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Condition: Liver Disease

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Total 328 results found since Jan 2013.

Hyperhomocysteinemia Activates the Aryl Hydrocarbon Receptor‐CD36 Pathway to Promote Hepatic Steatosis in Mice
In conclusion, our results strongly suggest that HHcy activated the AHR‐CD36 pathway by increasing hepatic LXA4 content, which resulted in hepatic steatosis. This article is protected by copyright. All rights reserved.
Source: Hepatology - February 29, 2016 Category: Internal Medicine Authors: Liu Yao, Chunjiong Wang, Xu Zhang, Liyuan Peng, Wenli Liu, Xuejiao Zhang, Yajin Liu, Jinlong He, Changtao Jiang, Ding Ai, Yi Zhu Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research

Palmitate-induced Regulation of PPARγ via PGC1α: a Mechanism for Lipid Accumulation in the Liver in Nonalcoholic Fatty Liver Disease.
In conclusion, palmitate appear to up-regulate PPARγ via PGC1α in Huh7 cells, and both PGC1α and PPARγ are up-regulated in the NAFLD mice liver, suggesting an effect on lipid metabolism leading to intrahepatic triglyceride accumulation. PMID: 26941577 [PubMed - in process]
Source: International Journal of Medical Sciences - March 6, 2016 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Punicalagin attenuates palmitate‐induced lipotoxicity in HepG2 cells by activating the Keap1‐Nrf2 antioxidant defense system
Conclusions: These findings suggest that punicalagin could effectively attenuate FFA‐induced lipotoxicity by activating Keap1‐Nrf2 cytoprotective signaling pathway.This article is protected by copyright. All rights reserved
Source: Nahrung / Food - March 15, 2016 Category: Nutrition Authors: Chunhong Yan, Wenyan Sun, Xun Wang, Jiangang Long, Xuebo Liu, Zhihui Feng, Jiankang Liu Tags: Research Article Source Type: research

Hyperhomocysteinemia activates the aryl hydrocarbon receptor/CD36 pathway to promote hepatic steatosis in mice
Conclusion: In conclusion, our results strongly suggest that HHcy activated the AHR‐CD36 pathway by increasing hepatic LXA4 content, which resulted in HS. (Hepatology 2016; 00:000–000)
Source: Hepatology - April 4, 2016 Category: Internal Medicine Authors: Liu Yao, Chunjiong Wang, Xu Zhang, Liyuan Peng, Wenli Liu, Xuejiao Zhang, Yajin Liu, Jinlong He, Changtao Jiang, Ding Ai, Yi Zhu Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research

Peroxisome proliferator-activated receptor alpha acts as a mediator of endoplasmic reticulum stress-induced hepatocyte apoptosis in acute liver failure RESEARCH ARTICLE
This study aimed to investigate whether PPARα activation inhibits ER stress-induced hepatocyte apoptosis, thereby protecting against ALF. In a murine model of D-galactosamine (D-GalN)- and lipopolysaccharide (LPS)-induced ALF, Wy-14643 was administered to activate PPARα, and 4-phenylbutyric acid (4-PBA) was administered to attenuate ER stress. PPARα activation ameliorated liver injury, because pre-administration of its specific inducer, Wy-14643, reduced the serum aminotransferase levels and preserved liver architecture compared with that of controls. The protective effect of PPARα activation result...
Source: DMM Disease Models and Mechanisms - July 5, 2016 Category: Biomedical Science Authors: Zhang, L., Ren, F., Zhang, X., Wang, X., Shi, H., Zhou, L., Zheng, S., Chen, Y., Chen, D., Li, L., Zhao, C., Duan, Z. Tags: RESEARCH ARTICLE Source Type: research

Nrf2 Is Crucial For The Down-Regulation Of Cyp7a1 Induced By Arachidonic Acid In Hepg2 Cells
In conclusion, Nrf2 plays a significant role in the down-regulation of CYP7A1 induced by AA in HepG2 cells.Abbreviations: AA, arachidonic acid; CYP7A1, cholesterol 7α-hydroxylase; FA, fatty acid; HFD, high-fat diet; NAFLD, non-alcoholic fatty liver disease; Nrf2, nuclear factor erythroid-derived 2-like 2; siRNA, small interfering RNA.
Source: Environmental Toxicology and Pharmacology - March 7, 2017 Category: Environmental Health Source Type: research

SIRT3 Acts As a Negative Regulator of Autophagy Dictating Hepatocyte Susceptibility to Lipotoxicity
Conclusion: our data identified SIRT3 to be a novel negative regulator of autophagy, whose activation by SFAs contributes to lipotoxicity in hepatocytes and suggest that restraining SIRT3 overactivation can be a potential therapeutic choice for the treatment of NAFLD as well as other metabolic disorders, with lipotoxicity being the principal pathomechanism. This article is protected by copyright. All rights reserved.
Source: Hepatology - April 24, 2017 Category: Internal Medicine Authors: Songtao Li, Xiaobing Dou, Hua Ning, Qing Song, Wei Wei, Ximei Zhang, Chen Shen, Jiaxin Li, Changhao Sun, Zhenyuan Song Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research

