study investigated HBV replication‐related host proteins and the effect of candidate proteins on HBV replication. Isobaric tags for relative and absolute quantitation (iTRAQ) were used to measure HBV replication‐related proteins in HepG2 cells and HepG2.2.15 cells. KRT8 was up‐regulated in HepG2.2.15 cells but not in HepG2 cells, and KRT8 was overexpressed in an HBV‐infected patient's liver tissue. This result suggested that KRT8 is involved in HBV replication. To further clarify the relationship between KRT8 and HBV replication, KRT8 gene expression was inhibited by siRNA. The silencing of KRT8 mildly suppres...
Source: Journal of Medical Virology - December 30, 2013 Category: Virology Authors: Qing Zhong, Xuan An, Yi‐Xuan Yang, Huai‐Dong Hu, Hong Ren, Peng Hu Tags: Research Article Source Type: research
Exendin-4 attenuates endoplasmic reticulum stress through a SIRT1-dependent mechanism.
In conclusion, increased SIRT1 by exendin-4 attenuates PA-induced ER stress and mitochondrial dysfunction in hepatocytes.
PMID: 24446069 [PubMed - as supplied by publisher]
Source: Cell Stress and Chaperones - January 21, 2014 Category: Cytology Authors: Lee J, Hong SW, Park SE, Rhee EJ, Park CY, Oh KW, Park SW, Lee WY Tags: Cell Stress Chaperones Source Type: research
4-Hydroxynonenal induces an increase in expression of Receptor for Activating C Kinase 1 (RACK1) in Chinese hamster V79-4 lung cells.
In this study, the effect of HNE on the levels of proteins in V79-4 Chinese hamster lung cells was investigated using two-dimensional electrophoresis and mass spectrometry. The results revealed that the expression of 23 proteins was increased by at least 2-fold and the expression of 19 proteins was decreased by at least 2-fold after exposure to 10 μM HNE for 24 hours. Decreased proteins included the metabolic enzyme phosphoglycerate kinase 1 (PGK1), levels of which were decreased by 47%. Levels of the apoptotic indicator Lamin C were decreased by 33%. In contrast, levels of the scaffolding protein Receptor for Activating ...
Source: Chemico-Biological Interactions - February 10, 2014 Category: Molecular Biology Authors: Li D, Ellis EM Tags: Chem Biol Interact Source Type: research
Metabolic profiling reveals that pnpla3 induces widespread effects on metabolism beyond triacylglycerol remodeling in huh-7 hepatoma cells.
METABOLIC PROFILING REVEALS THAT PNPLA3 INDUCES WIDESPREAD EFFECTS ON METABOLISM BEYOND TRIACYLGLYCEROL REMODELING IN HUH-7 HEPATOMA CELLS.
Am J Physiol Gastrointest Liver Physiol. 2014 Apr 24;
Authors: Min HK, Sookoian SC, Pirola CJ, Cheng J, Mirshahi F, Sanyal AJ
Abstract
PNPLA3 was recently associated with the susceptibility to nonalcoholic fatty liver disease, a common cause of chronic liver disease characterized by abnormal triglyceride accumulation. While it is established that PNPLA3 has both triacylglycerol lipase and acylglycerol O-acyltransferase activities, is still unknown whether the gene...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - April 24, 2014 Category: Physiology Authors: Min HK, Sookoian SC, Pirola CJ, Cheng J, Mirshahi F, Sanyal AJ Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research
The role of von Willebrand factor as a biomarker of tumor development in hepatitis B virus-associated human hepatocellular carcinoma: a quantitative proteomic based study.
We report comparative plasma proteome profiles of HBV-associated HCC and nonmalignant chronic liver diseases, including chronic hepatitis B and cirrhosis. The quantification of these datasets showed altered abundance of 21 proteins in HBV-related HCC and provides a reference point for future applied and basic research. In addition, we have demonstrated that the candidate protein vWF is involved in the pathogenesis of HBV infection and replication, and also associated with clinicopathologic staging of HCC patients with HBV infection. Overall these findings provide information on the mechanism of HCC development, which may a...
Source: Journal of Proteomics - April 23, 2014 Category: Biochemistry Authors: Liu Y, Wang X, Li S, Hu H, Zhang D, Hu P, Yang Y, Ren H Tags: J Proteomics Source Type: research
Metabolic profiling reveals that PNPLA3 induces widespread effects on metabolism beyond triacylglycerol remodeling in Huh-7 hepatoma cells
PNPLA3 was recently associated with the susceptibility to nonalcoholic fatty liver disease, a common cause of chronic liver disease characterized by abnormal triglyceride accumulation. Although it is established that PNPLA3 has both triacylglycerol lipase and acylglycerol O-acyltransferase activities, is still unknown whether the gene has any additional role in the modulation of the human liver metabolome. To uncover the functional role of PNPLA3 on liver metabolism, we performed high-throughput metabolic profiling of PNPLA3 siRNA-silencing and overexpression of wild-type and mutant Ile148Met variants (isoleucine/methionin...
Source: AJP: Gastrointestinal and Liver Physiology - July 1, 2014 Category: Gastroenterology Authors: Min, H.-K., Sookoian, S., Pirola, C. J., Cheng, J., Mirshahi, F., Sanyal, A. J. Tags: LIVER AND BILIARY TRACT Source Type: research
Shp/Npas2 axis in regulating the oscillation of liver lipid metabolism
Conclusion: Shp and Npas2 crosstalk is essential to maintain hepatic lipid homeostasis. (Hepatology 2014)
Source: Hepatology - September 12, 2014 Category: Internal Medicine Authors: Sang Min Lee, Yuxia Zhang, Hiroyuki Tsuchiya, Rana Smalling, Anton M. Jetten, Li Wang Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
ASPP2 attenuates triglycerides to protect against hepatocyte injury by reducing autophagy in a cell and mouse model of non‐alcoholic fatty liver disease
In conclusion, ASPP2 may participate in the lipid metabolism of non‐alcoholic steatohepatitis and attenuate liver failure.
Source: Journal of Cellular and Molecular Medicine - September 25, 2014 Category: Molecular Biology Authors: Fang Xie, Lin Jia, Minghua Lin, Ying Shi, Jiming Yin, Yin Liu, Dexi Chen, Qinghua Meng Tags: Original Article Source Type: research