Down-regulation of the expression of alcohol dehydrogenase 4 and CYP2E1 by the combination of α-endosulfan and dioxin in HepaRG human cells.
Abstract Pesticides and other persistent organic pollutants are considered as risk factors for liver diseases. We treated the human hepatic cell line HepaRG with both 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) and the organochlorine pesticide, α-endosulfan, to evaluate their combined impact on the expression of hepatic genes involved in alcohol metabolism. We show that the combination of the two pollutants (25nM TCDD and 10μM α-endosulfan) led to marked decreases in the amounts of both the mRNA (up to 90%) and protein (up to 60%) of ADH4 and CYP2E1. Similar results were obtained following 24h or 8days of treatm...
Source: Toxicology in Vitro - June 30, 2017 Category: Toxicology Authors: Attignon EA, Distel E, Le-Grand B, Leblanc AF, Barouki R, de Oliveira E, Aggerbeck M, Blanc EB Tags: Toxicol In Vitro Source Type: research

Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity
Conclusion: Our data indicate that SIRT3 is a negative regulator of autophagy whose activation by SFAs contributes to lipotoxicity in hepatocytes and suggest that restraining SIRT3 overactivation can be a potential therapeutic choice for the treatment of NAFLD as well as other metabolic disorders, with lipotoxicity being the principal pathomechanism. (Hepatology 2017).
Source: Hepatology - July 20, 2017 Category: Internal Medicine Authors: Songtao Li, Xiaobing Dou, Hua Ning, Qing Song, Wei Wei, Ximei Zhang, Chen Shen, Jiaxin Li, Changhao Sun, Zhenyuan Song Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research

CREB Mediates Alcohol ‐Induced Circadian Disruption and Intestinal Permeability
ConclusionsTaken together, these data suggest that strategies to reduce alcohol‐induced oxidative stress may alleviate alcohol mediated circadian disruption and intestinal leakiness, critical drivers of ALD.This article is protected by copyright. All rights reserved.
Source: Alcoholism: Clinical and Experimental Research - September 1, 2017 Category: Addiction Authors: Booker T Davis, Robin M. Voigt, Maliha Shaikh, Christopher B. Forsyth, Ali Keshavarzian Tags: Original Research Article Source Type: research

CREB Mediates Alcohol-Induced Circadian Disruption and Intestinal Permeability.
CONCLUSIONS: Taken together, these data suggest that strategies to reduce alcohol-induced oxidative stress may alleviate alcohol mediated circadian disruption and intestinal leakiness, critical drivers of ALD. This article is protected by copyright. All rights reserved. PMID: 28960346 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - September 27, 2017 Category: Addiction Authors: Davis BT, Voigt RM, Shaikh M, Forsyth CB, Keshavarzian A Tags: Alcohol Clin Exp Res Source Type: research

CREB Protein Mediates Alcohol ‐Induced Circadian Disruption and Intestinal Permeability
ConclusionsTaken together, these data suggest that strategies to reduce alcohol‐induced oxidative stress may alleviate alcohol‐mediated circadian disruption and intestinal leakiness, critical drivers of ALD. CREB Mediates Alcohol‐Induced Circadian Disruption and Intestinal Permeability (A) CLOCK and BMAL1 initiate the transcription of circadian clock genes like PER2. PER2 forms a heterodimer with CRY1 inhibiting clock gene expression. This process takes approximately 24 h. (B) We hypothesize that Cyp2e1‐mediated alcohol metabolism activates cAMP response element‐binding (CREB) protein to induce circadian gene e...
Source: Alcoholism: Clinical and Experimental Research - October 30, 2017 Category: Addiction Authors: Booker T Davis, Robin M. Voigt, Maliha Shaikh, Christopher B. Forsyth, Ali Keshavarzian Tags: Original Article Source Type: research

miR-192-5p regulates lipid synthesis in non-alcoholic fatty liver disease through SCD-1.
CONCLUSION: This study demonstrates that miR-192-5p has a negative regulatory role in lipid synthesis, which is mediated through its direct regulation of SCD-1. PMID: 29290651 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 14, 2017 Category: Gastroenterology Authors: Liu XL, Cao HX, Wang BC, Xin FZ, Zhang RN, Zhou D, Yang RX, Zhao ZH, Pan Q, Fan JG Tags: World J Gastroenterol Source Type: research

Oroxylin A inhibits ethanol ‐induced hepatocyte senescence via YAP pathway
ConclusionTherefore, these aggregated data suggested that oroxylin A relieved alcoholic liver injury possibly by inhibiting the senescence of hepatocyte, which was dependent on its activation of YAP in hepatocytes.
Source: Cell Proliferation - January 10, 2018 Category: Cytology Authors: Huanhuan Jin, Naqi Lian, Mianli Bian, Chenxi Zhang, Xingran Chen, Jiangjuan Shao, Li Wu, Anping Chen, Qinglong Guo, Feng Zhang, Shizhong Zheng Tags: ORIGINAL ARTICLE Source Type: research

Farnesoid X Receptor Signaling Activates the Hepatic X ‐box Binding Protein 1 Pathway in vitro and in Mice
Conclusion: FXR signaling activates the IRE1α/XBP1 pathway in vivo and in vitro. FXR pathway activation increases XBP1 splicing and enhances phosphorylated‐IRE1α expression. These effects are mediated, at least in part, by SHP. IRE1α/XBP1 pathway activation by bile acids and pharmacologic FXR agonists may be protective during liver injury and may have therapeutic implications for liver diseases. This article is protected by copyright. All rights reserved.
Source: Hepatology - January 30, 2018 Category: Internal Medicine Authors: Xiaoying Liu, Grace L. Guo, Bo Kong, David B. Hilburn, Susan C. Hubchak, Seong Park, Brian LeCuyer, Antony Hsieh, Li Wang, Deyu Fang, Richard M. Green Tags: Liver Biology and Pathobiology Source Type: research